Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CX00

- IST1_MOUSE

UniProt

Q9CX00 - IST1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

IST1 homolog

Gene

Ist1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (By similarity).By similarity

GO - Biological processi

  1. abscission Source: Ensembl
  2. cytokinesis Source: Ensembl
  3. establishment of protein localization Source: Ensembl
  4. positive regulation of collateral sprouting Source: MGI
  5. positive regulation of proteolysis Source: Ensembl
  6. viral capsid secondary envelopment Source: Ensembl
  7. viral release from host cell Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
IST1 homolog
Gene namesi
Name:Ist1
Synonyms:Kiaa0174
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1919205. Ist1.

Subcellular locationi

Cytoplasmic vesicle By similarity
Note: Localizes to the midbody of dividing cells.By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. cytosol Source: Ensembl
  4. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  5. extracellular vesicular exosome Source: Ensembl
  6. Flemming body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362IST1 homologPRO_0000050728Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CX00.
PaxDbiQ9CX00.
PRIDEiQ9CX00.

PTM databases

PhosphoSiteiQ9CX00.

Expressioni

Gene expression databases

BgeeiQ9CX00.
CleanExiMM_2400003C14RIK.
GenevestigatoriQ9CX00.

Interactioni

Subunit structurei

Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CX00. 2 interactions.
MINTiMINT-4125720.

Structurei

3D structure databases

ProteinModelPortaliQ9CX00.
SMRiQ9CX00. Positions 2-187.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IST1 family.Curated

Phylogenomic databases

eggNOGiNOG273475.
GeneTreeiENSGT00390000007453.
HOGENOMiHOG000205346.
InParanoidiQ9CX00.
OMAiPTYESID.
OrthoDBiEOG7K3TNC.
PhylomeDBiQ9CX00.
TreeFamiTF314258.

Family and domain databases

InterProiIPR005061. DUF292_euk.
[Graphical view]
PfamiPF03398. Ist1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CX00-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE
60 70 80 90 100
RARIRVEHII REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV
110 120 130 140 150
STLIWAAPRL QSEVAELKIV ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH
160 170 180 190 200
KLSVEAPPKI LVERYLIEIA KNYNVPYEPD SVVMAEAPVG VETDLIDVGF
210 220 230 240 250
TDDVKKGGPG RGGGGGFTAP VGGPDGIVPM PMPMPMPSPN APFAYPLPKG
260 270 280 290 300
PSDFSGLPVG TYQAFPNIHP PQIPATPPSY ESVDDINGDK TVSSAQIVGP
310 320 330 340 350
KPEAPAKPPS RPVDNYNTFV LPELPSVPDT LPTASAGAST SASEDIDFDD
360
LSRRFEELKK KT
Length:362
Mass (Da):39,468
Last modified:June 1, 2001 - v1
Checksum:iF3FB378DDBCD8BE7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti252 – 2565SDFSG → VSMCV in BAC65497. (PubMed:12693553)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010262 mRNA. Translation: BAB26804.1.
AK088192 mRNA. Translation: BAC40200.1.
AK152830 mRNA. Translation: BAE31530.1.
BC017605 mRNA. Translation: AAH17605.1.
AK122215 mRNA. Translation: BAC65497.1.
CCDSiCCDS22655.1.
RefSeqiNP_082294.1. NM_028018.2.
UniGeneiMm.290036.

Genome annotation databases

EnsembliENSMUST00000034164; ENSMUSP00000034164; ENSMUSG00000031729.
GeneIDi71955.
KEGGimmu:71955.
UCSCiuc009niy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010262 mRNA. Translation: BAB26804.1 .
AK088192 mRNA. Translation: BAC40200.1 .
AK152830 mRNA. Translation: BAE31530.1 .
BC017605 mRNA. Translation: AAH17605.1 .
AK122215 mRNA. Translation: BAC65497.1 .
CCDSi CCDS22655.1.
RefSeqi NP_082294.1. NM_028018.2.
UniGenei Mm.290036.

3D structure databases

ProteinModelPortali Q9CX00.
SMRi Q9CX00. Positions 2-187.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9CX00. 2 interactions.
MINTi MINT-4125720.

PTM databases

PhosphoSitei Q9CX00.

Proteomic databases

MaxQBi Q9CX00.
PaxDbi Q9CX00.
PRIDEi Q9CX00.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034164 ; ENSMUSP00000034164 ; ENSMUSG00000031729 .
GeneIDi 71955.
KEGGi mmu:71955.
UCSCi uc009niy.2. mouse.

Organism-specific databases

CTDi 9798.
MGIi MGI:1919205. Ist1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG273475.
GeneTreei ENSGT00390000007453.
HOGENOMi HOG000205346.
InParanoidi Q9CX00.
OMAi PTYESID.
OrthoDBi EOG7K3TNC.
PhylomeDBi Q9CX00.
TreeFami TF314258.

Miscellaneous databases

NextBioi 335044.
PROi Q9CX00.
SOURCEi Search...

Gene expression databases

Bgeei Q9CX00.
CleanExi MM_2400003C14RIK.
Genevestigatori Q9CX00.

Family and domain databases

InterProi IPR005061. DUF292_euk.
[Graphical view ]
Pfami PF03398. Ist1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-256.
    Tissue: Brain.

Entry informationi

Entry nameiIST1_MOUSE
AccessioniPrimary (citable) accession number: Q9CX00
Secondary accession number(s): Q80U68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3