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Protein

DNA repair protein XRCC3

Gene

Xrcc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 114ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates
R-MMU-5693579 Homologous DNA Pairing and Strand Exchange

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC3
Alternative name(s):
X-ray repair cross-complementing protein 3
Gene namesi
Name:Xrcc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921585 Xrcc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001229521 – 349DNA repair protein XRCC3Add BLAST349

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9CXE6
PRIDEiQ9CXE6

PTM databases

iPTMnetiQ9CXE6
PhosphoSitePlusiQ9CXE6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021287
ExpressionAtlasiQ9CXE6 baseline and differential
GenevisibleiQ9CXE6 MM

Interactioni

Subunit structurei

Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216673, 1 interactor
IntActiQ9CXE6, 1 interactor
MINTiQ9CXE6
STRINGi10090.ENSMUSP00000021715

Structurei

3D structure databases

ProteinModelPortaliQ9CXE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

eggNOGiKOG1564 Eukaryota
COG0468 LUCA
GeneTreeiENSGT00860000133731
HOGENOMiHOG000239162
HOVERGENiHBG054179
InParanoidiQ9CXE6
KOiK10880
OMAiLCINQVT
OrthoDBiEOG091G0SMJ
PhylomeDBiQ9CXE6
TreeFamiTF101203

Family and domain databases

CDDicd01123 Rad51_DMC1_radA, 1 hit
InterProiView protein in InterPro
IPR013632 DNA_recomb/repair_Rad51_C
IPR016467 DNA_recomb/repair_RecA-like
IPR027417 P-loop_NTPase
IPR033925 Rad51_DMC1_RadA
IPR020588 RecA_ATP-bd
PfamiView protein in Pfam
PF08423 Rad51, 1 hit
PIRSFiPIRSF005856 Rad51, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50162 RECA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CXE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDQLDLNP RITAAVKRGR LKSVKEILCY SGPDLQRLTG LPSHDVQCLL
60 70 80 90 100
RAASLHLRGS RVLSALHLFQ QKESFPEQHQ RLSLGCPVLD QFLGGGLPLE
110 120 130 140 150
GITGLAGCSS AGKTQLALQL CLAVQFPRQY GGLEAGAVYI CTEDAFPSKR
160 170 180 190 200
LWQLIAQQRR LRTDAPEELI EKIRFSNHIF IEHAADVDTL LECVSKKVPI
210 220 230 240 250
LLSRGMARLV VVDSIAAPFR CEFHLQASAI RAKLLLSLGA TLRRLSSTFR
260 270 280 290 300
SPVLCINQVT DMVEDQQSVS RSLGASEERL SPALGITWAN QLLMRLMVDR
310 320 330 340
THEDDVTTGL PRSPVRTLRV LFAPHLPLSS CCYTVSGEGI RGMPGTQSY
Length:349
Mass (Da):38,446
Last modified:June 1, 2001 - v1
Checksum:i15E5AFBBDEB9AAEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014491 mRNA Translation: BAB29391.1
CCDSiCCDS26187.1
RefSeqiNP_083151.1, NM_028875.3
UniGeneiMm.19082

Genome annotation databases

EnsembliENSMUST00000021715; ENSMUSP00000021715; ENSMUSG00000021287
GeneIDi74335
KEGGimmu:74335
UCSCiuc007pdz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiXRCC3_MOUSE
AccessioniPrimary (citable) accession number: Q9CXE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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