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Q9CXR4

- PIGC_MOUSE

UniProt

Q9CXR4 - PIGC_MOUSE

Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

Pigc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    GPI-anchor biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00196.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
    Alternative name(s):
    Phosphatidylinositol-glycan biosynthesis class C protein
    Short name:
    PIG-C
    Gene namesi
    Name:Pigc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1914542. Pigc.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CPRO_0000058432Add
    BLAST

    Proteomic databases

    PRIDEiQ9CXR4.

    PTM databases

    PhosphoSiteiQ9CXR4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CXR4.
    BgeeiQ9CXR4.
    GenevestigatoriQ9CXR4.

    Interactioni

    Subunit structurei

    Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXR4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei67 – 8721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei153 – 17321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PIGC family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275923.
    GeneTreeiENSGT00390000005496.
    HOGENOMiHOG000194668.
    HOVERGENiHBG009071.
    InParanoidiQ9CXR4.
    KOiK03859.
    OMAiNIHARKY.
    OrthoDBiEOG7KSX8X.
    PhylomeDBiQ9CXR4.
    TreeFamiTF314325.

    Family and domain databases

    InterProiIPR009450. Plno_GlcNAc_GPI2.
    [Graphical view]
    PANTHERiPTHR12982. PTHR12982. 1 hit.
    PfamiPF06432. GPI2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF016104. GPI2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CXR4-1 [UniParc]FASTAAdd to Basket

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    MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA    50
    VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF 100
    DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY 150
    AMAVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF 200
    IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISAVG 250
    AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS 297
    Length:297
    Mass (Da):33,724
    Last modified:June 1, 2001 - v1
    Checksum:i3116EF0B412E58BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014096 mRNA. Translation: BAB29152.1.
    AK152660 mRNA. Translation: BAE31396.1.
    BC006938 mRNA. Translation: AAH06938.1.
    CCDSiCCDS15419.1.
    RefSeqiNP_001034134.1. NM_001039045.1.
    NP_080354.1. NM_026078.2.
    XP_006497022.1. XM_006496959.1.
    UniGeneiMm.45106.

    Genome annotation databases

    EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
    ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
    GeneIDi67292.
    KEGGimmu:67292.
    UCSCiuc007dfx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014096 mRNA. Translation: BAB29152.1 .
    AK152660 mRNA. Translation: BAE31396.1 .
    BC006938 mRNA. Translation: AAH06938.1 .
    CCDSi CCDS15419.1.
    RefSeqi NP_001034134.1. NM_001039045.1.
    NP_080354.1. NM_026078.2.
    XP_006497022.1. XM_006496959.1.
    UniGenei Mm.45106.

    3D structure databases

    ProteinModelPortali Q9CXR4.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CXR4.

    Proteomic databases

    PRIDEi Q9CXR4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028021 ; ENSMUSP00000028021 ; ENSMUSG00000026698 .
    ENSMUST00000111594 ; ENSMUSP00000107221 ; ENSMUSG00000026698 .
    GeneIDi 67292.
    KEGGi mmu:67292.
    UCSCi uc007dfx.1. mouse.

    Organism-specific databases

    CTDi 5279.
    MGIi MGI:1914542. Pigc.

    Phylogenomic databases

    eggNOGi NOG275923.
    GeneTreei ENSGT00390000005496.
    HOGENOMi HOG000194668.
    HOVERGENi HBG009071.
    InParanoidi Q9CXR4.
    KOi K03859.
    OMAi NIHARKY.
    OrthoDBi EOG7KSX8X.
    PhylomeDBi Q9CXR4.
    TreeFami TF314325.

    Enzyme and pathway databases

    UniPathwayi UPA00196 .

    Miscellaneous databases

    NextBioi 324140.
    PROi Q9CXR4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CXR4.
    Bgeei Q9CXR4.
    Genevestigatori Q9CXR4.

    Family and domain databases

    InterProi IPR009450. Plno_GlcNAc_GPI2.
    [Graphical view ]
    PANTHERi PTHR12982. PTHR12982. 1 hit.
    Pfami PF06432. GPI2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF016104. GPI2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Embryonic head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiPIGC_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXR4
    Secondary accession number(s): Q3U7H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3