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Protein

Chondrolectin

Gene

Chodl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the development of the nervous system such as in neurite outgrowth and elongation (PubMed:24067532). May be involved in motor axon growth and guidance (By similarity).By similarity1 Publication

Miscellaneous

Isoform 1 but not isoform 2 expression is down-regulated at postnatal day (P) 7 in spinal muscular atrophy (SMA) model motor neurons before onset of disease.1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of neuron projection development Source: MGI

Keywordsi

Biological processNeurogenesis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrolectin
Alternative name(s):
Transmembrane protein MT75
Gene namesi
Name:Chodl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2179069. Chodl.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 216ExtracellularSequence analysisAdd BLAST195
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 273CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: HGNC

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001741622 – 273ChondrolectinAdd BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 178PROSITE-ProRule annotation
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi144 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CXM0.
PRIDEiQ9CXM0.

PTM databases

PhosphoSitePlusiQ9CXM0.

Expressioni

Tissue specificityi

In adult mice preferentially expressed in skeletal muscle, testis, brain, and lung. Expressed in striated muscle (at protein level). Expressed in spinal chord. Detected in spinal chord fast motor neurons (at protein level).3 Publications

Developmental stagei

During gestation (embryonic day (E) 7-15) its expression is up-regulated. In E15 embryo is expressed in muscle cells of heterogeneous origin, including those from tongue, trunk, and tail. In newborn mice localized to limb striated muscle cells. Expressed in myoblasts undergoing myogenic differentiation during proliferation and differentiation phases (PubMed:12711387). Expressed in spinal chord motor neurons at E10.5. Detected in the plexus region of the developing limb bud at E10.5 and E11.5 (PubMed:20437528).2 Publications

Gene expression databases

BgeeiENSMUSG00000022860.
CleanExiMM_CHODL.
ExpressionAtlasiQ9CXM0. baseline and differential.
GenevisibleiQ9CXM0. MM.

Interactioni

Subunit structurei

Interacts with RABGGTB (PubMed:18161010).

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023568.

Structurei

3D structure databases

ProteinModelPortaliQ9CXM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 179C-type lectinPROSITE-ProRule annotationAdd BLAST145

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9CXM0.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG091G0FDX.
TreeFamiTF330715.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.1 Publication
Isoform 1 (identifier: Q9CXM0-1) [UniParc]FASTAAdd to basket
Also known as: Chodl-001

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIRIASLLLG AALLCAQGAF ARRVVSGQKV CFADVKHPCY KMAYFHELSS
60 70 80 90 100
RVSFQEARLA CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW
110 120 130 140 150
IGLLRSGDGQ TSGACPDLYQ WSDGSSSQFR NWYTDEPSCG SEKCVVMYHQ
160 170 180 190 200
PTANPGLGGP YLYQWNDDRC NMKHNYICKY EPEIHPTEPA EKPYLTNQPE
210 220 230 240 250
ETHENVVVTE AGIIPNLIYV IIPTIPLLLL ILVALGTCCF QMLHKSKGRS
260 270
KTSPNQSTLW ISKSTRKESG MEV
Length:273
Mass (Da):30,331
Last modified:October 3, 2012 - v3
Checksum:iF3EAE2B059D4EA28
GO
Isoform 2 (identifier: Q9CXM0-2) [UniParc]FASTAAdd to basket
Also known as: Chodl-002

The sequence of this isoform differs from the canonical sequence as follows:
     246-273: SKGRSKTSPNQSTLWISKSTRKESGMEV → RKARRHFIKDSTPLSSECLAESLNSNLVHMAGSLIPYHFQNNSPSLN

Show »
Length:292
Mass (Da):32,502
Checksum:i73E631C0714D54E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24V → W in BAB29226 (PubMed:16141072).Curated1
Sequence conflicti179K → T in AAL50354 (PubMed:12711387).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058918246 – 273SKGRS…SGMEV → RKARRHFIKDSTPLSSECLA ESLNSNLVHMAGSLIPYHFQ NNSPSLN in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311699 mRNA. Translation: AAL50354.1.
AK014255 mRNA. Translation: BAB29226.1.
AK076523 mRNA. Translation: BAC36378.1.
AK140910 mRNA. Translation: BAE24517.1.
AC114925 Genomic DNA. No translation available.
AC161815 Genomic DNA. No translation available.
BC117071 mRNA. Translation: AAI17072.1.
BC117073 mRNA. Translation: AAI17074.1.
CCDSiCCDS28279.1. [Q9CXM0-1]
RefSeqiNP_624360.2. NM_139134.3.
XP_006523093.1. XM_006523030.3.
UniGeneiMm.77895.

Genome annotation databases

EnsembliENSMUST00000023568; ENSMUSP00000023568; ENSMUSG00000022860. [Q9CXM0-1]
ENSMUST00000069148; ENSMUSP00000063961; ENSMUSG00000022860. [Q9CXM0-2]
GeneIDi246048.
KEGGimmu:246048.
UCSCiuc007zsw.1. mouse. [Q9CXM0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Chondrolectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311699 mRNA. Translation: AAL50354.1.
AK014255 mRNA. Translation: BAB29226.1.
AK076523 mRNA. Translation: BAC36378.1.
AK140910 mRNA. Translation: BAE24517.1.
AC114925 Genomic DNA. No translation available.
AC161815 Genomic DNA. No translation available.
BC117071 mRNA. Translation: AAI17072.1.
BC117073 mRNA. Translation: AAI17074.1.
CCDSiCCDS28279.1. [Q9CXM0-1]
RefSeqiNP_624360.2. NM_139134.3.
XP_006523093.1. XM_006523030.3.
UniGeneiMm.77895.

3D structure databases

ProteinModelPortaliQ9CXM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023568.

PTM databases

PhosphoSitePlusiQ9CXM0.

Proteomic databases

PaxDbiQ9CXM0.
PRIDEiQ9CXM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023568; ENSMUSP00000023568; ENSMUSG00000022860. [Q9CXM0-1]
ENSMUST00000069148; ENSMUSP00000063961; ENSMUSG00000022860. [Q9CXM0-2]
GeneIDi246048.
KEGGimmu:246048.
UCSCiuc007zsw.1. mouse. [Q9CXM0-1]

Organism-specific databases

CTDi140578.
MGIiMGI:2179069. Chodl.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9CXM0.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG091G0FDX.
TreeFamiTF330715.

Miscellaneous databases

PROiPR:Q9CXM0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022860.
CleanExiMM_CHODL.
ExpressionAtlasiQ9CXM0. baseline and differential.
GenevisibleiQ9CXM0. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS50041. C_TYPE_LECTIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCHODL_MOUSE
AccessioniPrimary (citable) accession number: Q9CXM0
Secondary accession number(s): Q3US20, Q8BVU2, Q8VI31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 3, 2012
Last modified: June 7, 2017
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.