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Protein

B-cell CLL/lymphoma 7 protein family member A

Gene

Bcl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member A
Gene namesi
Name:Bcl7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924295. Bcl7a.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210B-cell CLL/lymphoma 7 protein family member APRO_0000239824Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki199 – 199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei203 – 2031PhosphoserineBy similarity
Modified residuei207 – 2071PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CXE2.
MaxQBiQ9CXE2.
PaxDbiQ9CXE2.
PeptideAtlasiQ9CXE2.
PRIDEiQ9CXE2.

PTM databases

iPTMnetiQ9CXE2.
PhosphoSiteiQ9CXE2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029438.
CleanExiMM_BCL7A.
GenevisibleiQ9CXE2. MM.

Interactioni

Protein-protein interaction databases

BioGridi218481. 3 interactions.
STRINGi10090.ENSMUSP00000031391.

Structurei

3D structure databases

ProteinModelPortaliQ9CXE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ9CXE2.
OMAiKLETSQQ.
OrthoDBiEOG091G0T7O.
PhylomeDBiQ9CXE2.
TreeFamiTF317441.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CXE2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRSVRAET RSRAKDDIKR VMAAIEKVRK WEKKWVTVGD TSLRIYKWVP
60 70 80 90 100
VTEPKVDDKN KNKKKGKDEK CGSEVTTPEN SSSPGMMDMH DDNSNQSSIA
110 120 130 140 150
DASPIKQENS SNSSPAPETN PPVPSDGTEA KADEAQADGK EHPGAEDASE
160 170 180 190 200
EQNSQSSMEN SVNSSEKAER QPSAESGLAA ETSAVSQDLE GVPPSKKMKL
210
EASQQNSEEM
Length:210
Mass (Da):22,781
Last modified:June 1, 2001 - v1
Checksum:i9AEB5745EE0E42F7
GO
Isoform 2 (identifier: Q9CXE2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-112: DDNSNQSSIADASPIKQENSSN → GEPRPSRSPCLGLSCVFVSLTG
     113-210: Missing.

Note: May be due to an intron retention.
Show »
Length:112
Mass (Da):12,554
Checksum:iD39A296E6B5A4BFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1081E → V in BAC32088 (PubMed:16141072).Curated
Sequence conflicti170 – 1701R → L in BAC39745 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 11222DDNSN…ENSSN → GEPRPSRSPCLGLSCVFVSL TG in isoform 2. 2 PublicationsVSP_019272Add
BLAST
Alternative sequencei113 – 21098Missing in isoform 2. 2 PublicationsVSP_019273Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014498 mRNA. Translation: BAB29397.1.
AK044782 mRNA. Translation: BAC32088.1.
AK086803 mRNA. Translation: BAC39745.1.
AK157720 mRNA. Translation: BAE34167.1.
BC017640 mRNA. Translation: AAH17640.1.
BC038481 mRNA. Translation: AAH38481.1.
BC046777 mRNA. Translation: AAH46777.1.
CCDSiCCDS19661.1. [Q9CXE2-1]
RefSeqiNP_084126.1. NM_029850.3. [Q9CXE2-1]
UniGeneiMm.151960.

Genome annotation databases

EnsembliENSMUST00000031391; ENSMUSP00000031391; ENSMUSG00000029438. [Q9CXE2-1]
ENSMUST00000117971; ENSMUSP00000113264; ENSMUSG00000029438. [Q9CXE2-2]
GeneIDi77045.
KEGGimmu:77045.
UCSCiuc008znn.2. mouse. [Q9CXE2-2]
uc008zno.2. mouse. [Q9CXE2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014498 mRNA. Translation: BAB29397.1.
AK044782 mRNA. Translation: BAC32088.1.
AK086803 mRNA. Translation: BAC39745.1.
AK157720 mRNA. Translation: BAE34167.1.
BC017640 mRNA. Translation: AAH17640.1.
BC038481 mRNA. Translation: AAH38481.1.
BC046777 mRNA. Translation: AAH46777.1.
CCDSiCCDS19661.1. [Q9CXE2-1]
RefSeqiNP_084126.1. NM_029850.3. [Q9CXE2-1]
UniGeneiMm.151960.

3D structure databases

ProteinModelPortaliQ9CXE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218481. 3 interactions.
STRINGi10090.ENSMUSP00000031391.

PTM databases

iPTMnetiQ9CXE2.
PhosphoSiteiQ9CXE2.

Proteomic databases

EPDiQ9CXE2.
MaxQBiQ9CXE2.
PaxDbiQ9CXE2.
PeptideAtlasiQ9CXE2.
PRIDEiQ9CXE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031391; ENSMUSP00000031391; ENSMUSG00000029438. [Q9CXE2-1]
ENSMUST00000117971; ENSMUSP00000113264; ENSMUSG00000029438. [Q9CXE2-2]
GeneIDi77045.
KEGGimmu:77045.
UCSCiuc008znn.2. mouse. [Q9CXE2-2]
uc008zno.2. mouse. [Q9CXE2-1]

Organism-specific databases

CTDi605.
MGIiMGI:1924295. Bcl7a.

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ9CXE2.
OMAiKLETSQQ.
OrthoDBiEOG091G0T7O.
PhylomeDBiQ9CXE2.
TreeFamiTF317441.

Miscellaneous databases

ChiTaRSiBcl7a. mouse.
PROiQ9CXE2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029438.
CleanExiMM_BCL7A.
GenevisibleiQ9CXE2. MM.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL7A_MOUSE
AccessioniPrimary (citable) accession number: Q9CXE2
Secondary accession number(s): Q8C361, Q8C8M8, Q8VD15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.