ID   ARMX1_MOUSE             Reviewed;         456 AA.
AC   Q9CX83;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   24-JAN-2024, entry version 141.
DE   RecName: Full=Armadillo repeat-containing X-linked protein 1;
GN   Name=Armcx1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, and Heart;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N-3; TISSUE=Brain, Eye, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=22569362; DOI=10.1038/ncomms1829;
RA   Lopez-Domenech G., Serrat R., Mirra S., D'Aniello S., Somorjai I., Abad A.,
RA   Vitureira N., Garcia-Arumi E., Alonso M.T., Rodriguez-Prados M.,
RA   Burgaya F., Andreu A.L., Garcia-Sancho J., Trullas R., Garcia-Fernandez J.,
RA   Soriano E.;
RT   "The eutherian Armcx genes regulate mitochondrial trafficking in neurons
RT   and interact with Miro and Trak2.";
RL   Nat. Commun. 3:814-814(2012).
RN   [4]
RP   SUBCELLULAR LOCATION, INDUCTION, AND INTERACTION WITH MIRO1.
RX   PubMed=28009275; DOI=10.1016/j.neuron.2016.10.060;
RA   Cartoni R., Norsworthy M.W., Bei F., Wang C., Li S., Zhang Y., Gabel C.V.,
RA   Schwarz T.L., He Z.;
RT   "The mammalian-specific protein Armcx1 regulates mitochondrial transport
RT   during axon regeneration.";
RL   Neuron 92:1294-1307(2016).
RN   [5]
RP   ERRATUM OF PUBMED:28009275.
RX   PubMed=28472662; DOI=10.1016/j.neuron.2017.04.028;
RA   Cartoni R., Norsworthy M.W., Bei F., Wang C., Li S., Zhang Y., Gabel C.V.,
RA   Schwarz T.L., He Z.;
RL   Neuron 94:689-689(2017).
CC   -!- FUNCTION: Regulates mitochondrial transport during axon regeneration.
CC       Increases the proportion of motile mitochondria by recruiting
CC       stationary mitochondria into the motile pool. Enhances mitochondria
CC       movement and neurite growth in both adult axons and embryonic neurons.
CC       Promotes neuronal survival and axon regeneration after nerve injury.
CC       May link mitochondria to the Trak1-kinesin motor complex via its
CC       interaction with Miro1. {ECO:0000269|PubMed:28009275}.
CC   -!- SUBUNIT: Interacts with MIRO1. {ECO:0000269|PubMed:28009275}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22569362,
CC       ECO:0000269|PubMed:28009275}. Mitochondrion outer membrane
CC       {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Widely expressed in the adult nervous tissue,
CC       especially in the forebrain, including the cerebral cortex, hippocampus
CC       and thalamus. {ECO:0000269|PubMed:22569362}.
CC   -!- INDUCTION: After axonal injury. {ECO:0000269|PubMed:28009275}.
CC   -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC       family. {ECO:0000305}.
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DR   EMBL; AK019405; BAB31705.1; -; mRNA.
DR   EMBL; AK147002; BAE27599.1; -; mRNA.
DR   EMBL; BC021410; AAH21410.1; -; mRNA.
DR   EMBL; BC026488; AAH26488.1; -; mRNA.
DR   EMBL; BC068228; AAH68228.1; -; mRNA.
DR   CCDS; CCDS30398.1; -.
DR   RefSeq; NP_001159849.1; NM_001166377.1.
DR   RefSeq; NP_001159850.1; NM_001166378.1.
DR   RefSeq; NP_001159851.1; NM_001166379.1.
DR   RefSeq; NP_001159852.1; NM_001166380.1.
DR   RefSeq; NP_084342.1; NM_030066.3.
DR   RefSeq; XP_006528687.1; XM_006528624.2.
DR   RefSeq; XP_006528688.1; XM_006528625.2.
DR   RefSeq; XP_006528689.1; XM_006528626.2.
DR   RefSeq; XP_006528690.1; XM_006528627.2.
DR   AlphaFoldDB; Q9CX83; -.
DR   SMR; Q9CX83; -.
DR   BioGRID; 219279; 1.
DR   STRING; 10090.ENSMUSP00000108824; -.
