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Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

Abcb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi489 – 4968ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Gene namesi
Name:Abcb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1351667. Abcb8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei127 – 14721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei178 – 19821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei278 – 29821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei365 – 38521HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3838MitochondrionBy similarityAdd
BLAST
Chaini39 – 717679ATP-binding cassette sub-family B member 8, mitochondrialPRO_0000356233Add
BLAST

Proteomic databases

EPDiQ9CXJ4.
MaxQBiQ9CXJ4.
PaxDbiQ9CXJ4.
PRIDEiQ9CXJ4.

PTM databases

iPTMnetiQ9CXJ4.
PhosphoSiteiQ9CXJ4.

Expressioni

Gene expression databases

BgeeiQ9CXJ4.
ExpressionAtlasiQ9CXJ4. baseline and differential.
GenevisibleiQ9CXJ4. MM.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

IntActiQ9CXJ4. 1 interaction.
STRINGi10090.ENSMUSP00000072826.

Structurei

3D structure databases

ProteinModelPortaliQ9CXJ4.
SMRiQ9CXJ4. Positions 124-693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini130 – 419290ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini454 – 691238ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9CXJ4.
KOiK05655.
OMAiNTIRQAD.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ9CXJ4.
TreeFamiTF105196.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVHLFRFGI RGGPVPGWSL QSLRFQTFSA ARSSDDRLSS HLLRTVAQLR
60 70 80 90 100
VQLRAHLPRA PPASHWSPSA WCWVGGTLVV PAVLWQHPRL CLIALCEAKE
110 120 130 140 150
SPPAQPTRAP ELRFNWKLFW HFLHPHLLAL GAAIVLALGA ALVNVQIPLL
160 170 180 190 200
LGQLVEIVAK YTRDHMGSFV SESRKLSVQL LLLYGVQGLL TFGYLVLLSH
210 220 230 240 250
IGERMAMDMR KALFSSLLRQ DIAFFDAKKT GQLVSRLTTD VQEFKSSFKL
260 270 280 290 300
VISQGLRSCT QVIGSLVSLS MLSPRLTLML AVVTPALMGV GTLMGSGLRK
310 320 330 340 350
LSRQCQEQIA RATGVADEAL GNVRTVRAFA MEKREEERYQ AELESCCCKA
360 370 380 390 400
EELGRGIALF QGLSNIAFNC MVLGTLFIGG SLVAGQQLKG GDLMSFLVAS
410 420 430 440 450
QTVQRSMASL SVLFGQVVRG LSAGARVFEY MALSPVIPLT GGYCIPNKDI
460 470 480 490 500
RGSITFQNVT FSYPCRPGFN VLKDFTLKLP SGKIVALVGQ SGGGKTTVAS
510 520 530 540 550
LLERFYDPEA GSVTLDGHDL RTLNPSWLRG QVIGFISQEP VLFATTIMEN
560 570 580 590 600
IRFGKLDASD EEVYTAAREA NAHEFISSFP DGYSTVVGER GTTLSGGQKQ
610 620 630 640 650
RLAIARALIK QPTVLILDEA TSALDAESER VVQEALDRAS AGRTVLVIAH
660 670 680 690 700
RLSTVRAAHS IIVMANGQVC EAGTHEELLK KGGLYSELIR RQTLDASLTS
710
TPPAEKPEDP KSCQSKA
Length:717
Mass (Da):78,000
Last modified:June 1, 2001 - v1
Checksum:iE573D4276B9658EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti101 – 1011S → Y in BAC33571 (PubMed:16141072).Curated
Sequence conflicti157 – 1571I → M in BAC36297 (PubMed:16141072).Curated
Sequence conflicti225 – 2251F → L in BAC36297 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014319 mRNA. Translation: BAB29270.1.
AK030624 mRNA. Translation: BAC27052.1.
AK049152 mRNA. Translation: BAC33571.1.
AK076315 mRNA. Translation: BAC36297.1.
AK166704 mRNA. Translation: BAE38958.1.
BC015301 mRNA. Translation: AAH15301.1.
CCDSiCCDS19118.1.
RefSeqiNP_083296.2. NM_029020.2.
XP_006535875.1. XM_006535812.1.
UniGeneiMm.283914.

Genome annotation databases

EnsembliENSMUST00000073076; ENSMUSP00000072826; ENSMUSG00000028973.
ENSMUST00000115077; ENSMUSP00000110729; ENSMUSG00000028973.
GeneIDi74610.
KEGGimmu:74610.
UCSCiuc008wrh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014319 mRNA. Translation: BAB29270.1.
AK030624 mRNA. Translation: BAC27052.1.
AK049152 mRNA. Translation: BAC33571.1.
AK076315 mRNA. Translation: BAC36297.1.
AK166704 mRNA. Translation: BAE38958.1.
BC015301 mRNA. Translation: AAH15301.1.
CCDSiCCDS19118.1.
RefSeqiNP_083296.2. NM_029020.2.
XP_006535875.1. XM_006535812.1.
UniGeneiMm.283914.

3D structure databases

ProteinModelPortaliQ9CXJ4.
SMRiQ9CXJ4. Positions 124-693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CXJ4. 1 interaction.
STRINGi10090.ENSMUSP00000072826.

PTM databases

iPTMnetiQ9CXJ4.
PhosphoSiteiQ9CXJ4.

Proteomic databases

EPDiQ9CXJ4.
MaxQBiQ9CXJ4.
PaxDbiQ9CXJ4.
PRIDEiQ9CXJ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073076; ENSMUSP00000072826; ENSMUSG00000028973.
ENSMUST00000115077; ENSMUSP00000110729; ENSMUSG00000028973.
GeneIDi74610.
KEGGimmu:74610.
UCSCiuc008wrh.1. mouse.

Organism-specific databases

CTDi11194.
MGIiMGI:1351667. Abcb8.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9CXJ4.
KOiK05655.
OMAiNTIRQAD.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ9CXJ4.
TreeFamiTF105196.

Miscellaneous databases

PROiQ9CXJ4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXJ4.
ExpressionAtlasiQ9CXJ4. baseline and differential.
GenevisibleiQ9CXJ4. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Pituitary and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Pancreas and Testis.

Entry informationi

Entry nameiABCB8_MOUSE
AccessioniPrimary (citable) accession number: Q9CXJ4
Secondary accession number(s): Q8C695, Q8C7W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.