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Q9CXC9

- ETV5_MOUSE

UniProt

Q9CXC9 - ETV5_MOUSE

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Protein

ETS translocation variant 5

Gene

Etv5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi368 – 44881ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. cell differentiation Source: RefGenome
  2. cellular response to oxidative stress Source: UniProtKB
  3. locomotory behavior Source: MGI
  4. male germ-line stem cell asymmetric division Source: Ensembl
  5. neuromuscular synaptic transmission Source: MGI
  6. positive regulation of glial cell proliferation Source: Ensembl
  7. positive regulation of neuron differentiation Source: Ensembl
  8. positive regulation of transcription, DNA-templated Source: MGI
  9. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
  10. regulation of synapse organization Source: MGI
  11. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  12. skeletal muscle acetylcholine-gated channel clustering Source: MGI
  13. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS translocation variant 5
Gene namesi
Name:Etv5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1096867. Etv5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510ETS translocation variant 5PRO_0000204119Add
BLAST

Proteomic databases

PRIDEiQ9CXC9.

PTM databases

PhosphoSiteiQ9CXC9.

Expressioni

Gene expression databases

BgeeiQ9CXC9.
CleanExiMM_ETV5.
ExpressionAtlasiQ9CXC9. baseline and differential.
GenevestigatoriQ9CXC9.

Interactioni

Protein-protein interaction databases

DIPiDIP-60467N.

Structurei

3D structure databases

ProteinModelPortaliQ9CXC9.
SMRiQ9CXC9. Positions 367-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258471.
GeneTreeiENSGT00760000118907.
HOGENOMiHOG000230986.
HOVERGENiHBG000231.
InParanoidiQ9CXC9.
KOiK15593.
OrthoDBiEOG7K9K2M.
TreeFamiTF316214.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
[Graphical view]
PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXC9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGFCDQQVP FMVPGKSRSE DCRGRPLIDR KRKFVDTDLA HDSEELFQDL
60 70 80 90 100
SQLQEAWLAE AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS
110 120 130 140 150
SCSHEQALGA KYGEKCLYNY CAYDRKPPSG FKPLTPPATP LSPTHQNSLF
160 170 180 190 200
PPPQATLPTS GLTPGAGPVQ GVGPAPTPHS LPEPGSQQQT FAVPRPPHQP
210 220 230 240 250
LQMPKMMPES QYPSEQRFQR QLSEPSHPFP PQSGVPGDSR PSYHRQMSEP
260 270 280 290 300
IVPAAPPPLQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC
310 320 330 340 350
ADSEVPNCQS SYMRGGYFSS SHEGFPYEKD PRLYFDDTCV VPERLEGKVK
360 370 380 390 400
QEPTMYREGP PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE
410 420 430 440 450
PEEVARRWGI QKNRPAMNYD KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD
460 470 480 490 500
PDALFSMAFP DNQRPFLKAE SECPLNEEDT LPLTHFEDNP AYLLDMDRCS
510
SLPYTEGFAY
Length:510
Mass (Da):57,712
Last modified:June 1, 2001 - v1
Checksum:i371560F7E84A8F74
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711Y → F in AAF85761. (PubMed:9285689)Curated
Sequence conflicti283 – 2831A → V in AAF85761. (PubMed:9285689)Curated
Sequence conflicti396 – 3961F → I in BAC27412. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004174 mRNA. Translation: AAF85761.1.
AK018368 mRNA. Translation: BAB31180.1.
AK031452 mRNA. Translation: BAC27412.1.
AK168881 mRNA. Translation: BAE40699.1.
BC034680 mRNA. Translation: AAH34680.1.
CCDSiCCDS37299.1.
RefSeqiNP_076283.2. NM_023794.2.
XP_006521720.1. XM_006521657.1.
UniGeneiMm.155708.

Genome annotation databases

EnsembliENSMUST00000079601; ENSMUSP00000078551; ENSMUSG00000013089.
GeneIDi104156.
KEGGimmu:104156.
UCSCiuc007yse.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004174 mRNA. Translation: AAF85761.1 .
AK018368 mRNA. Translation: BAB31180.1 .
AK031452 mRNA. Translation: BAC27412.1 .
AK168881 mRNA. Translation: BAE40699.1 .
BC034680 mRNA. Translation: AAH34680.1 .
CCDSi CCDS37299.1.
RefSeqi NP_076283.2. NM_023794.2.
XP_006521720.1. XM_006521657.1.
UniGenei Mm.155708.

3D structure databases

ProteinModelPortali Q9CXC9.
SMRi Q9CXC9. Positions 367-461.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60467N.

PTM databases

PhosphoSitei Q9CXC9.

Proteomic databases

PRIDEi Q9CXC9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000079601 ; ENSMUSP00000078551 ; ENSMUSG00000013089 .
GeneIDi 104156.
KEGGi mmu:104156.
UCSCi uc007yse.1. mouse.

Organism-specific databases

CTDi 2119.
MGIi MGI:1096867. Etv5.

Phylogenomic databases

eggNOGi NOG258471.
GeneTreei ENSGT00760000118907.
HOGENOMi HOG000230986.
HOVERGENi HBG000231.
InParanoidi Q9CXC9.
KOi K15593.
OrthoDBi EOG7K9K2M.
TreeFami TF316214.

Miscellaneous databases

NextBioi 356630.
PROi Q9CXC9.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXC9.
CleanExi MM_ETV5.
ExpressionAtlasi Q9CXC9. baseline and differential.
Genevestigatori Q9CXC9.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR000418. Ets_dom.
IPR006715. ETS_PEA3_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF04621. ETS_PEA3_N. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
[Graphical view ]
PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression patterns of the PEA3 group transcription factors through murine embryonic development."
    Chotteau-Lelievre A., Desbiens X., Pelczar H., Defossez P.-A., de Launoit Y.
    Oncogene 15:937-952(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney, Lung and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiETV5_MOUSE
AccessioniPrimary (citable) accession number: Q9CXC9
Secondary accession number(s): Q3TG49, Q8C0F3, Q9JHB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3