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Protein

RPA-interacting protein

Gene

Rpain

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 212RIP-typeAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RPA-interacting protein
Gene namesi
Name:Rpain
Synonyms:Rip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916973 Rpain

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000763001 – 219RPA-interacting proteinAdd BLAST219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated; required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9CWY9
PaxDbiQ9CWY9
PRIDEiQ9CWY9

PTM databases

iPTMnetiQ9CWY9
PhosphoSitePlusiQ9CWY9

Expressioni

Gene expression databases

BgeeiENSMUSG00000018449
CleanExiMM_RPAIN
ExpressionAtlasiQ9CWY9 baseline and differential
GenevisibleiQ9CWY9 MM

Interactioni

Subunit structurei

Interacts with the RPA1 subunit of RPA complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018593

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni164 – 180Mediates nuclear exportBy similarityAdd BLAST17

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri137 – 212RIP-typeAdd BLAST76

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX54 Eukaryota
ENOG4111K6G LUCA
GeneTreeiENSGT00390000006416
HOGENOMiHOG000251596
HOVERGENiHBG082800
InParanoidiQ9CWY9
OMAiEEWNALQ
OrthoDBiEOG091G0IK2
PhylomeDBiQ9CWY9
TreeFamiTF326215

Family and domain databases

InterProiView protein in InterPro
IPR028156 RIP
IPR028159 RPA_interact_C_dom
IPR028155 RPA_interact_central
IPR028158 RPA_interact_N_dom
PANTHERiPTHR31742 PTHR31742, 1 hit
PfamiView protein in Pfam
PF14768 RPA_interact_C, 1 hit
PF14767 RPA_interact_M, 1 hit
PF14766 RPA_interact_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESSGSPHR LLYKQVGSPH WKETFRQGCL ERMRNSRHRL LNKYRQAAGS
60 70 80 90 100
TPGTASDRLL VQEVMEEEWA SLQSVENCPE ALLQLELPLD LAVLQDIEQE
110 120 130 140 150
LCNEEKSIIS EYEEDLEFDE SCLRRMLAEW EANSLICPVC IKYNLRIMNS
160 170 180 190 200
VVTCPCGLHI PVHSTDLTEQ KLRACLEENV NEHSVHCPHT PVFSVTGGTE
210
EKPSLLMNCL TCDTWAVIL
Length:219
Mass (Da):24,897
Last modified:June 1, 2001 - v1
Checksum:i6802C83809EB3EAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010289 mRNA Translation: BAB26825.1
AL596136 Genomic DNA No translation available.
BC047996 mRNA Translation: AAH47996.1
CCDSiCCDS24969.1
RefSeqiNP_001239342.1, NM_001252413.1
NP_001239343.1, NM_001252414.1
NP_001239344.1, NM_001252415.1
NP_081462.1, NM_027186.2
UniGeneiMm.275691

Genome annotation databases

EnsembliENSMUST00000018593; ENSMUSP00000018593; ENSMUSG00000018449
GeneIDi69723
KEGGimmu:69723
UCSCiuc007jxa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRIP_MOUSE
AccessioniPrimary (citable) accession number: Q9CWY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health