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Protein

Dehydrogenase/reductase SDR family member 7

Gene

Dhrs7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei190 – 1901SubstrateBy similarity
Active sitei203 – 2031Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 7825NADBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7 (EC:1.1.-.-)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 4
Short name:
retSDR4
Gene namesi
Name:Dhrs7
Synonyms:Retsdr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913625. Dhrs7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 338310Dehydrogenase/reductase SDR family member 7PRO_0000031969Add
BLAST

Proteomic databases

EPDiQ9CXR1.
MaxQBiQ9CXR1.
PaxDbiQ9CXR1.
PRIDEiQ9CXR1.

PTM databases

iPTMnetiQ9CXR1.
PhosphoSiteiQ9CXR1.

Expressioni

Gene expression databases

BgeeiQ9CXR1.
CleanExiMM_DHRS7.
GenevisibleiQ9CXR1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CXR1. 1 interaction.
MINTiMINT-4093056.
STRINGi10090.ENSMUSP00000021512.

Structurei

3D structure databases

ProteinModelPortaliQ9CXR1.
SMRiQ9CXR1. Positions 47-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IUBT. Eukaryota.
COG0300. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG054346.
InParanoidiQ9CXR1.
KOiK11165.
OMAiLITMAND.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ9CXR1.
TreeFamiTF354276.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWELLLWLL ALCALILPLV QLLRFLRADA DLTLLWAEWQ GRRPEWELTD
60 70 80 90 100
MVVWVTGASS GIGEELAFQL SKLGVSLVLS ARRAQELERV KRRCLENGNL
110 120 130 140 150
KEKDILVLPL DLTDTSSHEA ATKAVLQEFG KIDILVNNGG RSQRSLVLET
160 170 180 190 200
NLDVFKELIN LNYIGTVSLT KCVLPHMIER KQGKIVTVNS IAGIASVSLS
210 220 230 240 250
SGYCASKHAL RGFFNALHSE LGQYPGITFC NVYPGPVQSD IVKNAFTEEV
260 270 280 290 300
TKSMRNNIDQ SYKMPTSRCV RLMLISMAND LKEVWISDHP VLLGAYIWQY
310 320 330
MPTWAAWLNC KLGKERIQNF KNNLDPDLPY KFLKAKKD
Length:338
Mass (Da):38,167
Last modified:August 29, 2003 - v2
Checksum:i5D12F0117BD1070D
GO

Sequence cautioni

The sequence AAH16189.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB29156.1 differs from that shown. Reason: Frameshift at positions 11 and 15. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101L → R (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014100 mRNA. Translation: BAB29156.1. Frameshift.
BC016189 mRNA. Translation: AAH16189.1. Different initiation.
CCDSiCCDS49086.1.
RefSeqiNP_079798.2. NM_025522.5.
UniGeneiMm.289653.

Genome annotation databases

EnsembliENSMUST00000021512; ENSMUSP00000021512; ENSMUSG00000021094.
GeneIDi66375.
KEGGimmu:66375.
UCSCiuc007nvs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014100 mRNA. Translation: BAB29156.1. Frameshift.
BC016189 mRNA. Translation: AAH16189.1. Different initiation.
CCDSiCCDS49086.1.
RefSeqiNP_079798.2. NM_025522.5.
UniGeneiMm.289653.

3D structure databases

ProteinModelPortaliQ9CXR1.
SMRiQ9CXR1. Positions 47-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CXR1. 1 interaction.
MINTiMINT-4093056.
STRINGi10090.ENSMUSP00000021512.

PTM databases

iPTMnetiQ9CXR1.
PhosphoSiteiQ9CXR1.

Proteomic databases

EPDiQ9CXR1.
MaxQBiQ9CXR1.
PaxDbiQ9CXR1.
PRIDEiQ9CXR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021512; ENSMUSP00000021512; ENSMUSG00000021094.
GeneIDi66375.
KEGGimmu:66375.
UCSCiuc007nvs.2. mouse.

Organism-specific databases

CTDi51635.
MGIiMGI:1913625. Dhrs7.

Phylogenomic databases

eggNOGiENOG410IUBT. Eukaryota.
COG0300. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG054346.
InParanoidiQ9CXR1.
KOiK11165.
OMAiLITMAND.
OrthoDBiEOG7W6WM5.
PhylomeDBiQ9CXR1.
TreeFamiTF354276.

Miscellaneous databases

PROiQ9CXR1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXR1.
CleanExiMM_DHRS7.
GenevisibleiQ9CXR1. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiDHRS7_MOUSE
AccessioniPrimary (citable) accession number: Q9CXR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.