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Q9CXE6 (XRCC3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA repair protein XRCC3
Alternative name(s):
X-ray repair cross-complementing protein 3
Gene names
Name:Xrcc3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C By similarity.

Subunit structure

Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3 By similarity. Forms a complex with FANCD2, BRCA2 and FANCG By similarity. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasm › perinuclear region By similarity. Mitochondrion matrix By similarity. Note: Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair By similarity.

Sequence similarities

Belongs to the RecA family. RAD51 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349DNA repair protein XRCC3
PRO_0000122952

Regions

Nucleotide binding107 – 1148ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q9CXE6 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 15E5AFBBDEB9AAEB

FASTA34938,446
        10         20         30         40         50         60 
MDLDQLDLNP RITAAVKRGR LKSVKEILCY SGPDLQRLTG LPSHDVQCLL RAASLHLRGS 

        70         80         90        100        110        120 
RVLSALHLFQ QKESFPEQHQ RLSLGCPVLD QFLGGGLPLE GITGLAGCSS AGKTQLALQL 

       130        140        150        160        170        180 
CLAVQFPRQY GGLEAGAVYI CTEDAFPSKR LWQLIAQQRR LRTDAPEELI EKIRFSNHIF 

       190        200        210        220        230        240 
IEHAADVDTL LECVSKKVPI LLSRGMARLV VVDSIAAPFR CEFHLQASAI RAKLLLSLGA 

       250        260        270        280        290        300 
TLRRLSSTFR SPVLCINQVT DMVEDQQSVS RSLGASEERL SPALGITWAN QLLMRLMVDR 

       310        320        330        340 
THEDDVTTGL PRSPVRTLRV LFAPHLPLSS CCYTVSGEGI RGMPGTQSY

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK014491 mRNA. Translation: BAB29391.1.
IPIIPI00110210.
RefSeqNP_083151.1. NM_028875.2.
UniGeneMm.19082.

3D structure databases

ProteinModelPortalQ9CXE6.
SMRQ9CXE6. Positions 26-341.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4140445.

PTM databases

PhosphoSiteQ9CXE6.

Proteomic databases

PaxDbQ9CXE6.
PRIDEQ9CXE6.

Protocols and materials databases

DNASU74335.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021715; ENSMUSP00000021715; ENSMUSG00000021287.
GeneID74335.
KEGGmmu:74335.
UCSCuc007pdz.1. mouse.

Organism-specific databases

CTD7517.
MGIMGI:1921585. Xrcc3.

Phylogenomic databases

eggNOGCOG0468.
GeneTreeENSGT00550000074609.
HOGENOMHOG000239162.
HOVERGENHBG054179.
InParanoidQ9CXE6.
KOK10880.
OMAINQVTEA.
OrthoDBEOG47D9GS.

Gene expression databases

ArrayExpressQ9CXE6.
BgeeQ9CXE6.
GenevestigatorQ9CXE6.
GermOnlineENSMUSG00000021287. Mus musculus.

Family and domain databases

InterProIPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR020588. DNA_recomb_RecA/RadB_ATP-bd.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF08423. Rad51. 1 hit.
[Graphical view]
PIRSFPIRSF005856. Rad51. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio340475.
SOURCESearch...

Entry information

Entry nameXRCC3_MOUSE
AccessionPrimary (citable) accession number: Q9CXE6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: May 29, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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