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Q9CXF7

- CHD1L_MOUSE

UniProt

Q9CXF7 - CHD1L_MOUSE

Protein

Chromodomain-helicase-DNA-binding protein 1-like

Gene

Chd1l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. DNA binding Source: InterPro
    4. helicase activity Source: UniProtKB-KW
    5. nucleotide binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. chromatin remodeling Source: UniProtKB
    3. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 1-like (EC:3.6.4.12)
    Gene namesi
    Name:Chd1l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915308. Chd1l.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 900900Chromodomain-helicase-DNA-binding protein 1-likePRO_0000332142Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei641 – 6411PhosphoserineBy similarity
    Modified residuei894 – 8941PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9CXF7.
    PRIDEiQ9CXF7.

    PTM databases

    PhosphoSiteiQ9CXF7.

    Expressioni

    Gene expression databases

    BgeeiQ9CXF7.
    GenevestigatoriQ9CXF7.

    Interactioni

    Subunit structurei

    Interacts with PARP1; interacts only when PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).By similarity

    Protein-protein interaction databases

    BioGridi212634. 1 interaction.
    DIPiDIP-58953N.
    STRINGi10090.ENSMUSP00000029730.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXF7.
    SMRiQ9CXF7. Positions 22-547, 722-878.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini52 – 217166Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 507163Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini709 – 900192MacroPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili643 – 68038Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi168 – 1714DEAH box

    Domaini

    The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.By similarity

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
    Contains 1 Macro domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00680000100002.
    HOGENOMiHOG000030789.
    HOVERGENiHBG077542.
    InParanoidiQ9CXF7.
    OMAiNWKEEME.
    OrthoDBiEOG72G16M.
    PhylomeDBiQ9CXF7.
    TreeFamiTF333326.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR002589. Macro_dom.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51154. MACRO. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CXF7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASGLPRFLQ ALPAEHGPEP LRTRVQEPDL QQWGLTGIRL RSYQLEGVNW    50
    LVQCFHCQNG CILGDEMGLG KTCQTIALLI YLVGRLNDEG PFLVLCPLSV 100
    LSNWKEEMER FAPGLSCVTY TGDKEERARL QQDLRQESGF HVLLTTYEIC 150
    LKDASFLKSF SWSVLAVDEA HRLKNQSSLL HRTLSEFSAV FRLLLTGTPI 200
    QNSLRELYSL LCVVEPDLFC REQVEDFVQR YQDIEKESKS ASELHRLLQP 250
    FLLRRVKAQV ATELPKKTEV VVYHGMSALQ KKYYKAILMK DLDAFENETA 300
    KKVKLQNILT QLRKCVDHPY LFDGVEPEPF EVGEHLIEAS GKLHLLDRLL 350
    AFLYSGGHRV LLFSQMTHML DILQDYMDYR GYSYERVDGS VRGEERHLAI 400
    KNFGNQPIFV FLLSTRAGGV GMNLTAADTV IFVDSDFNPQ NDLQAAARAH 450
    RIGQNKSVKV IRLIGRDTVE EIVYRKAASK LQLTNMVIEG GHFTPGAQKP 500
    SAEADFQLSE ILKFGLDKLL SSEGSSMEDI DLKSILGETK DGQWTPDALP 550
    AAAAAGGGSL EPEEGSELES RSYENHMYLF EGRDYSKEPS KEDRKSFEQL 600
    VNLQKTLLEK TSHGGRTLRN KGSVLIPGLA EGPIKRKKIL SPEELEDRRK 650
    KRQEAAAKRK RLMEEKRKEK EEAEHRKKMA WWESNGYQSF CLSSEDSELE 700
    DLEGGDESSA ELAYEDLDST SINYVSGDVT HPQAGEEDAV IVHCVDDSGR 750
    WGRGGLFTAL EVRSAEPRKI YELAGKMEDL SLGDVLLFPI DDKESRDKGQ 800
    DLLALVVAQH RDRTNVLSGI KMAALEEGLK KIFLAAKKKK ASVHLPRIGH 850
    ATKGFNWYGT ERLIRKHLAT RGIPTYIYYF PRSKARHSQP ASSSSAPLVP 900
    Length:900
    Mass (Da):101,438
    Last modified:June 1, 2001 - v1
    Checksum:i89FEE484E71BBE09
    GO
    Isoform 2 (identifier: Q9CXF7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         877-900: IYYFPRSKARHSQPASSSSAPLVP → MYPSVV

    Show »
    Length:882
    Mass (Da):99,485
    Checksum:i3109C6228FD48C9E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti300 – 3001A → S in AAH62966. (PubMed:15489334)Curated
    Sequence conflicti300 – 3001A → S in AAH57567. (PubMed:15489334)Curated
    Sequence conflicti558 – 5581G → GG in BAE38319. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei877 – 90024IYYFP…APLVP → MYPSVV in isoform 2. 1 PublicationVSP_033343Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014473 mRNA. Translation: BAB29376.1.
    AK165656 mRNA. Translation: BAE38319.1.
    BC052385 mRNA. Translation: AAH52385.1.
    BC057567 mRNA. Translation: AAH57567.1.
    BC062966 mRNA. Translation: AAH62966.1.
    CCDSiCCDS38561.1. [Q9CXF7-1]
    RefSeqiNP_080815.1. NM_026539.2. [Q9CXF7-1]
    UniGeneiMm.41447.

    Genome annotation databases

    EnsembliENSMUST00000029730; ENSMUSP00000029730; ENSMUSG00000028089. [Q9CXF7-1]
    GeneIDi68058.
    KEGGimmu:68058.
    UCSCiuc008qow.1. mouse. [Q9CXF7-1]
    uc008qox.1. mouse. [Q9CXF7-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014473 mRNA. Translation: BAB29376.1 .
    AK165656 mRNA. Translation: BAE38319.1 .
    BC052385 mRNA. Translation: AAH52385.1 .
    BC057567 mRNA. Translation: AAH57567.1 .
    BC062966 mRNA. Translation: AAH62966.1 .
    CCDSi CCDS38561.1. [Q9CXF7-1 ]
    RefSeqi NP_080815.1. NM_026539.2. [Q9CXF7-1 ]
    UniGenei Mm.41447.

    3D structure databases

    ProteinModelPortali Q9CXF7.
    SMRi Q9CXF7. Positions 22-547, 722-878.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212634. 1 interaction.
    DIPi DIP-58953N.
    STRINGi 10090.ENSMUSP00000029730.

    PTM databases

    PhosphoSitei Q9CXF7.

    Proteomic databases

    PaxDbi Q9CXF7.
    PRIDEi Q9CXF7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029730 ; ENSMUSP00000029730 ; ENSMUSG00000028089 . [Q9CXF7-1 ]
    GeneIDi 68058.
    KEGGi mmu:68058.
    UCSCi uc008qow.1. mouse. [Q9CXF7-1 ]
    uc008qox.1. mouse. [Q9CXF7-2 ]

    Organism-specific databases

    CTDi 9557.
    MGIi MGI:1915308. Chd1l.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00680000100002.
    HOGENOMi HOG000030789.
    HOVERGENi HBG077542.
    InParanoidi Q9CXF7.
    OMAi NWKEEME.
    OrthoDBi EOG72G16M.
    PhylomeDBi Q9CXF7.
    TreeFami TF333326.

    Miscellaneous databases

    ChiTaRSi CHD1L. mouse.
    NextBioi 326336.
    PROi Q9CXF7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXF7.
    Genevestigatori Q9CXF7.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR002589. Macro_dom.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51154. MACRO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Kidney and Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCHD1L_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXF7
    Secondary accession number(s): Q3TMX1, Q6P5C0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3