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Protein

Gem-associated protein 7

Gene

Gemin7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).By similarity

GO - Biological processi

  1. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiREACT_333207. snRNP Assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Gem-associated protein 7
Short name:
Gemin-7
Gene namesi
Name:Gemin7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916981. Gemin7.

Subcellular locationi

  1. Nucleusnucleoplasm By similarity
  2. Nucleusgem By similarity
  3. Cytoplasm By similarity

  4. Note: Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. Gemini of coiled bodies Source: UniProtKB-SubCell
  4. nuclear body Source: UniProtKB
  5. nucleoplasm Source: UniProtKB
  6. nucleus Source: MGI
  7. SMN complex Source: UniProtKB
  8. SMN-Sm protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 129129Gem-associated protein 7PRO_0000087463Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9CWY4.
PRIDEiQ9CWY4.

PTM databases

PhosphoSiteiQ9CWY4.

Expressioni

Gene expression databases

BgeeiQ9CWY4.
CleanExiMM_GEMIN7.
ExpressionAtlasiQ9CWY4. baseline and differential.
GenevestigatoriQ9CWY4.

Interactioni

Subunit structurei

Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN6, SNRPB, SNRPD2, SNRPD3 and SNRPE (By similarity).By similarity

Protein-protein interaction databases

BioGridi213643. 1 interaction.
IntActiQ9CWY4. 1 interaction.
MINTiMINT-218552.
STRINGi10090.ENSMUSP00000113583.

Structurei

3D structure databases

ProteinModelPortaliQ9CWY4.
SMRiQ9CWY4. Positions 50-128.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gemin-7 family.Curated

Phylogenomic databases

eggNOGiNOG40574.
GeneTreeiENSGT00390000018039.
HOGENOMiHOG000112710.
HOVERGENiHBG051723.
InParanoidiQ9CWY4.
KOiK13135.
OMAiCSDIIAY.
OrthoDBiEOG7SXW57.
PhylomeDBiQ9CWY4.
TreeFamiTF328578.

Family and domain databases

InterProiIPR020338. SMN_gemin7.
[Graphical view]
PfamiPF11095. Gemin7. 1 hit.
[Graphical view]
ProDomiPD296126. SMN_cplx_gem-assoc_protein_7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9CWY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSPLTIPVP VPVLRLPRGP DGFSRGFASD GRRTILRPEV GEGHIQDPPE
60 70 80 90 100
SQEQRARATL RERYLRSLLA MVGHPVSFTL HEGVHVTAQF GATDLDVANF
110 120
YVSQLQTPIG VQAEALLRCS DIISYSFKL
Length:129
Mass (Da):14,251
Last modified:June 1, 2001 - v1
Checksum:i23F108FA3961A8B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010303 mRNA. Translation: BAB26836.1.
BC028527 mRNA. Translation: AAH28527.1.
CCDSiCCDS20907.1.
RefSeqiNP_081465.1. NM_027189.2.
UniGeneiMm.24540.

Genome annotation databases

EnsembliENSMUST00000051364; ENSMUSP00000055844; ENSMUSG00000044709.
ENSMUST00000117222; ENSMUSP00000113266; ENSMUSG00000044709.
ENSMUST00000119912; ENSMUSP00000112742; ENSMUSG00000044709.
ENSMUST00000122055; ENSMUSP00000113583; ENSMUSG00000044709.
ENSMUST00000122127; ENSMUSP00000113709; ENSMUSG00000044709.
GeneIDi69731.
KEGGimmu:69731.
UCSCiuc009fmi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010303 mRNA. Translation: BAB26836.1.
BC028527 mRNA. Translation: AAH28527.1.
CCDSiCCDS20907.1.
RefSeqiNP_081465.1. NM_027189.2.
UniGeneiMm.24540.

3D structure databases

ProteinModelPortaliQ9CWY4.
SMRiQ9CWY4. Positions 50-128.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213643. 1 interaction.
IntActiQ9CWY4. 1 interaction.
MINTiMINT-218552.
STRINGi10090.ENSMUSP00000113583.

PTM databases

PhosphoSiteiQ9CWY4.

Proteomic databases

MaxQBiQ9CWY4.
PRIDEiQ9CWY4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051364; ENSMUSP00000055844; ENSMUSG00000044709.
ENSMUST00000117222; ENSMUSP00000113266; ENSMUSG00000044709.
ENSMUST00000119912; ENSMUSP00000112742; ENSMUSG00000044709.
ENSMUST00000122055; ENSMUSP00000113583; ENSMUSG00000044709.
ENSMUST00000122127; ENSMUSP00000113709; ENSMUSG00000044709.
GeneIDi69731.
KEGGimmu:69731.
UCSCiuc009fmi.1. mouse.

Organism-specific databases

CTDi79760.
MGIiMGI:1916981. Gemin7.

Phylogenomic databases

eggNOGiNOG40574.
GeneTreeiENSGT00390000018039.
HOGENOMiHOG000112710.
HOVERGENiHBG051723.
InParanoidiQ9CWY4.
KOiK13135.
OMAiCSDIIAY.
OrthoDBiEOG7SXW57.
PhylomeDBiQ9CWY4.
TreeFamiTF328578.

Enzyme and pathway databases

ReactomeiREACT_333207. snRNP Assembly.

Miscellaneous databases

NextBioi330206.
PROiQ9CWY4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWY4.
CleanExiMM_GEMIN7.
ExpressionAtlasiQ9CWY4. baseline and differential.
GenevestigatoriQ9CWY4.

Family and domain databases

InterProiIPR020338. SMN_gemin7.
[Graphical view]
PfamiPF11095. Gemin7. 1 hit.
[Graphical view]
ProDomiPD296126. SMN_cplx_gem-assoc_protein_7. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.

Entry informationi

Entry nameiGEMI7_MOUSE
AccessioniPrimary (citable) accession number: Q9CWY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.