SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CXR4

- PIGC_MOUSE

UniProt

Q9CXR4 - PIGC_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
Gene
Pigc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis By similarity.

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathwayi

GO - Molecular functioni

  1. phosphatidylinositol N-acetylglucosaminyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. GPI anchor biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:Pigc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914542. Pigc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei153 – 17321Helical; Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
PRO_0000058432Add
BLAST

Proteomic databases

PRIDEiQ9CXR4.

PTM databases

PhosphoSiteiQ9CXR4.

Expressioni

Gene expression databases

ArrayExpressiQ9CXR4.
BgeeiQ9CXR4.
GenevestigatoriQ9CXR4.

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9CXR4.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ9CXR4.
KOiK03859.
OMAiNIHARKY.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ9CXR4.
TreeFamiTF314325.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CXR4-1 [UniParc]FASTAAdd to Basket

« Hide

MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA    50
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF 100
DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY 150
AMAVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF 200
IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISAVG 250
AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS 297
Length:297
Mass (Da):33,724
Last modified:June 1, 2001 - v1
Checksum:i3116EF0B412E58BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014096 mRNA. Translation: BAB29152.1.
AK152660 mRNA. Translation: BAE31396.1.
BC006938 mRNA. Translation: AAH06938.1.
CCDSiCCDS15419.1.
RefSeqiNP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGeneiMm.45106.

Genome annotation databases

EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
GeneIDi67292.
KEGGimmu:67292.
UCSCiuc007dfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014096 mRNA. Translation: BAB29152.1 .
AK152660 mRNA. Translation: BAE31396.1 .
BC006938 mRNA. Translation: AAH06938.1 .
CCDSi CCDS15419.1.
RefSeqi NP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGenei Mm.45106.

3D structure databases

ProteinModelPortali Q9CXR4.
ModBasei Search...

PTM databases

PhosphoSitei Q9CXR4.

Proteomic databases

PRIDEi Q9CXR4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028021 ; ENSMUSP00000028021 ; ENSMUSG00000026698 .
ENSMUST00000111594 ; ENSMUSP00000107221 ; ENSMUSG00000026698 .
GeneIDi 67292.
KEGGi mmu:67292.
UCSCi uc007dfx.1. mouse.

Organism-specific databases

CTDi 5279.
MGIi MGI:1914542. Pigc.

Phylogenomic databases

eggNOGi NOG275923.
GeneTreei ENSGT00390000005496.
HOGENOMi HOG000194668.
HOVERGENi HBG009071.
InParanoidi Q9CXR4.
KOi K03859.
OMAi NIHARKY.
OrthoDBi EOG7KSX8X.
PhylomeDBi Q9CXR4.
TreeFami TF314325.

Enzyme and pathway databases

UniPathwayi UPA00196 .

Miscellaneous databases

NextBioi 324140.
PROi Q9CXR4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CXR4.
Bgeei Q9CXR4.
Genevestigatori Q9CXR4.

Family and domain databases

InterProi IPR009450. Plno_GlcNAc_GPI2.
[Graphical view ]
PANTHERi PTHR12982. PTHR12982. 1 hit.
Pfami PF06432. GPI2. 1 hit.
[Graphical view ]
PIRSFi PIRSF016104. GPI2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPIGC_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR4
Secondary accession number(s): Q3U7H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi