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Protein

Cytoglobin

Gene

Cygb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi113Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-203615 eNOS activation
R-MMU-8981607 Intracellular oxygen transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Gene namesi
Name:Cygb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2149481 Cygb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000533851 – 190CytoglobinAdd BLAST190

Proteomic databases

MaxQBiQ9CX80
PaxDbiQ9CX80
PRIDEiQ9CX80

PTM databases

iPTMnetiQ9CX80
PhosphoSitePlusiQ9CX80

Expressioni

Gene expression databases

BgeeiENSMUSG00000020810
CleanExiMM_CYGB
ExpressionAtlasiQ9CX80 baseline and differential
GenevisibleiQ9CX80 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CX80, 1 interactor
MINTiQ9CX80
STRINGi10090.ENSMUSP00000021166

Structurei

3D structure databases

ProteinModelPortaliQ9CX80
SMRiQ9CX80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 167GlobinAdd BLAST151

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000112127
HOVERGENiHBG100250
InParanoidiQ9CX80
KOiK21894
OMAiTHVTAAY
OrthoDBiEOG091G0OAO
PhylomeDBiQ9CX80
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR013314 Globin_lamprey/hagfish
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR01906 FISHGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CX80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVPGDMEI ERRERSEELS EAERKAVQAT WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFRHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PMYFKILSGV ILEVIAEEFA NDFPVETQKA
160 170 180 190
WAKLRGLIYS HVTAAYKEVG WVQQVPNTTT PPATLPSSGP
Length:190
Mass (Da):21,466
Last modified:June 1, 2001 - v1
Checksum:i6B1A50403F790FF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315163 mRNA Translation: CAC86187.1
AK019410 mRNA Translation: BAB31709.1
BC055040 mRNA Translation: AAH55040.1
CCDSiCCDS25673.1
RefSeqiNP_084482.1, NM_030206.4
UniGeneiMm.34598

Genome annotation databases

EnsembliENSMUST00000021166; ENSMUSP00000021166; ENSMUSG00000020810
GeneIDi114886
KEGGimmu:114886
UCSCiuc007mlv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCYGB_MOUSE
AccessioniPrimary (citable) accession number: Q9CX80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health