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Protein

TBC1 domain family member 15

Gene

Tbc1d15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6.2 Publications

GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 15
Alternative name(s):
GTPase-activating protein RAB7
Short name:
GAP for RAB7
Short name:
Rab7-GAP
Gene namesi
Name:Tbc1d15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913937. Tbc1d15.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endomembrane system Source: GO_Central
  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 671670TBC1 domain family member 15PRO_0000208043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei32 – 321PhosphoserineCombined sources
Modified residuei70 – 701PhosphoserineBy similarity
Modified residuei205 – 2051PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineBy similarity
Modified residuei623 – 6231PhosphoserineBy similarity
Modified residuei655 – 6551PhosphoserineBy similarity
Modified residuei669 – 6691PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CXF4.
MaxQBiQ9CXF4.
PaxDbiQ9CXF4.
PRIDEiQ9CXF4.

PTM databases

iPTMnetiQ9CXF4.
PhosphoSiteiQ9CXF4.

Expressioni

Tissue specificityi

Ubiquitous, with highest expression in heart, liver and testis and lower expression in brain, spleen, lung, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000020130.
CleanExiMM_TBC1D15.
GenevisibleiQ9CXF4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211646. 1 interaction.
IntActiQ9CXF4. 2 interactions.
MINTiMINT-1726912.
STRINGi10090.ENSMUSP00000020339.

Structurei

3D structure databases

ProteinModelPortaliQ9CXF4.
SMRiQ9CXF4. Positions 305-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini329 – 539211Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2197. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000012710.
HOVERGENiHBG057668.
InParanoidiQ9CXF4.
KOiK20168.
OMAiDVEDVLC.
OrthoDBiEOG091G04IX.
PhylomeDBiQ9CXF4.
TreeFamiTF314296.

Family and domain databases

InterProiIPR021935. DUF3548.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF12068. DUF3548. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGVVSGK IIYEQEGVYI HSSCGKANDQ DSLISGILRV LEKDAEVIVD
60 70 80 90 100
WRPLDDALDS SSILCAGKDS SSVVEWTQAP KERAHRGSDQ QSSYEAEWDM
110 120 130 140 150
VTTVSFKKKP HTNGDAPGHR NGKSKWSFLF SLADLKSVKQ SKEGMGWSYL
160 170 180 190 200
VFCLKDDVML PALHFHQGDS KLLIESLEKY VVLCESPQDS RTLLVNCQNK
210 220 230 240 250
SLSQSFENLL DEPAYGLIQK IKKDPYTATM VGFSKVTNYI FDSLRGSDPS
260 270 280 290 300
THQRPPSEMA DFLSDAIPGL KINQQEEPGF EVITRIDLGE RPVVQRREPV
310 320 330 340 350
SLEEWNKSLD PEGRLVAVES MKQKIFRGGL SHSLRKQAWK FLLGYFPWDS
360 370 380 390 400
TKEERTQLQK QKTDEYFRMK LQWKSVSEAQ EKRNSRLRDY RSLIEKDVNR
410 420 430 440 450
TDRTNKFYEG QDNPGLILLH DILMTYCMYD FDLGYVQGMS DLLSPLLYVM
460 470 480 490 500
ENEVDAFWCF ASYMDQMHQN FEEQMQGMKT QLIQLSTLLR LLDSGFCSYL
510 520 530 540 550
ESQDSGYLYF CFRWLLIRFK REFSFLDILR LWEVMWTELP CKNFHLLLCC
560 570 580 590 600
AILESEKQQI MAKHYGFNEI LKHINELSMK IDVEDILCKA EAISLQMAQC
610 620 630 640 650
KELPQAVCEI LGLQDSEITT PDSDTDENVG SPCPVSAFPS STLPILAASE
660 670
AKDDSPTQTL ASPNACRLTP A
Length:671
Mass (Da):76,527
Last modified:June 1, 2001 - v1
Checksum:iA822B14AE4268FDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014477 mRNA. Translation: BAB29380.1.
AK078875 mRNA. Translation: BAC37435.1.
AK147085 mRNA. Translation: BAE27665.1.
CCDSiCCDS24176.1.
RefSeqiNP_079982.3. NM_025706.3.
UniGeneiMm.22252.

Genome annotation databases

EnsembliENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130.
GeneIDi66687.
KEGGimmu:66687.
UCSCiuc007hax.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014477 mRNA. Translation: BAB29380.1.
AK078875 mRNA. Translation: BAC37435.1.
AK147085 mRNA. Translation: BAE27665.1.
CCDSiCCDS24176.1.
RefSeqiNP_079982.3. NM_025706.3.
UniGeneiMm.22252.

3D structure databases

ProteinModelPortaliQ9CXF4.
SMRiQ9CXF4. Positions 305-598.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211646. 1 interaction.
IntActiQ9CXF4. 2 interactions.
MINTiMINT-1726912.
STRINGi10090.ENSMUSP00000020339.

PTM databases

iPTMnetiQ9CXF4.
PhosphoSiteiQ9CXF4.

Proteomic databases

EPDiQ9CXF4.
MaxQBiQ9CXF4.
PaxDbiQ9CXF4.
PRIDEiQ9CXF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020339; ENSMUSP00000020339; ENSMUSG00000020130.
GeneIDi66687.
KEGGimmu:66687.
UCSCiuc007hax.2. mouse.

Organism-specific databases

CTDi64786.
MGIiMGI:1913937. Tbc1d15.

Phylogenomic databases

eggNOGiKOG2197. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00550000074386.
HOGENOMiHOG000012710.
HOVERGENiHBG057668.
InParanoidiQ9CXF4.
KOiK20168.
OMAiDVEDVLC.
OrthoDBiEOG091G04IX.
PhylomeDBiQ9CXF4.
TreeFamiTF314296.

Miscellaneous databases

ChiTaRSiTbc1d15. mouse.
PROiQ9CXF4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020130.
CleanExiMM_TBC1D15.
GenevisibleiQ9CXF4. MM.

Family and domain databases

InterProiIPR021935. DUF3548.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF12068. DUF3548. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC15_MOUSE
AccessioniPrimary (citable) accession number: Q9CXF4
Secondary accession number(s): Q3UI41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:16055087 showns that TBC1D15 can also functions as GTPase activating for RAB11 at a lower extend than for RAB7A, however this function is not confirmed by PubMed:20363736.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.