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Protein

N-lysine methyltransferase SETD6

Gene

Setd6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (PubMed:23324626).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
N-lysine methyltransferase SETD6 (EC:2.1.1.-)
Alternative name(s):
SET domain-containing protein 6
Gene namesi
Name:Setd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913333. Setd6.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473N-lysine methyltransferase SETD6PRO_0000281890Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWY3.
MaxQBiQ9CWY3.
PaxDbiQ9CWY3.
PeptideAtlasiQ9CWY3.
PRIDEiQ9CWY3.

PTM databases

iPTMnetiQ9CWY3.
PhosphoSiteiQ9CWY3.

Expressioni

Gene expression databases

BgeeiQ9CWY3.
CleanExiMM_SETD6.
GenevisibleiQ9CWY3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CWY3. 1 interaction.
STRINGi10090.ENSMUSP00000034096.

Structurei

3D structure databases

ProteinModelPortaliQ9CWY3.
SMRiQ9CWY3. Positions 44-473.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 286225SETPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1338. Eukaryota.
ENOG410ZN0H. LUCA.
GeneTreeiENSGT00730000111144.
HOGENOMiHOG000264234.
HOVERGENiHBG108475.
InParanoidiQ9CWY3.
KOiK05302.
OMAiDEFITWL.
OrthoDBiEOG747PJ3.
PhylomeDBiQ9CWY3.
TreeFamiTF106399.

Family and domain databases

Gene3Di3.90.1420.10. 1 hit.
InterProiIPR011383. N-lys_methylase_SETD6.
IPR015353. Rubisco_LSMT_subst-bd.
IPR001214. SET_dom.
[Graphical view]
PfamiPF09273. Rubis-subs-bind. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF011771. RMS1_SET. 1 hit.
SUPFAMiSSF81822. SSF81822. 1 hit.
PROSITEiPS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAKRARV SGGSPLVAPC PSPRAARAPL PLPAGSSGGE PEGDAVAGFL
60 70 80 90 100
RWCRRVGLEL SPKVTVSRQG TVAGYGMVAR ESVRAGELLF AVPRSALLSP
110 120 130 140 150
HTCSISGLLE RERGALQSLS GWVPLLLALL HELQAPASPW SPYFALWPEL
160 170 180 190 200
GRLEHPMFWP EEERLRLLKG TGVPEAVEKD LVNIRSEYYS IVLPFMEAHS
210 220 230 240 250
DLFSPSVRSL ELYQQLVALV MAYSFQEPLE EDDDEKEPNS PLMVPAADIL
260 270 280 290 300
NHIANHNANL EYSADYLRMV ATQPILEGHE IFNTYGQMAN WQLIHMYGFA
310 320 330 340 350
EPYPNNTDDT ADIQMVTVRD AALQGTKDET EKLLVCERWD FLCKQEMVGE
360 370 380 390 400
EGAFVIGCEE VLTEEELATT LKVLCMPAEE FRDYKERAGW GEEETEDDSL
410 420 430 440 450
AITDIPKLQE SWKRLLRNSV LLTLQTYTTD LKTDQDLLSN KEAYATLSWR
460 470
EQQALQVRYG QKMILHRVLE LTN
Length:473
Mass (Da):52,960
Last modified:June 1, 2001 - v1
Checksum:i36B10A092DF43ECF
GO

Sequence cautioni

The sequence BAC35846.1 differs from that shown. Reason: Frameshift at position 449. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871E → T in BAC35846 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010304 mRNA. Translation: BAB26837.1.
AK075597 mRNA. Translation: BAC35846.1. Frameshift.
AK167753 mRNA. Translation: BAE39788.1.
CH466525 Genomic DNA. Translation: EDL11181.1.
BC139198 mRNA. Translation: AAI39199.1.
BC139199 mRNA. Translation: AAI39200.1.
CCDSiCCDS22566.1.
RefSeqiNP_001030295.1. NM_001035123.3.
UniGeneiMm.261321.

Genome annotation databases

EnsembliENSMUST00000034096; ENSMUSP00000034096; ENSMUSG00000031671.
GeneIDi66083.
KEGGimmu:66083.
UCSCiuc009myv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010304 mRNA. Translation: BAB26837.1.
AK075597 mRNA. Translation: BAC35846.1. Frameshift.
AK167753 mRNA. Translation: BAE39788.1.
CH466525 Genomic DNA. Translation: EDL11181.1.
BC139198 mRNA. Translation: AAI39199.1.
BC139199 mRNA. Translation: AAI39200.1.
CCDSiCCDS22566.1.
RefSeqiNP_001030295.1. NM_001035123.3.
UniGeneiMm.261321.

3D structure databases

ProteinModelPortaliQ9CWY3.
SMRiQ9CWY3. Positions 44-473.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWY3. 1 interaction.
STRINGi10090.ENSMUSP00000034096.

PTM databases

iPTMnetiQ9CWY3.
PhosphoSiteiQ9CWY3.

Proteomic databases

EPDiQ9CWY3.
MaxQBiQ9CWY3.
PaxDbiQ9CWY3.
PeptideAtlasiQ9CWY3.
PRIDEiQ9CWY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034096; ENSMUSP00000034096; ENSMUSG00000031671.
GeneIDi66083.
KEGGimmu:66083.
UCSCiuc009myv.1. mouse.

Organism-specific databases

CTDi79918.
MGIiMGI:1913333. Setd6.

Phylogenomic databases

eggNOGiKOG1338. Eukaryota.
ENOG410ZN0H. LUCA.
GeneTreeiENSGT00730000111144.
HOGENOMiHOG000264234.
HOVERGENiHBG108475.
InParanoidiQ9CWY3.
KOiK05302.
OMAiDEFITWL.
OrthoDBiEOG747PJ3.
PhylomeDBiQ9CWY3.
TreeFamiTF106399.

Miscellaneous databases

PROiQ9CWY3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWY3.
CleanExiMM_SETD6.
GenevisibleiQ9CWY3. MM.

Family and domain databases

Gene3Di3.90.1420.10. 1 hit.
InterProiIPR011383. N-lys_methylase_SETD6.
IPR015353. Rubisco_LSMT_subst-bd.
IPR001214. SET_dom.
[Graphical view]
PfamiPF09273. Rubis-subs-bind. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF011771. RMS1_SET. 1 hit.
SUPFAMiSSF81822. SSF81822. 1 hit.
PROSITEiPS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/cJ and C57BL/6J.
    Tissue: Kidney.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14 AND SER-22, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver and Testis.
  6. "SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal."
    Binda O., Sevilla A., LeRoy G., Lemischka I.R., Garcia B.A., Richard S.
    Epigenetics 8:177-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSETD6_MOUSE
AccessioniPrimary (citable) accession number: Q9CWY3
Secondary accession number(s): B2RTA7, Q8C6I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.