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Q9CX47 (XRCC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA repair protein XRCC2
Alternative name(s):
X-ray repair cross-complementing protein 2
Gene names
Name:Xrcc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA By similarity.

Subunit structure

Interacts with RAD51D. Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed at low level in somatic tissues and at high level in testis.

Sequence similarities

Belongs to the RecA family. RAD51 subfamily.

Ontologies

Keywords
   Biological processDNA damage
DNA recombination
DNA repair
   Cellular componentNucleus
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to DNA damage stimulus

Inferred from mutant phenotype PubMed 15979950PubMed 16777961. Source: MGI

centrosome organization

Inferred from sequence or structural similarity. Source: UniProtKB

double-strand break repair via homologous recombination

Inferred from mutant phenotype PubMed 16777961. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 16777961. Source: MGI

mitotic cell cycle

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of neuron apoptotic process

Inferred from genetic interaction PubMed 16777961. Source: MGI

positive regulation of neurogenesis

Inferred from mutant phenotype PubMed 16777961. Source: MGI

response to X-ray

Inferred from mutant phenotype PubMed 15979950. Source: MGI

response to gamma radiation

Inferred from mutant phenotype PubMed 16777961. Source: MGI

strand invasion

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentRad51B-Rad51C-Rad51D-XRCC2 complex

Inferred from sequence or structural similarity. Source: UniProtKB

centrosome

Inferred from sequence or structural similarity. Source: UniProtKB

replication fork

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA-dependent ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278DNA repair protein XRCC2
PRO_0000122949

Sequences

Sequence LengthMass (Da)Tools
Q9CX47 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 8E65467596E604FD

FASTA27831,391
        10         20         30         40         50         60 
MCSDFRRAES GTELLARLEG RSSLKELEPN LFADEDSPVH GDIFEFHGPE GTGKTEMLYH 

        70         80         90        100        110        120 
LTARCILPKS EGGLQIEVLF IDTDYHFDML RLVTVLEHRL SQSSEEAMKL CLARLFLAYC 

       130        140        150        160        170        180 
SSSMQLLLTL HSLEALLCSR PSLCLLIVDS LSSFYWIDRV SGGESVALQE STLQKCSQLL 

       190        200        210        220        230        240 
ERLVTEYRLL LFATTQSLMQ KGSDSADGPS SSKHPCDGDM GYRAYLCKAW QRVVKHRVIF 

       250        260        270 
SRDDEAKSSR FSLVSRHLKS NSLKKHSFMV RESGVEFC 

« Hide

References

« Hide 'large scale' references
[1]"The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family."
Cartwright R., Tambini C.E., Simpson P.J., Thacker J.
Nucleic Acids Res. 26:3084-3089(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: L929.
Tissue: Testis.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17040 mRNA. Translation: CAA76599.1.
AK020192 mRNA. Translation: BAB32023.1.
AK014963 mRNA. No translation available.
BC033417 mRNA. Translation: AAH33417.1.
RefSeqNP_065595.2. NM_020570.2.
UniGeneMm.143767.

3D structure databases

ProteinModelPortalQ9CX47.
SMRQ9CX47. Positions 22-276.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000030773.

Proteomic databases

PRIDEQ9CX47.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000030773; ENSMUSP00000030773; ENSMUSG00000028933.
GeneID57434.
KEGGmmu:57434.
UCSCuc008wta.1. mouse.

Organism-specific databases

CTD7516.
MGIMGI:1927345. Xrcc2.

Phylogenomic databases

eggNOGCOG0468.
GeneTreeENSGT00390000020445.
HOGENOMHOG000004802.
HOVERGENHBG079347.
InParanoidQ9CX47.
KOK10879.
OMADTDYHFD.
OrthoDBEOG7K9K4C.
PhylomeDBQ9CX47.
TreeFamTF101202.

Gene expression databases

ArrayExpressQ9CX47.
BgeeQ9CX47.
GenevestigatorQ9CX47.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR013632. DNA_recomb/repair_Rad51_C.
IPR027417. P-loop_NTPase.
IPR020588. RecA_ATP-bd.
[Graphical view]
PfamPF08423. Rad51. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50162. RECA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313806.
PROQ9CX47.
SOURCESearch...

Entry information

Entry nameXRCC2_MOUSE
AccessionPrimary (citable) accession number: Q9CX47
Secondary accession number(s): O88730, Q9D5T1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot