Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CXB8

- ALPK1_MOUSE

UniProt

Q9CXB8 - ALPK1_MOUSE

Protein

Alpha-protein kinase 1

Gene

Alpk1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-protein kinase 1 (EC:2.7.11.-)
    Alternative name(s):
    Lymphocyte alpha-protein kinase
    Gene namesi
    Name:Alpk1
    Synonyms:Kiaa1527, Lak
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1918731. Alpk1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12311231Alpha-protein kinase 1PRO_0000260029Add
    BLAST

    Proteomic databases

    PRIDEiQ9CXB8.

    PTM databases

    PhosphoSiteiQ9CXB8.

    Expressioni

    Gene expression databases

    BgeeiQ9CXB8.
    CleanExiMM_ALPK1.
    GenevestigatoriQ9CXB8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXB8.
    SMRiQ9CXB8. Positions 1049-1220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1003 – 1223221Alpha-type protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi902 – 94645Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG73232.
    GeneTreeiENSGT00740000115539.
    HOGENOMiHOG000169279.
    HOVERGENiHBG079770.
    InParanoidiQ9CXB8.
    PhylomeDBiQ9CXB8.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view]
    PfamiPF02816. Alpha_kinase. 1 hit.
    [Graphical view]
    SMARTiSM00811. Alpha_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51158. ALPHA_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNQDAVASI LHECKQVLDR LLLETPDVST EDKSEDQRCR ASLPSELRTL     50
    IQEAEEMKWP FVPEKWQYKQ AMSPEDKTNL QDVIGAGLQQ LLAALRASIL 100
    VQDCAAASAI VFLMDRFLYG LDVSGKLLQV AKGLHKLKPA TPIAPQVVIR 150
    QARVSVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 200
    GQILQKLGMW YEAAELIWAS VIGYLTLPQP DKKGISTSLG ILADIFVSMS 250
    KTDYEKFKKS PKVNLALLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLRAV 300
    NIRGTCLLSY SCSADCPPGM KSVHLCEAKE AFEIGLLTKK DGELVSGKQE 350
    LHSFIKAAFG LTTVHSRLHG ETDAVRAARQ LCSEAVGKLY TFSTSPTSQD 400
    REGLSQEIMS LISQVKGHLR VQSFPNLDVC SYVPESFKCG LDRLILHGHV 450
    DFQQILETYS QHHTSVCEVF ESTCGNSKSN QRDTKSEVCI TTLKTETNTA 500
    DTMVATLERV SSQDSRSTAS SKMSKKDQGK LQRERGRSWT RSKAFRVSLD 550
    LDMETETEPP NHSNGGTDVF NKSLRDNSSS CSWGRLSGLS SSTSWEEVNC 600
    AVQDVVRKGS GQEKHPVEAQ SSEAVSEEPK RNRSSRAVFL SSKLRGVSLQ 650
    TTGDDNLESS PSQLHNHTSI LPFNAKDTCL ASGAGLVETA EGSNNTSLQS 700
    SHSCGSDSWS LSSSDRFTDV TTNPSVQEEE PSGIMGDVPE SKYDFKDWHG 750
    EKNGGTLTEI CTGPELTFAP SSVDPEGETA ESTDDGLSPS QVALGCLEGS 800
    HSMSTRRTFF PDGSVQNADS AKTGCSVRDQ TVDPDASTVD EEGQMLDSTE 850
    VCSIGQDGAH RPRALRSGQS AEGPKSFVNG SRPSPIFDED FSTTEEGEEL 900
    GSMLKSSQNS SSYSPWWLKS PAFSRSSSDG ESSWSLLNSS RSSFASLAGQ 950
    TSQEILEART LQPDDLEKLL AGVRHDWLLQ RLENTGVLKS NQLQQAHSAL 1000
    LLKYSKKSEL WTAQETVVYL GDYLKVKKKG KQRNAFWVHY LHQEETLGRY 1050
    VGKEYKERKG LRHHFTDVER QMTAQHYVTE FNKRLYEQKI PTQIFYVPST 1100
    ILLILEDRTI KGCISVEPYI LGEFVKLSNN TKVVKNEYKA TEYGLAYGHF 1150
    SYEFSNHRDV VVDLQGWVTG NGKGLIYLTD PQIHSVDQKD VTTNFGKRGI 1200
    FYFFNNQHAS CNEICHRLSL TRPSLEQTSK V 1231
    Length:1,231
    Mass (Da):136,134
    Last modified:November 28, 2006 - v2
    Checksum:i94C2C68F6C74241D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti93 – 11018AALRA…AASAI → VGRILPPVPLTSPREAFR in BAC30902. (PubMed:16141072)CuratedAdd
    BLAST
    Sequence conflicti209 – 2102MW → TD in BAB31195. (PubMed:16141072)Curated
    Sequence conflicti233 – 2331K → Q in BAD32469. (PubMed:15368895)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC158308 Genomic DNA. No translation available.
    AC163391 Genomic DNA. No translation available.
    AK018401 mRNA. Translation: BAB31195.1.
    AK041315 mRNA. Translation: BAC30902.1.
    AK173191 mRNA. Translation: BAD32469.1.
    CCDSiCCDS51067.1.
    UniGeneiMm.158704.

    Genome annotation databases

    EnsembliENSMUST00000161239; ENSMUSP00000123967; ENSMUSG00000028028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC158308 Genomic DNA. No translation available.
    AC163391 Genomic DNA. No translation available.
    AK018401 mRNA. Translation: BAB31195.1 .
    AK041315 mRNA. Translation: BAC30902.1 .
    AK173191 mRNA. Translation: BAD32469.1 .
    CCDSi CCDS51067.1.
    UniGenei Mm.158704.

    3D structure databases

    ProteinModelPortali Q9CXB8.
    SMRi Q9CXB8. Positions 1049-1220.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CXB8.

    Proteomic databases

    PRIDEi Q9CXB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000161239 ; ENSMUSP00000123967 ; ENSMUSG00000028028 .

    Organism-specific databases

    MGIi MGI:1918731. Alpk1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG73232.
    GeneTreei ENSGT00740000115539.
    HOGENOMi HOG000169279.
    HOVERGENi HBG079770.
    InParanoidi Q9CXB8.
    PhylomeDBi Q9CXB8.

    Miscellaneous databases

    ChiTaRSi ALPK1. mouse.
    PROi Q9CXB8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXB8.
    CleanExi MM_ALPK1.
    Genevestigatori Q9CXB8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR004166. MHCK_EF2_kinase.
    [Graphical view ]
    Pfami PF02816. Alpha_kinase. 1 hit.
    [Graphical view ]
    SMARTi SM00811. Alpha_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51158. ALPHA_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-209.
      Strain: C57BL/6J.
      Tissue: Aorta, Lung and Vein.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-1231.
      Tissue: Brain.

    Entry informationi

    Entry nameiALPK1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXB8
    Secondary accession number(s): Q69ZH5, Q8BLT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3