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Protein

Protein LBH

Gene

Lbh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of key transcription factors involved in cardiogenesis.2 Publications

Miscellaneous

Mice overexpressing Lbh in heart exhibit severe cardiac abnormalities and dysfunction.

GO - Biological processi

  • mammary gland development Source: CAFA
  • mammary gland epithelial cell differentiation Source: CAFA
  • negative regulation of intracellular estrogen receptor signaling pathway Source: CAFA
  • negative regulation of stem cell differentiation Source: CAFA
  • positive regulation of mammary stem cell proliferation Source: CAFA
  • positive regulation of somatic stem cell division Source: CAFA
  • positive regulation of somatic stem cell population maintenance Source: CAFA
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of blood coagulation Source: MGI
  • regulation of gene expression Source: CAFA
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LBH
Alternative name(s):
Limb bud and heart-expressed protein
Gene namesi
Name:Lbh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1925139. Lbh.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: CACAO

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003248031 – 105Protein LBHAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CX60.
MaxQBiQ9CX60.
PaxDbiQ9CX60.
PeptideAtlasiQ9CX60.
PRIDEiQ9CX60.

PTM databases

iPTMnetiQ9CX60.
PhosphoSitePlusiQ9CX60.

Expressioni

Tissue specificityi

Expressed at highest levels in heart, and at lower levels in brain, spleen, lung, liver and kidney.1 Publication

Developmental stagei

First detected at E7.5 in the mesendoderm that forms the anterior gut and the heart. At midgestation, expressed in the limb bud ectoderm and other specialized epithelia, as well as in the branchial arches and some neural crest derivatives. In the heart, expression initiates in the myocardial plate at the presomitic stage, with highest levels in the anterior myocardium. During heart chamber formation, expressed transiently in the right ventricle, atrioventricular canal and inflow tract. In the limb bud, expression is restricted to the ventral ectodermal compartment and the apical ectodermal ridge.1 Publication

Gene expression databases

BgeeiENSMUSG00000024063.
CleanExiMM_LBH.
ExpressionAtlasiQ9CX60. baseline and differential.
GenevisibleiQ9CX60. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024857.

Structurei

3D structure databases

DisProtiDP00661.
SMRiQ9CX60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LBH family.Curated

Phylogenomic databases

eggNOGiENOG410IYIC. Eukaryota.
ENOG4111VQ7. LUCA.
GeneTreeiENSGT00390000009189.
HOGENOMiHOG000074061.
HOVERGENiHBG105431.
InParanoidiQ9CX60.
OMAiFDRYCKL.
OrthoDBiEOG091G12RS.
PhylomeDBiQ9CX60.
TreeFamiTF332770.

Family and domain databases

InterProiView protein in InterPro
IPR013294. LBH.
PIRSFiPIRSF008130. LBH. 1 hit.
PRINTSiPR01881. LBHPROTEIN.

Sequencei

Sequence statusi: Complete.

Q9CX60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYFPIHCS DYLRSAEMTE VMMNAPSMEE IGLSPRKDGL SYQIFPDPSD
60 70 80 90 100
FDRCCKLKDR LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETTN

EKKDQ
Length:105
Mass (Da):12,138
Last modified:June 1, 2001 - v1
Checksum:i0F794B2BAF966EEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti98T → A in AAK38204 (PubMed:11336496).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317517 mRNA. Translation: AAK38204.1.
AK020110 mRNA. Translation: BAB31998.1.
BC026827 mRNA. Translation: AAH26827.1.
BC052470 mRNA. Translation: AAH52470.1.
CCDSiCCDS28964.1.
RefSeqiNP_084275.3. NM_029999.4.
UniGeneiMm.154109.

Genome annotation databases

EnsembliENSMUST00000024857; ENSMUSP00000024857; ENSMUSG00000024063.
GeneIDi77889.
KEGGimmu:77889.
UCSCiuc008dng.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLBH_MOUSE
AccessioniPrimary (citable) accession number: Q9CX60
Secondary accession number(s): Q99MQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families