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Q9CXC9

- ETV5_MOUSE

UniProt

Q9CXC9 - ETV5_MOUSE

Protein

ETS translocation variant 5

Gene

Etv5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi368 – 44881ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    4. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: RefGenome
    2. cellular response to oxidative stress Source: UniProtKB
    3. locomotory behavior Source: MGI
    4. male germ-line stem cell asymmetric division Source: Ensembl
    5. neuromuscular synaptic transmission Source: MGI
    6. positive regulation of glial cell proliferation Source: Ensembl
    7. positive regulation of neuron differentiation Source: Ensembl
    8. positive regulation of transcription, DNA-templated Source: MGI
    9. regulation of branching involved in mammary gland duct morphogenesis Source: MGI
    10. regulation of synapse organization Source: MGI
    11. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    12. skeletal muscle acetylcholine-gated channel clustering Source: MGI
    13. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS translocation variant 5
    Gene namesi
    Name:Etv5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1096867. Etv5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510ETS translocation variant 5PRO_0000204119Add
    BLAST

    Proteomic databases

    PRIDEiQ9CXC9.

    PTM databases

    PhosphoSiteiQ9CXC9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CXC9.
    BgeeiQ9CXC9.
    CleanExiMM_ETV5.
    GenevestigatoriQ9CXC9.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60467N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXC9.
    SMRiQ9CXC9. Positions 367-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258471.
    GeneTreeiENSGT00750000117517.
    HOGENOMiHOG000230986.
    HOVERGENiHBG000231.
    KOiK15593.
    OrthoDBiEOG7K9K2M.
    TreeFamiTF316214.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    [Graphical view]
    PROSITEiPS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXC9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGFCDQQVP FMVPGKSRSE DCRGRPLIDR KRKFVDTDLA HDSEELFQDL    50
    SQLQEAWLAE AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS 100
    SCSHEQALGA KYGEKCLYNY CAYDRKPPSG FKPLTPPATP LSPTHQNSLF 150
    PPPQATLPTS GLTPGAGPVQ GVGPAPTPHS LPEPGSQQQT FAVPRPPHQP 200
    LQMPKMMPES QYPSEQRFQR QLSEPSHPFP PQSGVPGDSR PSYHRQMSEP 250
    IVPAAPPPLQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 300
    ADSEVPNCQS SYMRGGYFSS SHEGFPYEKD PRLYFDDTCV VPERLEGKVK 350
    QEPTMYREGP PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE 400
    PEEVARRWGI QKNRPAMNYD KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD 450
    PDALFSMAFP DNQRPFLKAE SECPLNEEDT LPLTHFEDNP AYLLDMDRCS 500
    SLPYTEGFAY 510
    Length:510
    Mass (Da):57,712
    Last modified:June 1, 2001 - v1
    Checksum:i371560F7E84A8F74
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti271 – 2711Y → F in AAF85761. (PubMed:9285689)Curated
    Sequence conflicti283 – 2831A → V in AAF85761. (PubMed:9285689)Curated
    Sequence conflicti396 – 3961F → I in BAC27412. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY004174 mRNA. Translation: AAF85761.1.
    AK018368 mRNA. Translation: BAB31180.1.
    AK031452 mRNA. Translation: BAC27412.1.
    AK168881 mRNA. Translation: BAE40699.1.
    BC034680 mRNA. Translation: AAH34680.1.
    CCDSiCCDS37299.1.
    RefSeqiNP_076283.2. NM_023794.2.
    XP_006521720.1. XM_006521657.1.
    UniGeneiMm.155708.

    Genome annotation databases

    EnsembliENSMUST00000079601; ENSMUSP00000078551; ENSMUSG00000013089.
    GeneIDi104156.
    KEGGimmu:104156.
    UCSCiuc007yse.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY004174 mRNA. Translation: AAF85761.1 .
    AK018368 mRNA. Translation: BAB31180.1 .
    AK031452 mRNA. Translation: BAC27412.1 .
    AK168881 mRNA. Translation: BAE40699.1 .
    BC034680 mRNA. Translation: AAH34680.1 .
    CCDSi CCDS37299.1.
    RefSeqi NP_076283.2. NM_023794.2.
    XP_006521720.1. XM_006521657.1.
    UniGenei Mm.155708.

    3D structure databases

    ProteinModelPortali Q9CXC9.
    SMRi Q9CXC9. Positions 367-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60467N.

    PTM databases

    PhosphoSitei Q9CXC9.

    Proteomic databases

    PRIDEi Q9CXC9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000079601 ; ENSMUSP00000078551 ; ENSMUSG00000013089 .
    GeneIDi 104156.
    KEGGi mmu:104156.
    UCSCi uc007yse.1. mouse.

    Organism-specific databases

    CTDi 2119.
    MGIi MGI:1096867. Etv5.

    Phylogenomic databases

    eggNOGi NOG258471.
    GeneTreei ENSGT00750000117517.
    HOGENOMi HOG000230986.
    HOVERGENi HBG000231.
    KOi K15593.
    OrthoDBi EOG7K9K2M.
    TreeFami TF316214.

    Miscellaneous databases

    NextBioi 356630.
    PROi Q9CXC9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CXC9.
    Bgeei Q9CXC9.
    CleanExi MM_ETV5.
    Genevestigatori Q9CXC9.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR006715. ETS_PEA3_N.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF04621. ETS_PEA3_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    [Graphical view ]
    PROSITEi PS00345. ETS_DOMAIN_1. 1 hit.
    PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression patterns of the PEA3 group transcription factors through murine embryonic development."
      Chotteau-Lelievre A., Desbiens X., Pelczar H., Defossez P.-A., de Launoit Y.
      Oncogene 15:937-952(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney, Lung and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiETV5_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXC9
    Secondary accession number(s): Q3TG49, Q8C0F3, Q9JHB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3