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Protein

Rho GTPase-activating protein 8

Gene

Arhgap8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 8
Alternative name(s):
Rho-type GTPase-activating protein 8
Gene namesi
Name:Arhgap8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920417 Arhgap8

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567111 – 425Rho GTPase-activating protein 8Add BLAST425

Proteomic databases

MaxQBiQ9CXP4
PaxDbiQ9CXP4
PRIDEiQ9CXP4

PTM databases

iPTMnetiQ9CXP4
PhosphoSitePlusiQ9CXP4

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, lung and testis, and at lower levels in kidney, stomach and colon. Not detected in heart, liver, spleen, breast, brain, neonatal head or pancreas.1 Publication

Gene expression databases

BgeeiENSMUSG00000078954
CleanExiMM_ARHGAP8
GenevisibleiQ9CXP4 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006029

Structurei

3D structure databases

ProteinModelPortaliQ9CXP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 168CRAL-TRIOPROSITE-ProRule annotationAdd BLAST156
Domaini195 – 381Rho-GAPPROSITE-ProRule annotationAdd BLAST187

Phylogenomic databases

eggNOGiKOG4406 Eukaryota
ENOG410XR4J LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000231442
HOVERGENiHBG054433
InParanoidiQ9CXP4
KOiK20633
OMAiTCCRQIL
OrthoDBiEOG091G07HT
PhylomeDBiQ9CXP4
TreeFamiTF324164

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di1.10.555.10, 1 hit
3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF13716 CRAL_TRIO_2, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLDPTLST SHPFYDVARH GILQVAGDDR QGRRIFTFSC CRLPPLHQLN
60 70 80 90 100
HQRLLEYLKY TLDQHVENDY TIVYFHYGLS SQNKPSLGWL QNTYKEFDRK
110 120 130 140 150
YKKNLKALYV VHPTSLIKAL WNIFKPLISH KFGKKVTYCS NLRELREHLQ
160 170 180 190 200
CDQLLIPPEV VRYDEKLQNL HKGQPPPPTK TPPPRPPLPT QQFGVSLQYL
210 220 230 240 250
RDKNQGELIP PVLRWTVTYL REKGLRTEGL FRRSASAQTV RQVQRLYDQG
260 270 280 290 300
KPVNFDDYGD MHLPAVILKT FLRELPQPLL TFQAYEQILG ITSVESSLRV
310 320 330 340 350
THCRLILRSL PEHNYAVLRY LMGFLHEVSL ESISNKMNSS NLACVFGLNL
360 370 380 390 400
IWPSQGVASL SALVPLNLFT ELLIEYYDKV FSCQEAPGEH TRDTVEVQQA
410 420
GPVTKEFMKT GTPRASPYLS RLRIS
Length:425
Mass (Da):48,972
Last modified:August 30, 2002 - v3
Checksum:i4CC08499D7A81F43
GO

Sequence cautioni

The sequence AAH10306 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62L → P in BAB29190 (PubMed:16141072).Curated1
Sequence conflicti174 – 175QP → HT in BAB29190 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014171 mRNA Translation: BAB29190.1
AK086816 mRNA Translation: BAC39750.1
BC005563 mRNA Translation: AAH05563.1
BC010306 mRNA Translation: AAH10306.2 Different initiation.
CCDSiCCDS27712.1
RefSeqiNP_001158099.1, NM_001164627.1
NP_001158100.1, NM_001164628.1
NP_001192263.1, NM_001205334.1
NP_082731.2, NM_028455.4
XP_006521533.1, XM_006521470.3
XP_006521534.1, XM_006521471.3
UniGeneiMm.128411

Genome annotation databases

EnsembliENSMUST00000006029; ENSMUSP00000006029; ENSMUSG00000078954
ENSMUST00000168811; ENSMUSP00000130977; ENSMUSG00000078954
ENSMUST00000172307; ENSMUSP00000132008; ENSMUSG00000078954
GeneIDi73167
KEGGimmu:73167
UCSCiuc007xci.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRHG08_MOUSE
AccessioniPrimary (citable) accession number: Q9CXP4
Secondary accession number(s): Q99JY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 30, 2002
Last modified: April 25, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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