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Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

Abcb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi489 – 496ATPPROSITE-ProRule annotation8

GO - Molecular functioni

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1369007 Mitochondrial ABC transporters

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Gene namesi
Name:Abcb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1351667 Abcb8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei127 – 147HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei178 – 198HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei278 – 298HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei365 – 385HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionBy similarityAdd BLAST38
ChainiPRO_000035623339 – 717ATP-binding cassette sub-family B member 8, mitochondrialAdd BLAST679

Proteomic databases

EPDiQ9CXJ4
MaxQBiQ9CXJ4
PaxDbiQ9CXJ4
PeptideAtlasiQ9CXJ4
PRIDEiQ9CXJ4

PTM databases

iPTMnetiQ9CXJ4
PhosphoSitePlusiQ9CXJ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000028973
ExpressionAtlasiQ9CXJ4 baseline and differential
GenevisibleiQ9CXJ4 MM

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

IntActiQ9CXJ4, 1 interactor
STRINGi10090.ENSMUSP00000072826

Structurei

3D structure databases

ProteinModelPortaliQ9CXJ4
SMRiQ9CXJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini130 – 419ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST290
Domaini454 – 691ABC transporterPROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00550000074497
HOVERGENiHBG008358
InParanoidiQ9CXJ4
KOiK05655
OMAiAWGTYLV
OrthoDBiEOG091G0HVA
PhylomeDBiQ9CXJ4
TreeFamiTF105196

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRFGI RGGPVPGWSL QSLRFQTFSA ARSSDDRLSS HLLRTVAQLR
60 70 80 90 100
VQLRAHLPRA PPASHWSPSA WCWVGGTLVV PAVLWQHPRL CLIALCEAKE
110 120 130 140 150
SPPAQPTRAP ELRFNWKLFW HFLHPHLLAL GAAIVLALGA ALVNVQIPLL
160 170 180 190 200
LGQLVEIVAK YTRDHMGSFV SESRKLSVQL LLLYGVQGLL TFGYLVLLSH
210 220 230 240 250
IGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD VQEFKSSFKL
260 270 280 290 300
VISQGLRSCT QVIGSLVSLS MLSPRLTLML AVVTPALMGV GTLMGSGLRK
310 320 330 340 350
LSRQCQEQIA RATGVADEAL GNVRTVRAFA MEKREEERYQ AELESCCCKA
360 370 380 390 400
EELGRGIALF QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS
410 420 430 440 450
QTVQRSMASL SVLFGQVVRG LSAGARVFEY MALSPVIPLT GGYCIPNKDI
460 470 480 490 500
RGSITFQNVT FSYPCRPGFN VLKDFTLKLP SGKIVALVGQ SGGGKTTVAS
510 520 530 540 550
LLERFYDPEA GSVTLDGHDL RTLNPSWLRG QVIGFISQEP VLFATTIMEN
560 570 580 590 600
IRFGKLDASD EEVYTAAREA NAHEFISSFP DGYSTVVGER GTTLSGGQKQ
610 620 630 640 650
RLAIARALIK QPTVLILDEA TSALDAESER VVQEALDRAS AGRTVLVIAH
660 670 680 690 700
RLSTVRAAHS IIVMANGQVC EAGTHEELLK KGGLYSELIR RQTLDASLTS
710
TPPAEKPEDP KSCQSKA
Length:717
Mass (Da):78,000
Last modified:June 1, 2001 - v1
Checksum:iE573D4276B9658EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101S → Y in BAC33571 (PubMed:16141072).Curated1
Sequence conflicti157I → M in BAC36297 (PubMed:16141072).Curated1
Sequence conflicti225F → L in BAC36297 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014319 mRNA Translation: BAB29270.1
AK030624 mRNA Translation: BAC27052.1
AK049152 mRNA Translation: BAC33571.1
AK076315 mRNA Translation: BAC36297.1
AK166704 mRNA Translation: BAE38958.1
BC015301 mRNA Translation: AAH15301.1
CCDSiCCDS19118.1
RefSeqiNP_083296.2, NM_029020.2
XP_006535875.1, XM_006535812.1
UniGeneiMm.283914

Genome annotation databases

EnsembliENSMUST00000073076; ENSMUSP00000072826; ENSMUSG00000028973
ENSMUST00000115077; ENSMUSP00000110729; ENSMUSG00000028973
GeneIDi74610
KEGGimmu:74610
UCSCiuc008wrh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiABCB8_MOUSE
AccessioniPrimary (citable) accession number: Q9CXJ4
Secondary accession number(s): Q8C695, Q8C7W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health