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Q9CX00

- IST1_MOUSE

UniProt

Q9CX00 - IST1_MOUSE

Protein

IST1 homolog

Gene

Ist1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProt

    GO - Biological processi

    1. abscission Source: Ensembl
    2. cytokinesis Source: Ensembl
    3. positive regulation of collateral sprouting Source: MGI
    4. positive regulation of proteolysis Source: Ensembl
    5. protein localization Source: Ensembl
    6. viral capsid secondary envelopment Source: Ensembl
    7. viral release from host cell Source: Ensembl

    Keywords - Biological processi

    Cell cycle, Cell division

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    IST1 homolog
    Gene namesi
    Name:Ist1
    Synonyms:Kiaa0174
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1919205. Ist1.

    Subcellular locationi

    Cytoplasmic vesicle By similarity
    Note: Localizes to the midbody of dividing cells.By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    3. cytosol Source: Ensembl
    4. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    5. extracellular vesicular exosome Source: Ensembl
    6. Flemming body Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362IST1 homologPRO_0000050728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9CX00.
    PaxDbiQ9CX00.
    PRIDEiQ9CX00.

    PTM databases

    PhosphoSiteiQ9CX00.

    Expressioni

    Gene expression databases

    BgeeiQ9CX00.
    CleanExiMM_2400003C14RIK.
    GenevestigatoriQ9CX00.

    Interactioni

    Subunit structurei

    Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ9CX00. 2 interactions.
    MINTiMINT-4125720.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CX00.
    SMRiQ9CX00. Positions 2-187.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IST1 family.Curated

    Phylogenomic databases

    eggNOGiNOG273475.
    GeneTreeiENSGT00390000007453.
    HOGENOMiHOG000205346.
    InParanoidiQ9CX00.
    OMAiPTYESID.
    OrthoDBiEOG7K3TNC.
    PhylomeDBiQ9CX00.
    TreeFamiTF314258.

    Family and domain databases

    InterProiIPR005061. DUF292_euk.
    [Graphical view]
    PfamiPF03398. Ist1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CX00-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGSGFKAER LRVNLRLVIN RLKLLEKKKT ELAQKARKEI ADYLAAGKDE    50
    RARIRVEHII REDYLVEAME ILELYCDLLL ARFGLIQSMK ELDSGLAESV 100
    STLIWAAPRL QSEVAELKIV ADQLCAKYSK EYGKLCRTNQ IGTVNDRLMH 150
    KLSVEAPPKI LVERYLIEIA KNYNVPYEPD SVVMAEAPVG VETDLIDVGF 200
    TDDVKKGGPG RGGGGGFTAP VGGPDGIVPM PMPMPMPSPN APFAYPLPKG 250
    PSDFSGLPVG TYQAFPNIHP PQIPATPPSY ESVDDINGDK TVSSAQIVGP 300
    KPEAPAKPPS RPVDNYNTFV LPELPSVPDT LPTASAGAST SASEDIDFDD 350
    LSRRFEELKK KT 362
    Length:362
    Mass (Da):39,468
    Last modified:June 1, 2001 - v1
    Checksum:iF3FB378DDBCD8BE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti252 – 2565SDFSG → VSMCV in BAC65497. (PubMed:12693553)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010262 mRNA. Translation: BAB26804.1.
    AK088192 mRNA. Translation: BAC40200.1.
    AK152830 mRNA. Translation: BAE31530.1.
    BC017605 mRNA. Translation: AAH17605.1.
    AK122215 mRNA. Translation: BAC65497.1.
    CCDSiCCDS22655.1.
    RefSeqiNP_082294.1. NM_028018.2.
    UniGeneiMm.290036.

    Genome annotation databases

    EnsembliENSMUST00000034164; ENSMUSP00000034164; ENSMUSG00000031729.
    GeneIDi71955.
    KEGGimmu:71955.
    UCSCiuc009niy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010262 mRNA. Translation: BAB26804.1 .
    AK088192 mRNA. Translation: BAC40200.1 .
    AK152830 mRNA. Translation: BAE31530.1 .
    BC017605 mRNA. Translation: AAH17605.1 .
    AK122215 mRNA. Translation: BAC65497.1 .
    CCDSi CCDS22655.1.
    RefSeqi NP_082294.1. NM_028018.2.
    UniGenei Mm.290036.

    3D structure databases

    ProteinModelPortali Q9CX00.
    SMRi Q9CX00. Positions 2-187.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CX00. 2 interactions.
    MINTi MINT-4125720.

    PTM databases

    PhosphoSitei Q9CX00.

    Proteomic databases

    MaxQBi Q9CX00.
    PaxDbi Q9CX00.
    PRIDEi Q9CX00.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034164 ; ENSMUSP00000034164 ; ENSMUSG00000031729 .
    GeneIDi 71955.
    KEGGi mmu:71955.
    UCSCi uc009niy.2. mouse.

    Organism-specific databases

    CTDi 9798.
    MGIi MGI:1919205. Ist1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG273475.
    GeneTreei ENSGT00390000007453.
    HOGENOMi HOG000205346.
    InParanoidi Q9CX00.
    OMAi PTYESID.
    OrthoDBi EOG7K3TNC.
    PhylomeDBi Q9CX00.
    TreeFami TF314258.

    Miscellaneous databases

    NextBioi 335044.
    PROi Q9CX00.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CX00.
    CleanExi MM_2400003C14RIK.
    Genevestigatori Q9CX00.

    Family and domain databases

    InterProi IPR005061. DUF292_euk.
    [Graphical view ]
    Pfami PF03398. Ist1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-256.
      Tissue: Brain.

    Entry informationi

    Entry nameiIST1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CX00
    Secondary accession number(s): Q80U68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3