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Protein

Gamma-soluble NSF attachment protein

Gene

Napg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-soluble NSF attachment protein
Short name:
SNAP-gamma
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein gamma
Gene namesi
Name:Napg
Synonyms:Snapg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:104561. Napg.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • lysosomal membrane Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Gamma-soluble NSF attachment proteinPRO_0000219064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei284 – 2841PhosphoserineCombined sources
Modified residuei287 – 2871PhosphothreonineCombined sources
Modified residuei308 – 3081PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWZ7.
MaxQBiQ9CWZ7.
PaxDbiQ9CWZ7.
PRIDEiQ9CWZ7.

PTM databases

iPTMnetiQ9CWZ7.
PhosphoSiteiQ9CWZ7.

Expressioni

Gene expression databases

BgeeiQ9CWZ7.
ExpressionAtlasiQ9CWZ7. baseline and differential.
GenevisibleiQ9CWZ7. MM.

Interactioni

Subunit structurei

Binds RIP11 (By similarity). Interacts with VTI1A.By similarity1 Publication

Protein-protein interaction databases

BioGridi223846. 2 interactions.
IntActiQ9CWZ7. 3 interactions.
MINTiMINT-4135022.
STRINGi10090.ENSMUSP00000025474.

Structurei

3D structure databases

ProteinModelPortaliQ9CWZ7.
SMRiQ9CWZ7. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1585. Eukaryota.
ENOG410ZYD7. LUCA.
GeneTreeiENSGT00390000010109.
HOGENOMiHOG000007747.
HOVERGENiHBG001648.
InParanoidiQ9CWZ7.
OrthoDBiEOG7FFMS2.
PhylomeDBiQ9CWZ7.
TreeFamiTF312872.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ
60 70 80 90 100
FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK
110 120 130 140 150
ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL
160 170 180 190 200
RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ
210 220 230 240 250
VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV
260 270 280 290 300
SEVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGAAGMAA
310
EEEEDEYSGG LC
Length:312
Mass (Da):34,732
Last modified:June 1, 2001 - v1
Checksum:i12F47490EAFC57F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010275 mRNA. Translation: BAB26812.1.
AK154573 mRNA. Translation: BAE32685.1.
AK164149 mRNA. Translation: BAE37651.1.
AK167372 mRNA. Translation: BAE39468.1.
BC026977 mRNA. Translation: AAH26977.1.
CCDSiCCDS29295.1.
RefSeqiNP_082293.1. NM_028017.1.
UniGeneiMm.292687.

Genome annotation databases

EnsembliENSMUST00000025474; ENSMUSP00000025474; ENSMUSG00000024581.
GeneIDi108123.
KEGGimmu:108123.
UCSCiuc008fdp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010275 mRNA. Translation: BAB26812.1.
AK154573 mRNA. Translation: BAE32685.1.
AK164149 mRNA. Translation: BAE37651.1.
AK167372 mRNA. Translation: BAE39468.1.
BC026977 mRNA. Translation: AAH26977.1.
CCDSiCCDS29295.1.
RefSeqiNP_082293.1. NM_028017.1.
UniGeneiMm.292687.

3D structure databases

ProteinModelPortaliQ9CWZ7.
SMRiQ9CWZ7. Positions 2-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223846. 2 interactions.
IntActiQ9CWZ7. 3 interactions.
MINTiMINT-4135022.
STRINGi10090.ENSMUSP00000025474.

PTM databases

iPTMnetiQ9CWZ7.
PhosphoSiteiQ9CWZ7.

Proteomic databases

EPDiQ9CWZ7.
MaxQBiQ9CWZ7.
PaxDbiQ9CWZ7.
PRIDEiQ9CWZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025474; ENSMUSP00000025474; ENSMUSG00000024581.
GeneIDi108123.
KEGGimmu:108123.
UCSCiuc008fdp.2. mouse.

Organism-specific databases

CTDi8774.
MGIiMGI:104561. Napg.

Phylogenomic databases

eggNOGiKOG1585. Eukaryota.
ENOG410ZYD7. LUCA.
GeneTreeiENSGT00390000010109.
HOGENOMiHOG000007747.
HOVERGENiHBG001648.
InParanoidiQ9CWZ7.
OrthoDBiEOG7FFMS2.
PhylomeDBiQ9CWZ7.
TreeFamiTF312872.

Miscellaneous databases

ChiTaRSiNapg. mouse.
NextBioi360112.
PROiQ9CWZ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWZ7.
ExpressionAtlasiQ9CWZ7. baseline and differential.
GenevisibleiQ9CWZ7. MM.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR011990. TPR-like_helical_dom.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Retina.
  3. "A 29-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (Vti1-rp2) implicated in protein trafficking in the secretory pathway."
    Xu Y., Wong S.H., Tang B.L., Subramaniam V.N., Zhang T., Hong W.
    J. Biol. Chem. 273:21783-21789(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH VTI1A.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-284; THR-287 AND SER-308, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSNAG_MOUSE
AccessioniPrimary (citable) accession number: Q9CWZ7
Secondary accession number(s): Q3TPT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.