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Q9CWX9 (DDX47_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-dependent RNA helicase DDX47
EC=3.6.4.13
Alternative name(s):
DEAD box protein 47
Gene names
Name:Ddx47
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subunit structure

Interacts with EIF2C1 and EIF2C2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent By similarity.

Subcellular location

Nucleus › nucleolus By similarity. Note: Localizes in the nucleolar-organizing region during ribosome biogenesis By similarity.

Sequence similarities

Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 455454Probable ATP-dependent RNA helicase DDX47
PRO_0000055051

Regions

Domain55 – 226172Helicase ATP-binding
Domain237 – 397161Helicase C-terminal
Nucleotide binding68 – 758ATP By similarity
Motif24 – 5229Q motif
Motif174 – 1774DEAD box

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CWX9 [UniParc].

Last modified March 1, 2003. Version 2.
Checksum: AEAEC9287BD86DFA

FASTA45550,639
        10         20         30         40         50         60 
MAADEEPDSP SGALQTAAEE EETKTFKDLG VTDVLCEACD QLGWAKPTKI QIEAIPLALQ 

        70         80         90        100        110        120 
GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP TRELAFQISE QFEALGSSIG 

       130        140        150        160        170        180 
VQCAVIVGGI DSMSQSLALA KKPHIVIATP GRLIDHLENT KGFNLRALKY LVMDEADRIL 

       190        200        210        220        230        240 
NMDFETEVDK ILKVIPRDRK TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ 

       250        260        270        280        290        300 
YYLFIPSKFK DTYLVYILNE LAGNSFMIFC STCNNTQRTA LLLRNLGFTA IPLHGQMSQS 

       310        320        330        340        350        360 
KRLGSLNKFK AKARSILLAT DVASRGLDIP HVDVVVNFDI PTHSKDYIHR VGRTARAGRS 

       370        380        390        400        410        420 
GKAITFVTQY DVELFQRIEH LIGKKLPVFP TQDEEVMMLT ERVNEAQRFA RMELREHGEK 

       430        440        450 
KKRKREDAGD DDDKEGAIGV RNKVAGGKMK KRKGR

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK010310 mRNA. Translation: BAB26843.2.
AK076982 mRNA. Translation: BAC36547.1.
IPIIPI00187240.
RefSeqNP_080636.2. NM_026360.3.
UniGeneMm.166524.

3D structure databases

ProteinModelPortalQ9CWX9.
SMRQ9CWX9. Positions 13-386.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9CWX9. 1 interaction.

PTM databases

PhosphoSiteQ9CWX9.

Proteomic databases

PaxDbQ9CWX9.
PRIDEQ9CWX9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032326; ENSMUSP00000032326; ENSMUSG00000030204.
GeneID67755.
KEGGmmu:67755.

Organism-specific databases

CTD51202.
MGIMGI:1915005. Ddx47.

Phylogenomic databases

eggNOGCOG0513.
GeneTreeENSGT00670000098028.
HOGENOMHOG000268802.
HOVERGENHBG100512.
InParanoidQ9CWX9.
KOK14777.
OMAIFIPSKF.
OrthoDBEOG4TXBRS.

Gene expression databases

ArrayExpressQ9CWX9.
BgeeQ9CWX9.
CleanExMM_DDX47.
GenevestigatorQ9CWX9.
GermOnlineENSMUSG00000030204. Mus musculus.

Family and domain databases

InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
PROSITEPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDDX47. mouse.
NextBio325481.
SOURCESearch...

Entry information

Entry nameDDX47_MOUSE
AccessionPrimary (citable) accession number: Q9CWX9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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