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Protein

Cytochrome P450 2U1

Gene

Cyp2u1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (By similarity).By similarity

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi476Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-MMU-211958. Miscellaneous substrates.
R-MMU-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2U1 (EC:1.14.14.1)
Gene namesi
Name:Cyp2u1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1918769. Cyp2u1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002917571 – 530Cytochrome P450 2U1Add BLAST530

Proteomic databases

PaxDbiQ9CX98.
PRIDEiQ9CX98.

PTM databases

iPTMnetiQ9CX98.
PhosphoSitePlusiQ9CX98.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Developmental stagei

Expressed at all stages after E7.1 Publication

Gene expression databases

BgeeiENSMUSG00000027983.
GenevisibleiQ9CX98. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101944.

Structurei

3D structure databases

ProteinModelPortaliQ9CX98.
SMRiQ9CX98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ9CX98.
KOiK07422.
OMAiIEEFAYV.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ9CX98.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CX98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLGDQRPA AGEQPGARLH VRATGGALLL CLLAVLLGWV WLRRQRACGI
60 70 80 90 100
PPGPKPRPLV GNFGHLLVPR FLRPQFWLGS GSQTDTVGQH VYLARMARVY
110 120 130 140 150
GNIFSFFIGH RLVVVLSDFH SVREALVQQA EVFSDRPRMP LISIMTKEKG
160 170 180 190 200
IVFAHYGPIW KQQRRFSHST LRHFGLGKLS LEPRIIEEFA YVKEAMQKHG
210 220 230 240 250
EAPFSPFPII SNAVSNIICS LCFGQRFDYT NKEFKKVLDF MSRGLEICLH
260 270 280 290 300
SQLFLINICP WFYYLPFGPF KELRQIERDI SCFLKNIIRE HQESLDASNP
310 320 330 340 350
QDFIDMYLLH MEEEQGASRR SSFDEDYLFY IIGDLFIAGT DTTTNSLLWC
360 370 380 390 400
LLYMSLNPDV QKKVHEEIER VIGCDRAPSL TDKAQMPYTE ATIMEVQRLS
410 420 430 440 450
MVVPLAIPHM TSEKTVLQGF TIPKGTVVLI NLWSVHRDPA IWEKPDDFCP
460 470 480 490 500
HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ LAKMELFLMF VSLMQTFTFA
510 520 530
LPEGSEKPVM TGRFGLTLAP HPFNVTISKR
Length:530
Mass (Da):60,578
Last modified:June 26, 2007 - v2
Checksum:iFCB595EADA88A213
GO
Isoform 2 (identifier: Q9CX98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     473-501: KRVCMGEQLAKMELFLMFVSLMQTFTFAL → QLKLGFNLFFTLSLVCVCVCVCVCVYRHV
     502-530: Missing.

Show »
Length:501
Mass (Da):57,321
Checksum:i4A409AA7E463D369
GO
Isoform 3 (identifier: Q9CX98-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-270: Missing.
     416-416: V → A
     417-530: Missing.

Note: No experimental confirmation available.
Show »
Length:381
Mass (Da):43,367
Checksum:iE9832B9102B2DF99
GO

Sequence cautioni

The sequence AK142740 differs from that shown. Reason: Frameshift at position 245.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026224236 – 270Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_026225416V → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_026226417 – 530Missing in isoform 3. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_026227473 – 501KRVCM…FTFAL → QLKLGFNLFFTLSLVCVCVC VCVCVYRHV in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_026228502 – 530Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018458 mRNA. Translation: BAB31223.1.
AK041477 mRNA. Translation: BAC30954.1.
AK142740 mRNA. No translation available.
CCDSiCCDS51069.1. [Q9CX98-1]
RefSeqiNP_082092.2. NM_027816.3. [Q9CX98-1]
UniGeneiMm.473179.

Genome annotation databases

EnsembliENSMUST00000106337; ENSMUSP00000101944; ENSMUSG00000027983. [Q9CX98-1]
ENSMUST00000200236; ENSMUSP00000142519; ENSMUSG00000027983. [Q9CX98-2]
GeneIDi71519.
KEGGimmu:71519.
UCSCiuc008rjn.1. mouse. [Q9CX98-1]
uc008rjo.1. mouse. [Q9CX98-2]
uc008rjp.1. mouse. [Q9CX98-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018458 mRNA. Translation: BAB31223.1.
AK041477 mRNA. Translation: BAC30954.1.
AK142740 mRNA. No translation available.
CCDSiCCDS51069.1. [Q9CX98-1]
RefSeqiNP_082092.2. NM_027816.3. [Q9CX98-1]
UniGeneiMm.473179.

3D structure databases

ProteinModelPortaliQ9CX98.
SMRiQ9CX98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101944.

PTM databases

iPTMnetiQ9CX98.
PhosphoSitePlusiQ9CX98.

Proteomic databases

PaxDbiQ9CX98.
PRIDEiQ9CX98.

Protocols and materials databases

DNASUi71519.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106337; ENSMUSP00000101944; ENSMUSG00000027983. [Q9CX98-1]
ENSMUST00000200236; ENSMUSP00000142519; ENSMUSG00000027983. [Q9CX98-2]
GeneIDi71519.
KEGGimmu:71519.
UCSCiuc008rjn.1. mouse. [Q9CX98-1]
uc008rjo.1. mouse. [Q9CX98-2]
uc008rjp.1. mouse. [Q9CX98-3]

Organism-specific databases

CTDi113612.
MGIiMGI:1918769. Cyp2u1.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiQ9CX98.
KOiK07422.
OMAiIEEFAYV.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ9CX98.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiR-MMU-211958. Miscellaneous substrates.
R-MMU-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

PROiQ9CX98.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027983.
GenevisibleiQ9CX98. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2U1_MOUSE
AccessioniPrimary (citable) accession number: Q9CX98
Secondary accession number(s): Q8BIM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.