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Q9CX86

- ROA0_MOUSE

UniProt

Q9CX86 - ROA0_MOUSE

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Protein

Heterogeneous nuclear ribonucleoprotein A0

Gene

Hnrnpa0

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.1 Publication

GO - Molecular functioni

  1. AU-rich element binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  2. inflammatory response Source: UniProtKB
  3. response to lipopolysaccharide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A0
Short name:
hnRNP A0
Gene namesi
Name:Hnrnpa0
Synonyms:Hnrpa0
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1924384. Hnrnpa0.

Subcellular locationi

Nucleus By similarity
Note: Component of ribonucleosomes.By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Heterogeneous nuclear ribonucleoprotein A0PRO_0000415269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei84 – 841Phosphoserine; by MAPKAPK21 Publication
Modified residuei133 – 1331N6-acetyllysine1 Publication
Modified residuei293 – 2931Dimethylated arginineBy similarity

Post-translational modificationi

Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.1 Publication
Arg-293 is dimethylated, probably to asymmetric dimethylarginine.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CX86.
PaxDbiQ9CX86.
PRIDEiQ9CX86.

PTM databases

PhosphoSiteiQ9CX86.

Expressioni

Gene expression databases

BgeeiQ9CX86.
GenevestigatoriQ9CX86.

Interactioni

Protein-protein interaction databases

IntActiQ9CX86. 2 interactions.
MINTiMINT-1868039.
STRINGi10090.ENSMUSP00000007980.

Structurei

3D structure databases

ProteinModelPortaliQ9CX86.
SMRiQ9CX86. Positions 2-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8680RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini98 – 17578RRM 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi182 – 303122Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00760000118873.
HOGENOMiHOG000234442.
HOVERGENiHBG002295.
InParanoidiQ9CX86.
KOiK12894.
OMAiPKEDIHA.
OrthoDBiEOG715Q6V.
PhylomeDBiQ9CX86.
TreeFamiTF351342.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CX86-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF
60 70 80 90 100
GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL
110 120 130 140 150
FVGGLKGDVA EGDLIEHFSQ FGAVEKAEII ADKQSGKKRG FGFVYFQSHD
160 170 180 190 200
AADKAAVVKF HPIQGHRVEV KKAVPKEDIH AGGGGARAAR GGRGGGRGRG
210 220 230 240 250
GGGGGGGRDQ NGLAKGGGGG GGGYNSYGGY GGYGAYGGGG GGGGSYGGSD
260 270 280 290 300
YGNGFGGFGS YSQHQSSYGP MKSGGGGGGG GSWGGRSNSG PYRGGYGGGY

GGGSF
Length:305
Mass (Da):30,530
Last modified:June 1, 2001 - v1
Checksum:iB3F3BB8C5480BB56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019388 mRNA. Translation: BAB31694.1.
AC165251 Genomic DNA. No translation available.
CCDSiCCDS49280.1.
RefSeqiNP_084148.1. NM_029872.1.
UniGeneiMm.490274.

Genome annotation databases

EnsembliENSMUST00000007980; ENSMUSP00000007980; ENSMUSG00000007836.
GeneIDi77134.
KEGGimmu:77134.
UCSCiuc007qtf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019388 mRNA. Translation: BAB31694.1 .
AC165251 Genomic DNA. No translation available.
CCDSi CCDS49280.1.
RefSeqi NP_084148.1. NM_029872.1.
UniGenei Mm.490274.

3D structure databases

ProteinModelPortali Q9CX86.
SMRi Q9CX86. Positions 2-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CX86. 2 interactions.
MINTi MINT-1868039.
STRINGi 10090.ENSMUSP00000007980.

PTM databases

PhosphoSitei Q9CX86.

Proteomic databases

MaxQBi Q9CX86.
PaxDbi Q9CX86.
PRIDEi Q9CX86.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007980 ; ENSMUSP00000007980 ; ENSMUSG00000007836 .
GeneIDi 77134.
KEGGi mmu:77134.
UCSCi uc007qtf.2. mouse.

Organism-specific databases

CTDi 10949.
MGIi MGI:1924384. Hnrnpa0.

Phylogenomic databases

eggNOGi COG0724.
GeneTreei ENSGT00760000118873.
HOGENOMi HOG000234442.
HOVERGENi HBG002295.
InParanoidi Q9CX86.
KOi K12894.
OMAi PKEDIHA.
OrthoDBi EOG715Q6V.
PhylomeDBi Q9CX86.
TreeFami TF351342.

Miscellaneous databases

ChiTaRSi HNRNPA0. mouse.
NextBioi 346544.
PROi Q9CX86.
SOURCEi Search...

Gene expression databases

Bgeei Q9CX86.
Genevestigatori Q9CX86.

Family and domain databases

Gene3Di 3.30.70.330. 2 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 2 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs."
    Rousseau S., Morrice N., Peggie M., Campbell D.G., Gaestel M., Cohen P.
    EMBO J. 21:6505-6514(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, RNA-BINDING, PHOSPHORYLATION AT SER-84 BY MAPKAPK2.
  4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiROA0_MOUSE
AccessioniPrimary (citable) accession number: Q9CX86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3