Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Gene

Pigc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathway:iglycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiREACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC:2.4.1.198)
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name:
PIG-C
Gene namesi
Name:Pigc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914542. Pigc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei67 – 8721HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit CPRO_0000058432Add
BLAST

Proteomic databases

PRIDEiQ9CXR4.

PTM databases

PhosphoSiteiQ9CXR4.

Expressioni

Gene expression databases

BgeeiQ9CXR4.
ExpressionAtlasiQ9CXR4. baseline and differential.
GenevisibleiQ9CXR4. MM.

Interactioni

Subunit structurei

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028021.

Structurei

3D structure databases

ProteinModelPortaliQ9CXR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ9CXR4.
KOiK03859.
OMAiYVDQRFL.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ9CXR4.
TreeFamiTF314325.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CXR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA
60 70 80 90 100
VVFESSVVIQ QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF
110 120 130 140 150
DLIDGGDGRK KSGRTRWADL KSTLVFITFT YGFSPVLKTL TESVSTDTIY
160 170 180 190 200
AMAVFMLLGH LIFFDYGANA AIVSSTLSLN MAIFASVCLA SRLPRSLHAF
210 220 230 240 250
IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF GGLLSISAVG
260 270 280 290
AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
Length:297
Mass (Da):33,724
Last modified:June 1, 2001 - v1
Checksum:i3116EF0B412E58BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014096 mRNA. Translation: BAB29152.1.
AK152660 mRNA. Translation: BAE31396.1.
BC006938 mRNA. Translation: AAH06938.1.
CCDSiCCDS15419.1.
RefSeqiNP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGeneiMm.45106.

Genome annotation databases

EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
ENSMUST00000193784; ENSMUSP00000141646; ENSMUSG00000026698.
GeneIDi67292.
KEGGimmu:67292.
UCSCiuc007dfx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014096 mRNA. Translation: BAB29152.1.
AK152660 mRNA. Translation: BAE31396.1.
BC006938 mRNA. Translation: AAH06938.1.
CCDSiCCDS15419.1.
RefSeqiNP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
XP_006497022.1. XM_006496959.1.
UniGeneiMm.45106.

3D structure databases

ProteinModelPortaliQ9CXR4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028021.

PTM databases

PhosphoSiteiQ9CXR4.

Proteomic databases

PRIDEiQ9CXR4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
ENSMUST00000193784; ENSMUSP00000141646; ENSMUSG00000026698.
GeneIDi67292.
KEGGimmu:67292.
UCSCiuc007dfx.1. mouse.

Organism-specific databases

CTDi5279.
MGIiMGI:1914542. Pigc.

Phylogenomic databases

eggNOGiNOG275923.
GeneTreeiENSGT00390000005496.
HOGENOMiHOG000194668.
HOVERGENiHBG009071.
InParanoidiQ9CXR4.
KOiK03859.
OMAiYVDQRFL.
OrthoDBiEOG7KSX8X.
PhylomeDBiQ9CXR4.
TreeFamiTF314325.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiREACT_336927. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

NextBioi324140.
PROiQ9CXR4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXR4.
ExpressionAtlasiQ9CXR4. baseline and differential.
GenevisibleiQ9CXR4. MM.

Family and domain databases

InterProiIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERiPTHR12982. PTHR12982. 1 hit.
PfamiPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFiPIRSF016104. GPI2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiPIGC_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR4
Secondary accession number(s): Q3U7H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.