Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho GTPase-activating protein 8

Gene

Arhgap8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 8
Alternative name(s):
Rho-type GTPase-activating protein 8
Gene namesi
Name:Arhgap8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1920417. Arhgap8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Rho GTPase-activating protein 8PRO_0000056711Add
BLAST

Proteomic databases

EPDiQ9CXP4.
MaxQBiQ9CXP4.
PaxDbiQ9CXP4.
PRIDEiQ9CXP4.

PTM databases

iPTMnetiQ9CXP4.
PhosphoSiteiQ9CXP4.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle, lung and testis, and at lower levels in kidney, stomach and colon. Not detected in heart, liver, spleen, breast, brain, neonatal head or pancreas.1 Publication

Gene expression databases

BgeeiQ9CXP4.
CleanExiMM_ARHGAP8.
GenevisibleiQ9CXP4. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006029.

Structurei

3D structure databases

ProteinModelPortaliQ9CXP4.
SMRiQ9CXP4. Positions 184-381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 168156CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Domaini195 – 381187Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000231442.
HOVERGENiHBG054433.
InParanoidiQ9CXP4.
OMAiSDYTIVY.
OrthoDBiEOG7JMGD7.
PhylomeDBiQ9CXP4.
TreeFamiTF324164.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLDPTLST SHPFYDVARH GILQVAGDDR QGRRIFTFSC CRLPPLHQLN
60 70 80 90 100
HQRLLEYLKY TLDQHVENDY TIVYFHYGLS SQNKPSLGWL QNTYKEFDRK
110 120 130 140 150
YKKNLKALYV VHPTSLIKAL WNIFKPLISH KFGKKVTYCS NLRELREHLQ
160 170 180 190 200
CDQLLIPPEV VRYDEKLQNL HKGQPPPPTK TPPPRPPLPT QQFGVSLQYL
210 220 230 240 250
RDKNQGELIP PVLRWTVTYL REKGLRTEGL FRRSASAQTV RQVQRLYDQG
260 270 280 290 300
KPVNFDDYGD MHLPAVILKT FLRELPQPLL TFQAYEQILG ITSVESSLRV
310 320 330 340 350
THCRLILRSL PEHNYAVLRY LMGFLHEVSL ESISNKMNSS NLACVFGLNL
360 370 380 390 400
IWPSQGVASL SALVPLNLFT ELLIEYYDKV FSCQEAPGEH TRDTVEVQQA
410 420
GPVTKEFMKT GTPRASPYLS RLRIS
Length:425
Mass (Da):48,972
Last modified:August 30, 2002 - v3
Checksum:i4CC08499D7A81F43
GO

Sequence cautioni

The sequence AAH10306.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621L → P in BAB29190 (PubMed:16141072).Curated
Sequence conflicti174 – 1752QP → HT in BAB29190 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014171 mRNA. Translation: BAB29190.1.
AK086816 mRNA. Translation: BAC39750.1.
BC005563 mRNA. Translation: AAH05563.1.
BC010306 mRNA. Translation: AAH10306.2. Different initiation.
CCDSiCCDS27712.1.
RefSeqiNP_001158099.1. NM_001164627.1.
NP_001158100.1. NM_001164628.1.
NP_001192263.1. NM_001205334.1.
NP_082731.2. NM_028455.4.
XP_006521533.1. XM_006521470.2.
XP_006521534.1. XM_006521471.2.
XP_006521535.1. XM_006521472.2.
UniGeneiMm.128411.

Genome annotation databases

EnsembliENSMUST00000006029; ENSMUSP00000006029; ENSMUSG00000078954.
ENSMUST00000168811; ENSMUSP00000130977; ENSMUSG00000078954.
ENSMUST00000172307; ENSMUSP00000132008; ENSMUSG00000078954.
GeneIDi73167.
KEGGimmu:73167.
UCSCiuc007xci.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014171 mRNA. Translation: BAB29190.1.
AK086816 mRNA. Translation: BAC39750.1.
BC005563 mRNA. Translation: AAH05563.1.
BC010306 mRNA. Translation: AAH10306.2. Different initiation.
CCDSiCCDS27712.1.
RefSeqiNP_001158099.1. NM_001164627.1.
NP_001158100.1. NM_001164628.1.
NP_001192263.1. NM_001205334.1.
NP_082731.2. NM_028455.4.
XP_006521533.1. XM_006521470.2.
XP_006521534.1. XM_006521471.2.
XP_006521535.1. XM_006521472.2.
UniGeneiMm.128411.

3D structure databases

ProteinModelPortaliQ9CXP4.
SMRiQ9CXP4. Positions 184-381.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006029.

PTM databases

iPTMnetiQ9CXP4.
PhosphoSiteiQ9CXP4.

Proteomic databases

EPDiQ9CXP4.
MaxQBiQ9CXP4.
PaxDbiQ9CXP4.
PRIDEiQ9CXP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006029; ENSMUSP00000006029; ENSMUSG00000078954.
ENSMUST00000168811; ENSMUSP00000130977; ENSMUSG00000078954.
ENSMUST00000172307; ENSMUSP00000132008; ENSMUSG00000078954.
GeneIDi73167.
KEGGimmu:73167.
UCSCiuc007xci.2. mouse.

Organism-specific databases

CTDi23779.
MGIiMGI:1920417. Arhgap8.

Phylogenomic databases

eggNOGiKOG4406. Eukaryota.
ENOG410XR4J. LUCA.
GeneTreeiENSGT00760000118863.
HOGENOMiHOG000231442.
HOVERGENiHBG054433.
InParanoidiQ9CXP4.
OMAiSDYTIVY.
OrthoDBiEOG7JMGD7.
PhylomeDBiQ9CXP4.
TreeFamiTF324164.

Enzyme and pathway databases

ReactomeiR-MMU-194840. Rho GTPase cycle.

Miscellaneous databases

PROiQ9CXP4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXP4.
CleanExiMM_ARHGAP8.
GenevisibleiQ9CXP4. MM.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers."
    Johnstone C.N., Castellvi-Bel S., Chang L.M., Bessa X., Nakagawa H., Harada H., Sung R.K., Pique J.M., Castells A., Rustgi A.K.
    Gene 336:59-71(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRHG08_MOUSE
AccessioniPrimary (citable) accession number: Q9CXP4
Secondary accession number(s): Q99JY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: August 30, 2002
Last modified: July 6, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.