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Protein

Peptidyl-prolyl cis-trans isomerase-like 4

Gene

Ppil4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 4 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL4
Rotamase PPIL4
Gene namesi
Name:Ppil4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914668. Ppil4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330531 – 492Peptidyl-prolyl cis-trans isomerase-like 4Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CXG3.
MaxQBiQ9CXG3.
PaxDbiQ9CXG3.
PeptideAtlasiQ9CXG3.
PRIDEiQ9CXG3.

PTM databases

iPTMnetiQ9CXG3.
PhosphoSitePlusiQ9CXG3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015757.
CleanExiMM_PPIL4.
ExpressionAtlasiQ9CXG3. baseline and differential.
GenevisibleiQ9CXG3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015901.

Structurei

3D structure databases

ProteinModelPortaliQ9CXG3.
SMRiQ9CXG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini240 – 318RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 388Lys-richAdd BLAST68

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000186284.
HOVERGENiHBG057731.
InParanoidiQ9CXG3.
KOiK12735.
OMAiDPYPDPA.
OrthoDBiEOG091G0DCF.
PhylomeDBiQ9CXG3.
TreeFamiTF351865.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI
60 70 80 90 100
IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG
110 120 130 140 150
SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIVKKIN ETFVDKDFVP
160 170 180 190 200
YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTKEQLDSGR IGADEEIDDF
210 220 230 240 250
KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV
260 270 280 290 300
TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK
310 320 330 340 350
MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPANLV
360 370 380 390 400
LKEKVKPKQD AKYDLILDEQ GEDSKSSHSH TSKKHKKKTR HCSEEKEDEE
410 420 430 440 450
YMPIKNPNQD IYREMGFGHY EEEESCWEKQ KNEKRDRRQN RSRSRSRERD
460 470 480 490
GHYSNSHKPK YQTEPYERER SRKRDRSRSP KKSKAKEKSK YR
Length:492
Mass (Da):57,230
Last modified:April 18, 2006 - v2
Checksum:i8938D66664EF640E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234D → E in BAB29330 (PubMed:16141072).Curated1
Sequence conflicti258I → L in BAB29330 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011443 mRNA. Translation: BAB27623.1.
AK014406 mRNA. Translation: BAB29330.1.
AK167258 mRNA. Translation: BAE39374.1.
BC079912 mRNA. Translation: AAH79912.1.
CCDSiCCDS23690.1.
RefSeqiNP_080417.2. NM_026141.3.
UniGeneiMm.38927.

Genome annotation databases

EnsembliENSMUST00000015901; ENSMUSP00000015901; ENSMUSG00000015757.
GeneIDi67418.
KEGGimmu:67418.
UCSCiuc007eip.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011443 mRNA. Translation: BAB27623.1.
AK014406 mRNA. Translation: BAB29330.1.
AK167258 mRNA. Translation: BAE39374.1.
BC079912 mRNA. Translation: AAH79912.1.
CCDSiCCDS23690.1.
RefSeqiNP_080417.2. NM_026141.3.
UniGeneiMm.38927.

3D structure databases

ProteinModelPortaliQ9CXG3.
SMRiQ9CXG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015901.

PTM databases

iPTMnetiQ9CXG3.
PhosphoSitePlusiQ9CXG3.

Proteomic databases

EPDiQ9CXG3.
MaxQBiQ9CXG3.
PaxDbiQ9CXG3.
PeptideAtlasiQ9CXG3.
PRIDEiQ9CXG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015901; ENSMUSP00000015901; ENSMUSG00000015757.
GeneIDi67418.
KEGGimmu:67418.
UCSCiuc007eip.2. mouse.

Organism-specific databases

CTDi85313.
MGIiMGI:1914668. Ppil4.

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000186284.
HOVERGENiHBG057731.
InParanoidiQ9CXG3.
KOiK12735.
OMAiDPYPDPA.
OrthoDBiEOG091G0DCF.
PhylomeDBiQ9CXG3.
TreeFamiTF351865.

Miscellaneous databases

PROiQ9CXG3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015757.
CleanExiMM_PPIL4.
ExpressionAtlasiQ9CXG3. baseline and differential.
GenevisibleiQ9CXG3. MM.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL4_MOUSE
AccessioniPrimary (citable) accession number: Q9CXG3
Secondary accession number(s): Q3TJX1, Q68FC7, Q9CT22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 2, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.