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Protein

Sugar transporter SWEET1

Gene

Slc50a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates sugar transport across membranes (By similarity). May regulate the expression of RAG1 a gene involved in V(D)J recombination.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • carbohydrate transport Source: GO_Central
  • positive regulation of gene expression, epigenetic Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sugar transporter SWEET1
Short name:
MmSWEET1
Alternative name(s):
RAG1-activating protein 1
Solute carrier family 50 member 1
Gene namesi
Name:Slc50a1
Synonyms:Rag1ap1, Rga
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:107417. Slc50a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei3 – 2321Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei129 – 14921Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei186 – 20621Helical; Name=7Sequence analysisAdd
BLAST

GO - Cellular componenti

  • Golgi apparatus Source: MGI
  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: GO_Central
  • nucleus Source: HGNC
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Sugar transporter SWEET1PRO_0000345117Add
BLAST

Proteomic databases

PaxDbiQ9CXK4.
PRIDEiQ9CXK4.

PTM databases

PhosphoSiteiQ9CXK4.

Expressioni

Tissue specificityi

Expressed at high levels in lung, placenta, spleen and thymus, at intermediate levels in brain, heart, kidney and testis, and at low levels in bone marrow, liver and lymph node. Within the thymus expression is highest in non-lymphoid cells.1 Publication

Inductioni

Up-regulated in mammary gland during lactation.1 Publication

Gene expression databases

BgeeiENSMUSG00000027953.
ExpressionAtlasiQ9CXK4. baseline and differential.
GenevisibleiQ9CXK4. MM.

Interactioni

Subunit structurei

Interacts with TRPV2; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029565.

Structurei

3D structure databases

ProteinModelPortaliQ9CXK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9485MtN3/slv 1Add
BLAST
Domaini127 – 21286MtN3/slv 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 22173Mediates interaction with TRPV2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SWEET sugar transporter family.Curated
Contains 2 MtN3/slv domains.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1623. Eukaryota.
ENOG4111M4R. LUCA.
GeneTreeiENSGT00390000007801.
HOVERGENiHBG055287.
InParanoidiQ9CXK4.
KOiK15382.
OMAiINNLSWL.
OrthoDBiEOG091G0J82.
PhylomeDBiQ9CXK4.
TreeFamiTF313635.

Family and domain databases

InterProiIPR004316. SWEET_sugar_transpr.
[Graphical view]
PfamiPF03083. MtN3_slv. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAGGVADSF LSSACVLFTL GMFSTGLSDL RHMQRTRSVD NIQFLPFLTT
60 70 80 90 100
DVNNLSWLSY GVLKGDGTLI IVNSVGAVLQ TLYILAYLHY SPQKHGVLLQ
110 120 130 140 150
TATLLAVLLL GYGYFWLLVP DLEARLQQLG LFCSVFTISM YLSPLADLAK
160 170 180 190 200
IVQTKSTQRL SFSLTIATLF CSASWSIYGF RLRDPYITVP NLPGILTSLI
210 220
RLGLFCKYPP EQDRKYRLLQ T
Length:221
Mass (Da):24,649
Last modified:June 1, 2001 - v1
Checksum:i60FA342447ABA45C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti188 – 1881T → A in CAA65438 (PubMed:8630032).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96618 mRNA. Translation: CAA65438.1.
AK014305 mRNA. Translation: BAB29259.1.
AK170162 mRNA. Translation: BAE41608.1.
BC014292 mRNA. Translation: AAH14292.1.
CCDSiCCDS17500.1.
PIRiJC4761.
RefSeqiNP_033083.2. NM_009057.3.
UniGeneiMm.17958.

Genome annotation databases

EnsembliENSMUST00000029565; ENSMUSP00000029565; ENSMUSG00000027953.
GeneIDi19729.
KEGGimmu:19729.
UCSCiuc008pyn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96618 mRNA. Translation: CAA65438.1.
AK014305 mRNA. Translation: BAB29259.1.
AK170162 mRNA. Translation: BAE41608.1.
BC014292 mRNA. Translation: AAH14292.1.
CCDSiCCDS17500.1.
PIRiJC4761.
RefSeqiNP_033083.2. NM_009057.3.
UniGeneiMm.17958.

3D structure databases

ProteinModelPortaliQ9CXK4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029565.

PTM databases

PhosphoSiteiQ9CXK4.

Proteomic databases

PaxDbiQ9CXK4.
PRIDEiQ9CXK4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029565; ENSMUSP00000029565; ENSMUSG00000027953.
GeneIDi19729.
KEGGimmu:19729.
UCSCiuc008pyn.2. mouse.

Organism-specific databases

CTDi55974.
MGIiMGI:107417. Slc50a1.

Phylogenomic databases

eggNOGiKOG1623. Eukaryota.
ENOG4111M4R. LUCA.
GeneTreeiENSGT00390000007801.
HOVERGENiHBG055287.
InParanoidiQ9CXK4.
KOiK15382.
OMAiINNLSWL.
OrthoDBiEOG091G0J82.
PhylomeDBiQ9CXK4.
TreeFamiTF313635.

Miscellaneous databases

PROiQ9CXK4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027953.
ExpressionAtlasiQ9CXK4. baseline and differential.
GenevisibleiQ9CXK4. MM.

Family and domain databases

InterProiIPR004316. SWEET_sugar_transpr.
[Graphical view]
PfamiPF03083. MtN3_slv. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWET1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXK4
Secondary accession number(s): Q62275
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.