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Q9CXK8

- NIP7_MOUSE

UniProt

Q9CXK8 - NIP7_MOUSE

Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

Nip7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. ribosome assembly Source: InterPro

    Keywords - Biological processi

    Ribosome biogenesis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosome subunit biogenesis protein NIP7 homolog
    Alternative name(s):
    PEachy
    kDa93
    Gene namesi
    Name:Nip7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1913414. Nip7.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18018060S ribosome subunit biogenesis protein NIP7 homologPRO_0000218774Add
    BLAST

    Proteomic databases

    MaxQBiQ9CXK8.
    PaxDbiQ9CXK8.
    PRIDEiQ9CXK8.

    PTM databases

    PhosphoSiteiQ9CXK8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CXK8.
    BgeeiQ9CXK8.
    CleanExiMM_NIP7.
    GenevestigatoriQ9CXK8.

    Interactioni

    Subunit structurei

    Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211262. 2 interactions.
    IntActiQ9CXK8. 2 interactions.
    MINTiMINT-4103777.
    STRINGi10090.ENSMUSP00000034392.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXK8.
    SMRiQ9CXK8. Positions 1-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 17077PUAPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9292N-terminal domainBy similarityAdd
    BLAST
    Regioni93 – 18088C-terminal domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NIP7 family.Curated
    Contains 1 PUA domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1374.
    GeneTreeiENSGT00390000003591.
    HOGENOMiHOG000168475.
    HOVERGENiHBG052625.
    InParanoidiQ9CXK8.
    KOiK07565.
    OMAiCFGKFSK.
    OrthoDBiEOG7FFMT4.
    PhylomeDBiQ9CXK8.
    TreeFamiTF300081.

    Family and domain databases

    Gene3Di2.30.130.10. 1 hit.
    InterProiIPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR005155. Rbsml_synth_fac_NIP7-like.
    IPR016686. Ribosomal_synth_fac_NIP7.
    [Graphical view]
    PfamiPF03657. UPF0113. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
    SMARTiSM00359. PUA. 1 hit.
    [Graphical view]
    SUPFAMiSSF88697. SSF88697. 1 hit.
    PROSITEiPS50890. PUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEM    50
    MLKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWVK 100
    PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST 150
    QDCRKVDPMA IVVFHQADIG EYVRHEETLT 180
    Length:180
    Mass (Da):20,452
    Last modified:June 1, 2001 - v1
    Checksum:i4F1256165370F2AF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101R → P in BAB22972. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003739 mRNA. Translation: BAB22972.1.
    AK014290 mRNA. Translation: BAB29247.1.
    BC003972 mRNA. Translation: AAH03972.1.
    CCDSiCCDS22644.1.
    RefSeqiNP_079667.2. NM_025391.2.
    UniGeneiMm.334789.

    Genome annotation databases

    EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917.
    GeneIDi66164.
    KEGGimmu:66164.
    UCSCiuc009ngz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003739 mRNA. Translation: BAB22972.1 .
    AK014290 mRNA. Translation: BAB29247.1 .
    BC003972 mRNA. Translation: AAH03972.1 .
    CCDSi CCDS22644.1.
    RefSeqi NP_079667.2. NM_025391.2.
    UniGenei Mm.334789.

    3D structure databases

    ProteinModelPortali Q9CXK8.
    SMRi Q9CXK8. Positions 1-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211262. 2 interactions.
    IntActi Q9CXK8. 2 interactions.
    MINTi MINT-4103777.
    STRINGi 10090.ENSMUSP00000034392.

    PTM databases

    PhosphoSitei Q9CXK8.

    Proteomic databases

    MaxQBi Q9CXK8.
    PaxDbi Q9CXK8.
    PRIDEi Q9CXK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034392 ; ENSMUSP00000034392 ; ENSMUSG00000031917 .
    GeneIDi 66164.
    KEGGi mmu:66164.
    UCSCi uc009ngz.2. mouse.

    Organism-specific databases

    CTDi 51388.
    MGIi MGI:1913414. Nip7.

    Phylogenomic databases

    eggNOGi COG1374.
    GeneTreei ENSGT00390000003591.
    HOGENOMi HOG000168475.
    HOVERGENi HBG052625.
    InParanoidi Q9CXK8.
    KOi K07565.
    OMAi CFGKFSK.
    OrthoDBi EOG7FFMT4.
    PhylomeDBi Q9CXK8.
    TreeFami TF300081.

    Miscellaneous databases

    NextBioi 320822.
    PROi Q9CXK8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CXK8.
    Bgeei Q9CXK8.
    CleanExi MM_NIP7.
    Genevestigatori Q9CXK8.

    Family and domain databases

    Gene3Di 2.30.130.10. 1 hit.
    InterProi IPR002478. PUA.
    IPR015947. PUA-like_domain.
    IPR005155. Rbsml_synth_fac_NIP7-like.
    IPR016686. Ribosomal_synth_fac_NIP7.
    [Graphical view ]
    Pfami PF03657. UPF0113. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
    SMARTi SM00359. PUA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88697. SSF88697. 1 hit.
    PROSITEi PS50890. PUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Embryonic head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiNIP7_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXK8
    Secondary accession number(s): Q9D1B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3