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Q9CXE6

- XRCC3_MOUSE

UniProt

Q9CXE6 - XRCC3_MOUSE

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Protein
DNA repair protein XRCC3
Gene
Xrcc3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1148ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. DNA-dependent ATPase activity Source: InterPro

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: UniProtKB
  2. positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
  3. regulation of centrosome duplication Source: UniProtKB
  4. resolution of mitotic recombination intermediates Source: UniProtKB
  5. response to organic substance Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC3
Alternative name(s):
X-ray repair cross-complementing protein 3
Gene namesi
Name:Xrcc3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1921585. Xrcc3.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Mitochondrion matrix By similarity
Note: Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair By similarity.

GO - Cellular componenti

  1. Rad51C-XRCC3 complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. mitochondrial matrix Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB
  5. perinuclear region of cytoplasm Source: UniProtKB
  6. replication fork Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349DNA repair protein XRCC3
PRO_0000122952Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9CXE6.
PRIDEiQ9CXE6.

PTM databases

PhosphoSiteiQ9CXE6.

Expressioni

Gene expression databases

BgeeiQ9CXE6.
GenevestigatoriQ9CXE6.

Interactioni

Subunit structurei

Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3 By similarity.

Protein-protein interaction databases

IntActiQ9CXE6. 1 interaction.
MINTiMINT-4140445.

Structurei

3D structure databases

ProteinModelPortaliQ9CXE6.
SMRiQ9CXE6. Positions 26-341.

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.

Phylogenomic databases

eggNOGiCOG0468.
GeneTreeiENSGT00710000106840.
HOGENOMiHOG000239162.
HOVERGENiHBG054179.
InParanoidiQ9CXE6.
KOiK10880.
OMAiLLMRLMV.
PhylomeDBiQ9CXE6.
TreeFamiTF101203.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFiPIRSF005856. Rad51. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXE6-1 [UniParc]FASTAAdd to Basket

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MDLDQLDLNP RITAAVKRGR LKSVKEILCY SGPDLQRLTG LPSHDVQCLL    50
RAASLHLRGS RVLSALHLFQ QKESFPEQHQ RLSLGCPVLD QFLGGGLPLE 100
GITGLAGCSS AGKTQLALQL CLAVQFPRQY GGLEAGAVYI CTEDAFPSKR 150
LWQLIAQQRR LRTDAPEELI EKIRFSNHIF IEHAADVDTL LECVSKKVPI 200
LLSRGMARLV VVDSIAAPFR CEFHLQASAI RAKLLLSLGA TLRRLSSTFR 250
SPVLCINQVT DMVEDQQSVS RSLGASEERL SPALGITWAN QLLMRLMVDR 300
THEDDVTTGL PRSPVRTLRV LFAPHLPLSS CCYTVSGEGI RGMPGTQSY 349
Length:349
Mass (Da):38,446
Last modified:June 1, 2001 - v1
Checksum:i15E5AFBBDEB9AAEB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014491 mRNA. Translation: BAB29391.1.
CCDSiCCDS26187.1.
RefSeqiNP_083151.1. NM_028875.2.
XP_006516362.1. XM_006516299.1.
UniGeneiMm.19082.

Genome annotation databases

EnsembliENSMUST00000021715; ENSMUSP00000021715; ENSMUSG00000021287.
GeneIDi74335.
KEGGimmu:74335.
UCSCiuc007pdz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK014491 mRNA. Translation: BAB29391.1 .
CCDSi CCDS26187.1.
RefSeqi NP_083151.1. NM_028875.2.
XP_006516362.1. XM_006516299.1.
UniGenei Mm.19082.

3D structure databases

ProteinModelPortali Q9CXE6.
SMRi Q9CXE6. Positions 26-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CXE6. 1 interaction.
MINTi MINT-4140445.

PTM databases

PhosphoSitei Q9CXE6.

Proteomic databases

PaxDbi Q9CXE6.
PRIDEi Q9CXE6.

Protocols and materials databases

DNASUi 74335.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021715 ; ENSMUSP00000021715 ; ENSMUSG00000021287 .
GeneIDi 74335.
KEGGi mmu:74335.
UCSCi uc007pdz.1. mouse.

Organism-specific databases

CTDi 7517.
MGIi MGI:1921585. Xrcc3.

Phylogenomic databases

eggNOGi COG0468.
GeneTreei ENSGT00710000106840.
HOGENOMi HOG000239162.
HOVERGENi HBG054179.
InParanoidi Q9CXE6.
KOi K10880.
OMAi LLMRLMV.
PhylomeDBi Q9CXE6.
TreeFami TF101203.

Miscellaneous databases

NextBioi 340475.
PROi Q9CXE6.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXE6.
Genevestigatori Q9CXE6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view ]
Pfami PF08423. Rad51. 1 hit.
[Graphical view ]
PIRSFi PIRSF005856. Rad51. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50162. RECA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic liver.

Entry informationi

Entry nameiXRCC3_MOUSE
AccessioniPrimary (citable) accession number: Q9CXE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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