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Protein

Chondrolectin

Gene

Chodl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • regulation of neuron projection development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Chondrolectin
Alternative name(s):
Transmembrane protein MT75
Gene namesi
Name:Chodl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2179069. Chodl.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 216195ExtracellularSequence analysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence analysisAdd
BLAST
Topological domaini238 – 27336CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 273252ChondrolectinPRO_0000017416Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi61 ↔ 178PROSITE-ProRule annotation
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi144 ↔ 170PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CXM0.
PaxDbiQ9CXM0.
PRIDEiQ9CXM0.

Expressioni

Gene expression databases

CleanExiMM_CHODL.
ExpressionAtlasiQ9CXM0. baseline and differential.
GenevisibleiQ9CXM0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023568.

Structurei

3D structure databases

ProteinModelPortaliQ9CXM0.
SMRiQ9CXM0. Positions 31-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 179145C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9CXM0.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG7FV3RQ.
TreeFamiTF330715.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRIASLLLG AALLCAQGAF ARRVVSGQKV CFADVKHPCY KMAYFHELSS
60 70 80 90 100
RVSFQEARLA CESEGGVLLS LENEAEQKLI ESMLQNLTKP GTGISDGDFW
110 120 130 140 150
IGLLRSGDGQ TSGACPDLYQ WSDGSSSQFR NWYTDEPSCG SEKCVVMYHQ
160 170 180 190 200
PTANPGLGGP YLYQWNDDRC NMKHNYICKY EPEIHPTEPA EKPYLTNQPE
210 220 230 240 250
ETHENVVVTE AGIIPNLIYV IIPTIPLLLL ILVALGTCCF QMLHKSKGRS
260 270
KTSPNQSTLW ISKSTRKESG MEV
Length:273
Mass (Da):30,331
Last modified:October 3, 2012 - v3
Checksum:iF3EAE2B059D4EA28
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241V → W in BAB29226 (PubMed:16141072).Curated
Sequence conflicti179 – 1791K → T in AAL50354 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311699 mRNA. Translation: AAL50354.1.
AK014255 mRNA. Translation: BAB29226.1.
AK140910 mRNA. Translation: BAE24517.1.
AC114925 Genomic DNA. No translation available.
AC161815 Genomic DNA. No translation available.
BC117071 mRNA. Translation: AAI17072.1.
BC117073 mRNA. Translation: AAI17074.1.
CCDSiCCDS28279.1.
RefSeqiNP_624360.2. NM_139134.3.
UniGeneiMm.77895.

Genome annotation databases

EnsembliENSMUST00000023568; ENSMUSP00000023568; ENSMUSG00000022860.
GeneIDi246048.
KEGGimmu:246048.
UCSCiuc007zsw.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Chondrolectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF311699 mRNA. Translation: AAL50354.1.
AK014255 mRNA. Translation: BAB29226.1.
AK140910 mRNA. Translation: BAE24517.1.
AC114925 Genomic DNA. No translation available.
AC161815 Genomic DNA. No translation available.
BC117071 mRNA. Translation: AAI17072.1.
BC117073 mRNA. Translation: AAI17074.1.
CCDSiCCDS28279.1.
RefSeqiNP_624360.2. NM_139134.3.
UniGeneiMm.77895.

3D structure databases

ProteinModelPortaliQ9CXM0.
SMRiQ9CXM0. Positions 31-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023568.

Proteomic databases

MaxQBiQ9CXM0.
PaxDbiQ9CXM0.
PRIDEiQ9CXM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023568; ENSMUSP00000023568; ENSMUSG00000022860.
GeneIDi246048.
KEGGimmu:246048.
UCSCiuc007zsw.1. mouse.

Organism-specific databases

CTDi140578.
MGIiMGI:2179069. Chodl.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00390000001844.
HOGENOMiHOG000294068.
HOVERGENiHBG050945.
InParanoidiQ9CXM0.
KOiK10078.
OMAiSACPDLY.
OrthoDBiEOG7FV3RQ.
TreeFamiTF330715.

Miscellaneous databases

PROiQ9CXM0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CHODL.
ExpressionAtlasiQ9CXM0. baseline and differential.
GenevisibleiQ9CXM0. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mt75, a low expressed c-type lectin gene involving in chondrogenesis."
    Weng L., Smits P., Hubner R., Wouters J., Merregaert J.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head and Head.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCHODL_MOUSE
AccessioniPrimary (citable) accession number: Q9CXM0
Secondary accession number(s): Q3US20, Q8VI31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.