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Protein

Protein LBH

Gene

Lbh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of key transcription factors involved in cardiogenesis.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LBH
Alternative name(s):
Limb bud and heart-expressed protein
Gene namesi
Name:Lbh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1925139. Lbh.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: CACAO
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Protein LBHPRO_0000324803Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CX60.
MaxQBiQ9CX60.
PaxDbiQ9CX60.
PRIDEiQ9CX60.

PTM databases

iPTMnetiQ9CX60.
PhosphoSiteiQ9CX60.

Expressioni

Tissue specificityi

Expressed at highest levels in heart, and at lower levels in brain, spleen, lung, liver and kidney.1 Publication

Developmental stagei

First detected at E7.5 in the mesendoderm that forms the anterior gut and the heart. At midgestation, expressed in the limb bud ectoderm and other specialized epithelia, as well as in the branchial arches and some neural crest derivatives. In the heart, expression initiates in the myocardial plate at the presomitic stage, with highest levels in the anterior myocardium. During heart chamber formation, expressed transiently in the right ventricle, atrioventricular canal and inflow tract. In the limb bud, expression is restricted to the ventral ectodermal compartment and the apical ectodermal ridge.1 Publication

Gene expression databases

BgeeiQ9CX60.
CleanExiMM_LBH.
ExpressionAtlasiQ9CX60. baseline and differential.
GenevisibleiQ9CX60. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024857.

Structurei

3D structure databases

DisProtiDP00661.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LBH family.Curated

Phylogenomic databases

eggNOGiENOG410IYIC. Eukaryota.
ENOG4111VQ7. LUCA.
GeneTreeiENSGT00390000009189.
HOGENOMiHOG000074061.
HOVERGENiHBG105431.
InParanoidiQ9CX60.
OMAiFDRYCKL.
OrthoDBiEOG7TQV35.
PhylomeDBiQ9CX60.
TreeFamiTF332770.

Family and domain databases

InterProiIPR013294. LBH.
[Graphical view]
PIRSFiPIRSF008130. LBH. 1 hit.
PRINTSiPR01881. LBHPROTEIN.

Sequencei

Sequence statusi: Complete.

Q9CX60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVYFPIHCS DYLRSAEMTE VMMNAPSMEE IGLSPRKDGL SYQIFPDPSD
60 70 80 90 100
FDRCCKLKDR LPSIVVEPTE GEVESGELRW PPEEFLVQED EQDNCEETTN

EKKDQ
Length:105
Mass (Da):12,138
Last modified:June 1, 2001 - v1
Checksum:i0F794B2BAF966EEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981T → A in AAK38204 (PubMed:11336496).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317517 mRNA. Translation: AAK38204.1.
AK020110 mRNA. Translation: BAB31998.1.
BC026827 mRNA. Translation: AAH26827.1.
BC052470 mRNA. Translation: AAH52470.1.
CCDSiCCDS28964.1.
RefSeqiNP_084275.3. NM_029999.4.
UniGeneiMm.154109.

Genome annotation databases

EnsembliENSMUST00000024857; ENSMUSP00000024857; ENSMUSG00000024063.
GeneIDi77889.
KEGGimmu:77889.
UCSCiuc008dng.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317517 mRNA. Translation: AAK38204.1.
AK020110 mRNA. Translation: BAB31998.1.
BC026827 mRNA. Translation: AAH26827.1.
BC052470 mRNA. Translation: AAH52470.1.
CCDSiCCDS28964.1.
RefSeqiNP_084275.3. NM_029999.4.
UniGeneiMm.154109.

3D structure databases

DisProtiDP00661.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024857.

PTM databases

iPTMnetiQ9CX60.
PhosphoSiteiQ9CX60.

Proteomic databases

EPDiQ9CX60.
MaxQBiQ9CX60.
PaxDbiQ9CX60.
PRIDEiQ9CX60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024857; ENSMUSP00000024857; ENSMUSG00000024063.
GeneIDi77889.
KEGGimmu:77889.
UCSCiuc008dng.2. mouse.

Organism-specific databases

CTDi81606.
MGIiMGI:1925139. Lbh.

Phylogenomic databases

eggNOGiENOG410IYIC. Eukaryota.
ENOG4111VQ7. LUCA.
GeneTreeiENSGT00390000009189.
HOGENOMiHOG000074061.
HOVERGENiHBG105431.
InParanoidiQ9CX60.
OMAiFDRYCKL.
OrthoDBiEOG7TQV35.
PhylomeDBiQ9CX60.
TreeFamiTF332770.

Miscellaneous databases

PROiQ9CX60.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CX60.
CleanExiMM_LBH.
ExpressionAtlasiQ9CX60. baseline and differential.
GenevisibleiQ9CX60. MM.

Family and domain databases

InterProiIPR013294. LBH.
[Graphical view]
PIRSFiPIRSF008130. LBH. 1 hit.
PRINTSiPR01881. LBHPROTEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development."
    Briegel K.J., Joyner A.L.
    Dev. Biol. 233:291-304(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Swiss Webster / NIH.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
    Tissue: Brain and Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. "Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh."
    Briegel K.J., Baldwin H.S., Epstein J.A., Joyner A.L.
    Development 132:3305-3316(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiLBH_MOUSE
AccessioniPrimary (citable) accession number: Q9CX60
Secondary accession number(s): Q99MQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mice overexpressing Lbh in heart exhibit severe cardiac abnormalities and dysfunction.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.