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Q9CX80

- CYGB_MOUSE

UniProt

Q9CX80 - CYGB_MOUSE

Protein

Cytoglobin

Gene

Cygb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
    Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW
    5. peroxidase activity Source: UniProtKB

    GO - Biological processi

    1. oxidation-reduction process Source: GOC
    2. response to oxidative stress Source: UniProtKB

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytoglobin
    Alternative name(s):
    Histoglobin
    Short name:
    HGb
    Gene namesi
    Name:Cygb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2149481. Cygb.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. neuronal cell body Source: MGI
    3. neuron projection Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190CytoglobinPRO_0000053385Add
    BLAST

    Proteomic databases

    MaxQBiQ9CX80.
    PaxDbiQ9CX80.
    PRIDEiQ9CX80.

    PTM databases

    PhosphoSiteiQ9CX80.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CX80.
    BgeeiQ9CX80.
    CleanExiMM_CYGB.
    GenevestigatoriQ9CX80.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9CX80. 1 interaction.
    MINTiMINT-4092722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX80.
    SMRiQ9CX80. Positions 21-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni17 – 167151GlobinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278586.
    GeneTreeiENSGT00730000110844.
    HOGENOMiHOG000112127.
    HOVERGENiHBG100250.
    InParanoidiQ9CX80.
    OMAiTHVTAAY.
    OrthoDBiEOG7KSX9V.
    PhylomeDBiQ9CX80.
    TreeFamiTF332967.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR01906. FISHGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CX80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKVPGDMEI ERRERSEELS EAERKAVQAT WARLYANCED VGVAILVRFF    50
    VNFPSAKQYF SQFRHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD 100
    KVSSVLALVG KAHALKHKVE PMYFKILSGV ILEVIAEEFA NDFPVETQKA 150
    WAKLRGLIYS HVTAAYKEVG WVQQVPNTTT PPATLPSSGP 190
    Length:190
    Mass (Da):21,466
    Last modified:June 1, 2001 - v1
    Checksum:i6B1A50403F790FF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315163 mRNA. Translation: CAC86187.1.
    AK019410 mRNA. Translation: BAB31709.1.
    BC055040 mRNA. Translation: AAH55040.1.
    CCDSiCCDS25673.1.
    RefSeqiNP_084482.1. NM_030206.4.
    UniGeneiMm.34598.

    Genome annotation databases

    EnsembliENSMUST00000021166; ENSMUSP00000021166; ENSMUSG00000020810.
    GeneIDi114886.
    KEGGimmu:114886.
    UCSCiuc007mlv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ315163 mRNA. Translation: CAC86187.1 .
    AK019410 mRNA. Translation: BAB31709.1 .
    BC055040 mRNA. Translation: AAH55040.1 .
    CCDSi CCDS25673.1.
    RefSeqi NP_084482.1. NM_030206.4.
    UniGenei Mm.34598.

    3D structure databases

    ProteinModelPortali Q9CX80.
    SMRi Q9CX80. Positions 21-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CX80. 1 interaction.
    MINTi MINT-4092722.

    PTM databases

    PhosphoSitei Q9CX80.

    Proteomic databases

    MaxQBi Q9CX80.
    PaxDbi Q9CX80.
    PRIDEi Q9CX80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021166 ; ENSMUSP00000021166 ; ENSMUSG00000020810 .
    GeneIDi 114886.
    KEGGi mmu:114886.
    UCSCi uc007mlv.1. mouse.

    Organism-specific databases

    CTDi 114757.
    MGIi MGI:2149481. Cygb.

    Phylogenomic databases

    eggNOGi NOG278586.
    GeneTreei ENSGT00730000110844.
    HOGENOMi HOG000112127.
    HOVERGENi HBG100250.
    InParanoidi Q9CX80.
    OMAi THVTAAY.
    OrthoDBi EOG7KSX9V.
    PhylomeDBi Q9CX80.
    TreeFami TF332967.

    Miscellaneous databases

    NextBioi 368903.
    PROi Q9CX80.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CX80.
    Bgeei Q9CX80.
    CleanExi MM_CYGB.
    Genevestigatori Q9CX80.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR01906. FISHGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
      Burmester T., Ebner B., Weich B., Hankeln T.
      Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiCYGB_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3