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Q9CXF7 (CHD1L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromodomain-helicase-DNA-binding protein 1-like

EC=3.6.4.12
Gene names
Name:Chd1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length900 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with PARP1; interacts only when PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated) By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1 By similarity.

Domain

The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites By similarity.

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Contains 1 Macro domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CXF7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CXF7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     877-900: IYYFPRSKARHSQPASSSSAPLVP → MYPSVV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 900900Chromodomain-helicase-DNA-binding protein 1-like
PRO_0000332142

Regions

Domain52 – 217166Helicase ATP-binding
Domain345 – 507163Helicase C-terminal
Domain709 – 900192Macro
Nucleotide binding65 – 728ATP By similarity
Coiled coil643 – 68038 Potential
Motif168 – 1714DEAH box

Amino acid modifications

Modified residue6411Phosphoserine By similarity
Modified residue8941Phosphoserine By similarity

Natural variations

Alternative sequence877 – 90024IYYFP…APLVP → MYPSVV in isoform 2.
VSP_033343

Experimental info

Sequence conflict3001A → S in AAH62966. Ref.2
Sequence conflict3001A → S in AAH57567. Ref.2
Sequence conflict5581G → GG in BAE38319. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 89FEE484E71BBE09

FASTA900101,438
        10         20         30         40         50         60 
MASGLPRFLQ ALPAEHGPEP LRTRVQEPDL QQWGLTGIRL RSYQLEGVNW LVQCFHCQNG 

        70         80         90        100        110        120 
CILGDEMGLG KTCQTIALLI YLVGRLNDEG PFLVLCPLSV LSNWKEEMER FAPGLSCVTY 

       130        140        150        160        170        180 
TGDKEERARL QQDLRQESGF HVLLTTYEIC LKDASFLKSF SWSVLAVDEA HRLKNQSSLL 

       190        200        210        220        230        240 
HRTLSEFSAV FRLLLTGTPI QNSLRELYSL LCVVEPDLFC REQVEDFVQR YQDIEKESKS 

       250        260        270        280        290        300 
ASELHRLLQP FLLRRVKAQV ATELPKKTEV VVYHGMSALQ KKYYKAILMK DLDAFENETA 

       310        320        330        340        350        360 
KKVKLQNILT QLRKCVDHPY LFDGVEPEPF EVGEHLIEAS GKLHLLDRLL AFLYSGGHRV 

       370        380        390        400        410        420 
LLFSQMTHML DILQDYMDYR GYSYERVDGS VRGEERHLAI KNFGNQPIFV FLLSTRAGGV 

       430        440        450        460        470        480 
GMNLTAADTV IFVDSDFNPQ NDLQAAARAH RIGQNKSVKV IRLIGRDTVE EIVYRKAASK 

       490        500        510        520        530        540 
LQLTNMVIEG GHFTPGAQKP SAEADFQLSE ILKFGLDKLL SSEGSSMEDI DLKSILGETK 

       550        560        570        580        590        600 
DGQWTPDALP AAAAAGGGSL EPEEGSELES RSYENHMYLF EGRDYSKEPS KEDRKSFEQL 

       610        620        630        640        650        660 
VNLQKTLLEK TSHGGRTLRN KGSVLIPGLA EGPIKRKKIL SPEELEDRRK KRQEAAAKRK 

       670        680        690        700        710        720 
RLMEEKRKEK EEAEHRKKMA WWESNGYQSF CLSSEDSELE DLEGGDESSA ELAYEDLDST 

       730        740        750        760        770        780 
SINYVSGDVT HPQAGEEDAV IVHCVDDSGR WGRGGLFTAL EVRSAEPRKI YELAGKMEDL 

       790        800        810        820        830        840 
SLGDVLLFPI DDKESRDKGQ DLLALVVAQH RDRTNVLSGI KMAALEEGLK KIFLAAKKKK 

       850        860        870        880        890        900 
ASVHLPRIGH ATKGFNWYGT ERLIRKHLAT RGIPTYIYYF PRSKARHSQP ASSSSAPLVP 

« Hide

Isoform 2 [UniParc].

Checksum: 3109C6228FD48C9E
Show »

FASTA88299,485

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Kidney and Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014473 mRNA. Translation: BAB29376.1.
AK165656 mRNA. Translation: BAE38319.1.
BC052385 mRNA. Translation: AAH52385.1.
BC057567 mRNA. Translation: AAH57567.1.
BC062966 mRNA. Translation: AAH62966.1.
CCDSCCDS38561.1. [Q9CXF7-1]
RefSeqNP_080815.1. NM_026539.2. [Q9CXF7-1]
UniGeneMm.41447.

3D structure databases

ProteinModelPortalQ9CXF7.
SMRQ9CXF7. Positions 22-547, 722-878.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid212634. 1 interaction.
DIPDIP-58953N.
STRING10090.ENSMUSP00000029730.

PTM databases

PhosphoSiteQ9CXF7.

Proteomic databases

PaxDbQ9CXF7.
PRIDEQ9CXF7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029730; ENSMUSP00000029730; ENSMUSG00000028089. [Q9CXF7-1]
GeneID68058.
KEGGmmu:68058.
UCSCuc008qow.1. mouse. [Q9CXF7-1]
uc008qox.1. mouse. [Q9CXF7-2]

Organism-specific databases

CTD9557.
MGIMGI:1915308. Chd1l.

Phylogenomic databases

eggNOGCOG0553.
GeneTreeENSGT00680000100002.
HOGENOMHOG000030789.
HOVERGENHBG077542.
InParanoidQ9CXF7.
OMANWKEEME.
OrthoDBEOG72G16M.
PhylomeDBQ9CXF7.
TreeFamTF333326.

Gene expression databases

BgeeQ9CXF7.
GenevestigatorQ9CXF7.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR002589. Macro_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51154. MACRO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCHD1L. mouse.
NextBio326336.
PROQ9CXF7.
SOURCESearch...

Entry information

Entry nameCHD1L_MOUSE
AccessionPrimary (citable) accession number: Q9CXF7
Secondary accession number(s): Q3TMX1, Q6P5C0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot