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Q9CX98

- CP2U1_MOUSE

UniProt

Q9CX98 - CP2U1_MOUSE

Protein

Cytochrome P450 2U1

Gene

Cyp2u1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.By similarity

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi476 – 4761Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    ReactomeiREACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_216259. Miscellaneous substrates.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2U1 (EC:1.14.14.1)
    Gene namesi
    Name:Cyp2u1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1918769. Cyp2u1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 530530Cytochrome P450 2U1PRO_0000291757Add
    BLAST

    Proteomic databases

    PRIDEiQ9CX98.

    PTM databases

    PhosphoSiteiQ9CX98.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Developmental stagei

    Expressed at all stages after E7.1 Publication

    Gene expression databases

    BgeeiQ9CX98.
    GenevestigatoriQ9CX98.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX98.
    SMRiQ9CX98. Positions 50-530.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei481 – 50121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00750000117392.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiQ9CX98.
    KOiK07422.
    OMAiIEEFAYV.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ9CX98.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CX98-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSLGDQRPA AGEQPGARLH VRATGGALLL CLLAVLLGWV WLRRQRACGI    50
    PPGPKPRPLV GNFGHLLVPR FLRPQFWLGS GSQTDTVGQH VYLARMARVY 100
    GNIFSFFIGH RLVVVLSDFH SVREALVQQA EVFSDRPRMP LISIMTKEKG 150
    IVFAHYGPIW KQQRRFSHST LRHFGLGKLS LEPRIIEEFA YVKEAMQKHG 200
    EAPFSPFPII SNAVSNIICS LCFGQRFDYT NKEFKKVLDF MSRGLEICLH 250
    SQLFLINICP WFYYLPFGPF KELRQIERDI SCFLKNIIRE HQESLDASNP 300
    QDFIDMYLLH MEEEQGASRR SSFDEDYLFY IIGDLFIAGT DTTTNSLLWC 350
    LLYMSLNPDV QKKVHEEIER VIGCDRAPSL TDKAQMPYTE ATIMEVQRLS 400
    MVVPLAIPHM TSEKTVLQGF TIPKGTVVLI NLWSVHRDPA IWEKPDDFCP 450
    HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ LAKMELFLMF VSLMQTFTFA 500
    LPEGSEKPVM TGRFGLTLAP HPFNVTISKR 530
    Length:530
    Mass (Da):60,578
    Last modified:June 26, 2007 - v2
    Checksum:iFCB595EADA88A213
    GO
    Isoform 2 (identifier: Q9CX98-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         473-501: KRVCMGEQLAKMELFLMFVSLMQTFTFAL → QLKLGFNLFFTLSLVCVCVCVCVCVYRHV
         502-530: Missing.

    Show »
    Length:501
    Mass (Da):57,321
    Checksum:i4A409AA7E463D369
    GO
    Isoform 3 (identifier: Q9CX98-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         236-270: Missing.
         416-416: V → A
         417-530: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:381
    Mass (Da):43,367
    Checksum:iE9832B9102B2DF99
    GO

    Sequence cautioni

    The sequence AK142740 differs from that shown. Reason: Frameshift at position 245.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei236 – 27035Missing in isoform 3. 1 PublicationVSP_026224Add
    BLAST
    Alternative sequencei416 – 4161V → A in isoform 3. 1 PublicationVSP_026225
    Alternative sequencei417 – 530114Missing in isoform 3. 1 PublicationVSP_026226Add
    BLAST
    Alternative sequencei473 – 50129KRVCM…FTFAL → QLKLGFNLFFTLSLVCVCVC VCVCVYRHV in isoform 2. 1 PublicationVSP_026227Add
    BLAST
    Alternative sequencei502 – 53029Missing in isoform 2. 1 PublicationVSP_026228Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018458 mRNA. Translation: BAB31223.1.
    AK041477 mRNA. Translation: BAC30954.1.
    AK142740 mRNA. No translation available.
    CCDSiCCDS51069.1. [Q9CX98-1]
    RefSeqiNP_082092.2. NM_027816.3. [Q9CX98-1]
    UniGeneiMm.473179.

    Genome annotation databases

    EnsembliENSMUST00000106337; ENSMUSP00000101944; ENSMUSG00000027983. [Q9CX98-1]
    GeneIDi71519.
    KEGGimmu:71519.
    UCSCiuc008rjn.1. mouse. [Q9CX98-1]
    uc008rjo.1. mouse. [Q9CX98-2]
    uc008rjp.1. mouse. [Q9CX98-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018458 mRNA. Translation: BAB31223.1 .
    AK041477 mRNA. Translation: BAC30954.1 .
    AK142740 mRNA. No translation available.
    CCDSi CCDS51069.1. [Q9CX98-1 ]
    RefSeqi NP_082092.2. NM_027816.3. [Q9CX98-1 ]
    UniGenei Mm.473179.

    3D structure databases

    ProteinModelPortali Q9CX98.
    SMRi Q9CX98. Positions 50-530.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CX98.

    Proteomic databases

    PRIDEi Q9CX98.

    Protocols and materials databases

    DNASUi 71519.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106337 ; ENSMUSP00000101944 ; ENSMUSG00000027983 . [Q9CX98-1 ]
    GeneIDi 71519.
    KEGGi mmu:71519.
    UCSCi uc008rjn.1. mouse. [Q9CX98-1 ]
    uc008rjo.1. mouse. [Q9CX98-2 ]
    uc008rjp.1. mouse. [Q9CX98-3 ]

    Organism-specific databases

    CTDi 113612.
    MGIi MGI:1918769. Cyp2u1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00750000117392.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi Q9CX98.
    KOi K07422.
    OMAi IEEFAYV.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q9CX98.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_196572. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
    REACT_216259. Miscellaneous substrates.

    Miscellaneous databases

    ChiTaRSi CYP2U1. mouse.
    NextBioi 333927.
    PROi Q9CX98.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CX98.
    Genevestigatori Q9CX98.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Strain: C57BL/6J.
      Tissue: Heart, Lung and Thymus.
    2. "Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues."
      Choudhary D., Jansson I., Stoilov I., Sarfarazi M., Schenkman J.B.
      Arch. Biochem. Biophys. 436:50-61(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCP2U1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX98
    Secondary accession number(s): Q8BIM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3