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Q9CXR4

- PIGC_MOUSE

UniProt

Q9CXR4 - PIGC_MOUSE

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Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

Pigc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:Pigc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914542. Pigc.

Subcellular locationi

GO - Cellular componenti

  1. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CPRO_0000058432Add
BLAST

Proteomic databases

PRIDEiQ9CXR4.

PTM databases

PhosphoSiteiQ9CXR4.

Expressioni

Gene expression databases

BgeeiQ9CXR4.
ExpressionAtlasiQ9CXR4. baseline and differential.
GenevestigatoriQ9CXR4.

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CXR4.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ9CXR4.
KOiK03859.
OMAiNIHARKY.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ9CXR4.
TreeFamiTF314325.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CXR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF
110 120 130 140 150
DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMAVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISAVG
260 270 280 290
AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,724
Last modified:June 1, 2001 - v1
Checksum:i3116EF0B412E58BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014096 mRNA. Translation: BAB29152.1.
AK152660 mRNA. Translation: BAE31396.1.
BC006938 mRNA. Translation: AAH06938.1.
CCDSiCCDS15419.1.
RefSeqiNP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGeneiMm.45106.

Genome annotation databases

EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
GeneIDi67292.
KEGGimmu:67292.
UCSCiuc007dfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014096 mRNA. Translation: BAB29152.1 .
AK152660 mRNA. Translation: BAE31396.1 .
BC006938 mRNA. Translation: AAH06938.1 .
CCDSi CCDS15419.1.
RefSeqi NP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGenei Mm.45106.

3D structure databases

ProteinModelPortali Q9CXR4.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CXR4.

Proteomic databases

PRIDEi Q9CXR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028021 ; ENSMUSP00000028021 ; ENSMUSG00000026698 .
ENSMUST00000111594 ; ENSMUSP00000107221 ; ENSMUSG00000026698 .
GeneIDi 67292.
KEGGi mmu:67292.
UCSCi uc007dfx.1. mouse.

Organism-specific databases

CTDi 5279.
MGIi MGI:1914542. Pigc.

Phylogenomic databases

eggNOGi NOG275923.
GeneTreei ENSGT00390000005496.
HOGENOMi HOG000194668.
HOVERGENi HBG009071.
InParanoidi Q9CXR4.
KOi K03859.
OMAi NIHARKY.
OrthoDBi EOG7KSX8X.
PhylomeDBi Q9CXR4.
TreeFami TF314325.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

NextBioi 324140.
PROi Q9CXR4.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXR4.
ExpressionAtlasi Q9CXR4. baseline and differential.
Genevestigatori Q9CXR4.

Family and domain databases

InterProi IPR009450. Plno_GlcNAc_GPI2.
[Graphical view ]
PANTHERi PTHR12982. PTHR12982. 1 hit.
Pfami PF06432. GPI2. 1 hit.
[Graphical view ]
PIRSFi PIRSF016104. GPI2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPIGC_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR4
Secondary accession number(s): Q3U7H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3