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Q9CX84 (RGS19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 19

Short name=RGS19
Gene names
Name:Rgs19
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein By similarity.

Subunit structure

Interacts with GIPC PDZ domain By similarity.

Subcellular location

Membrane; Lipid-anchor By similarity.

Post-translational modification

Fatty acylated. Heavily palmitoylated in the cysteine string motif By similarity.

Phosphorylated, mainly on serine residues By similarity.

Sequence similarities

Contains 1 RGS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Regulator of G-protein signaling 19
PRO_0000204230

Regions

Domain90 – 206117RGS
Region207 – 21610Interaction with GIPC By similarity
Compositional bias39 – 4911Poly-Cys

Amino acid modifications

Modified residue241Phosphoserine By similarity
Modified residue971Phosphoserine By similarity
Modified residue1511Phosphoserine; by MAPK1 and MAPK3 By similarity

Experimental info

Sequence conflict821K → E in AAH03838. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CX84 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4F166A6607184F31

FASTA21624,678
        10         20         30         40         50         60 
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS WNQERQRAWQ 

        70         80         90        100        110        120 
VSRESKLQPL PSCEVCTPPS PKEVQSWAQS FDKLMHSPTG RSVFRAFLRT EYSEENMLFW 

       130        140        150        160        170        180 
LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINRKMQ EPSPHTFDDA 

       190        200        210 
QLQIYTLMHR DSYPRFLTSP TYRSLLLQGA PQSSEA 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK019401 mRNA. Translation: BAB31703.1.
BC003838 mRNA. Translation: AAH03838.1.
CCDSCCDS17220.1.
RefSeqNP_001278135.1. NM_001291206.1.
NP_001278136.1. NM_001291207.1.
NP_001278138.1. NM_001291209.1.
NP_001278139.1. NM_001291210.1.
NP_080722.1. NM_026446.4.
XP_006500748.1. XM_006500685.1.
UniGeneMm.274366.

3D structure databases

ProteinModelPortalQ9CX84.
SMRQ9CX84. Positions 24-212.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208006. 1 interaction.
IntActQ9CX84. 2 interactions.
MINTMINT-1341963.

PTM databases

PhosphoSiteQ9CX84.

Proteomic databases

PaxDbQ9CX84.
PRIDEQ9CX84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002532; ENSMUSP00000002532; ENSMUSG00000002458.
ENSMUST00000108776; ENSMUSP00000104406; ENSMUSG00000002458.
ENSMUST00000165416; ENSMUSP00000129026; ENSMUSG00000002458.
GeneID56470.
KEGGmmu:56470.
UCSCuc008onc.1. mouse.

Organism-specific databases

CTD10287.
MGIMGI:1915153. Rgs19.

Phylogenomic databases

eggNOGNOG258376.
GeneTreeENSGT00750000117371.
HOGENOMHOG000233513.
HOVERGENHBG013233.
InParanoidQ9CX84.
KOK16449.
PhylomeDBQ9CX84.
TreeFamTF315837.

Gene expression databases

ArrayExpressQ9CX84.
BgeeQ9CX84.
CleanExMM_RGS19.
GenevestigatorQ9CX84.

Family and domain databases

Gene3D1.10.196.10. 1 hit.
InterProIPR024066. Regulat_G_prot_signal_dom1.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
[Graphical view]
PfamPF00615. RGS. 1 hit.
[Graphical view]
PRINTSPR01301. RGSPROTEIN.
SMARTSM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
PROSITEPS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312734.
PROQ9CX84.
SOURCESearch...

Entry information

Entry nameRGS19_MOUSE
AccessionPrimary (citable) accession number: Q9CX84
Secondary accession number(s): Q99L50
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot