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Q9CXF7

- CHD1L_MOUSE

UniProt

Q9CXF7 - CHD1L_MOUSE

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Protein

Chromodomain-helicase-DNA-binding protein 1-like

Gene

Chd1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: InterPro
  4. helicase activity Source: UniProtKB-KW
  5. nucleotide binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cellular response to DNA damage stimulus Source: UniProtKB
  3. chromatin remodeling Source: UniProtKB
  4. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 1-like (EC:3.6.4.12)
Gene namesi
Name:Chd1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915308. Chd1l.

Subcellular locationi

Nucleus By similarity
Note: Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 900900Chromodomain-helicase-DNA-binding protein 1-likePRO_0000332142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei641 – 6411PhosphoserineBy similarity
Modified residuei894 – 8941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CXF7.
PaxDbiQ9CXF7.
PRIDEiQ9CXF7.

PTM databases

PhosphoSiteiQ9CXF7.

Expressioni

Gene expression databases

BgeeiQ9CXF7.
GenevestigatoriQ9CXF7.

Interactioni

Subunit structurei

Interacts with PARP1; interacts only when PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).By similarity

Protein-protein interaction databases

BioGridi212634. 1 interaction.
DIPiDIP-58953N.
STRINGi10090.ENSMUSP00000029730.

Structurei

3D structure databases

ProteinModelPortaliQ9CXF7.
SMRiQ9CXF7. Positions 22-547, 722-878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 217166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini345 – 507163Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini709 – 900192MacroPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili643 – 68038Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi168 – 1714DEAH box

Domaini

The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.By similarity

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 Macro domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00680000100002.
HOGENOMiHOG000030789.
HOVERGENiHBG077542.
InParanoidiQ9CXF7.
OMAiNWKEEME.
OrthoDBiEOG72G16M.
PhylomeDBiQ9CXF7.
TreeFamiTF333326.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR002589. Macro_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51154. MACRO. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CXF7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGLPRFLQ ALPAEHGPEP LRTRVQEPDL QQWGLTGIRL RSYQLEGVNW
60 70 80 90 100
LVQCFHCQNG CILGDEMGLG KTCQTIALLI YLVGRLNDEG PFLVLCPLSV
110 120 130 140 150
LSNWKEEMER FAPGLSCVTY TGDKEERARL QQDLRQESGF HVLLTTYEIC
160 170 180 190 200
LKDASFLKSF SWSVLAVDEA HRLKNQSSLL HRTLSEFSAV FRLLLTGTPI
210 220 230 240 250
QNSLRELYSL LCVVEPDLFC REQVEDFVQR YQDIEKESKS ASELHRLLQP
260 270 280 290 300
FLLRRVKAQV ATELPKKTEV VVYHGMSALQ KKYYKAILMK DLDAFENETA
310 320 330 340 350
KKVKLQNILT QLRKCVDHPY LFDGVEPEPF EVGEHLIEAS GKLHLLDRLL
360 370 380 390 400
AFLYSGGHRV LLFSQMTHML DILQDYMDYR GYSYERVDGS VRGEERHLAI
410 420 430 440 450
KNFGNQPIFV FLLSTRAGGV GMNLTAADTV IFVDSDFNPQ NDLQAAARAH
460 470 480 490 500
RIGQNKSVKV IRLIGRDTVE EIVYRKAASK LQLTNMVIEG GHFTPGAQKP
510 520 530 540 550
SAEADFQLSE ILKFGLDKLL SSEGSSMEDI DLKSILGETK DGQWTPDALP
560 570 580 590 600
AAAAAGGGSL EPEEGSELES RSYENHMYLF EGRDYSKEPS KEDRKSFEQL
610 620 630 640 650
VNLQKTLLEK TSHGGRTLRN KGSVLIPGLA EGPIKRKKIL SPEELEDRRK
660 670 680 690 700
KRQEAAAKRK RLMEEKRKEK EEAEHRKKMA WWESNGYQSF CLSSEDSELE
710 720 730 740 750
DLEGGDESSA ELAYEDLDST SINYVSGDVT HPQAGEEDAV IVHCVDDSGR
760 770 780 790 800
WGRGGLFTAL EVRSAEPRKI YELAGKMEDL SLGDVLLFPI DDKESRDKGQ
810 820 830 840 850
DLLALVVAQH RDRTNVLSGI KMAALEEGLK KIFLAAKKKK ASVHLPRIGH
860 870 880 890 900
ATKGFNWYGT ERLIRKHLAT RGIPTYIYYF PRSKARHSQP ASSSSAPLVP
Length:900
Mass (Da):101,438
Last modified:June 1, 2001 - v1
Checksum:i89FEE484E71BBE09
GO
Isoform 2 (identifier: Q9CXF7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     877-900: IYYFPRSKARHSQPASSSSAPLVP → MYPSVV

Show »
Length:882
Mass (Da):99,485
Checksum:i3109C6228FD48C9E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti300 – 3001A → S in AAH62966. (PubMed:15489334)Curated
Sequence conflicti300 – 3001A → S in AAH57567. (PubMed:15489334)Curated
Sequence conflicti558 – 5581G → GG in BAE38319. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei877 – 90024IYYFP…APLVP → MYPSVV in isoform 2. 1 PublicationVSP_033343Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014473 mRNA. Translation: BAB29376.1.
AK165656 mRNA. Translation: BAE38319.1.
BC052385 mRNA. Translation: AAH52385.1.
BC057567 mRNA. Translation: AAH57567.1.
BC062966 mRNA. Translation: AAH62966.1.
CCDSiCCDS38561.1. [Q9CXF7-1]
RefSeqiNP_080815.1. NM_026539.2. [Q9CXF7-1]
UniGeneiMm.41447.

Genome annotation databases

EnsembliENSMUST00000029730; ENSMUSP00000029730; ENSMUSG00000028089. [Q9CXF7-1]
GeneIDi68058.
KEGGimmu:68058.
UCSCiuc008qow.1. mouse. [Q9CXF7-1]
uc008qox.1. mouse. [Q9CXF7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014473 mRNA. Translation: BAB29376.1 .
AK165656 mRNA. Translation: BAE38319.1 .
BC052385 mRNA. Translation: AAH52385.1 .
BC057567 mRNA. Translation: AAH57567.1 .
BC062966 mRNA. Translation: AAH62966.1 .
CCDSi CCDS38561.1. [Q9CXF7-1 ]
RefSeqi NP_080815.1. NM_026539.2. [Q9CXF7-1 ]
UniGenei Mm.41447.

3D structure databases

ProteinModelPortali Q9CXF7.
SMRi Q9CXF7. Positions 22-547, 722-878.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212634. 1 interaction.
DIPi DIP-58953N.
STRINGi 10090.ENSMUSP00000029730.

PTM databases

PhosphoSitei Q9CXF7.

Proteomic databases

MaxQBi Q9CXF7.
PaxDbi Q9CXF7.
PRIDEi Q9CXF7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029730 ; ENSMUSP00000029730 ; ENSMUSG00000028089 . [Q9CXF7-1 ]
GeneIDi 68058.
KEGGi mmu:68058.
UCSCi uc008qow.1. mouse. [Q9CXF7-1 ]
uc008qox.1. mouse. [Q9CXF7-2 ]

Organism-specific databases

CTDi 9557.
MGIi MGI:1915308. Chd1l.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00680000100002.
HOGENOMi HOG000030789.
HOVERGENi HBG077542.
InParanoidi Q9CXF7.
OMAi NWKEEME.
OrthoDBi EOG72G16M.
PhylomeDBi Q9CXF7.
TreeFami TF333326.

Miscellaneous databases

ChiTaRSi Chd1l. mouse.
NextBioi 326336.
PROi Q9CXF7.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXF7.
Genevestigatori Q9CXF7.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR002589. Macro_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51154. MACRO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Kidney and Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCHD1L_MOUSE
AccessioniPrimary (citable) accession number: Q9CXF7
Secondary accession number(s): Q3TMX1, Q6P5C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3