DR   iPTMnet; Q9CX83; -.
DR   PhosphoSitePlus; Q9CX83; -.
DR   MaxQB; Q9CX83; -.
DR   PaxDb; 10090-ENSMUSP00000108824; -.
DR   PeptideAtlas; Q9CX83; -.
DR   ProteomicsDB; 277304; -.
DR   Pumba; Q9CX83; -.
DR   Antibodypedia; 28759; 285 antibodies from 29 providers.
DR   DNASU; 78248; -.
DR   Ensembl; ENSMUST00000035748.14; ENSMUSP00000043965.8; ENSMUSG00000033460.15.
DR   Ensembl; ENSMUST00000051256.10; ENSMUSP00000053909.4; ENSMUSG00000033460.15.
DR   Ensembl; ENSMUST00000113197.2; ENSMUSP00000108822.2; ENSMUSG00000033460.15.
DR   Ensembl; ENSMUST00000113198.8; ENSMUSP00000108823.2; ENSMUSG00000033460.15.
DR   Ensembl; ENSMUST00000113199.8; ENSMUSP00000108824.2; ENSMUSG00000033460.15.
DR   Ensembl; ENSMUST00000113201.8; ENSMUSP00000108826.2; ENSMUSG00000033460.15.
DR   GeneID; 78248; -.
DR   KEGG; mmu:78248; -.
DR   UCSC; uc009ugj.2; mouse.
DR   AGR; MGI:1925498; -.
DR   CTD; 51309; -.
DR   MGI; MGI:1925498; Armcx1.
DR   VEuPathDB; HostDB:ENSMUSG00000033460; -.
DR   eggNOG; ENOG502QYZW; Eukaryota.
DR   GeneTree; ENSGT00940000162561; -.
DR   HOGENOM; CLU_037187_0_0_1; -.
DR   InParanoid; Q9CX83; -.
DR   OMA; DVKAEAH; -.
DR   OrthoDB; 2912889at2759; -.
DR   PhylomeDB; Q9CX83; -.
DR   TreeFam; TF335652; -.
DR   BioGRID-ORCS; 78248; 3 hits in 78 CRISPR screens.
DR   PRO; PR:Q9CX83; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q9CX83; Protein.
DR   Bgee; ENSMUSG00000033460; Expressed in superior cervical ganglion and 238 other cell types or tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   PANTHER; PTHR15712; ARMADILLO REPEAT CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15712:SF14; ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 1; 1.
DR   Pfam; PF04826; Arm_2; 1.
DR   SMART; SM00185; ARM; 2.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
DR   Genevisible; Q9CX83; MM.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..456
FT                   /note="Armadillo repeat-containing X-linked protein 1"
FT                   /id="PRO_0000191362"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   TRANSMEM        7..29
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..456
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   REPEAT          198..238
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          240..279
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          361..401
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          418..456
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REGION          1..6
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305|PubMed:22569362"
FT   REGION          26..36
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305|PubMed:22569362"
FT   REGION          37..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..51
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..180
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  50643 MW;  159EFAEF1B536406 CRC64;
     MGRTREAGCV AAGMVIGAGA CYCVYRLTWG KDENEKLWDE EEEEEEEEEE KSCSDKTEKE
     LKTNVGVGAR GKPQDDSKSK VEVNVGPENG PGVKKEVHPE SQSGGGLEAK AKALFKTLKE
     QARAKAGRGI RLPNISRNRT LTSSLPCPGG RGGGCHPGRT GSRARNRTSG KVKRKNRSKS
     NKAPATAWPV RKGKFSFPYK IDDILSAPDL QKVLNILERT NDPFTQEVAL VTLGNNAAYS
     FNQNAIRELG GVPIIAKLIK TRDPIIREKT YNALNNLSVN SENQGKIKTY ISQVCDDTMV
     CRLDSAVQMA GLRLLTNMTV TNHYQHLLSY SFPDFFALLF LGNHFTKIQT MKLIINFTEN
     PAMTRELVSC KVPSELISLF NKEWDREILL NILTLFENIN DNIKSEGLAS SRKEFSRSSL
     FFLFKESGVC VKKIKALASH KDLVVKVKVL KVLTKL
//