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Q9CX47

- XRCC2_MOUSE

UniProt

Q9CX47 - XRCC2_MOUSE

Protein

DNA repair protein XRCC2

Gene

Xrcc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB-KW
    3. DNA-dependent ATPase activity Source: InterPro

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: MGI
    2. centrosome organization Source: UniProtKB
    3. double-strand break repair via homologous recombination Source: MGI
    4. in utero embryonic development Source: MGI
    5. mitotic cell cycle Source: UniProtKB
    6. negative regulation of neuron apoptotic process Source: MGI
    7. positive regulation of neurogenesis Source: MGI
    8. response to gamma radiation Source: MGI
    9. response to X-ray Source: MGI
    10. strand invasion Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA repair protein XRCC2
    Alternative name(s):
    X-ray repair cross-complementing protein 2
    Gene namesi
    Name:Xrcc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1927345. Xrcc2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. Rad51B-Rad51C-Rad51D-XRCC2 complex Source: UniProtKB
    3. replication fork Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278DNA repair protein XRCC2PRO_0000122949Add
    BLAST

    Proteomic databases

    PRIDEiQ9CX47.

    Expressioni

    Tissue specificityi

    Expressed at low level in somatic tissues and at high level in testis.

    Gene expression databases

    ArrayExpressiQ9CX47.
    BgeeiQ9CX47.
    GenevestigatoriQ9CX47.

    Interactioni

    Subunit structurei

    Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000030773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX47.
    SMRiQ9CX47. Positions 43-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RecA family. RAD51 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0468.
    GeneTreeiENSGT00390000020445.
    HOGENOMiHOG000004802.
    HOVERGENiHBG079347.
    InParanoidiQ9CX47.
    KOiK10879.
    OMAiDTDYHFD.
    OrthoDBiEOG7K9K4C.
    PhylomeDBiQ9CX47.
    TreeFamiTF101202.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR013632. DNA_recomb/repair_Rad51_C.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    [Graphical view]
    PfamiPF08423. Rad51. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50162. RECA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CX47-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCSDFRRAES GTELLARLEG RSSLKELEPN LFADEDSPVH GDIFEFHGPE    50
    GTGKTEMLYH LTARCILPKS EGGLQIEVLF IDTDYHFDML RLVTVLEHRL 100
    SQSSEEAMKL CLARLFLAYC SSSMQLLLTL HSLEALLCSR PSLCLLIVDS 150
    LSSFYWIDRV SGGESVALQE STLQKCSQLL ERLVTEYRLL LFATTQSLMQ 200
    KGSDSADGPS SSKHPCDGDM GYRAYLCKAW QRVVKHRVIF SRDDEAKSSR 250
    FSLVSRHLKS NSLKKHSFMV RESGVEFC 278
    Length:278
    Mass (Da):31,391
    Last modified:June 1, 2001 - v1
    Checksum:i8E65467596E604FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17040 mRNA. Translation: CAA76599.1.
    AK020192 mRNA. Translation: BAB32023.1.
    AK014963 mRNA. No translation available.
    BC033417 mRNA. Translation: AAH33417.1.
    CCDSiCCDS19135.1.
    RefSeqiNP_065595.2. NM_020570.2.
    UniGeneiMm.143767.

    Genome annotation databases

    EnsembliENSMUST00000030773; ENSMUSP00000030773; ENSMUSG00000028933.
    GeneIDi57434.
    KEGGimmu:57434.
    UCSCiuc008wta.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17040 mRNA. Translation: CAA76599.1 .
    AK020192 mRNA. Translation: BAB32023.1 .
    AK014963 mRNA. No translation available.
    BC033417 mRNA. Translation: AAH33417.1 .
    CCDSi CCDS19135.1.
    RefSeqi NP_065595.2. NM_020570.2.
    UniGenei Mm.143767.

    3D structure databases

    ProteinModelPortali Q9CX47.
    SMRi Q9CX47. Positions 43-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000030773.

    Proteomic databases

    PRIDEi Q9CX47.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030773 ; ENSMUSP00000030773 ; ENSMUSG00000028933 .
    GeneIDi 57434.
    KEGGi mmu:57434.
    UCSCi uc008wta.1. mouse.

    Organism-specific databases

    CTDi 7516.
    MGIi MGI:1927345. Xrcc2.

    Phylogenomic databases

    eggNOGi COG0468.
    GeneTreei ENSGT00390000020445.
    HOGENOMi HOG000004802.
    HOVERGENi HBG079347.
    InParanoidi Q9CX47.
    KOi K10879.
    OMAi DTDYHFD.
    OrthoDBi EOG7K9K4C.
    PhylomeDBi Q9CX47.
    TreeFami TF101202.

    Miscellaneous databases

    NextBioi 313806.
    PROi Q9CX47.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CX47.
    Bgeei Q9CX47.
    Genevestigatori Q9CX47.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR013632. DNA_recomb/repair_Rad51_C.
    IPR027417. P-loop_NTPase.
    IPR020588. RecA_ATP-bd.
    [Graphical view ]
    Pfami PF08423. Rad51. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50162. RECA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family."
      Cartwright R., Tambini C.E., Simpson P.J., Thacker J.
      Nucleic Acids Res. 26:3084-3089(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: L929.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.

    Entry informationi

    Entry nameiXRCC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX47
    Secondary accession number(s): O88730, Q9D5T1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3