Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Centromere protein V

Gene

Cenpv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • ameboidal-type cell migration Source: MGI
  • cell division Source: UniProtKB-KW
  • centromere complex assembly Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • pericentric heterochromatin assembly Source: UniProtKB
  • positive regulation of cytokinesis Source: UniProtKB
  • regulation of chromosome organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein V
Short name:
CENP-V
Alternative name(s):
Proline-rich protein 6
Gene namesi
Name:Cenpv
Synonyms:Prr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1920389. Cenpv.

Subcellular locationi

  • Chromosomecentromerekinetochore By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeletonspindle By similarity

  • Note: Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis.By similarity

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • kinetochore Source: UniProtKB
  • microtubule cytoskeleton Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Centromere protein VPRO_0000244360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei78 – 781PhosphothreonineBy similarity
Modified residuei234 – 2341PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CXS4.
MaxQBiQ9CXS4.
PaxDbiQ9CXS4.
PRIDEiQ9CXS4.

PTM databases

iPTMnetiQ9CXS4.
PhosphoSiteiQ9CXS4.

Expressioni

Gene expression databases

BgeeiQ9CXS4.
ExpressionAtlasiQ9CXS4. baseline and differential.
GenevisibleiQ9CXS4. MM.

Interactioni

Protein-protein interaction databases

BioGridi215794. 2 interactions.
IntActiQ9CXS4. 4 interactions.
MINTiMINT-4125766.
STRINGi10090.ENSMUSP00000018653.

Structurei

3D structure databases

ProteinModelPortaliQ9CXS4.
SMRiQ9CXS4. Positions 127-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 477Poly-Gly

Sequence similaritiesi

Belongs to the Gfa family.Curated

Phylogenomic databases

eggNOGiKOG4192. Eukaryota.
COG3791. LUCA.
GeneTreeiENSGT00390000003183.
HOGENOMiHOG000090254.
InParanoidiQ9CXS4.
OMAiNGSNWEK.
OrthoDBiEOG7X3QTD.
PhylomeDBiQ9CXS4.
TreeFamiTF313636.

Family and domain databases

Gene3Di3.90.1590.10. 1 hit.
InterProiIPR006913. GFA/CENP-V.
IPR011057. Mss4-like.
[Graphical view]
PfamiPF04828. GFA. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CXS4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRTRSAVAT GPREQRRSGA TGGLSGGESR AQRSRSRTRA GAGGGGGAVG
60 70 80 90 100
PQPSAKPRPK PPPRAQEAAA EEPPPAVTPA ASVSALDLGE QRERWETFQK
110 120 130 140 150
RQRLSFEGAA KLLLDTFEYQ GLVKHTGGCH CGAVRFEVWA SADLHIFDCN
160 170 180 190 200
CSICKKKQNR HFIVPASRFK LLKGAESITT YTFNTHKAQH TFCKRCGVQS
210 220 230 240 250
FYTPRSNPGG FGIAPHCLDE GTVRSVVTEE FNGSDWERAM KEHKTIKNMS

KE
Length:252
Mass (Da):27,541
Last modified:June 27, 2006 - v2
Checksum:i8F63A72A21DAAE20
GO
Isoform 2 (identifier: Q9CXS4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: MRRTRSAVAT...VPASRFKLLK → MINVYLSLFSQ

Show »
Length:90
Mass (Da):10,180
Checksum:i3C18E14BF84D0D6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301R → P in BAB29130 (PubMed:16141072).Curated
Sequence conflicti30 – 301R → P in AAH38868 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 173173MRRTR…FKLLK → MINVYLSLFSQ in isoform 2. 1 PublicationVSP_019551Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014046 mRNA. Translation: BAB29130.1.
AL596181 Genomic DNA. Translation: CAI24673.1.
CH466601 Genomic DNA. Translation: EDL10349.1.
BC038868 mRNA. Translation: AAH38868.1.
BC147794 mRNA. Translation: AAI47795.1.
BC147795 mRNA. Translation: AAI47796.1.
BC147835 mRNA. Translation: AAI47836.1.
BC147837 mRNA. Translation: AAI47838.1.
CCDSiCCDS48818.1. [Q9CXS4-1]
RefSeqiNP_082724.1. NM_028448.1. [Q9CXS4-1]
UniGeneiMm.390409.
Mm.483809.

Genome annotation databases

EnsembliENSMUST00000018653; ENSMUSP00000018653; ENSMUSG00000018509. [Q9CXS4-1]
GeneIDi73139.
KEGGimmu:73139.
UCSCiuc007jjf.2. mouse. [Q9CXS4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014046 mRNA. Translation: BAB29130.1.
AL596181 Genomic DNA. Translation: CAI24673.1.
CH466601 Genomic DNA. Translation: EDL10349.1.
BC038868 mRNA. Translation: AAH38868.1.
BC147794 mRNA. Translation: AAI47795.1.
BC147795 mRNA. Translation: AAI47796.1.
BC147835 mRNA. Translation: AAI47836.1.
BC147837 mRNA. Translation: AAI47838.1.
CCDSiCCDS48818.1. [Q9CXS4-1]
RefSeqiNP_082724.1. NM_028448.1. [Q9CXS4-1]
UniGeneiMm.390409.
Mm.483809.

3D structure databases

ProteinModelPortaliQ9CXS4.
SMRiQ9CXS4. Positions 127-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215794. 2 interactions.
IntActiQ9CXS4. 4 interactions.
MINTiMINT-4125766.
STRINGi10090.ENSMUSP00000018653.

PTM databases

iPTMnetiQ9CXS4.
PhosphoSiteiQ9CXS4.

Proteomic databases

EPDiQ9CXS4.
MaxQBiQ9CXS4.
PaxDbiQ9CXS4.
PRIDEiQ9CXS4.

Protocols and materials databases

DNASUi73139.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018653; ENSMUSP00000018653; ENSMUSG00000018509. [Q9CXS4-1]
GeneIDi73139.
KEGGimmu:73139.
UCSCiuc007jjf.2. mouse. [Q9CXS4-1]

Organism-specific databases

CTDi201161.
MGIiMGI:1920389. Cenpv.

Phylogenomic databases

eggNOGiKOG4192. Eukaryota.
COG3791. LUCA.
GeneTreeiENSGT00390000003183.
HOGENOMiHOG000090254.
InParanoidiQ9CXS4.
OMAiNGSNWEK.
OrthoDBiEOG7X3QTD.
PhylomeDBiQ9CXS4.
TreeFamiTF313636.

Miscellaneous databases

ChiTaRSiCenpv. mouse.
PROiQ9CXS4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXS4.
ExpressionAtlasiQ9CXS4. baseline and differential.
GenevisibleiQ9CXS4. MM.

Family and domain databases

Gene3Di3.90.1590.10. 1 hit.
InterProiIPR006913. GFA/CENP-V.
IPR011057. Mss4-like.
[Graphical view]
PfamiPF04828. GFA. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Brain and Mammary gland.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-234, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiCENPV_MOUSE
AccessioniPrimary (citable) accession number: Q9CXS4
Secondary accession number(s): B2RWK8
, B9EK22, Q5SX21, Q6PIA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.