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Protein

RPA-interacting protein

Gene

Rpain

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri137 – 21276RIP-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RPA-interacting protein
Gene namesi
Name:Rpain
Synonyms:Rip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916973. Rpain.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219RPA-interacting proteinPRO_0000076300Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineBy similarity

Post-translational modificationi

Sumoylated; required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9CWY9.
PaxDbiQ9CWY9.
PRIDEiQ9CWY9.

PTM databases

iPTMnetiQ9CWY9.
PhosphoSiteiQ9CWY9.

Expressioni

Gene expression databases

BgeeiQ9CWY9.
CleanExiMM_RPAIN.
ExpressionAtlasiQ9CWY9. baseline and differential.
GenevisibleiQ9CWY9. MM.

Interactioni

Subunit structurei

Interacts with the RPA1 subunit of RPA complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018593.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni164 – 18017Mediates nuclear exportBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 RIP-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri137 – 21276RIP-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IX54. Eukaryota.
ENOG4111K6G. LUCA.
GeneTreeiENSGT00390000006416.
HOGENOMiHOG000251596.
HOVERGENiHBG082800.
InParanoidiQ9CWY9.
OMAiEKCLSIM.
OrthoDBiEOG7673BZ.
PhylomeDBiQ9CWY9.
TreeFamiTF326215.

Family and domain databases

InterProiIPR028156. RIP.
IPR028159. RPA_interact_C_dom.
IPR028155. RPA_interact_central.
IPR028158. RPA_interact_N_dom.
[Graphical view]
PANTHERiPTHR31742. PTHR31742. 1 hit.
PfamiPF14768. RPA_interact_C. 1 hit.
PF14767. RPA_interact_M. 1 hit.
PF14766. RPA_interact_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESSGSPHR LLYKQVGSPH WKETFRQGCL ERMRNSRHRL LNKYRQAAGS
60 70 80 90 100
TPGTASDRLL VQEVMEEEWA SLQSVENCPE ALLQLELPLD LAVLQDIEQE
110 120 130 140 150
LCNEEKSIIS EYEEDLEFDE SCLRRMLAEW EANSLICPVC IKYNLRIMNS
160 170 180 190 200
VVTCPCGLHI PVHSTDLTEQ KLRACLEENV NEHSVHCPHT PVFSVTGGTE
210
EKPSLLMNCL TCDTWAVIL
Length:219
Mass (Da):24,897
Last modified:June 1, 2001 - v1
Checksum:i6802C83809EB3EAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010289 mRNA. Translation: BAB26825.1.
AL596136 Genomic DNA. Translation: CAI26063.1.
BC047996 mRNA. Translation: AAH47996.1.
CCDSiCCDS24969.1.
RefSeqiNP_001239342.1. NM_001252413.1.
NP_001239343.1. NM_001252414.1.
NP_001239344.1. NM_001252415.1.
NP_081462.1. NM_027186.2.
UniGeneiMm.275691.

Genome annotation databases

EnsembliENSMUST00000018593; ENSMUSP00000018593; ENSMUSG00000018449.
GeneIDi69723.
KEGGimmu:69723.
UCSCiuc007jxa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010289 mRNA. Translation: BAB26825.1.
AL596136 Genomic DNA. Translation: CAI26063.1.
BC047996 mRNA. Translation: AAH47996.1.
CCDSiCCDS24969.1.
RefSeqiNP_001239342.1. NM_001252413.1.
NP_001239343.1. NM_001252414.1.
NP_001239344.1. NM_001252415.1.
NP_081462.1. NM_027186.2.
UniGeneiMm.275691.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018593.

PTM databases

iPTMnetiQ9CWY9.
PhosphoSiteiQ9CWY9.

Proteomic databases

MaxQBiQ9CWY9.
PaxDbiQ9CWY9.
PRIDEiQ9CWY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018593; ENSMUSP00000018593; ENSMUSG00000018449.
GeneIDi69723.
KEGGimmu:69723.
UCSCiuc007jxa.2. mouse.

Organism-specific databases

CTDi84268.
MGIiMGI:1916973. Rpain.

Phylogenomic databases

eggNOGiENOG410IX54. Eukaryota.
ENOG4111K6G. LUCA.
GeneTreeiENSGT00390000006416.
HOGENOMiHOG000251596.
HOVERGENiHBG082800.
InParanoidiQ9CWY9.
OMAiEKCLSIM.
OrthoDBiEOG7673BZ.
PhylomeDBiQ9CWY9.
TreeFamiTF326215.

Miscellaneous databases

ChiTaRSiRpain. mouse.
PROiQ9CWY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWY9.
CleanExiMM_RPAIN.
ExpressionAtlasiQ9CWY9. baseline and differential.
GenevisibleiQ9CWY9. MM.

Family and domain databases

InterProiIPR028156. RIP.
IPR028159. RPA_interact_C_dom.
IPR028155. RPA_interact_central.
IPR028158. RPA_interact_N_dom.
[Graphical view]
PANTHERiPTHR31742. PTHR31742. 1 hit.
PfamiPF14768. RPA_interact_C. 1 hit.
PF14767. RPA_interact_M. 1 hit.
PF14766. RPA_interact_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiRIP_MOUSE
AccessioniPrimary (citable) accession number: Q9CWY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.