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Q9CXE6

- XRCC3_MOUSE

UniProt

Q9CXE6 - XRCC3_MOUSE

Protein

DNA repair protein XRCC3

Gene

Xrcc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi107 – 1148ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. DNA-dependent ATPase activity Source: InterPro

    GO - Biological processi

    1. double-strand break repair via homologous recombination Source: UniProtKB
    2. positive regulation of mitotic cell cycle spindle assembly checkpoint Source: UniProtKB
    3. regulation of centrosome duplication Source: UniProtKB
    4. resolution of mitotic recombination intermediates Source: UniProtKB
    5. response to organic substance Source: Ensembl

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA repair protein XRCC3
    Alternative name(s):
    X-ray repair cross-complementing protein 3
    Gene namesi
    Name:Xrcc3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1921585. Xrcc3.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Mitochondrion matrix By similarity
    Note: Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrial matrix Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB
    5. Rad51C-XRCC3 complex Source: UniProtKB
    6. replication fork Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349DNA repair protein XRCC3PRO_0000122952Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9CXE6.
    PRIDEiQ9CXE6.

    PTM databases

    PhosphoSiteiQ9CXE6.

    Expressioni

    Gene expression databases

    BgeeiQ9CXE6.
    GenevestigatoriQ9CXE6.

    Interactioni

    Subunit structurei

    Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9CXE6. 1 interaction.
    MINTiMINT-4140445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXE6.
    SMRiQ9CXE6. Positions 26-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RecA family. RAD51 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0468.
    GeneTreeiENSGT00710000106840.
    HOGENOMiHOG000239162.
    HOVERGENiHBG054179.
    InParanoidiQ9CXE6.
    KOiK10880.
    OMAiLLMRLMV.
    PhylomeDBiQ9CXE6.
    TreeFamiTF101203.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR013632. DNA_recomb/repair_Rad51_C.
    IPR016467. DNA_recomb/repair_RecA-like.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    [Graphical view]
    PfamiPF08423. Rad51. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005856. Rad51. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50162. RECA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLDQLDLNP RITAAVKRGR LKSVKEILCY SGPDLQRLTG LPSHDVQCLL    50
    RAASLHLRGS RVLSALHLFQ QKESFPEQHQ RLSLGCPVLD QFLGGGLPLE 100
    GITGLAGCSS AGKTQLALQL CLAVQFPRQY GGLEAGAVYI CTEDAFPSKR 150
    LWQLIAQQRR LRTDAPEELI EKIRFSNHIF IEHAADVDTL LECVSKKVPI 200
    LLSRGMARLV VVDSIAAPFR CEFHLQASAI RAKLLLSLGA TLRRLSSTFR 250
    SPVLCINQVT DMVEDQQSVS RSLGASEERL SPALGITWAN QLLMRLMVDR 300
    THEDDVTTGL PRSPVRTLRV LFAPHLPLSS CCYTVSGEGI RGMPGTQSY 349
    Length:349
    Mass (Da):38,446
    Last modified:June 1, 2001 - v1
    Checksum:i15E5AFBBDEB9AAEB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014491 mRNA. Translation: BAB29391.1.
    CCDSiCCDS26187.1.
    RefSeqiNP_083151.1. NM_028875.2.
    XP_006516362.1. XM_006516299.1.
    UniGeneiMm.19082.

    Genome annotation databases

    EnsembliENSMUST00000021715; ENSMUSP00000021715; ENSMUSG00000021287.
    GeneIDi74335.
    KEGGimmu:74335.
    UCSCiuc007pdz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014491 mRNA. Translation: BAB29391.1 .
    CCDSi CCDS26187.1.
    RefSeqi NP_083151.1. NM_028875.2.
    XP_006516362.1. XM_006516299.1.
    UniGenei Mm.19082.

    3D structure databases

    ProteinModelPortali Q9CXE6.
    SMRi Q9CXE6. Positions 26-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CXE6. 1 interaction.
    MINTi MINT-4140445.

    PTM databases

    PhosphoSitei Q9CXE6.

    Proteomic databases

    PaxDbi Q9CXE6.
    PRIDEi Q9CXE6.

    Protocols and materials databases

    DNASUi 74335.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021715 ; ENSMUSP00000021715 ; ENSMUSG00000021287 .
    GeneIDi 74335.
    KEGGi mmu:74335.
    UCSCi uc007pdz.1. mouse.

    Organism-specific databases

    CTDi 7517.
    MGIi MGI:1921585. Xrcc3.

    Phylogenomic databases

    eggNOGi COG0468.
    GeneTreei ENSGT00710000106840.
    HOGENOMi HOG000239162.
    HOVERGENi HBG054179.
    InParanoidi Q9CXE6.
    KOi K10880.
    OMAi LLMRLMV.
    PhylomeDBi Q9CXE6.
    TreeFami TF101203.

    Miscellaneous databases

    NextBioi 340475.
    PROi Q9CXE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXE6.
    Genevestigatori Q9CXE6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR013632. DNA_recomb/repair_Rad51_C.
    IPR016467. DNA_recomb/repair_RecA-like.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    [Graphical view ]
    Pfami PF08423. Rad51. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005856. Rad51. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50162. RECA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic liver.

    Entry informationi

    Entry nameiXRCC3_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3