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Q9CXU1

- MED31_MOUSE

UniProt

Q9CXU1 - MED31_MOUSE

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Protein
Mediator of RNA polymerase II transcription subunit 31
Gene
Med31, Soh1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. limb development Source: MGI
  2. negative regulation of fibroblast proliferation Source: MGI
  3. protein complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_206529. Generic Transcription Pathway.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 31
Alternative name(s):
Mediator complex subunit 31
Mediator complex subunit SOH1
Gene namesi
Name:Med31
Synonyms:Soh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1914529. Med31.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. mediator complex Source: MGI
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 131130Mediator of RNA polymerase II transcription subunit 31
PRO_0000212528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9CXU1.
PRIDEiQ9CXU1.

PTM databases

PhosphoSiteiQ9CXU1.

Expressioni

Gene expression databases

BgeeiQ9CXU1.
GenevestigatoriQ9CXU1.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Med19Q8C1S02EBI-309355,EBI-398761

Protein-protein interaction databases

BioGridi212068. 2 interactions.
IntActiQ9CXU1. 6 interactions.
MINTiMINT-219187.
STRINGi10090.ENSMUSP00000021157.

Structurei

3D structure databases

ProteinModelPortaliQ9CXU1.
SMRiQ9CXU1. Positions 17-79.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi122 – 1254Poly-Gln

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5088.
GeneTreeiENSGT00390000015531.
HOGENOMiHOG000242147.
HOVERGENiHBG052449.
InParanoidiQ9CXU1.
KOiK15153.
OMAiSCKSEMA.
OrthoDBiEOG761BWW.
PhylomeDBiQ9CXU1.
TreeFamiTF105799.

Family and domain databases

InterProiIPR008831. Mediator_Med31.
[Graphical view]
PANTHERiPTHR13186. PTHR13186. 1 hit.
PfamiPF05669. Med31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXU1-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN    50
YLKYLLYWKE PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ 100
QILHWQHYSR KRVRLQQALA EQQQQNNTAG K 131
Length:131
Mass (Da):15,771
Last modified:October 31, 2003 - v2
Checksum:iA9837A88EC94D014
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861K → E in BAB29102. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005655 mRNA. Translation: BAB24169.1.
AK013990 mRNA. Translation: BAB29102.1.
BX119911 Genomic DNA. Translation: CAI24479.1.
BC019685 mRNA. Translation: AAH19685.1.
BC051929 mRNA. Translation: AAH51929.1.
CCDSiCCDS24981.1.
RefSeqiNP_080344.2. NM_026068.2.
UniGeneiMm.159496.

Genome annotation databases

EnsembliENSMUST00000021157; ENSMUSP00000021157; ENSMUSG00000020801.
GeneIDi67279.
KEGGimmu:67279.
UCSCiuc007jyk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005655 mRNA. Translation: BAB24169.1 .
AK013990 mRNA. Translation: BAB29102.1 .
BX119911 Genomic DNA. Translation: CAI24479.1 .
BC019685 mRNA. Translation: AAH19685.1 .
BC051929 mRNA. Translation: AAH51929.1 .
CCDSi CCDS24981.1.
RefSeqi NP_080344.2. NM_026068.2.
UniGenei Mm.159496.

3D structure databases

ProteinModelPortali Q9CXU1.
SMRi Q9CXU1. Positions 17-79.
ModBasei Search...

Protein-protein interaction databases

BioGridi 212068. 2 interactions.
IntActi Q9CXU1. 6 interactions.
MINTi MINT-219187.
STRINGi 10090.ENSMUSP00000021157.

PTM databases

PhosphoSitei Q9CXU1.

Proteomic databases

PaxDbi Q9CXU1.
PRIDEi Q9CXU1.

Protocols and materials databases

DNASUi 67279.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021157 ; ENSMUSP00000021157 ; ENSMUSG00000020801 .
GeneIDi 67279.
KEGGi mmu:67279.
UCSCi uc007jyk.1. mouse.

Organism-specific databases

CTDi 51003.
MGIi MGI:1914529. Med31.

Phylogenomic databases

eggNOGi COG5088.
GeneTreei ENSGT00390000015531.
HOGENOMi HOG000242147.
HOVERGENi HBG052449.
InParanoidi Q9CXU1.
KOi K15153.
OMAi SCKSEMA.
OrthoDBi EOG761BWW.
PhylomeDBi Q9CXU1.
TreeFami TF105799.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_206529. Generic Transcription Pathway.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

NextBioi 324090.
PROi Q9CXU1.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXU1.
Genevestigatori Q9CXU1.

Family and domain databases

InterProi IPR008831. Mediator_Med31.
[Graphical view ]
PANTHERi PTHR13186. PTHR13186. 1 hit.
Pfami PF05669. Med31. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiMED31_MOUSE
AccessioniPrimary (citable) accession number: Q9CXU1
Secondary accession number(s): Q9DAP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: September 3, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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