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Protein

Gap junction epsilon-1 protein

Gene

Gje1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • cell communication Source: InterPro
  • cell morphogenesis Source: MGI
  • lens development in camera-type eye Source: MGI
  • organ growth Source: MGI

Protein family/group databases

TCDBi1.A.24.1.9. the gap junction-forming connexin (connexin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction epsilon-1 protein
Alternative name(s):
Connexin-23
Short name:
Cx23
Gene namesi
Name:Gje1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923993. Gje1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 74ExtracellularSequence analysisAdd BLAST31
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 111CytoplasmicSequence analysisAdd BLAST16
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 170ExtracellularSequence analysisAdd BLAST38
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 205CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176121 – 205Gap junction epsilon-1 proteinAdd BLAST205

Proteomic databases

PaxDbiQ9CX92.
PRIDEiQ9CX92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019867.
CleanExiMM_GJE1.
GenevisibleiQ9CX92. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020016.

Structurei

3D structure databases

ProteinModelPortaliQ9CX92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEBX. Eukaryota.
ENOG410Y93T. LUCA.
GeneTreeiENSGT00390000010547.
HOGENOMiHOG000112114.
HOVERGENiHBG094838.
InParanoidiQ9CX92.
KOiK22039.
OMAiYAACKSI.
OrthoDBiEOG091G0JO4.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 2 hits.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM01089. Connexin_CCC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CX92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS VRMFFLGVLG FAVYGNEALH
60 70 80 90 100
FSCDPDKREI NLFCYNQFRP ITPQVFWALQ LVIVLLPGAI FHLYAACKSI
110 120 130 140 150
NQDCILQKPV YTVIYVLSVL LRISLEVFAF WLQIHLFGFQ VKPIYLCDTE
160 170 180 190 200
SLGKKPNILK CMVPEHFEKT IFLIAMYTFT VITMVLCVAE VFEIIFRRSC

FLFKR
Length:205
Mass (Da):23,831
Last modified:June 1, 2001 - v1
Checksum:i6250FACFCB7A4C86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018698 mRNA. Translation: BAB31350.1.
CCDSiCCDS48505.1.
RefSeqiNP_083998.1. NM_029722.1.
UniGeneiMm.136985.

Genome annotation databases

EnsembliENSMUST00000020016; ENSMUSP00000020016; ENSMUSG00000019867.
GeneIDi76743.
KEGGimmu:76743.
UCSCiuc007elo.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCXE1_MOUSE
AccessioniPrimary (citable) accession number: Q9CX92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families