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Q9CX00 (IST1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
IST1 homolog
Gene names
Name:Ist1
Synonyms:Kiaa0174
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells By similarity.

Subunit structure

Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 By similarity.

Subcellular location

Cytoplasmic vesicle By similarity. Note: Localizes to the midbody of dividing cells By similarity.

Sequence similarities

Belongs to the IST1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362IST1 homolog
PRO_0000050728

Amino acid modifications

Modified residue431Phosphotyrosine By similarity

Experimental info

Sequence conflict252 – 2565SDFSG → VSMCV in BAC65497. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9CX00 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: F3FB378DDBCD8BE7

FASTA36239,468
        10         20         30         40         50         60 
MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE RARIRVEHII 

        70         80         90        100        110        120 
REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV STLIWAAPRL QSEVAELKIV 

       130        140        150        160        170        180 
ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH KLSVEAPPKI LVERYLIEIA KNYNVPYEPD 

       190        200        210        220        230        240 
SVVMAEAPVG VETDLIDVGF TDDVKKGGPG RGGGGGFTAP VGGPDGIVPM PMPMPMPSPN 

       250        260        270        280        290        300 
APFAYPLPKG PSDFSGLPVG TYQAFPNIHP PQIPATPPSY ESVDDINGDK TVSSAQIVGP 

       310        320        330        340        350        360 
KPEAPAKPPS RPVDNYNTFV LPELPSVPDT LPTASAGAST SASEDIDFDD LSRRFEELKK 


KT 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Bone marrow and Thymus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-256.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK010262 mRNA. Translation: BAB26804.1.
AK088192 mRNA. Translation: BAC40200.1.
AK152830 mRNA. Translation: BAE31530.1.
BC017605 mRNA. Translation: AAH17605.1.
AK122215 mRNA. Translation: BAC65497.1.
RefSeqNP_082294.1. NM_028018.2.
UniGeneMm.290036.

3D structure databases

ProteinModelPortalQ9CX00.
SMRQ9CX00. Positions 2-187.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9CX00. 2 interactions.
MINTMINT-4125720.

PTM databases

PhosphoSiteQ9CX00.

Proteomic databases

PaxDbQ9CX00.
PRIDEQ9CX00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034164; ENSMUSP00000034164; ENSMUSG00000031729.
GeneID71955.
KEGGmmu:71955.
UCSCuc009niy.2. mouse.

Organism-specific databases

CTD9798.
MGIMGI:1919205. Ist1.
RougeSearch...

Phylogenomic databases

eggNOGNOG273475.
GeneTreeENSGT00390000007453.
HOGENOMHOG000205346.
InParanoidQ9CX00.
OMAPTYESID.
OrthoDBEOG7K3TNC.
PhylomeDBQ9CX00.
TreeFamTF314258.

Gene expression databases

BgeeQ9CX00.
CleanExMM_2400003C14RIK.
GenevestigatorQ9CX00.

Family and domain databases

InterProIPR005061. DUF292_euk.
[Graphical view]
PfamPF03398. Ist1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio335044.
PROQ9CX00.
SOURCESearch...

Entry information

Entry nameIST1_MOUSE
AccessionPrimary (citable) accession number: Q9CX00
Secondary accession number(s): Q80U68
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot