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Protein

Alpha-protein kinase 1

Gene

Alpk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 1 (EC:2.7.11.-)
Alternative name(s):
Lymphocyte alpha-protein kinase
Gene namesi
Name:Alpk1
Synonyms:Kiaa1527, Lak
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1918731. Alpk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12311231Alpha-protein kinase 1PRO_0000260029Add
BLAST

Proteomic databases

PRIDEiQ9CXB8.

PTM databases

PhosphoSiteiQ9CXB8.

Expressioni

Gene expression databases

BgeeiQ9CXB8.
CleanExiMM_ALPK1.
ExpressionAtlasiQ9CXB8. baseline and differential.
GenevestigatoriQ9CXB8.

Structurei

3D structure databases

ProteinModelPortaliQ9CXB8.
SMRiQ9CXB8. Positions 1049-1220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1003 – 1223221Alpha-type protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi902 – 94645Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 alpha-type protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG73232.
GeneTreeiENSGT00740000115539.
HOGENOMiHOG000169279.
HOVERGENiHBG079770.
InParanoidiQ9CXB8.
PhylomeDBiQ9CXB8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNQDAVASI LHECKQVLDR LLLETPDVST EDKSEDQRCR ASLPSELRTL
60 70 80 90 100
IQEAEEMKWP FVPEKWQYKQ AMSPEDKTNL QDVIGAGLQQ LLAALRASIL
110 120 130 140 150
VQDCAAASAI VFLMDRFLYG LDVSGKLLQV AKGLHKLKPA TPIAPQVVIR
160 170 180 190 200
QARVSVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR
210 220 230 240 250
GQILQKLGMW YEAAELIWAS VIGYLTLPQP DKKGISTSLG ILADIFVSMS
260 270 280 290 300
KTDYEKFKKS PKVNLALLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLRAV
310 320 330 340 350
NIRGTCLLSY SCSADCPPGM KSVHLCEAKE AFEIGLLTKK DGELVSGKQE
360 370 380 390 400
LHSFIKAAFG LTTVHSRLHG ETDAVRAARQ LCSEAVGKLY TFSTSPTSQD
410 420 430 440 450
REGLSQEIMS LISQVKGHLR VQSFPNLDVC SYVPESFKCG LDRLILHGHV
460 470 480 490 500
DFQQILETYS QHHTSVCEVF ESTCGNSKSN QRDTKSEVCI TTLKTETNTA
510 520 530 540 550
DTMVATLERV SSQDSRSTAS SKMSKKDQGK LQRERGRSWT RSKAFRVSLD
560 570 580 590 600
LDMETETEPP NHSNGGTDVF NKSLRDNSSS CSWGRLSGLS SSTSWEEVNC
610 620 630 640 650
AVQDVVRKGS GQEKHPVEAQ SSEAVSEEPK RNRSSRAVFL SSKLRGVSLQ
660 670 680 690 700
TTGDDNLESS PSQLHNHTSI LPFNAKDTCL ASGAGLVETA EGSNNTSLQS
710 720 730 740 750
SHSCGSDSWS LSSSDRFTDV TTNPSVQEEE PSGIMGDVPE SKYDFKDWHG
760 770 780 790 800
EKNGGTLTEI CTGPELTFAP SSVDPEGETA ESTDDGLSPS QVALGCLEGS
810 820 830 840 850
HSMSTRRTFF PDGSVQNADS AKTGCSVRDQ TVDPDASTVD EEGQMLDSTE
860 870 880 890 900
VCSIGQDGAH RPRALRSGQS AEGPKSFVNG SRPSPIFDED FSTTEEGEEL
910 920 930 940 950
GSMLKSSQNS SSYSPWWLKS PAFSRSSSDG ESSWSLLNSS RSSFASLAGQ
960 970 980 990 1000
TSQEILEART LQPDDLEKLL AGVRHDWLLQ RLENTGVLKS NQLQQAHSAL
1010 1020 1030 1040 1050
LLKYSKKSEL WTAQETVVYL GDYLKVKKKG KQRNAFWVHY LHQEETLGRY
1060 1070 1080 1090 1100
VGKEYKERKG LRHHFTDVER QMTAQHYVTE FNKRLYEQKI PTQIFYVPST
1110 1120 1130 1140 1150
ILLILEDRTI KGCISVEPYI LGEFVKLSNN TKVVKNEYKA TEYGLAYGHF
1160 1170 1180 1190 1200
SYEFSNHRDV VVDLQGWVTG NGKGLIYLTD PQIHSVDQKD VTTNFGKRGI
1210 1220 1230
FYFFNNQHAS CNEICHRLSL TRPSLEQTSK V
Length:1,231
Mass (Da):136,134
Last modified:November 28, 2006 - v2
Checksum:i94C2C68F6C74241D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 11018AALRA…AASAI → VGRILPPVPLTSPREAFR in BAC30902. (PubMed:16141072)CuratedAdd
BLAST
Sequence conflicti209 – 2102MW → TD in BAB31195. (PubMed:16141072)Curated
Sequence conflicti233 – 2331K → Q in BAD32469. (PubMed:15368895)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158308 Genomic DNA. No translation available.
AC163391 Genomic DNA. No translation available.
AK018401 mRNA. Translation: BAB31195.1.
AK041315 mRNA. Translation: BAC30902.1.
AK173191 mRNA. Translation: BAD32469.1.
CCDSiCCDS51067.1.
UniGeneiMm.158704.

Genome annotation databases

EnsembliENSMUST00000161239; ENSMUSP00000123967; ENSMUSG00000028028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC158308 Genomic DNA. No translation available.
AC163391 Genomic DNA. No translation available.
AK018401 mRNA. Translation: BAB31195.1.
AK041315 mRNA. Translation: BAC30902.1.
AK173191 mRNA. Translation: BAD32469.1.
CCDSiCCDS51067.1.
UniGeneiMm.158704.

3D structure databases

ProteinModelPortaliQ9CXB8.
SMRiQ9CXB8. Positions 1049-1220.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9CXB8.

Proteomic databases

PRIDEiQ9CXB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000161239; ENSMUSP00000123967; ENSMUSG00000028028.

Organism-specific databases

MGIiMGI:1918731. Alpk1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG73232.
GeneTreeiENSGT00740000115539.
HOGENOMiHOG000169279.
HOVERGENiHBG079770.
InParanoidiQ9CXB8.
PhylomeDBiQ9CXB8.

Miscellaneous databases

ChiTaRSiAlpk1. mouse.
PROiQ9CXB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXB8.
CleanExiMM_ALPK1.
ExpressionAtlasiQ9CXB8. baseline and differential.
GenevestigatoriQ9CXB8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-209.
    Strain: C57BL/6J.
    Tissue: Aorta, Lung and Vein.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-1231.
    Tissue: Brain.

Entry informationi

Entry nameiALPK1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXB8
Secondary accession number(s): Q69ZH5, Q8BLT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: January 7, 2015
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.