SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CXB8

- ALPK1_MOUSE

UniProt

Q9CXB8 - ALPK1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Alpha-protein kinase 1
Gene
Alpk1, Kiaa1527, Lak
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-protein kinase 1 (EC:2.7.11.-)
Alternative name(s):
Lymphocyte alpha-protein kinase
Gene namesi
Name:Alpk1
Synonyms:Kiaa1527, Lak
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1918731. Alpk1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12311231Alpha-protein kinase 1
PRO_0000260029Add
BLAST

Proteomic databases

PRIDEiQ9CXB8.

PTM databases

PhosphoSiteiQ9CXB8.

Expressioni

Gene expression databases

BgeeiQ9CXB8.
CleanExiMM_ALPK1.
GenevestigatoriQ9CXB8.

Structurei

3D structure databases

ProteinModelPortaliQ9CXB8.
SMRiQ9CXB8. Positions 1049-1220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1003 – 1223221Alpha-type protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi902 – 94645Ser-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG73232.
GeneTreeiENSGT00740000115539.
HOGENOMiHOG000169279.
HOVERGENiHBG079770.
InParanoidiQ9CXB8.
PhylomeDBiQ9CXB8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamiPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTiSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXB8-1 [UniParc]FASTAAdd to Basket

« Hide

MNNQDAVASI LHECKQVLDR LLLETPDVST EDKSEDQRCR ASLPSELRTL     50
IQEAEEMKWP FVPEKWQYKQ AMSPEDKTNL QDVIGAGLQQ LLAALRASIL 100
VQDCAAASAI VFLMDRFLYG LDVSGKLLQV AKGLHKLKPA TPIAPQVVIR 150
QARVSVNSGK LLKAEYILSS LISNNGATGT WLYRNESDKV LVQSVCIQIR 200
GQILQKLGMW YEAAELIWAS VIGYLTLPQP DKKGISTSLG ILADIFVSMS 250
KTDYEKFKKS PKVNLALLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLRAV 300
NIRGTCLLSY SCSADCPPGM KSVHLCEAKE AFEIGLLTKK DGELVSGKQE 350
LHSFIKAAFG LTTVHSRLHG ETDAVRAARQ LCSEAVGKLY TFSTSPTSQD 400
REGLSQEIMS LISQVKGHLR VQSFPNLDVC SYVPESFKCG LDRLILHGHV 450
DFQQILETYS QHHTSVCEVF ESTCGNSKSN QRDTKSEVCI TTLKTETNTA 500
DTMVATLERV SSQDSRSTAS SKMSKKDQGK LQRERGRSWT RSKAFRVSLD 550
LDMETETEPP NHSNGGTDVF NKSLRDNSSS CSWGRLSGLS SSTSWEEVNC 600
AVQDVVRKGS GQEKHPVEAQ SSEAVSEEPK RNRSSRAVFL SSKLRGVSLQ 650
TTGDDNLESS PSQLHNHTSI LPFNAKDTCL ASGAGLVETA EGSNNTSLQS 700
SHSCGSDSWS LSSSDRFTDV TTNPSVQEEE PSGIMGDVPE SKYDFKDWHG 750
EKNGGTLTEI CTGPELTFAP SSVDPEGETA ESTDDGLSPS QVALGCLEGS 800
HSMSTRRTFF PDGSVQNADS AKTGCSVRDQ TVDPDASTVD EEGQMLDSTE 850
VCSIGQDGAH RPRALRSGQS AEGPKSFVNG SRPSPIFDED FSTTEEGEEL 900
GSMLKSSQNS SSYSPWWLKS PAFSRSSSDG ESSWSLLNSS RSSFASLAGQ 950
TSQEILEART LQPDDLEKLL AGVRHDWLLQ RLENTGVLKS NQLQQAHSAL 1000
LLKYSKKSEL WTAQETVVYL GDYLKVKKKG KQRNAFWVHY LHQEETLGRY 1050
VGKEYKERKG LRHHFTDVER QMTAQHYVTE FNKRLYEQKI PTQIFYVPST 1100
ILLILEDRTI KGCISVEPYI LGEFVKLSNN TKVVKNEYKA TEYGLAYGHF 1150
SYEFSNHRDV VVDLQGWVTG NGKGLIYLTD PQIHSVDQKD VTTNFGKRGI 1200
FYFFNNQHAS CNEICHRLSL TRPSLEQTSK V 1231
Length:1,231
Mass (Da):136,134
Last modified:November 28, 2006 - v2
Checksum:i94C2C68F6C74241D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 11018AALRA…AASAI → VGRILPPVPLTSPREAFR in BAC30902. 1 Publication
Add
BLAST
Sequence conflicti209 – 2102MW → TD in BAB31195. 1 Publication
Sequence conflicti233 – 2331K → Q in BAD32469. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC158308 Genomic DNA. No translation available.
AC163391 Genomic DNA. No translation available.
AK018401 mRNA. Translation: BAB31195.1.
AK041315 mRNA. Translation: BAC30902.1.
AK173191 mRNA. Translation: BAD32469.1.
CCDSiCCDS51067.1.
UniGeneiMm.158704.

Genome annotation databases

EnsembliENSMUST00000161239; ENSMUSP00000123967; ENSMUSG00000028028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC158308 Genomic DNA. No translation available.
AC163391 Genomic DNA. No translation available.
AK018401 mRNA. Translation: BAB31195.1 .
AK041315 mRNA. Translation: BAC30902.1 .
AK173191 mRNA. Translation: BAD32469.1 .
CCDSi CCDS51067.1.
UniGenei Mm.158704.

3D structure databases

ProteinModelPortali Q9CXB8.
SMRi Q9CXB8. Positions 1049-1220.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CXB8.

Proteomic databases

PRIDEi Q9CXB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000161239 ; ENSMUSP00000123967 ; ENSMUSG00000028028 .

Organism-specific databases

MGIi MGI:1918731. Alpk1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG73232.
GeneTreei ENSGT00740000115539.
HOGENOMi HOG000169279.
HOVERGENi HBG079770.
InParanoidi Q9CXB8.
PhylomeDBi Q9CXB8.

Miscellaneous databases

ChiTaRSi ALPK1. mouse.
PROi Q9CXB8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXB8.
CleanExi MM_ALPK1.
Genevestigatori Q9CXB8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view ]
Pfami PF02816. Alpha_kinase. 1 hit.
[Graphical view ]
SMARTi SM00811. Alpha_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51158. ALPHA_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-209.
    Strain: C57BL/6J.
    Tissue: Aorta, Lung and Vein.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-1231.
    Tissue: Brain.

Entry informationi

Entry nameiALPK1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXB8
Secondary accession number(s): Q69ZH5, Q8BLT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi