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Q9CX86

- ROA0_MOUSE

UniProt

Q9CX86 - ROA0_MOUSE

Protein

Heterogeneous nuclear ribonucleoprotein A0

Gene

Hnrnpa0

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post-transcriptional regulation of cytokines mRNAs.1 Publication

    GO - Molecular functioni

    1. AU-rich element binding Source: UniProtKB
    2. nucleotide binding Source: InterPro

    GO - Biological processi

    1. 3'-UTR-mediated mRNA stabilization Source: UniProtKB
    2. inflammatory response Source: UniProtKB
    3. response to lipopolysaccharide Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A0
    Short name:
    hnRNP A0
    Gene namesi
    Name:Hnrnpa0
    Synonyms:Hnrpa0
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1924384. Hnrnpa0.

    Subcellular locationi

    Nucleus By similarity
    Note: Component of ribonucleosomes.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Heterogeneous nuclear ribonucleoprotein A0PRO_0000415269Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei84 – 841Phosphoserine; by MAPKAPK21 Publication
    Modified residuei133 – 1331N6-acetyllysine1 Publication
    Modified residuei293 – 2931Dimethylated arginineBy similarity

    Post-translational modificationi

    Phosphorylated at Ser-84 by MAPKAPK2 in response to LPS treatment, promoting stabilization of GADD45A mRNA.1 Publication
    Arg-293 is dimethylated, probably to asymmetric dimethylarginine.By similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CX86.
    PaxDbiQ9CX86.
    PRIDEiQ9CX86.

    PTM databases

    PhosphoSiteiQ9CX86.

    Expressioni

    Gene expression databases

    BgeeiQ9CX86.
    GenevestigatoriQ9CX86.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CX86. 2 interactions.
    MINTiMINT-1868039.
    STRINGi10090.ENSMUSP00000007980.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX86.
    SMRiQ9CX86. Positions 2-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 8680RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 17578RRM 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi182 – 303122Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    GeneTreeiENSGT00730000110184.
    HOGENOMiHOG000234442.
    HOVERGENiHBG002295.
    InParanoidiQ9CX86.
    KOiK12894.
    OMAiPKEDIHA.
    OrthoDBiEOG715Q6V.
    PhylomeDBiQ9CX86.
    TreeFamiTF351342.

    Family and domain databases

    Gene3Di3.30.70.330. 2 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 2 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CX86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENSQLCKLF IGGLNVQTSE SGLRGHFEAF GTLTDCVVVV NPQTKRSRCF    50
    GFVTYSNVEE ADAAMAASPH AVDGNTVELK RAVSREDSAR PGAHAKVKKL 100
    FVGGLKGDVA EGDLIEHFSQ FGAVEKAEII ADKQSGKKRG FGFVYFQSHD 150
    AADKAAVVKF HPIQGHRVEV KKAVPKEDIH AGGGGARAAR GGRGGGRGRG 200
    GGGGGGGRDQ NGLAKGGGGG GGGYNSYGGY GGYGAYGGGG GGGGSYGGSD 250
    YGNGFGGFGS YSQHQSSYGP MKSGGGGGGG GSWGGRSNSG PYRGGYGGGY 300
    GGGSF 305
    Length:305
    Mass (Da):30,530
    Last modified:June 1, 2001 - v1
    Checksum:iB3F3BB8C5480BB56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019388 mRNA. Translation: BAB31694.1.
    AC165251 Genomic DNA. No translation available.
    CCDSiCCDS49280.1.
    RefSeqiNP_084148.1. NM_029872.1.
    UniGeneiMm.490274.

    Genome annotation databases

    EnsembliENSMUST00000007980; ENSMUSP00000007980; ENSMUSG00000007836.
    GeneIDi77134.
    KEGGimmu:77134.
    UCSCiuc007qtf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019388 mRNA. Translation: BAB31694.1 .
    AC165251 Genomic DNA. No translation available.
    CCDSi CCDS49280.1.
    RefSeqi NP_084148.1. NM_029872.1.
    UniGenei Mm.490274.

    3D structure databases

    ProteinModelPortali Q9CX86.
    SMRi Q9CX86. Positions 2-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CX86. 2 interactions.
    MINTi MINT-1868039.
    STRINGi 10090.ENSMUSP00000007980.

    PTM databases

    PhosphoSitei Q9CX86.

    Proteomic databases

    MaxQBi Q9CX86.
    PaxDbi Q9CX86.
    PRIDEi Q9CX86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007980 ; ENSMUSP00000007980 ; ENSMUSG00000007836 .
    GeneIDi 77134.
    KEGGi mmu:77134.
    UCSCi uc007qtf.2. mouse.

    Organism-specific databases

    CTDi 10949.
    MGIi MGI:1924384. Hnrnpa0.

    Phylogenomic databases

    eggNOGi COG0724.
    GeneTreei ENSGT00730000110184.
    HOGENOMi HOG000234442.
    HOVERGENi HBG002295.
    InParanoidi Q9CX86.
    KOi K12894.
    OMAi PKEDIHA.
    OrthoDBi EOG715Q6V.
    PhylomeDBi Q9CX86.
    TreeFami TF351342.

    Miscellaneous databases

    ChiTaRSi HNRNPA0. mouse.
    NextBioi 346544.
    PROi Q9CX86.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CX86.
    Genevestigatori Q9CX86.

    Family and domain databases

    Gene3Di 3.30.70.330. 2 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 2 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs."
      Rousseau S., Morrice N., Peggie M., Campbell D.G., Gaestel M., Cohen P.
      EMBO J. 21:6505-6514(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, RNA-BINDING, PHOSPHORYLATION AT SER-84 BY MAPKAPK2.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiROA0_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3