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Q9CXU1

- MED31_MOUSE

UniProt

Q9CXU1 - MED31_MOUSE

Protein

Mediator of RNA polymerase II transcription subunit 31

Gene

Med31

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. RNA polymerase II transcription cofactor activity Source: InterPro

    GO - Biological processi

    1. limb development Source: MGI
    2. negative regulation of fibroblast proliferation Source: MGI
    3. protein complex assembly Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 31
    Alternative name(s):
    Mediator complex subunit 31
    Mediator complex subunit SOH1
    Gene namesi
    Name:Med31
    Synonyms:Soh1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1914529. Med31.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. mediator complex Source: MGI
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 131130Mediator of RNA polymerase II transcription subunit 31PRO_0000212528Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9CXU1.
    PRIDEiQ9CXU1.

    PTM databases

    PhosphoSiteiQ9CXU1.

    Expressioni

    Gene expression databases

    BgeeiQ9CXU1.
    GenevestigatoriQ9CXU1.

    Interactioni

    Subunit structurei

    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Med19Q8C1S02EBI-309355,EBI-398761

    Protein-protein interaction databases

    BioGridi212068. 2 interactions.
    IntActiQ9CXU1. 6 interactions.
    MINTiMINT-219187.
    STRINGi10090.ENSMUSP00000021157.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXU1.
    SMRiQ9CXU1. Positions 17-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi122 – 1254Poly-Gln

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 31 family.Curated

    Phylogenomic databases

    eggNOGiCOG5088.
    GeneTreeiENSGT00390000015531.
    HOGENOMiHOG000242147.
    HOVERGENiHBG052449.
    InParanoidiQ9CXU1.
    KOiK15153.
    OMAiSCKSEMA.
    OrthoDBiEOG761BWW.
    PhylomeDBiQ9CXU1.
    TreeFamiTF105799.

    Family and domain databases

    InterProiIPR008831. Mediator_Med31.
    [Graphical view]
    PANTHERiPTHR13186. PTHR13186. 1 hit.
    PfamiPF05669. Med31. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CXU1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVAMETD DAGNRLRFQL ELEFVQCLAN PNYLNFLAQR GYFKDKAFVN    50
    YLKYLLYWKE PEYAKYLKYP QCLHMLELLQ YEHFRKELVN AQCAKFIDEQ 100
    QILHWQHYSR KRVRLQQALA EQQQQNNTAG K 131
    Length:131
    Mass (Da):15,771
    Last modified:October 31, 2003 - v2
    Checksum:iA9837A88EC94D014
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861K → E in BAB29102. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005655 mRNA. Translation: BAB24169.1.
    AK013990 mRNA. Translation: BAB29102.1.
    BX119911 Genomic DNA. Translation: CAI24479.1.
    BC019685 mRNA. Translation: AAH19685.1.
    BC051929 mRNA. Translation: AAH51929.1.
    CCDSiCCDS24981.1.
    RefSeqiNP_080344.2. NM_026068.2.
    UniGeneiMm.159496.

    Genome annotation databases

    EnsembliENSMUST00000021157; ENSMUSP00000021157; ENSMUSG00000020801.
    GeneIDi67279.
    KEGGimmu:67279.
    UCSCiuc007jyk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005655 mRNA. Translation: BAB24169.1 .
    AK013990 mRNA. Translation: BAB29102.1 .
    BX119911 Genomic DNA. Translation: CAI24479.1 .
    BC019685 mRNA. Translation: AAH19685.1 .
    BC051929 mRNA. Translation: AAH51929.1 .
    CCDSi CCDS24981.1.
    RefSeqi NP_080344.2. NM_026068.2.
    UniGenei Mm.159496.

    3D structure databases

    ProteinModelPortali Q9CXU1.
    SMRi Q9CXU1. Positions 17-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212068. 2 interactions.
    IntActi Q9CXU1. 6 interactions.
    MINTi MINT-219187.
    STRINGi 10090.ENSMUSP00000021157.

    PTM databases

    PhosphoSitei Q9CXU1.

    Proteomic databases

    PaxDbi Q9CXU1.
    PRIDEi Q9CXU1.

    Protocols and materials databases

    DNASUi 67279.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021157 ; ENSMUSP00000021157 ; ENSMUSG00000020801 .
    GeneIDi 67279.
    KEGGi mmu:67279.
    UCSCi uc007jyk.1. mouse.

    Organism-specific databases

    CTDi 51003.
    MGIi MGI:1914529. Med31.

    Phylogenomic databases

    eggNOGi COG5088.
    GeneTreei ENSGT00390000015531.
    HOGENOMi HOG000242147.
    HOVERGENi HBG052449.
    InParanoidi Q9CXU1.
    KOi K15153.
    OMAi SCKSEMA.
    OrthoDBi EOG761BWW.
    PhylomeDBi Q9CXU1.
    TreeFami TF105799.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    NextBioi 324090.
    PROi Q9CXU1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXU1.
    Genevestigatori Q9CXU1.

    Family and domain databases

    InterProi IPR008831. Mediator_Med31.
    [Graphical view ]
    PANTHERi PTHR13186. PTHR13186. 1 hit.
    Pfami PF05669. Med31. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiMED31_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXU1
    Secondary accession number(s): Q9DAP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 31, 2003
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3