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Protein

60S ribosome subunit biogenesis protein NIP7 homolog

Gene

Nip7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processRibosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosome subunit biogenesis protein NIP7 homolog
Alternative name(s):
PEachy
kDa93
Gene namesi
Name:Nip7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913414. Nip7.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187741 – 18060S ribosome subunit biogenesis protein NIP7 homologAdd BLAST180

Proteomic databases

EPDiQ9CXK8.
MaxQBiQ9CXK8.
PaxDbiQ9CXK8.
PeptideAtlasiQ9CXK8.
PRIDEiQ9CXK8.

PTM databases

PhosphoSitePlusiQ9CXK8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031917.
CleanExiMM_NIP7.
ExpressionAtlasiQ9CXK8. baseline and differential.
GenevisibleiQ9CXK8. MM.

Interactioni

Subunit structurei

Monomer. Interacts with pre-ribosome complex. May bind to RNA. Interacts with NOL8. Interacts with FTSJ3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211262. 2 interactors.
IntActiQ9CXK8. 2 interactors.
MINTiMINT-4103777.
STRINGi10090.ENSMUSP00000034392.

Structurei

3D structure databases

ProteinModelPortaliQ9CXK8.
SMRiQ9CXK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170PUAPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 92N-terminal domainBy similarityAdd BLAST92
Regioni93 – 180C-terminal domainBy similarityAdd BLAST88

Sequence similaritiesi

Belongs to the NIP7 family.Curated

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9CXK8.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9CXK8.
TreeFamiTF300081.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CXK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLTEEETR VMFEKIAKYI GENLQLLVDR PDGTYCFRLH NDRVYYVSEM
60 70 80 90 100
MLKLAANISG DKLVSLGTCF GKFTKTHKFR LHVTALDYLA PYAKYKVWVK
110 120 130 140 150
PGAEQSFLYG NHVLKSGLGR ITENTSQYQG VVVYSMADIP LGFGVAAKST
160 170 180
QDCRKVDPMA IVVFHQADIG EYVRHEETLT
Length:180
Mass (Da):20,452
Last modified:June 1, 2001 - v1
Checksum:i4F1256165370F2AF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10R → P in BAB22972 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003739 mRNA. Translation: BAB22972.1.
AK014290 mRNA. Translation: BAB29247.1.
BC003972 mRNA. Translation: AAH03972.1.
CCDSiCCDS22644.1.
RefSeqiNP_079667.2. NM_025391.2.
UniGeneiMm.334789.

Genome annotation databases

EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917.
GeneIDi66164.
KEGGimmu:66164.
UCSCiuc009ngz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003739 mRNA. Translation: BAB22972.1.
AK014290 mRNA. Translation: BAB29247.1.
BC003972 mRNA. Translation: AAH03972.1.
CCDSiCCDS22644.1.
RefSeqiNP_079667.2. NM_025391.2.
UniGeneiMm.334789.

3D structure databases

ProteinModelPortaliQ9CXK8.
SMRiQ9CXK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211262. 2 interactors.
IntActiQ9CXK8. 2 interactors.
MINTiMINT-4103777.
STRINGi10090.ENSMUSP00000034392.

PTM databases

PhosphoSitePlusiQ9CXK8.

Proteomic databases

EPDiQ9CXK8.
MaxQBiQ9CXK8.
PaxDbiQ9CXK8.
PeptideAtlasiQ9CXK8.
PRIDEiQ9CXK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034392; ENSMUSP00000034392; ENSMUSG00000031917.
GeneIDi66164.
KEGGimmu:66164.
UCSCiuc009ngz.2. mouse.

Organism-specific databases

CTDi51388.
MGIiMGI:1913414. Nip7.

Phylogenomic databases

eggNOGiKOG3492. Eukaryota.
COG1374. LUCA.
GeneTreeiENSGT00390000003591.
HOGENOMiHOG000168475.
HOVERGENiHBG052625.
InParanoidiQ9CXK8.
KOiK07565.
OMAiYCFREHR.
OrthoDBiEOG091G0NVA.
PhylomeDBiQ9CXK8.
TreeFamiTF300081.

Miscellaneous databases

PROiPR:Q9CXK8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031917.
CleanExiMM_NIP7.
ExpressionAtlasiQ9CXK8. baseline and differential.
GenevisibleiQ9CXK8. MM.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR005155. Rbsml_synth_fac_NIP7-like.
IPR016686. Ribosomal_synth_fac_NIP7.
PfamiView protein in Pfam
PF03657. UPF0113. 1 hit.
PIRSFiPIRSF017190. Rbsml_synth_fac_NIP7. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIP7_MOUSE
AccessioniPrimary (citable) accession number: Q9CXK8
Secondary accession number(s): Q9D1B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.