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Q9CXC9 (ETV5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS translocation variant 5
Gene names
Name:Etv5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to DNA sequences containing the consensus nucleotide core sequence GGAA By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to oxidative stress

Inferred from sequence or structural similarity. Source: UniProtKB

locomotory behavior

Inferred from mutant phenotype PubMed 17785180. Source: MGI

male germ-line stem cell division

Inferred from electronic annotation. Source: Ensembl

neuromuscular synaptic transmission

Inferred from mutant phenotype PubMed 17785180. Source: MGI

positive regulation of glial cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15466854. Source: MGI

regulation of branching involved in mammary gland duct morphogenesis

Inferred from direct assay PubMed 12871699. Source: MGI

regulation of synapse organization

Inferred from mutant phenotype PubMed 17785180. Source: MGI

regulation of transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: RefGenome

skeletal muscle acetylcholine-gated channel clustering

Inferred from mutant phenotype PubMed 17785180. Source: MGI

transcription from RNA polymerase II promoter

Inferred from Biological aspect of Ancestor. Source: GOC

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transcription regulatory region DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510ETS translocation variant 5
PRO_0000204119

Regions

DNA binding368 – 44881ETS

Experimental info

Sequence conflict2711Y → F in AAF85761. Ref.1
Sequence conflict2831A → V in AAF85761. Ref.1
Sequence conflict3961F → I in BAC27412. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CXC9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 371560F7E84A8F74

FASTA51057,712
        10         20         30         40         50         60 
MDGFCDQQVP FMVPGKSRSE DCRGRPLIDR KRKFVDTDLA HDSEELFQDL SQLQEAWLAE 

        70         80         90        100        110        120 
AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA KYGEKCLYNY 

       130        140        150        160        170        180 
CAYDRKPPSG FKPLTPPATP LSPTHQNSLF PPPQATLPTS GLTPGAGPVQ GVGPAPTPHS 

       190        200        210        220        230        240 
LPEPGSQQQT FAVPRPPHQP LQMPKMMPES QYPSEQRFQR QLSEPSHPFP PQSGVPGDSR 

       250        260        270        280        290        300 
PSYHRQMSEP IVPAAPPPLQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 

       310        320        330        340        350        360 
ADSEVPNCQS SYMRGGYFSS SHEGFPYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP 

       370        380        390        400        410        420 
PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD 

       430        440        450        460        470        480 
KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECPLNEEDT 

       490        500        510 
LPLTHFEDNP AYLLDMDRCS SLPYTEGFAY 

« Hide

References

« Hide 'large scale' references
[1]"Differential expression patterns of the PEA3 group transcription factors through murine embryonic development."
Chotteau-Lelievre A., Desbiens X., Pelczar H., Defossez P.-A., de Launoit Y.
Oncogene 15:937-952(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney, Lung and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY004174 mRNA. Translation: AAF85761.1.
AK018368 mRNA. Translation: BAB31180.1.
AK031452 mRNA. Translation: BAC27412.1.
AK168881 mRNA. Translation: BAE40699.1.
BC034680 mRNA. Translation: AAH34680.1.
CCDSCCDS37299.1.
RefSeqNP_076283.2. NM_023794.2.
XP_006521720.1. XM_006521657.1.
UniGeneMm.155708.

3D structure databases

ProteinModelPortalQ9CXC9.
SMRQ9CXC9. Positions 367-459.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-60467N.

PTM databases

PhosphoSiteQ9CXC9.

Proteomic databases

PRIDEQ9CXC9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000079601; ENSMUSP00000078551; ENSMUSG00000013089.
GeneID104156.
KEGGmmu:104156.
UCSCuc007yse.1. mouse.

Organism-specific databases

CTD2119.
MGIMGI:1096867. Etv5.

Phylogenomic databases

eggNOGNOG258471.
GeneTreeENSGT00750000117517.
HOGENOMHOG000230986.
HOVERGENHBG000231.
KOK15593.
OrthoDBEOG7K9K2M.
TreeFamTF316214.

Gene expression databases

ArrayExpressQ9CXC9.
BgeeQ9CXC9.
CleanExMM_ETV5.
GenevestigatorQ9CXC9.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
[Graphical view]
PROSITEPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio356630.
PROQ9CXC9.
SOURCESearch...

Entry information

Entry nameETV5_MOUSE
AccessionPrimary (citable) accession number: Q9CXC9
Secondary accession number(s): Q3TG49, Q8C0F3, Q9JHB1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot