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Q9CX80

- CYGB_MOUSE

UniProt

Q9CX80 - CYGB_MOUSE

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Protein

Cytoglobin

Gene

Cygb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
  5. peroxidase activity Source: UniProtKB

GO - Biological processi

  1. oxidation-reduction process Source: GOC
  2. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Gene namesi
Name:Cygb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2149481. Cygb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. neuronal cell body Source: MGI
  3. neuron projection Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190CytoglobinPRO_0000053385Add
BLAST

Proteomic databases

MaxQBiQ9CX80.
PaxDbiQ9CX80.
PRIDEiQ9CX80.

PTM databases

PhosphoSiteiQ9CX80.

Expressioni

Gene expression databases

BgeeiQ9CX80.
CleanExiMM_CYGB.
ExpressionAtlasiQ9CX80. baseline and differential.
GenevestigatoriQ9CX80.

Interactioni

Protein-protein interaction databases

IntActiQ9CX80. 1 interaction.
MINTiMINT-4092722.

Structurei

3D structure databases

ProteinModelPortaliQ9CX80.
SMRiQ9CX80. Positions 21-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 167151GlobinAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278586.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ9CX80.
OMAiTHVTAAY.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ9CX80.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CX80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKVPGDMEI ERRERSEELS EAERKAVQAT WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFRHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PMYFKILSGV ILEVIAEEFA NDFPVETQKA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNTTT PPATLPSSGP
Length:190
Mass (Da):21,466
Last modified:June 1, 2001 - v1
Checksum:i6B1A50403F790FF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315163 mRNA. Translation: CAC86187.1.
AK019410 mRNA. Translation: BAB31709.1.
BC055040 mRNA. Translation: AAH55040.1.
CCDSiCCDS25673.1.
RefSeqiNP_084482.1. NM_030206.4.
UniGeneiMm.34598.

Genome annotation databases

EnsembliENSMUST00000021166; ENSMUSP00000021166; ENSMUSG00000020810.
GeneIDi114886.
KEGGimmu:114886.
UCSCiuc007mlv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ315163 mRNA. Translation: CAC86187.1 .
AK019410 mRNA. Translation: BAB31709.1 .
BC055040 mRNA. Translation: AAH55040.1 .
CCDSi CCDS25673.1.
RefSeqi NP_084482.1. NM_030206.4.
UniGenei Mm.34598.

3D structure databases

ProteinModelPortali Q9CX80.
SMRi Q9CX80. Positions 21-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CX80. 1 interaction.
MINTi MINT-4092722.

PTM databases

PhosphoSitei Q9CX80.

Proteomic databases

MaxQBi Q9CX80.
PaxDbi Q9CX80.
PRIDEi Q9CX80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021166 ; ENSMUSP00000021166 ; ENSMUSG00000020810 .
GeneIDi 114886.
KEGGi mmu:114886.
UCSCi uc007mlv.1. mouse.

Organism-specific databases

CTDi 114757.
MGIi MGI:2149481. Cygb.

Phylogenomic databases

eggNOGi NOG278586.
GeneTreei ENSGT00730000110844.
HOGENOMi HOG000112127.
HOVERGENi HBG100250.
InParanoidi Q9CX80.
OMAi THVTAAY.
OrthoDBi EOG7KSX9V.
PhylomeDBi Q9CX80.
TreeFami TF332967.

Miscellaneous databases

NextBioi 368903.
PROi Q9CX80.
SOURCEi Search...

Gene expression databases

Bgeei Q9CX80.
CleanExi MM_CYGB.
ExpressionAtlasi Q9CX80. baseline and differential.
Genevestigatori Q9CX80.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR01906. FISHGLOBIN.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues."
    Burmester T., Ebner B., Weich B., Hankeln T.
    Mol. Biol. Evol. 19:416-421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiCYGB_MOUSE
AccessioniPrimary (citable) accession number: Q9CX80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3