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Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of G-protein signaling 19
Short name:
RGS19
Gene namesi
Name:Rgs19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915153. Rgs19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Regulator of G-protein signaling 19PRO_0000204230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei151 – 1511Phosphoserine; by MAPK1 and MAPK3By similarity

Post-translational modificationi

Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity).By similarity
Phosphorylated, mainly on serine residues.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ9CX84.
PaxDbiQ9CX84.
PRIDEiQ9CX84.

PTM databases

PhosphoSiteiQ9CX84.

Expressioni

Gene expression databases

BgeeiQ9CX84.
CleanExiMM_RGS19.
ExpressionAtlasiQ9CX84. baseline and differential.
GenevisibleiQ9CX84. MM.

Interactioni

Subunit structurei

Interacts with GIPC PDZ domain.By similarity

Protein-protein interaction databases

BioGridi208006. 1 interaction.
IntActiQ9CX84. 2 interactions.
MINTiMINT-1341963.
STRINGi10090.ENSMUSP00000002532.

Structurei

3D structure databases

ProteinModelPortaliQ9CX84.
SMRiQ9CX84. Positions 24-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 206117RGSPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni207 – 21610Interaction with GIPCBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 4911Poly-CysAdd
BLAST

Sequence similaritiesi

Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258376.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ9CX84.
KOiK16449.
PhylomeDBiQ9CX84.
TreeFamiTF315837.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CX84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS
60 70 80 90 100
WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PKEVQSWAQS FDKLMHSPTG
110 120 130 140 150
RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL
160 170 180 190 200
SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP
210
TYRSLLLQGA PQSSEA
Length:216
Mass (Da):24,678
Last modified:June 1, 2001 - v1
Checksum:i4F166A6607184F31
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821K → E in AAH03838 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019401 mRNA. Translation: BAB31703.1.
BC003838 mRNA. Translation: AAH03838.1.
CCDSiCCDS17220.1.
RefSeqiNP_001278135.1. NM_001291206.1.
NP_001278136.1. NM_001291207.1.
NP_001278138.1. NM_001291209.1.
NP_001278139.1. NM_001291210.1.
NP_080722.1. NM_026446.4.
UniGeneiMm.274366.

Genome annotation databases

EnsembliENSMUST00000002532; ENSMUSP00000002532; ENSMUSG00000002458.
ENSMUST00000108776; ENSMUSP00000104406; ENSMUSG00000002458.
ENSMUST00000165416; ENSMUSP00000129026; ENSMUSG00000002458.
GeneIDi56470.
KEGGimmu:56470.
UCSCiuc008onc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019401 mRNA. Translation: BAB31703.1.
BC003838 mRNA. Translation: AAH03838.1.
CCDSiCCDS17220.1.
RefSeqiNP_001278135.1. NM_001291206.1.
NP_001278136.1. NM_001291207.1.
NP_001278138.1. NM_001291209.1.
NP_001278139.1. NM_001291210.1.
NP_080722.1. NM_026446.4.
UniGeneiMm.274366.

3D structure databases

ProteinModelPortaliQ9CX84.
SMRiQ9CX84. Positions 24-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208006. 1 interaction.
IntActiQ9CX84. 2 interactions.
MINTiMINT-1341963.
STRINGi10090.ENSMUSP00000002532.

PTM databases

PhosphoSiteiQ9CX84.

Proteomic databases

MaxQBiQ9CX84.
PaxDbiQ9CX84.
PRIDEiQ9CX84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002532; ENSMUSP00000002532; ENSMUSG00000002458.
ENSMUST00000108776; ENSMUSP00000104406; ENSMUSG00000002458.
ENSMUST00000165416; ENSMUSP00000129026; ENSMUSG00000002458.
GeneIDi56470.
KEGGimmu:56470.
UCSCiuc008onc.1. mouse.

Organism-specific databases

CTDi10287.
MGIiMGI:1915153. Rgs19.

Phylogenomic databases

eggNOGiNOG258376.
GeneTreeiENSGT00760000118903.
HOGENOMiHOG000233513.
HOVERGENiHBG013233.
InParanoidiQ9CX84.
KOiK16449.
PhylomeDBiQ9CX84.
TreeFamiTF315837.

Enzyme and pathway databases

ReactomeiREACT_331048. G alpha (i) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi312734.
PROiQ9CX84.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CX84.
CleanExiMM_RGS19.
ExpressionAtlasiQ9CX84. baseline and differential.
GenevisibleiQ9CX84. MM.

Family and domain databases

Gene3Di1.10.196.10. 1 hit.
InterProiIPR016137. RGS.
IPR024066. RGS_subdom1.
[Graphical view]
PfamiPF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
PROSITEiPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRGS19_MOUSE
AccessioniPrimary (citable) accession number: Q9CX84
Secondary accession number(s): Q99L50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.