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Q9CWY4 (GEMI7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gem-associated protein 7
Short name=Gemin-7
Gene names
Name:Gemin7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.

Subunit structure

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN6, SNRPB, SNRPD2, SNRPD3 and SNRPE By similarity.

Subcellular location

Nucleus › nucleoplasm By similarity. Nucleus › gem By similarity. Cytoplasm By similarity. Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm By similarity.

Sequence similarities

Belongs to the gemin-7 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 129129Gem-associated protein 7
PRO_0000087463

Sequences

Sequence LengthMass (Da)Tools
Q9CWY4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 23F108FA3961A8B8

FASTA12914,251
        10         20         30         40         50         60 
MQSPLTIPVP VPVLRLPRGP DGFSRGFASD GRRTILRPEV GEGHIQDPPE SQEQRARATL 

        70         80         90        100        110        120 
RERYLRSLLA MVGHPVSFTL HEGVHVTAQF GATDLDVANF YVSQLQTPIG VQAEALLRCS 


DIISYSFKL

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic stem cell.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK010303 mRNA. Translation: BAB26836.1.
BC028527 mRNA. Translation: AAH28527.1.
IPIIPI00109808.
RefSeqNP_081465.1. NM_027189.2.
UniGeneMm.24540.

3D structure databases

ProteinModelPortalQ9CWY4.
SMRQ9CWY4. Positions 50-128.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9CWY4. 1 interaction.
MINTMINT-218552.
STRING10090.ENSMUSP00000113583.

PTM databases

PhosphoSiteQ9CWY4.

Proteomic databases

PRIDEQ9CWY4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000051364; ENSMUSP00000055844; ENSMUSG00000044709.
ENSMUST00000117222; ENSMUSP00000113266; ENSMUSG00000044709.
ENSMUST00000119912; ENSMUSP00000112742; ENSMUSG00000044709.
ENSMUST00000122055; ENSMUSP00000113583; ENSMUSG00000044709.
ENSMUST00000122127; ENSMUSP00000113709; ENSMUSG00000044709.
GeneID69731.
KEGGmmu:69731.
UCSCuc009fmi.1. mouse.

Organism-specific databases

CTD79760.
MGIMGI:1916981. Gemin7.

Phylogenomic databases

eggNOGNOG40574.
GeneTreeENSGT00390000018039.
HOGENOMHOG000112710.
HOVERGENHBG051723.
InParanoidQ9CWY4.
KOK13135.
OMATLHEGVH.
OrthoDBEOG470TJR.

Gene expression databases

ArrayExpressQ9CWY4.
BgeeQ9CWY4.
CleanExMM_GEMIN7.
GenevestigatorQ9CWY4.
GermOnlineENSMUSG00000044709. Mus musculus.

Family and domain databases

InterProIPR020338. SMN_gemin7.
[Graphical view]
PfamPF11095. Gemin7. 1 hit.
[Graphical view]
ProDomPD296126. SMN_cplx_gem-assoc_protein_7. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio330206.
SOURCESearch...

Entry information

Entry nameGEMI7_MOUSE
AccessionPrimary (citable) accession number: Q9CWY4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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