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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

Coq5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171S-adenosyl-L-methionineUniRule annotation
Binding sitei171 – 1711S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialUniRule annotation (EC:2.1.1.201UniRule annotation)
Alternative name(s):
Ubiquinone biosynthesis methyltransferase COQ5UniRule annotation
Gene namesi
Name:Coq5UniRule annotation
Synonyms:D5Ertd33e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1098643. Coq5.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • extrinsic component of mitochondrial inner membrane Source: UniProtKB-HAMAP
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence analysisAdd
BLAST
Chaini50 – 3272782-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialPRO_0000228629Add
BLAST

Proteomic databases

EPDiQ9CXI0.
MaxQBiQ9CXI0.
PaxDbiQ9CXI0.
PeptideAtlasiQ9CXI0.
PRIDEiQ9CXI0.

PTM databases

iPTMnetiQ9CXI0.
PhosphoSiteiQ9CXI0.

Expressioni

Gene expression databases

BgeeiQ9CXI0.
CleanExiMM_COQ5.
ExpressionAtlasiQ9CXI0. baseline and differential.
GenevisibleiQ9CXI0. MM.

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.UniRule annotation

Protein-protein interaction databases

IntActiQ9CXI0. 2 interactions.
MINTiMINT-4127734.
STRINGi10090.ENSMUSP00000048001.

Structurei

3D structure databases

ProteinModelPortaliQ9CXI0.
SMRiQ9CXI0. Positions 74-327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni199 – 2002S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ9CXI0.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiQ9CXI0.
TreeFamiTF106217.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRCCVLW RVCGRGWWRA TGHCRLPGCH RSWPWATLGT RSLSQEKRAA
60 70 80 90 100
ETHFGFETVS EGEKGSKVYQ VFENVAKKYD LMNDMMSLGI HRAWKDLLIR
110 120 130 140 150
KMHPLPGTQL LDMAGGTGDI AFRFLSYVQA QHQRRQRRQL RTQQNLSWEE
160 170 180 190 200
IAKKYQNEED SLGGSLATVC DINREMLKVG KQKALDQGHT AGLAWVLGDA
210 220 230 240 250
EELPFDDDSF DVYTIAFGIR NVTHIDQALQ EAHRVLKPGG RFLCLEFGQV
260 270 280 290 300
NDPLISRLYD LYSFQVIPVI GEVIAGDWKS YQYLVESIRK FPNQEDFKDM
310 320
IEDAGFQRVT YENLTTGIVA IHSGFKL
Length:327
Mass (Da):37,336
Last modified:March 21, 2006 - v2
Checksum:iBFFD932B22F1A7CB
GO

Sequence cautioni

The sequence BAB26525.1 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121V → F in BAB29289 (PubMed:16141072).Curated
Sequence conflicti210 – 2101F → L in BAB26525 (PubMed:16141072).Curated
Sequence conflicti238 – 2381P → Q in BAB26525 (PubMed:16141072).Curated
Sequence conflicti267 – 2671I → T in BAB26525 (PubMed:16141072).Curated
Sequence conflicti272 – 2721E → G in BAB26525 (PubMed:16141072).Curated
Sequence conflicti290 – 2901K → E in BAB26525 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007496 mRNA. Translation: BAB25069.1.
AK009825 mRNA. Translation: BAB26525.1. Frameshift.
AK014348 mRNA. Translation: BAB29289.1.
AK045993 mRNA. Translation: BAC32564.1.
AK050334 mRNA. Translation: BAC34194.1.
BC052345 mRNA. Translation: AAH52345.1.
CCDSiCCDS19585.1.
RefSeqiNP_080780.1. NM_026504.2.
UniGeneiMm.290142.

Genome annotation databases

EnsembliENSMUST00000040421; ENSMUSP00000048001; ENSMUSG00000041733.
GeneIDi52064.
KEGGimmu:52064.
UCSCiuc008zdo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007496 mRNA. Translation: BAB25069.1.
AK009825 mRNA. Translation: BAB26525.1. Frameshift.
AK014348 mRNA. Translation: BAB29289.1.
AK045993 mRNA. Translation: BAC32564.1.
AK050334 mRNA. Translation: BAC34194.1.
BC052345 mRNA. Translation: AAH52345.1.
CCDSiCCDS19585.1.
RefSeqiNP_080780.1. NM_026504.2.
UniGeneiMm.290142.

3D structure databases

ProteinModelPortaliQ9CXI0.
SMRiQ9CXI0. Positions 74-327.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CXI0. 2 interactions.
MINTiMINT-4127734.
STRINGi10090.ENSMUSP00000048001.

PTM databases

iPTMnetiQ9CXI0.
PhosphoSiteiQ9CXI0.

Proteomic databases

EPDiQ9CXI0.
MaxQBiQ9CXI0.
PaxDbiQ9CXI0.
PeptideAtlasiQ9CXI0.
PRIDEiQ9CXI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040421; ENSMUSP00000048001; ENSMUSG00000041733.
GeneIDi52064.
KEGGimmu:52064.
UCSCiuc008zdo.1. mouse.

Organism-specific databases

CTDi84274.
MGIiMGI:1098643. Coq5.

Phylogenomic databases

eggNOGiKOG1540. Eukaryota.
COG2226. LUCA.
GeneTreeiENSGT00390000001654.
HOGENOMiHOG000249463.
HOVERGENiHBG081303.
InParanoidiQ9CXI0.
KOiK06127.
OMAiGGLHRAW.
OrthoDBiEOG712TXJ.
PhylomeDBiQ9CXI0.
TreeFamiTF106217.

Enzyme and pathway databases

UniPathwayiUPA00232.

Miscellaneous databases

ChiTaRSiCoq5. mouse.
PROiQ9CXI0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXI0.
CleanExiMM_COQ5.
ExpressionAtlasiQ9CXI0. baseline and differential.
GenevisibleiQ9CXI0. MM.

Family and domain databases

Gene3Di3.40.50.150. 2 hits.
HAMAPiMF_01813. MenG_UbiE_methyltr.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Head, Liver and Pancreas.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver and Pancreas.

Entry informationi

Entry nameiCOQ5_MOUSE
AccessioniPrimary (citable) accession number: Q9CXI0
Secondary accession number(s): Q9D6Y6, Q9D900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.