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Q9CXE0

- PRDM5_MOUSE

UniProt

Q9CXE0 - PRDM5_MOUSE

Protein

PR domain zinc finger protein 5

Gene

Prdm5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes By similarity. May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May caused G2/M arrest and apoptosis in cancer cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri167 – 19024C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25626C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri264 – 28623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42424C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri458 – 48023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri486 – 50823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53623C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri542 – 56423C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri571 – 59424C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. methyltransferase activity Source: UniProtKB-KW
    3. repressing transcription factor binding Source: UniProtKB
    4. sequence-specific DNA binding Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB
    6. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. histone deacetylation Source: UniProtKB
    2. histone H3-K9 methylation Source: UniProtKB
    3. mitotic cell cycle Source: UniProtKB
    4. negative regulation of transcription, DNA-templated Source: UniProtKB
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PR domain zinc finger protein 5 (EC:2.1.1.-)
    Alternative name(s):
    PR domain-containing protein 5
    Gene namesi
    Name:Prdm5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1918029. Prdm5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 599599PR domain zinc finger protein 5PRO_0000230794Add
    BLAST

    Proteomic databases

    PRIDEiQ9CXE0.

    PTM databases

    PhosphoSiteiQ9CXE0.

    Expressioni

    Gene expression databases

    BgeeiQ9CXE0.
    CleanExiMM_PRDM5.
    GenevestigatoriQ9CXE0.

    Interactioni

    Subunit structurei

    Interacts with EHMT2/G9A, GFI1 and HDAC1.By similarity

    Protein-protein interaction databases

    BioGridi214249. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXE0.
    SMRiQ9CXE0. Positions 9-589.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 124117SETPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi129 – 1346Poly-Glu

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri167 – 19024C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri199 – 22123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri231 – 25626C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri264 – 28623C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri373 – 39523C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42424C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri430 – 45223C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri458 – 48023C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri486 – 50823C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri514 – 53623C2H2-type 13; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri542 – 56423C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri571 – 59424C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    GeneTreeiENSGT00390000014166.
    HOGENOMiHOG000234617.
    HOVERGENiHBG098380.
    InParanoidiB2RSK8.
    OMAiLGCKEDY.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9CXE0.
    TreeFamiTF106478.

    Family and domain databases

    Gene3Di3.30.160.60. 14 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR017125. Znf_PRDM5.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 3 hits.
    [Graphical view]
    PIRSFiPIRSF037162. PRDM. 1 hit.
    SMARTiSM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGMYVPDRF ALKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE    50
    NMDYRLMWEV RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QERKNLAAIQ 100
    EGENIFYLAV DDIETDTELL IGYLDSDVEA EEEEQQALTM TKEGKVDHSK 150
    GQLAAGSKGH LGCEEDFACP QCESSFPSEE VLTEHLQSLH QKPTGEKEFK 200
    CENCGKKFPV RQALQRHFEQ HRKACRGEAR FVCKADSCGK RLKSKDALRR 250
    HQENVHTGDP KRKLICSVCN RKCTSVSSLQ EHRKIHEIFD CQECMKKFIS 300
    ANQLKRHMIT HSEKRPYNCE ICNKSFKRLD QVGAHKVIHS EDKPYQCKLC 350
    GKGFAHRNVY KNHKKTHSEE RPFQCDACKA LFRTPFSLQR HLLIHNSERT 400
    FKCHHCDATF KRKDTLNVHV QVVHERHKKY RCELCNKAFV TPSVLRSHKK 450
    THTGEKEKVC PYCGQKFASS GTLRVHIRSH TGERPYQCPY CEKGFSKNDG 500
    LKMHIRTHTR EKPYQCSECS KAFSQKRGLD EHKRTHTGEK PFQCDVCDLA 550
    FSLKKMLIRH KMTHNPNRPM AECHFCHKKF TRNDYLKVHM DNIHGVADS 599
    Length:599
    Mass (Da):69,550
    Last modified:July 7, 2009 - v2
    Checksum:i545824C2A54DAAF6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti531 – 5322EH → AT in BAB29400. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014501 mRNA. Translation: BAB29400.1.
    CH466523 Genomic DNA. Translation: EDK98780.1.
    BC138901 mRNA. Translation: AAI38902.1.
    BC138902 mRNA. Translation: AAI38903.1.
    CCDSiCCDS20208.1.
    RefSeqiNP_081823.2. NM_027547.2.
    UniGeneiMm.263355.

    Genome annotation databases

    EnsembliENSMUST00000031976; ENSMUSP00000031976; ENSMUSG00000029913.
    GeneIDi70779.
    KEGGimmu:70779.
    UCSCiuc009cek.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014501 mRNA. Translation: BAB29400.1 .
    CH466523 Genomic DNA. Translation: EDK98780.1 .
    BC138901 mRNA. Translation: AAI38902.1 .
    BC138902 mRNA. Translation: AAI38903.1 .
    CCDSi CCDS20208.1.
    RefSeqi NP_081823.2. NM_027547.2.
    UniGenei Mm.263355.

    3D structure databases

    ProteinModelPortali Q9CXE0.
    SMRi Q9CXE0. Positions 9-589.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 214249. 1 interaction.

    PTM databases

    PhosphoSitei Q9CXE0.

    Proteomic databases

    PRIDEi Q9CXE0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031976 ; ENSMUSP00000031976 ; ENSMUSG00000029913 .
    GeneIDi 70779.
    KEGGi mmu:70779.
    UCSCi uc009cek.1. mouse.

    Organism-specific databases

    CTDi 11107.
    MGIi MGI:1918029. Prdm5.

    Phylogenomic databases

    eggNOGi COG5048.
    GeneTreei ENSGT00390000014166.
    HOGENOMi HOG000234617.
    HOVERGENi HBG098380.
    InParanoidi B2RSK8.
    OMAi LGCKEDY.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9CXE0.
    TreeFami TF106478.

    Miscellaneous databases

    NextBioi 332236.
    PROi Q9CXE0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXE0.
    CleanExi MM_PRDM5.
    Genevestigatori Q9CXE0.

    Family and domain databases

    Gene3Di 3.30.160.60. 14 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    IPR017125. Znf_PRDM5.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF037162. PRDM. 1 hit.
    SMARTi SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 15 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 15 hits.
    PS50157. ZINC_FINGER_C2H2_2. 15 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPRDM5_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXE0
    Secondary accession number(s): B2RSK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3