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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

Coq5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Binding sitei171S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:Coq5UniRule annotation
Synonyms:D5Ertd33e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1098643 Coq5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionUniRule annotationAdd BLAST49
ChainiPRO_000022862950 – 3272-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialAdd BLAST278

Proteomic databases

EPDiQ9CXI0
MaxQBiQ9CXI0
PaxDbiQ9CXI0
PeptideAtlasiQ9CXI0
PRIDEiQ9CXI0

PTM databases

iPTMnetiQ9CXI0
PhosphoSitePlusiQ9CXI0

Expressioni

Gene expression databases

BgeeiENSMUSG00000041733
CleanExiMM_COQ5
ExpressionAtlasiQ9CXI0 baseline and differential
GenevisibleiQ9CXI0 MM

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

IntActiQ9CXI0 2 interactors.
MINTiQ9CXI0
STRINGi10090.ENSMUSP00000048001

Structurei

3D structure databases

ProteinModelPortaliQ9CXI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 200S-adenosyl-L-methionine bindingUniRule annotation2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540 Eukaryota
COG2226 LUCA
GeneTreeiENSGT00390000001654
HOGENOMiHOG000249463
HOVERGENiHBG081303
InParanoidiQ9CXI0
KOiK06127
OMAiVRNFENL
OrthoDBiEOG091G0G2Z
PhylomeDBiQ9CXI0
TreeFamiTF106217

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRCCVLW RVCGRGWWRA TGHCRLPGCH RSWPWATLGT RSLSQEKRAA
60 70 80 90 100
ETHFGFETVS EGEKGSKVYQ VFENVAKKYD LMNDMMSLGI HRAWKDLLIR
110 120 130 140 150
KMHPLPGTQL LDMAGGTGDI AFRFLSYVQA QHQRRQRRQL RTQQNLSWEE
160 170 180 190 200
IAKKYQNEED SLGGSLATVC DINREMLKVG KQKALDQGHT AGLAWVLGDA
210 220 230 240 250
EELPFDDDSF DVYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFGQV
260 270 280 290 300
NDPLISRLYD LYSFQVIPVI GEVIAGDWKS YQYLVESIRK FPNQEDFKDM
310 320
IEDAGFQRVT YENLTTGIVA IHSGFKL
Length:327
Mass (Da):37,336
Last modified:March 21, 2006 - v2
Checksum:iBFFD932B22F1A7CB
GO

Sequence cautioni

The sequence BAB26525 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12V → F in BAB29289 (PubMed:16141072).Curated1
Sequence conflicti210F → L in BAB26525 (PubMed:16141072).Curated1
Sequence conflicti238P → Q in BAB26525 (PubMed:16141072).Curated1
Sequence conflicti267I → T in BAB26525 (PubMed:16141072).Curated1
Sequence conflicti272E → G in BAB26525 (PubMed:16141072).Curated1
Sequence conflicti290K → E in BAB26525 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007496 mRNA Translation: BAB25069.1
AK009825 mRNA Translation: BAB26525.1 Frameshift.
AK014348 mRNA Translation: BAB29289.1
AK045993 mRNA Translation: BAC32564.1
AK050334 mRNA Translation: BAC34194.1
BC052345 mRNA Translation: AAH52345.1
CCDSiCCDS19585.1
RefSeqiNP_080780.1, NM_026504.2
UniGeneiMm.290142

Genome annotation databases

EnsembliENSMUST00000040421; ENSMUSP00000048001; ENSMUSG00000041733
GeneIDi52064
KEGGimmu:52064
UCSCiuc008zdo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOQ5_MOUSE
AccessioniPrimary (citable) accession number: Q9CXI0
Secondary accession number(s): Q9D6Y6, Q9D900
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: April 25, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome