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Protein

Chromodomain-helicase-DNA-binding protein 1-like

Gene

Chd1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5696395 Formation of Incision Complex in GG-NER
R-MMU-5696400 Dual Incision in GG-NER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 1-like (EC:3.6.4.12)
Gene namesi
Name:Chd1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915308 Chd1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321421 – 900Chromodomain-helicase-DNA-binding protein 1-likeAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534PhosphoserineBy similarity1
Modified residuei612PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei641PhosphoserineBy similarity1
Modified residuei894PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CXF7
PaxDbiQ9CXF7
PeptideAtlasiQ9CXF7
PRIDEiQ9CXF7

PTM databases

iPTMnetiQ9CXF7
PhosphoSitePlusiQ9CXF7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028089
GenevisibleiQ9CXF7 MM

Interactioni

Subunit structurei

Interacts with PARP1; interacts only when PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).By similarity

Protein-protein interaction databases

BioGridi212634, 1 interactor
DIPiDIP-58953N
IntActiQ9CXF7, 1 interactor
STRINGi10090.ENSMUSP00000029730

Structurei

3D structure databases

ProteinModelPortaliQ9CXF7
SMRiQ9CXF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 217Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini345 – 507Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163
Domaini709 – 900MacroPROSITE-ProRule annotationAdd BLAST192

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili643 – 680Sequence analysisAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi168 – 171DEAH box4

Domaini

The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.By similarity

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0385 Eukaryota
COG0553 LUCA
GeneTreeiENSGT00900000140963
HOGENOMiHOG000030789
HOVERGENiHBG077542
InParanoidiQ9CXF7
KOiK20092
OMAiKKMAWWE
OrthoDBiEOG091G023P
PhylomeDBiQ9CXF7
TreeFamiTF333326

Family and domain databases

CDDicd00079 HELICc, 1 hit
Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR031053 ALC1
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR002589 Macro_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR10799:SF813 PTHR10799:SF813, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51154 MACRO, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CXF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASGLPRFLQ ALPAEHGPEP LRTRVQEPDL QQWGLTGIRL RSYQLEGVNW
60 70 80 90 100
LVQCFHCQNG CILGDEMGLG KTCQTIALLI YLVGRLNDEG PFLVLCPLSV
110 120 130 140 150
LSNWKEEMER FAPGLSCVTY TGDKEERARL QQDLRQESGF HVLLTTYEIC
160 170 180 190 200
LKDASFLKSF SWSVLAVDEA HRLKNQSSLL HRTLSEFSAV FRLLLTGTPI
210 220 230 240 250
QNSLRELYSL LCVVEPDLFC REQVEDFVQR YQDIEKESKS ASELHRLLQP
260 270 280 290 300
FLLRRVKAQV ATELPKKTEV VVYHGMSALQ KKYYKAILMK DLDAFENETA
310 320 330 340 350
KKVKLQNILT QLRKCVDHPY LFDGVEPEPF EVGEHLIEAS GKLHLLDRLL
360 370 380 390 400
AFLYSGGHRV LLFSQMTHML DILQDYMDYR GYSYERVDGS VRGEERHLAI
410 420 430 440 450
KNFGNQPIFV FLLSTRAGGV GMNLTAADTV IFVDSDFNPQ NDLQAAARAH
460 470 480 490 500
RIGQNKSVKV IRLIGRDTVE EIVYRKAASK LQLTNMVIEG GHFTPGAQKP
510 520 530 540 550
SAEADFQLSE ILKFGLDKLL SSEGSSMEDI DLKSILGETK DGQWTPDALP
560 570 580 590 600
AAAAAGGGSL EPEEGSELES RSYENHMYLF EGRDYSKEPS KEDRKSFEQL
610 620 630 640 650
VNLQKTLLEK TSHGGRTLRN KGSVLIPGLA EGPIKRKKIL SPEELEDRRK
660 670 680 690 700
KRQEAAAKRK RLMEEKRKEK EEAEHRKKMA WWESNGYQSF CLSSEDSELE
710 720 730 740 750
DLEGGDESSA ELAYEDLDST SINYVSGDVT HPQAGEEDAV IVHCVDDSGR
760 770 780 790 800
WGRGGLFTAL EVRSAEPRKI YELAGKMEDL SLGDVLLFPI DDKESRDKGQ
810 820 830 840 850
DLLALVVAQH RDRTNVLSGI KMAALEEGLK KIFLAAKKKK ASVHLPRIGH
860 870 880 890 900
ATKGFNWYGT ERLIRKHLAT RGIPTYIYYF PRSKARHSQP ASSSSAPLVP
Length:900
Mass (Da):101,438
Last modified:June 1, 2001 - v1
Checksum:i89FEE484E71BBE09
GO
Isoform 2 (identifier: Q9CXF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     877-900: IYYFPRSKARHSQPASSSSAPLVP → MYPSVV

Show »
Length:882
Mass (Da):99,485
Checksum:i3109C6228FD48C9E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti300A → S in AAH62966 (PubMed:15489334).Curated1
Sequence conflicti300A → S in AAH57567 (PubMed:15489334).Curated1
Sequence conflicti558G → GG in BAE38319 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033343877 – 900IYYFP…APLVP → MYPSVV in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014473 mRNA Translation: BAB29376.1
AK165656 mRNA Translation: BAE38319.1
BC052385 mRNA Translation: AAH52385.1
BC057567 mRNA Translation: AAH57567.1
BC062966 mRNA Translation: AAH62966.1
CCDSiCCDS38561.1 [Q9CXF7-1]
RefSeqiNP_080815.1, NM_026539.2 [Q9CXF7-1]
UniGeneiMm.31761
Mm.41447

Genome annotation databases

EnsembliENSMUST00000029730; ENSMUSP00000029730; ENSMUSG00000028089 [Q9CXF7-1]
GeneIDi68058
KEGGimmu:68058
UCSCiuc008qow.1 mouse [Q9CXF7-1]
uc008qox.1 mouse [Q9CXF7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCHD1L_MOUSE
AccessioniPrimary (citable) accession number: Q9CXF7
Secondary accession number(s): Q3TMX1, Q6P5C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health