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Q9CXT8

- MPPB_MOUSE

UniProt

Q9CXT8 - MPPB_MOUSE

Protein

Mitochondrial-processing peptidase subunit beta

Gene

Pmpcb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Cleaves presequences (transit peptides) from mitochondrial protein precursors.By similarity

    Catalytic activityi

    Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi101 – 1011ZincPROSITE-ProRule annotation
    Active sitei104 – 1041Proton acceptorPROSITE-ProRule annotation
    Metal bindingi105 – 1051ZincPROSITE-ProRule annotation
    Metal bindingi181 – 1811ZincPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_199101. Mitochondrial protein import.

    Protein family/group databases

    MEROPSiM16.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial-processing peptidase subunit beta (EC:3.4.24.64)
    Alternative name(s):
    Beta-MPP
    P-52
    Gene namesi
    Name:Pmpcb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1920328. Pmpcb.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4545MitochondrionBy similarityAdd
    BLAST
    Chaini46 – 489444Mitochondrial-processing peptidase subunit betaPRO_0000026778Add
    BLAST

    Proteomic databases

    MaxQBiQ9CXT8.
    PaxDbiQ9CXT8.
    PRIDEiQ9CXT8.

    2D gel databases

    REPRODUCTION-2DPAGEQ9CXT8.

    PTM databases

    PhosphoSiteiQ9CXT8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CXT8.
    BgeeiQ9CXT8.
    CleanExiMM_PMPCB.
    GenevestigatoriQ9CXT8.

    Interactioni

    Subunit structurei

    Heterodimer of alpha and beta subunits.By similarity

    Protein-protein interaction databases

    IntActiQ9CXT8. 2 interactions.
    MINTiMINT-4102397.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXT8.
    SMRiQ9CXT8. Positions 50-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M16 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0612.
    GeneTreeiENSGT00550000074701.
    HOGENOMiHOG000242450.
    HOVERGENiHBG006393.
    InParanoidiQ9CXT8.
    KOiK17732.
    OMAiCTSVTEN.
    OrthoDBiEOG74R1QJ.
    PhylomeDBiQ9CXT8.
    TreeFamiTF105032.

    Family and domain databases

    Gene3Di3.30.830.10. 2 hits.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR001431. Pept_M16_Zn_BS.
    IPR007863. Peptidase_M16_C.
    [Graphical view]
    PfamiPF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF63411. SSF63411. 2 hits.
    PROSITEiPS00143. INSULINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CXT8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAALSRTL LPEARRRLWG FTRRLPLRRA AAQPLYFGGD RLRSTQAAPQ    50
    VVLNVPETQV TCLENGLRVA SENSGLSTCT VGLWIDAGSR YENEKNNGTA 100
    HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSRDL 150
    PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT 200
    AYQNTALGRT ILGPTENIKS INRKDLVDYI TTHYKGPRIV LAAAGGVCHN 250
    ELLELAKFHF GDSLCSHKGA IPALPPCKFT GSEIRVRDDK MPLAHLAIAV 300
    EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF 350
    QSFNTSYTDT GLWGLYMVCE QATVADMLHV VQNEWKRLCT DVTESEVARA 400
    KNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVDAETV 450
    RRVCTKYIHD KSPAIAALGP IERLPDFNQI CSNMRWIRD 489
    Length:489
    Mass (Da):54,614
    Last modified:June 1, 2001 - v1
    Checksum:i1B594EE0B6FE34A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013995 mRNA. Translation: BAB29105.1.
    CCDSiCCDS19106.1.
    RefSeqiNP_082707.1. NM_028431.2.
    UniGeneiMm.301655.

    Genome annotation databases

    EnsembliENSMUST00000030882; ENSMUSP00000030882; ENSMUSG00000029017.
    GeneIDi73078.
    KEGGimmu:73078.
    UCSCiuc008wox.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013995 mRNA. Translation: BAB29105.1 .
    CCDSi CCDS19106.1.
    RefSeqi NP_082707.1. NM_028431.2.
    UniGenei Mm.301655.

    3D structure databases

    ProteinModelPortali Q9CXT8.
    SMRi Q9CXT8. Positions 50-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CXT8. 2 interactions.
    MINTi MINT-4102397.

    Protein family/group databases

    MEROPSi M16.003.

    PTM databases

    PhosphoSitei Q9CXT8.

    2D gel databases

    REPRODUCTION-2DPAGE Q9CXT8.

    Proteomic databases

    MaxQBi Q9CXT8.
    PaxDbi Q9CXT8.
    PRIDEi Q9CXT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030882 ; ENSMUSP00000030882 ; ENSMUSG00000029017 .
    GeneIDi 73078.
    KEGGi mmu:73078.
    UCSCi uc008wox.1. mouse.

    Organism-specific databases

    CTDi 9512.
    MGIi MGI:1920328. Pmpcb.

    Phylogenomic databases

    eggNOGi COG0612.
    GeneTreei ENSGT00550000074701.
    HOGENOMi HOG000242450.
    HOVERGENi HBG006393.
    InParanoidi Q9CXT8.
    KOi K17732.
    OMAi CTSVTEN.
    OrthoDBi EOG74R1QJ.
    PhylomeDBi Q9CXT8.
    TreeFami TF105032.

    Enzyme and pathway databases

    Reactomei REACT_199101. Mitochondrial protein import.

    Miscellaneous databases

    NextBioi 337429.
    PROi Q9CXT8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CXT8.
    Bgeei Q9CXT8.
    CleanExi MM_PMPCB.
    Genevestigatori Q9CXT8.

    Family and domain databases

    Gene3Di 3.30.830.10. 2 hits.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR011237. Pept_M16_dom.
    IPR011765. Pept_M16_N.
    IPR001431. Pept_M16_Zn_BS.
    IPR007863. Peptidase_M16_C.
    [Graphical view ]
    Pfami PF00675. Peptidase_M16. 1 hit.
    PF05193. Peptidase_M16_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63411. SSF63411. 2 hits.
    PROSITEi PS00143. INSULINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head.

    Entry informationi

    Entry nameiMPPB_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3