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Q9CXR4 (PIGC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
EC=2.4.1.198
Alternative name(s):
Phosphatidylinositol-glycan biosynthesis class C protein
Short name=PIG-C
Gene names
Name:Pigc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis By similarity.

Catalytic activity

UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

Subunit structure

Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PIGC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Phosphatidylinositol N-acetylglucosaminyltransferase subunit C
PRO_0000058432

Regions

Transmembrane67 – 8721Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane153 – 17321Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CXR4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3116EF0B412E58BC

FASTA29733,724
        10         20         30         40         50         60 
MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA VVFESSVVIQ 

        70         80         90        100        110        120 
QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF DLIDGGDGRK KSGRTRWADL 

       130        140        150        160        170        180 
KSTLVFITFT YGFSPVLKTL TESVSTDTIY AMAVFMLLGH LIFFDYGANA AIVSSTLSLN 

       190        200        210        220        230        240 
MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF 

       250        260        270        280        290 
GGLLSISAVG AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Embryonic head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK014096 mRNA. Translation: BAB29152.1.
AK152660 mRNA. Translation: BAE31396.1.
BC006938 mRNA. Translation: AAH06938.1.
IPIIPI00110669.
RefSeqNP_001034134.1. NM_001039045.1.
NP_080354.1. NM_026078.2.
UniGeneMm.45106.

3D structure databases

ProteinModelPortalQ9CXR4.
ModBaseSearch...

PTM databases

PhosphoSiteQ9CXR4.

Proteomic databases

PRIDEQ9CXR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
GeneID67292.
KEGGmmu:67292.
UCSCuc007dfx.1. mouse.

Organism-specific databases

CTD5279.
MGIMGI:1914542. Pigc.

Phylogenomic databases

eggNOGNOG275923.
GeneTreeENSGT00390000005496.
HOGENOMHOG000194668.
HOVERGENHBG009071.
InParanoidQ9CXR4.
KOK03859.
OMANIHARKY.
OrthoDBEOG4PK28D.

Enzyme and pathway databases

UniPathwayUPA00196.

Gene expression databases

ArrayExpressQ9CXR4.
BgeeQ9CXR4.
GenevestigatorQ9CXR4.
GermOnlineENSMUSG00000026698. Mus musculus.

Family and domain databases

InterProIPR009450. Plno_GlcNAc_GPI2.
[Graphical view]
PANTHERPTHR12982. PTHR12982. 1 hit.
PfamPF06432. GPI2. 1 hit.
[Graphical view]
PIRSFPIRSF016104. GPI2. 1 hit.
ProtoNetSearch...

Other

NextBio324140.
SOURCESearch...

Entry information

Entry namePIGC_MOUSE
AccessionPrimary (citable) accession number: Q9CXR4
Secondary accession number(s): Q3U7H3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents