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Protein

DNA repair protein XRCC2

Gene

Xrcc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA-dependent ATPase activity Source: InterPro
  3. four-way junction DNA binding Source: Ensembl

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: MGI
  2. centrosome organization Source: UniProtKB
  3. DNA repair Source: MGI
  4. double-strand break repair via homologous recombination Source: MGI
  5. in utero embryonic development Source: MGI
  6. mitotic cell cycle Source: UniProtKB
  7. multicellular organism growth Source: MGI
  8. negative regulation of neuron apoptotic process Source: MGI
  9. neurogenesis Source: MGI
  10. positive regulation of neurogenesis Source: MGI
  11. regulation of fibroblast apoptotic process Source: MGI
  12. response to gamma radiation Source: MGI
  13. response to X-ray Source: MGI
  14. somitogenesis Source: MGI
  15. strand invasion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein XRCC2
Alternative name(s):
X-ray repair cross-complementing protein 2
Gene namesi
Name:Xrcc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:1927345. Xrcc2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. Rad51B-Rad51C-Rad51D-XRCC2 complex Source: UniProtKB
  3. replication fork Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278DNA repair protein XRCC2PRO_0000122949Add
BLAST

Proteomic databases

PRIDEiQ9CX47.

Expressioni

Tissue specificityi

Expressed at low level in somatic tissues and at high level in testis.

Gene expression databases

BgeeiQ9CX47.
ExpressionAtlasiQ9CX47. baseline and differential.
GenevestigatoriQ9CX47.

Interactioni

Subunit structurei

Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030773.

Structurei

3D structure databases

ProteinModelPortaliQ9CX47.
SMRiQ9CX47. Positions 43-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0468.
GeneTreeiENSGT00390000020445.
HOGENOMiHOG000004802.
HOVERGENiHBG079347.
InParanoidiQ9CX47.
KOiK10879.
OMAiDTDYHFD.
OrthoDBiEOG7K9K4C.
PhylomeDBiQ9CX47.
TreeFamiTF101202.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CX47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSDFRRAES GTELLARLEG RSSLKELEPN LFADEDSPVH GDIFEFHGPE
60 70 80 90 100
GTGKTEMLYH LTARCILPKS EGGLQIEVLF IDTDYHFDML RLVTVLEHRL
110 120 130 140 150
SQSSEEAMKL CLARLFLAYC SSSMQLLLTL HSLEALLCSR PSLCLLIVDS
160 170 180 190 200
LSSFYWIDRV SGGESVALQE STLQKCSQLL ERLVTEYRLL LFATTQSLMQ
210 220 230 240 250
KGSDSADGPS SSKHPCDGDM GYRAYLCKAW QRVVKHRVIF SRDDEAKSSR
260 270
FSLVSRHLKS NSLKKHSFMV RESGVEFC
Length:278
Mass (Da):31,391
Last modified:June 1, 2001 - v1
Checksum:i8E65467596E604FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17040 mRNA. Translation: CAA76599.1.
AK020192 mRNA. Translation: BAB32023.1.
AK014963 mRNA. No translation available.
BC033417 mRNA. Translation: AAH33417.1.
CCDSiCCDS19135.1.
RefSeqiNP_065595.2. NM_020570.2.
UniGeneiMm.143767.

Genome annotation databases

EnsembliENSMUST00000030773; ENSMUSP00000030773; ENSMUSG00000028933.
GeneIDi57434.
KEGGimmu:57434.
UCSCiuc008wta.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17040 mRNA. Translation: CAA76599.1.
AK020192 mRNA. Translation: BAB32023.1.
AK014963 mRNA. No translation available.
BC033417 mRNA. Translation: AAH33417.1.
CCDSiCCDS19135.1.
RefSeqiNP_065595.2. NM_020570.2.
UniGeneiMm.143767.

3D structure databases

ProteinModelPortaliQ9CX47.
SMRiQ9CX47. Positions 43-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030773.

Proteomic databases

PRIDEiQ9CX47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030773; ENSMUSP00000030773; ENSMUSG00000028933.
GeneIDi57434.
KEGGimmu:57434.
UCSCiuc008wta.1. mouse.

Organism-specific databases

CTDi7516.
MGIiMGI:1927345. Xrcc2.

Phylogenomic databases

eggNOGiCOG0468.
GeneTreeiENSGT00390000020445.
HOGENOMiHOG000004802.
HOVERGENiHBG079347.
InParanoidiQ9CX47.
KOiK10879.
OMAiDTDYHFD.
OrthoDBiEOG7K9K4C.
PhylomeDBiQ9CX47.
TreeFamiTF101202.

Miscellaneous databases

NextBioi313806.
PROiQ9CX47.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CX47.
ExpressionAtlasiQ9CX47. baseline and differential.
GenevestigatoriQ9CX47.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013632. DNA_recomb/repair_Rad51_C.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamiPF08423. Rad51. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family."
    Cartwright R., Tambini C.E., Simpson P.J., Thacker J.
    Nucleic Acids Res. 26:3084-3089(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: L929.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.

Entry informationi

Entry nameiXRCC2_MOUSE
AccessioniPrimary (citable) accession number: Q9CX47
Secondary accession number(s): O88730, Q9D5T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.