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Q9CXB8 (ALPK1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-protein kinase 1

EC=2.7.11.-
Alternative name(s):
Lymphocyte alpha-protein kinase
Gene names
Name:Alpk1
Synonyms:Kiaa1527, Lak
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1231 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinases that recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

Sequence similarities

Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.

Contains 1 alpha-type protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12311231Alpha-protein kinase 1
PRO_0000260029

Regions

Domain1003 – 1223221Alpha-type protein kinase
Compositional bias902 – 94645Ser-rich

Experimental info

Sequence conflict93 – 11018AALRA…AASAI → VGRILPPVPLTSPREAFR in BAC30902. Ref.2
Sequence conflict209 – 2102MW → TD in BAB31195. Ref.2
Sequence conflict2331K → Q in BAD32469. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9CXB8 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 94C2C68F6C74241D

FASTA1,231136,134
        10         20         30         40         50         60 
MNNQDAVASI LHECKQVLDR LLLETPDVST EDKSEDQRCR ASLPSELRTL IQEAEEMKWP 

        70         80         90        100        110        120 
FVPEKWQYKQ AMSPEDKTNL QDVIGAGLQQ LLAALRASIL VQDCAAASAI VFLMDRFLYG 

       130        140        150        160        170        180 
LDVSGKLLQV AKGLHKLKPA TPIAPQVVIR QARVSVNSGK LLKAEYILSS LISNNGATGT 

       190        200        210        220        230        240 
WLYRNESDKV LVQSVCIQIR GQILQKLGMW YEAAELIWAS VIGYLTLPQP DKKGISTSLG 

       250        260        270        280        290        300 
ILADIFVSMS KTDYEKFKKS PKVNLALLKE FDHHLLSAAE ACKLAAAFSA YTPLFVLRAV 

       310        320        330        340        350        360 
NIRGTCLLSY SCSADCPPGM KSVHLCEAKE AFEIGLLTKK DGELVSGKQE LHSFIKAAFG 

       370        380        390        400        410        420 
LTTVHSRLHG ETDAVRAARQ LCSEAVGKLY TFSTSPTSQD REGLSQEIMS LISQVKGHLR 

       430        440        450        460        470        480 
VQSFPNLDVC SYVPESFKCG LDRLILHGHV DFQQILETYS QHHTSVCEVF ESTCGNSKSN 

       490        500        510        520        530        540 
QRDTKSEVCI TTLKTETNTA DTMVATLERV SSQDSRSTAS SKMSKKDQGK LQRERGRSWT 

       550        560        570        580        590        600 
RSKAFRVSLD LDMETETEPP NHSNGGTDVF NKSLRDNSSS CSWGRLSGLS SSTSWEEVNC 

       610        620        630        640        650        660 
AVQDVVRKGS GQEKHPVEAQ SSEAVSEEPK RNRSSRAVFL SSKLRGVSLQ TTGDDNLESS 

       670        680        690        700        710        720 
PSQLHNHTSI LPFNAKDTCL ASGAGLVETA EGSNNTSLQS SHSCGSDSWS LSSSDRFTDV 

       730        740        750        760        770        780 
TTNPSVQEEE PSGIMGDVPE SKYDFKDWHG EKNGGTLTEI CTGPELTFAP SSVDPEGETA 

       790        800        810        820        830        840 
ESTDDGLSPS QVALGCLEGS HSMSTRRTFF PDGSVQNADS AKTGCSVRDQ TVDPDASTVD 

       850        860        870        880        890        900 
EEGQMLDSTE VCSIGQDGAH RPRALRSGQS AEGPKSFVNG SRPSPIFDED FSTTEEGEEL 

       910        920        930        940        950        960 
GSMLKSSQNS SSYSPWWLKS PAFSRSSSDG ESSWSLLNSS RSSFASLAGQ TSQEILEART 

       970        980        990       1000       1010       1020 
LQPDDLEKLL AGVRHDWLLQ RLENTGVLKS NQLQQAHSAL LLKYSKKSEL WTAQETVVYL 

      1030       1040       1050       1060       1070       1080 
GDYLKVKKKG KQRNAFWVHY LHQEETLGRY VGKEYKERKG LRHHFTDVER QMTAQHYVTE 

      1090       1100       1110       1120       1130       1140 
FNKRLYEQKI PTQIFYVPST ILLILEDRTI KGCISVEPYI LGEFVKLSNN TKVVKNEYKA 

      1150       1160       1170       1180       1190       1200 
TEYGLAYGHF SYEFSNHRDV VVDLQGWVTG NGKGLIYLTD PQIHSVDQKD VTTNFGKRGI 

      1210       1220       1230 
FYFFNNQHAS CNEICHRLSL TRPSLEQTSK V 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-209.
Strain: C57BL/6J.
Tissue: Aorta, Lung and Vein.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 233-1231.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC158308 Genomic DNA. No translation available.
AC163391 Genomic DNA. No translation available.
AK018401 mRNA. Translation: BAB31195.1.
AK041315 mRNA. Translation: BAC30902.1.
AK173191 mRNA. Translation: BAD32469.1.
UniGeneMm.158704.

3D structure databases

ProteinModelPortalQ9CXB8.
SMRQ9CXB8. Positions 986-1222.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CXB8.

Proteomic databases

PRIDEQ9CXB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000161239; ENSMUSP00000123967; ENSMUSG00000028028.

Organism-specific databases

MGIMGI:1918731. Alpk1.
RougeSearch...

Phylogenomic databases

eggNOGNOG73232.
GeneTreeENSGT00740000115539.
HOGENOMHOG000169279.
HOVERGENHBG079770.
InParanoidQ9CXB8.
PhylomeDBQ9CXB8.

Gene expression databases

BgeeQ9CXB8.
CleanExMM_ALPK1.
GenevestigatorQ9CXB8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR004166. MHCK_EF2_kinase.
[Graphical view]
PfamPF02816. Alpha_kinase. 1 hit.
[Graphical view]
SMARTSM00811. Alpha_kinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51158. ALPHA_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSALPK1. mouse.
PROQ9CXB8.
SOURCESearch...

Entry information

Entry nameALPK1_MOUSE
AccessionPrimary (citable) accession number: Q9CXB8
Secondary accession number(s): Q69ZH5, Q8BLT9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: April 16, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot