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Q9CX84

- RGS19_MOUSE

UniProt

Q9CX84 - RGS19_MOUSE

Protein

Regulator of G-protein signaling 19

Gene

Rgs19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein By similarity.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. positive regulation of GTPase activity Source: GOC
    2. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 19
    Short name:
    RGS19
    Gene namesi
    Name:Rgs19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1915153. Rgs19.

    Subcellular locationi

    Membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. brush border Source: Ensembl
    2. clathrin-coated vesicle Source: Ensembl
    3. cytoplasm Source: RefGenome
    4. plasma membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Regulator of G-protein signaling 19PRO_0000204230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphoserineBy similarity
    Modified residuei97 – 971PhosphoserineBy similarity
    Modified residuei151 – 1511Phosphoserine; by MAPK1 and MAPK3By similarity

    Post-translational modificationi

    Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity.By similarity
    Phosphorylated, mainly on serine residues.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiQ9CX84.
    PRIDEiQ9CX84.

    PTM databases

    PhosphoSiteiQ9CX84.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CX84.
    BgeeiQ9CX84.
    CleanExiMM_RGS19.
    GenevestigatoriQ9CX84.

    Interactioni

    Subunit structurei

    Interacts with GIPC PDZ domain.By similarity

    Protein-protein interaction databases

    BioGridi208006. 1 interaction.
    IntActiQ9CX84. 2 interactions.
    MINTiMINT-1341963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX84.
    SMRiQ9CX84. Positions 24-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 206117RGSPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni207 – 21610Interaction with GIPCBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 4911Poly-CysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258376.
    GeneTreeiENSGT00750000117371.
    HOGENOMiHOG000233513.
    HOVERGENiHBG013233.
    InParanoidiQ9CX84.
    KOiK16449.
    PhylomeDBiQ9CX84.
    TreeFamiTF315837.

    Family and domain databases

    Gene3Di1.10.196.10. 1 hit.
    InterProiIPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view]
    PfamiPF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    PROSITEiPS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CX84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS    50
    WNQERQRAWQ VSRESKLQPL PSCEVCTPPS PKEVQSWAQS FDKLMHSPTG 100
    RSVFRAFLRT EYSEENMLFW LACEELKAEA NQHVVDEKAR LIYEDYVSIL 150
    SPKEVSLDSR VREGINRKMQ EPSPHTFDDA QLQIYTLMHR DSYPRFLTSP 200
    TYRSLLLQGA PQSSEA 216
    Length:216
    Mass (Da):24,678
    Last modified:June 1, 2001 - v1
    Checksum:i4F166A6607184F31
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821K → E in AAH03838. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019401 mRNA. Translation: BAB31703.1.
    BC003838 mRNA. Translation: AAH03838.1.
    CCDSiCCDS17220.1.
    RefSeqiNP_001278135.1. NM_001291206.1.
    NP_001278136.1. NM_001291207.1.
    NP_001278138.1. NM_001291209.1.
    NP_001278139.1. NM_001291210.1.
    NP_080722.1. NM_026446.4.
    XP_006500748.1. XM_006500685.1.
    UniGeneiMm.274366.

    Genome annotation databases

    EnsembliENSMUST00000002532; ENSMUSP00000002532; ENSMUSG00000002458.
    ENSMUST00000108776; ENSMUSP00000104406; ENSMUSG00000002458.
    ENSMUST00000165416; ENSMUSP00000129026; ENSMUSG00000002458.
    GeneIDi56470.
    KEGGimmu:56470.
    UCSCiuc008onc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019401 mRNA. Translation: BAB31703.1 .
    BC003838 mRNA. Translation: AAH03838.1 .
    CCDSi CCDS17220.1.
    RefSeqi NP_001278135.1. NM_001291206.1.
    NP_001278136.1. NM_001291207.1.
    NP_001278138.1. NM_001291209.1.
    NP_001278139.1. NM_001291210.1.
    NP_080722.1. NM_026446.4.
    XP_006500748.1. XM_006500685.1.
    UniGenei Mm.274366.

    3D structure databases

    ProteinModelPortali Q9CX84.
    SMRi Q9CX84. Positions 24-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208006. 1 interaction.
    IntActi Q9CX84. 2 interactions.
    MINTi MINT-1341963.

    PTM databases

    PhosphoSitei Q9CX84.

    Proteomic databases

    PaxDbi Q9CX84.
    PRIDEi Q9CX84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002532 ; ENSMUSP00000002532 ; ENSMUSG00000002458 .
    ENSMUST00000108776 ; ENSMUSP00000104406 ; ENSMUSG00000002458 .
    ENSMUST00000165416 ; ENSMUSP00000129026 ; ENSMUSG00000002458 .
    GeneIDi 56470.
    KEGGi mmu:56470.
    UCSCi uc008onc.1. mouse.

    Organism-specific databases

    CTDi 10287.
    MGIi MGI:1915153. Rgs19.

    Phylogenomic databases

    eggNOGi NOG258376.
    GeneTreei ENSGT00750000117371.
    HOGENOMi HOG000233513.
    HOVERGENi HBG013233.
    InParanoidi Q9CX84.
    KOi K16449.
    PhylomeDBi Q9CX84.
    TreeFami TF315837.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 312734.
    PROi Q9CX84.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CX84.
    Bgeei Q9CX84.
    CleanExi MM_RGS19.
    Genevestigatori Q9CX84.

    Family and domain databases

    Gene3Di 1.10.196.10. 1 hit.
    InterProi IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    [Graphical view ]
    Pfami PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    PROSITEi PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiRGS19_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX84
    Secondary accession number(s): Q99L50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3