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Q9CWX9

- DDX47_MOUSE

UniProt

Q9CWX9 - DDX47_MOUSE

Protein

Probable ATP-dependent RNA helicase DDX47

Gene

Ddx47

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 758ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
    2. mRNA processing Source: UniProtKB-KW
    3. RNA splicing Source: UniProtKB
    4. rRNA processing Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    Apoptosis, mRNA processing, mRNA splicing, rRNA processing

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase DDX47 (EC:3.6.4.13)
    Alternative name(s):
    DEAD box protein 47
    Gene namesi
    Name:Ddx47
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1915005. Ddx47.

    Subcellular locationi

    Nucleusnucleolus By similarity
    Note: Localizes in the nucleolar-organizing region during ribosome biogenesis.By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 455454Probable ATP-dependent RNA helicase DDX47PRO_0000055051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei9 – 91PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ9CWX9.
    PRIDEiQ9CWX9.

    PTM databases

    PhosphoSiteiQ9CWX9.

    Expressioni

    Gene expression databases

    BgeeiQ9CWX9.
    CleanExiMM_DDX47.
    GenevestigatoriQ9CWX9.

    Interactioni

    Subunit structurei

    Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent By similarity.By similarity

    Protein-protein interaction databases

    BioGridi212421. 2 interactions.
    IntActiQ9CWX9. 2 interactions.
    MINTiMINT-4092978.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CWX9.
    SMRiQ9CWX9. Positions 13-383.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 226172Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini237 – 397161Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi24 – 5229Q motifAdd
    BLAST
    Motifi174 – 1774DEAD box

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    GeneTreeiENSGT00730000110914.
    HOGENOMiHOG000268802.
    HOVERGENiHBG100512.
    InParanoidiQ9CWX9.
    KOiK14777.
    OMAiNKFRAGS.
    OrthoDBiEOG7GTT3T.
    PhylomeDBiQ9CWX9.
    TreeFamiTF105714.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CWX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAADEEPDSP SGALQTAAEE EETKTFKDLG VTDVLCEACD QLGWAKPTKI    50
    QIEAIPLALQ GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP 100
    TRELAFQISE QFEALGSSIG VQCAVIVGGI DSMSQSLALA KKPHIVIATP 150
    GRLIDHLENT KGFNLRALKY LVMDEADRIL NMDFETEVDK ILKVIPRDRK 200
    TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ YYLFIPSKFK 250
    DTYLVYILNE LAGNSFMIFC STCNNTQRTA LLLRNLGFTA IPLHGQMSQS 300
    KRLGSLNKFK AKARSILLAT DVASRGLDIP HVDVVVNFDI PTHSKDYIHR 350
    VGRTARAGRS GKAITFVTQY DVELFQRIEH LIGKKLPVFP TQDEEVMMLT 400
    ERVNEAQRFA RMELREHGEK KKRKREDAGD DDDKEGAIGV RNKVAGGKMK 450
    KRKGR 455
    Length:455
    Mass (Da):50,639
    Last modified:March 1, 2003 - v2
    Checksum:iAEAEC9287BD86DFA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010310 mRNA. Translation: BAB26843.2.
    AK076982 mRNA. Translation: BAC36547.1.
    CCDSiCCDS20643.1.
    RefSeqiNP_080636.2. NM_026360.3.
    UniGeneiMm.166524.

    Genome annotation databases

    EnsembliENSMUST00000032326; ENSMUSP00000032326; ENSMUSG00000030204.
    GeneIDi67755.
    KEGGimmu:67755.
    UCSCiuc009eld.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010310 mRNA. Translation: BAB26843.2 .
    AK076982 mRNA. Translation: BAC36547.1 .
    CCDSi CCDS20643.1.
    RefSeqi NP_080636.2. NM_026360.3.
    UniGenei Mm.166524.

    3D structure databases

    ProteinModelPortali Q9CWX9.
    SMRi Q9CWX9. Positions 13-383.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212421. 2 interactions.
    IntActi Q9CWX9. 2 interactions.
    MINTi MINT-4092978.

    PTM databases

    PhosphoSitei Q9CWX9.

    Proteomic databases

    PaxDbi Q9CWX9.
    PRIDEi Q9CWX9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032326 ; ENSMUSP00000032326 ; ENSMUSG00000030204 .
    GeneIDi 67755.
    KEGGi mmu:67755.
    UCSCi uc009eld.2. mouse.

    Organism-specific databases

    CTDi 51202.
    MGIi MGI:1915005. Ddx47.

    Phylogenomic databases

    eggNOGi COG0513.
    GeneTreei ENSGT00730000110914.
    HOGENOMi HOG000268802.
    HOVERGENi HBG100512.
    InParanoidi Q9CWX9.
    KOi K14777.
    OMAi NKFRAGS.
    OrthoDBi EOG7GTT3T.
    PhylomeDBi Q9CWX9.
    TreeFami TF105714.

    Miscellaneous databases

    ChiTaRSi DDX47. mouse.
    NextBioi 325481.
    PROi Q9CWX9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CWX9.
    CleanExi MM_DDX47.
    Genevestigatori Q9CWX9.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.

    Entry informationi

    Entry nameiDDX47_MOUSE
    AccessioniPrimary (citable) accession number: Q9CWX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3