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Q9CX98 (CP2U1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2U1

EC=1.14.14.1
Gene names
Name:Cyp2u1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes By similarity.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Microsome membrane By similarity.

Tissue specificity

Widely expressed. Ref.2

Developmental stage

Expressed at all stages after E7. Ref.2

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence caution

The sequence AK142740 differs from that shown. Reason: Frameshift at position 245.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CX98-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CX98-2)

The sequence of this isoform differs from the canonical sequence as follows:
     473-501: KRVCMGEQLAKMELFLMFVSLMQTFTFAL → QLKLGFNLFFTLSLVCVCVCVCVCVYRHV
     502-530: Missing.
Isoform 3 (identifier: Q9CX98-3)

The sequence of this isoform differs from the canonical sequence as follows:
     236-270: Missing.
     416-416: V → A
     417-530: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Cytochrome P450 2U1
PRO_0000291757

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane99 – 11921Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane328 – 34821Helical; Potential
Transmembrane481 – 50121Helical; Potential

Sites

Metal binding4761Iron (heme axial ligand) By similarity

Natural variations

Alternative sequence236 – 27035Missing in isoform 3.
VSP_026224
Alternative sequence4161V → A in isoform 3.
VSP_026225
Alternative sequence417 – 530114Missing in isoform 3.
VSP_026226
Alternative sequence473 – 50129KRVCM…FTFAL → QLKLGFNLFFTLSLVCVCVC VCVCVYRHV in isoform 2.
VSP_026227
Alternative sequence502 – 53029Missing in isoform 2.
VSP_026228

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 26, 2007. Version 2.
Checksum: FCB595EADA88A213

FASTA53060,578
        10         20         30         40         50         60 
MSSLGDQRPA AGEQPGARLH VRATGGALLL CLLAVLLGWV WLRRQRACGI PPGPKPRPLV 

        70         80         90        100        110        120 
GNFGHLLVPR FLRPQFWLGS GSQTDTVGQH VYLARMARVY GNIFSFFIGH RLVVVLSDFH 

       130        140        150        160        170        180 
SVREALVQQA EVFSDRPRMP LISIMTKEKG IVFAHYGPIW KQQRRFSHST LRHFGLGKLS 

       190        200        210        220        230        240 
LEPRIIEEFA YVKEAMQKHG EAPFSPFPII SNAVSNIICS LCFGQRFDYT NKEFKKVLDF 

       250        260        270        280        290        300 
MSRGLEICLH SQLFLINICP WFYYLPFGPF KELRQIERDI SCFLKNIIRE HQESLDASNP 

       310        320        330        340        350        360 
QDFIDMYLLH MEEEQGASRR SSFDEDYLFY IIGDLFIAGT DTTTNSLLWC LLYMSLNPDV 

       370        380        390        400        410        420 
QKKVHEEIER VIGCDRAPSL TDKAQMPYTE ATIMEVQRLS MVVPLAIPHM TSEKTVLQGF 

       430        440        450        460        470        480 
TIPKGTVVLI NLWSVHRDPA IWEKPDDFCP HRFLDDQGQL LKRETFIPFG IGKRVCMGEQ 

       490        500        510        520        530 
LAKMELFLMF VSLMQTFTFA LPEGSEKPVM TGRFGLTLAP HPFNVTISKR 

« Hide

Isoform 2 [UniParc].

Checksum: 4A409AA7E463D369
Show »

FASTA50157,321
Isoform 3 [UniParc].

Checksum: E9832B9102B2DF99
Show »

FASTA38143,367

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: C57BL/6J.
Tissue: Heart, Lung and Thymus.
[2]"Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues."
Choudhary D., Jansson I., Stoilov I., Sarfarazi M., Schenkman J.B.
Arch. Biochem. Biophys. 436:50-61(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK018458 mRNA. Translation: BAB31223.1.
AK041477 mRNA. Translation: BAC30954.1.
AK142740 mRNA. No translation available.
CCDSCCDS51069.1. [Q9CX98-1]
RefSeqNP_082092.2. NM_027816.3. [Q9CX98-1]
UniGeneMm.473179.

3D structure databases

ProteinModelPortalQ9CX98.
SMRQ9CX98. Positions 50-530.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CX98.

Proteomic databases

PRIDEQ9CX98.

Protocols and materials databases

DNASU71519.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106337; ENSMUSP00000101944; ENSMUSG00000027983. [Q9CX98-1]
GeneID71519.
KEGGmmu:71519.
UCSCuc008rjn.1. mouse. [Q9CX98-1]
uc008rjo.1. mouse. [Q9CX98-2]
uc008rjp.1. mouse. [Q9CX98-3]

Organism-specific databases

CTD113612.
MGIMGI:1918769. Cyp2u1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00750000117392.
HOGENOMHOG000036991.
HOVERGENHBG015789.
InParanoidQ9CX98.
KOK07422.
OMAIEEFAYV.
OrthoDBEOG7RBZ85.
PhylomeDBQ9CX98.
TreeFamTF352043.

Gene expression databases

BgeeQ9CX98.
GenevestigatorQ9CX98.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCYP2U1. mouse.
NextBio333927.
PROQ9CX98.
SOURCESearch...

Entry information

Entry nameCP2U1_MOUSE
AccessionPrimary (citable) accession number: Q9CX98
Secondary accession number(s): Q8BIM3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: July 9, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot