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Q9CWY4

- GEMI7_MOUSE

UniProt

Q9CWY4 - GEMI7_MOUSE

Protein

Gem-associated protein 7

Gene

Gemin7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_206812. snRNP Assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gem-associated protein 7
    Short name:
    Gemin-7
    Gene namesi
    Name:Gemin7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1916981. Gemin7.

    Subcellular locationi

    Nucleusnucleoplasm By similarity. Nucleusgem By similarity. Cytoplasm By similarity
    Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. Gemini of coiled bodies Source: UniProtKB-SubCell
    4. nuclear body Source: UniProtKB
    5. nucleoplasm Source: UniProtKB
    6. SMN complex Source: UniProtKB
    7. SMN-Sm protein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 129129Gem-associated protein 7PRO_0000087463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ9CWY4.

    PTM databases

    PhosphoSiteiQ9CWY4.

    Expressioni

    Gene expression databases

    BgeeiQ9CWY4.
    CleanExiMM_GEMIN7.
    GenevestigatoriQ9CWY4.

    Interactioni

    Subunit structurei

    Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6, SNRPB, SNRPD2, SNRPD3 and SNRPE By similarity.By similarity

    Protein-protein interaction databases

    BioGridi213643. 1 interaction.
    IntActiQ9CWY4. 1 interaction.
    MINTiMINT-218552.
    STRINGi10090.ENSMUSP00000113583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CWY4.
    SMRiQ9CWY4. Positions 50-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the gemin-7 family.Curated

    Phylogenomic databases

    eggNOGiNOG40574.
    GeneTreeiENSGT00390000018039.
    HOGENOMiHOG000112710.
    HOVERGENiHBG051723.
    InParanoidiQ9CWY4.
    KOiK13135.
    OMAiCSDIIAY.
    OrthoDBiEOG7SXW57.
    PhylomeDBiQ9CWY4.
    TreeFamiTF328578.

    Family and domain databases

    InterProiIPR020338. SMN_gemin7.
    [Graphical view]
    PfamiPF11095. Gemin7. 1 hit.
    [Graphical view]
    ProDomiPD296126. SMN_cplx_gem-assoc_protein_7. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q9CWY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSPLTIPVP VPVLRLPRGP DGFSRGFASD GRRTILRPEV GEGHIQDPPE    50
    SQEQRARATL RERYLRSLLA MVGHPVSFTL HEGVHVTAQF GATDLDVANF 100
    YVSQLQTPIG VQAEALLRCS DIISYSFKL 129
    Length:129
    Mass (Da):14,251
    Last modified:June 1, 2001 - v1
    Checksum:i23F108FA3961A8B8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010303 mRNA. Translation: BAB26836.1.
    BC028527 mRNA. Translation: AAH28527.1.
    CCDSiCCDS20907.1.
    RefSeqiNP_081465.1. NM_027189.2.
    UniGeneiMm.24540.

    Genome annotation databases

    EnsembliENSMUST00000051364; ENSMUSP00000055844; ENSMUSG00000044709.
    ENSMUST00000117222; ENSMUSP00000113266; ENSMUSG00000044709.
    ENSMUST00000119912; ENSMUSP00000112742; ENSMUSG00000044709.
    ENSMUST00000122055; ENSMUSP00000113583; ENSMUSG00000044709.
    ENSMUST00000122127; ENSMUSP00000113709; ENSMUSG00000044709.
    GeneIDi69731.
    KEGGimmu:69731.
    UCSCiuc009fmi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010303 mRNA. Translation: BAB26836.1 .
    BC028527 mRNA. Translation: AAH28527.1 .
    CCDSi CCDS20907.1.
    RefSeqi NP_081465.1. NM_027189.2.
    UniGenei Mm.24540.

    3D structure databases

    ProteinModelPortali Q9CWY4.
    SMRi Q9CWY4. Positions 50-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213643. 1 interaction.
    IntActi Q9CWY4. 1 interaction.
    MINTi MINT-218552.
    STRINGi 10090.ENSMUSP00000113583.

    PTM databases

    PhosphoSitei Q9CWY4.

    Proteomic databases

    PRIDEi Q9CWY4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051364 ; ENSMUSP00000055844 ; ENSMUSG00000044709 .
    ENSMUST00000117222 ; ENSMUSP00000113266 ; ENSMUSG00000044709 .
    ENSMUST00000119912 ; ENSMUSP00000112742 ; ENSMUSG00000044709 .
    ENSMUST00000122055 ; ENSMUSP00000113583 ; ENSMUSG00000044709 .
    ENSMUST00000122127 ; ENSMUSP00000113709 ; ENSMUSG00000044709 .
    GeneIDi 69731.
    KEGGi mmu:69731.
    UCSCi uc009fmi.1. mouse.

    Organism-specific databases

    CTDi 79760.
    MGIi MGI:1916981. Gemin7.

    Phylogenomic databases

    eggNOGi NOG40574.
    GeneTreei ENSGT00390000018039.
    HOGENOMi HOG000112710.
    HOVERGENi HBG051723.
    InParanoidi Q9CWY4.
    KOi K13135.
    OMAi CSDIIAY.
    OrthoDBi EOG7SXW57.
    PhylomeDBi Q9CWY4.
    TreeFami TF328578.

    Enzyme and pathway databases

    Reactomei REACT_206812. snRNP Assembly.

    Miscellaneous databases

    NextBioi 330206.
    PROi Q9CWY4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CWY4.
    CleanExi MM_GEMIN7.
    Genevestigatori Q9CWY4.

    Family and domain databases

    InterProi IPR020338. SMN_gemin7.
    [Graphical view ]
    Pfami PF11095. Gemin7. 1 hit.
    [Graphical view ]
    ProDomi PD296126. SMN_cplx_gem-assoc_protein_7. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.

    Entry informationi

    Entry nameiGEMI7_MOUSE
    AccessioniPrimary (citable) accession number: Q9CWY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3