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Protein

PR domain zinc finger protein 5

Gene

Prdm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes (By similarity). May regulate the expression of proteins involved in extracellular matrix development and maintenance, connective tissue components and molecules regulating cell migration and adhesion. May caused G2/M arrest and apoptosis in cancer cells (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 424C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri430 – 452C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 5 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 5
Gene namesi
Name:Prdm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918029. Prdm5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307941 – 599PR domain zinc finger protein 5Add BLAST599

Proteomic databases

PaxDbiQ9CXE0.
PRIDEiQ9CXE0.

PTM databases

PhosphoSitePlusiQ9CXE0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029913.
CleanExiMM_PRDM5.
ExpressionAtlasiQ9CXE0. baseline and differential.
GenevisibleiQ9CXE0. MM.

Interactioni

Subunit structurei

Interacts with EHMT2/G9A, GFI1 and HDAC1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214249. 1 interactor.
STRINGi10090.ENSMUSP00000031976.

Structurei

3D structure databases

ProteinModelPortaliQ9CXE0.
SMRiQ9CXE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 124SETPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 134Poly-Glu6

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri167 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 256C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 339C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri345 – 367C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri373 – 395C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 424C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri430 – 452C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri571 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
KOG2461. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129942.
HOGENOMiHOG000234617.
HOVERGENiHBG098380.
InParanoidiQ9CXE0.
OMAiIHNSERT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9CXE0.
TreeFamiTF106478.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR001214. SET_dom.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR017125. Znf_PRDM5-like.
IPR013083. Znf_RING/FYVE/PHD.
PIRSFiPIRSF037162. PRDM. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequencei

Sequence statusi: Complete.

Q9CXE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGMYVPDRF ALKSSRVQDG MGLYTARRVR KGEKFGPFAG EKRMPEDLDE
60 70 80 90 100
NMDYRLMWEV RGSKGEVLYI LDATNPRHSN WLRFVHEAPS QERKNLAAIQ
110 120 130 140 150
EGENIFYLAV DDIETDTELL IGYLDSDVEA EEEEQQALTM TKEGKVDHSK
160 170 180 190 200
GQLAAGSKGH LGCEEDFACP QCESSFPSEE VLTEHLQSLH QKPTGEKEFK
210 220 230 240 250
CENCGKKFPV RQALQRHFEQ HRKACRGEAR FVCKADSCGK RLKSKDALRR
260 270 280 290 300
HQENVHTGDP KRKLICSVCN RKCTSVSSLQ EHRKIHEIFD CQECMKKFIS
310 320 330 340 350
ANQLKRHMIT HSEKRPYNCE ICNKSFKRLD QVGAHKVIHS EDKPYQCKLC
360 370 380 390 400
GKGFAHRNVY KNHKKTHSEE RPFQCDACKA LFRTPFSLQR HLLIHNSERT
410 420 430 440 450
FKCHHCDATF KRKDTLNVHV QVVHERHKKY RCELCNKAFV TPSVLRSHKK
460 470 480 490 500
THTGEKEKVC PYCGQKFASS GTLRVHIRSH TGERPYQCPY CEKGFSKNDG
510 520 530 540 550
LKMHIRTHTR EKPYQCSECS KAFSQKRGLD EHKRTHTGEK PFQCDVCDLA
560 570 580 590
FSLKKMLIRH KMTHNPNRPM AECHFCHKKF TRNDYLKVHM DNIHGVADS
Length:599
Mass (Da):69,550
Last modified:July 7, 2009 - v2
Checksum:i545824C2A54DAAF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531 – 532EH → AT in BAB29400 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014501 mRNA. Translation: BAB29400.1.
CH466523 Genomic DNA. Translation: EDK98780.1.
BC138901 mRNA. Translation: AAI38902.1.
BC138902 mRNA. Translation: AAI38903.1.
CCDSiCCDS20208.1.
RefSeqiNP_081823.2. NM_027547.2.
UniGeneiMm.263355.

Genome annotation databases

EnsembliENSMUST00000031976; ENSMUSP00000031976; ENSMUSG00000029913.
GeneIDi70779.
KEGGimmu:70779.
UCSCiuc009cek.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPRDM5_MOUSE
AccessioniPrimary (citable) accession number: Q9CXE0
Secondary accession number(s): B2RSK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 7, 2009
Last modified: October 25, 2017
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families