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Q9CXK8

- NIP7_MOUSE

UniProt

Q9CXK8 - NIP7_MOUSE

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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

Nip7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. ribosome assembly Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Alternative name(s):
PEachy
kDa93
Gene namesi
Name:Nip7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1913414. Nip7.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18018060S ribosome subunit biogenesis protein NIP7 homologPRO_0000218774Add
BLAST

Proteomic databases

MaxQBiQ9CXK8.
PaxDbiQ9CXK8.
PRIDEiQ9CXK8.

PTM databases

PhosphoSiteiQ9CXK8.

Expressioni

Gene expression databases

BgeeiQ9CXK8.
CleanExiMM_NIP7.
ExpressionAtlasiQ9CXK8. baseline and differential.
GenevestigatoriQ9CXK8.

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 By similarity.By similarity

Protein-protein interaction databases

BioGridi211262. 2 interactions.
IntActiQ9CXK8. 2 interactions.
MINTiMINT-4103777.
STRINGi10090.ENSMUSP00000034392.

Structurei

3D structure databases

ProteinModelPortaliQ9CXK8.
SMRiQ9CXK8. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17077PUAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9292N-terminal domainBy similarityAdd
BLAST
Regioni93 – 18088C-terminal domainBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the NIP7 family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1374.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9CXK8.
KOiK07565.
OMAiCFGKFSK.
OrthoDBiEOG7FFMT4.
PhylomeDBiQ9CXK8.
TreeFamiTF300081.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view]
PfamiPF03657. UPF0113. 1 hit.
[Graphical view]
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEM
60 70 80 90 100
MLKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWVK
110 120 130 140 150
PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST
160 170 180
QDCRKVDPMA IVVFHQADIG EYVRHEETLT
Length:180
Mass (Da):20,452
Last modified:June 1, 2001 - v1
Checksum:i4F1256165370F2AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101R → P in BAB22972. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003739 mRNA. Translation: BAB22972.1.
AK014290 mRNA. Translation: BAB29247.1.
BC003972 mRNA. Translation: AAH03972.1.
CCDSiCCDS22644.1.
RefSeqiNP_079667.2. NM_025391.2.
UniGeneiMm.334789.

Genome annotation databases

EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917.
GeneIDi66164.
KEGGimmu:66164.
UCSCiuc009ngz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK003739 mRNA. Translation: BAB22972.1 .
AK014290 mRNA. Translation: BAB29247.1 .
BC003972 mRNA. Translation: AAH03972.1 .
CCDSi CCDS22644.1.
RefSeqi NP_079667.2. NM_025391.2.
UniGenei Mm.334789.

3D structure databases

ProteinModelPortali Q9CXK8.
SMRi Q9CXK8. Positions 1-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211262. 2 interactions.
IntActi Q9CXK8. 2 interactions.
MINTi MINT-4103777.
STRINGi 10090.ENSMUSP00000034392.

PTM databases

PhosphoSitei Q9CXK8.

Proteomic databases

MaxQBi Q9CXK8.
PaxDbi Q9CXK8.
PRIDEi Q9CXK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034392 ; ENSMUSP00000034392 ; ENSMUSG00000031917 .
GeneIDi 66164.
KEGGi mmu:66164.
UCSCi uc009ngz.2. mouse.

Organism-specific databases

CTDi 51388.
MGIi MGI:1913414. Nip7.

Phylogenomic databases

eggNOGi COG1374.
GeneTreei ENSGT00390000003591.
HOGENOMi HOG000168475.
HOVERGENi HBG052625.
InParanoidi Q9CXK8.
KOi K07565.
OMAi CFGKFSK.
OrthoDBi EOG7FFMT4.
PhylomeDBi Q9CXK8.
TreeFami TF300081.

Miscellaneous databases

NextBioi 320822.
PROi Q9CXK8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXK8.
CleanExi MM_NIP7.
ExpressionAtlasi Q9CXK8. baseline and differential.
Genevestigatori Q9CXK8.

Family and domain databases

Gene3Di 2.30.130.10. 1 hit.
InterProi IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
[Graphical view ]
Pfami PF03657. UPF0113. 1 hit.
[Graphical view ]
PIRSFi PIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTi SM00359. PUA. 1 hit.
[Graphical view ]
SUPFAMi SSF88697. SSF88697. 1 hit.
PROSITEi PS50890. PUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNIP7_MOUSE
AccessioniPrimary (citable) accession number: Q9CXK8
Secondary accession number(s): Q9D1B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3