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Q9CXT8

- MPPB_MOUSE

UniProt

Q9CXT8 - MPPB_MOUSE

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Protein

Mitochondrial-processing peptidase subunit beta

Gene

Pmpcb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

Catalytic activityi

Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011ZincPROSITE-ProRule annotation
Active sitei104 – 1041Proton acceptorPROSITE-ProRule annotation
Metal bindingi105 – 1051ZincPROSITE-ProRule annotation
Metal bindingi181 – 1811ZincPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_199101. Mitochondrial protein import.

Protein family/group databases

MEROPSiM16.977.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
Alternative name(s):
Beta-MPP
P-52
Gene namesi
Name:Pmpcb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1920328. Pmpcb.

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: MGI
  2. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4545MitochondrionBy similarityAdd
BLAST
Chaini46 – 489444Mitochondrial-processing peptidase subunit betaPRO_0000026778Add
BLAST

Proteomic databases

MaxQBiQ9CXT8.
PaxDbiQ9CXT8.
PRIDEiQ9CXT8.

2D gel databases

REPRODUCTION-2DPAGEQ9CXT8.

PTM databases

PhosphoSiteiQ9CXT8.

Expressioni

Gene expression databases

BgeeiQ9CXT8.
CleanExiMM_PMPCB.
ExpressionAtlasiQ9CXT8. baseline and differential.
GenevestigatoriQ9CXT8.

Interactioni

Subunit structurei

Heterodimer of alpha and beta subunits.By similarity

Protein-protein interaction databases

IntActiQ9CXT8. 2 interactions.
MINTiMINT-4102397.

Structurei

3D structure databases

ProteinModelPortaliQ9CXT8.
SMRiQ9CXT8. Positions 50-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M16 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0612.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiQ9CXT8.
KOiK17732.
OMAiCTSVTEN.
OrthoDBiEOG74R1QJ.
PhylomeDBiQ9CXT8.
TreeFamiTF105032.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.
PROSITEiPS00143. INSULINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAALSRTL LPEARRRLWG FTRRLPLRRA AAQPLYFGGD RLRSTQAAPQ
60 70 80 90 100
VVLNVPETQV TCLENGLRVA SENSGLSTCT VGLWIDAGSR YENEKNNGTA
110 120 130 140 150
HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSRDL
160 170 180 190 200
PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT
210 220 230 240 250
AYQNTALGRT ILGPTENIKS INRKDLVDYI TTHYKGPRIV LAAAGGVCHN
260 270 280 290 300
ELLELAKFHF GDSLCSHKGA IPALPPCKFT GSEIRVRDDK MPLAHLAIAV
310 320 330 340 350
EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF
360 370 380 390 400
QSFNTSYTDT GLWGLYMVCE QATVADMLHV VQNEWKRLCT DVTESEVARA
410 420 430 440 450
KNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVDAETV
460 470 480
RRVCTKYIHD KSPAIAALGP IERLPDFNQI CSNMRWIRD
Length:489
Mass (Da):54,614
Last modified:June 1, 2001 - v1
Checksum:i1B594EE0B6FE34A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013995 mRNA. Translation: BAB29105.1.
CCDSiCCDS19106.1.
RefSeqiNP_082707.1. NM_028431.2.
UniGeneiMm.301655.

Genome annotation databases

EnsembliENSMUST00000030882; ENSMUSP00000030882; ENSMUSG00000029017.
GeneIDi73078.
KEGGimmu:73078.
UCSCiuc008wox.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013995 mRNA. Translation: BAB29105.1 .
CCDSi CCDS19106.1.
RefSeqi NP_082707.1. NM_028431.2.
UniGenei Mm.301655.

3D structure databases

ProteinModelPortali Q9CXT8.
SMRi Q9CXT8. Positions 50-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CXT8. 2 interactions.
MINTi MINT-4102397.

Protein family/group databases

MEROPSi M16.977.

PTM databases

PhosphoSitei Q9CXT8.

2D gel databases

REPRODUCTION-2DPAGE Q9CXT8.

Proteomic databases

MaxQBi Q9CXT8.
PaxDbi Q9CXT8.
PRIDEi Q9CXT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030882 ; ENSMUSP00000030882 ; ENSMUSG00000029017 .
GeneIDi 73078.
KEGGi mmu:73078.
UCSCi uc008wox.1. mouse.

Organism-specific databases

CTDi 9512.
MGIi MGI:1920328. Pmpcb.

Phylogenomic databases

eggNOGi COG0612.
GeneTreei ENSGT00550000074701.
HOGENOMi HOG000242450.
HOVERGENi HBG006393.
InParanoidi Q9CXT8.
KOi K17732.
OMAi CTSVTEN.
OrthoDBi EOG74R1QJ.
PhylomeDBi Q9CXT8.
TreeFami TF105032.

Enzyme and pathway databases

Reactomei REACT_199101. Mitochondrial protein import.

Miscellaneous databases

NextBioi 337429.
PROi Q9CXT8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXT8.
CleanExi MM_PMPCB.
ExpressionAtlasi Q9CXT8. baseline and differential.
Genevestigatori Q9CXT8.

Family and domain databases

Gene3Di 3.30.830.10. 2 hits.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR001431. Pept_M16_Zn_BS.
IPR007863. Peptidase_M16_C.
[Graphical view ]
Pfami PF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view ]
SUPFAMi SSF63411. SSF63411. 2 hits.
PROSITEi PS00143. INSULINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.

Entry informationi

Entry nameiMPPB_MOUSE
AccessioniPrimary (citable) accession number: Q9CXT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3