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Q9CWX9

- DDX47_MOUSE

UniProt

Q9CWX9 - DDX47_MOUSE

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Protein

Probable ATP-dependent RNA helicase DDX47

Gene

Ddx47

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 758ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
  2. mRNA processing Source: UniProtKB-KW
  3. RNA splicing Source: UniProtKB
  4. rRNA processing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Apoptosis, mRNA processing, mRNA splicing, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX47 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 47
Gene namesi
Name:Ddx47
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1915005. Ddx47.

Subcellular locationi

Nucleusnucleolus By similarity
Note: Localizes in the nucleolar-organizing region during ribosome biogenesis.By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 455454Probable ATP-dependent RNA helicase DDX47PRO_0000055051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei9 – 91PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CWX9.
PaxDbiQ9CWX9.
PRIDEiQ9CWX9.

PTM databases

PhosphoSiteiQ9CWX9.

Expressioni

Gene expression databases

BgeeiQ9CWX9.
CleanExiMM_DDX47.
ExpressionAtlasiQ9CWX9. baseline and differential.
GenevestigatoriQ9CWX9.

Interactioni

Subunit structurei

Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent (By similarity).By similarity

Protein-protein interaction databases

BioGridi212421. 2 interactions.
IntActiQ9CWX9. 2 interactions.
MINTiMINT-4092978.

Structurei

3D structure databases

ProteinModelPortaliQ9CWX9.
SMRiQ9CWX9. Positions 13-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 226172Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini237 – 397161Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 5229Q motifAdd
BLAST
Motifi174 – 1774DEAD box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00730000110914.
HOGENOMiHOG000268802.
HOVERGENiHBG100512.
InParanoidiQ9CWX9.
KOiK14777.
OMAiNKFRAGS.
OrthoDBiEOG7GTT3T.
PhylomeDBiQ9CWX9.
TreeFamiTF105714.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CWX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAADEEPDSP SGALQTAAEE EETKTFKDLG VTDVLCEACD QLGWAKPTKI
60 70 80 90 100
QIEAIPLALQ GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP
110 120 130 140 150
TRELAFQISE QFEALGSSIG VQCAVIVGGI DSMSQSLALA KKPHIVIATP
160 170 180 190 200
GRLIDHLENT KGFNLRALKY LVMDEADRIL NMDFETEVDK ILKVIPRDRK
210 220 230 240 250
TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ YYLFIPSKFK
260 270 280 290 300
DTYLVYILNE LAGNSFMIFC STCNNTQRTA LLLRNLGFTA IPLHGQMSQS
310 320 330 340 350
KRLGSLNKFK AKARSILLAT DVASRGLDIP HVDVVVNFDI PTHSKDYIHR
360 370 380 390 400
VGRTARAGRS GKAITFVTQY DVELFQRIEH LIGKKLPVFP TQDEEVMMLT
410 420 430 440 450
ERVNEAQRFA RMELREHGEK KKRKREDAGD DDDKEGAIGV RNKVAGGKMK

KRKGR
Length:455
Mass (Da):50,639
Last modified:March 1, 2003 - v2
Checksum:iAEAEC9287BD86DFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010310 mRNA. Translation: BAB26843.2.
AK076982 mRNA. Translation: BAC36547.1.
CCDSiCCDS20643.1.
RefSeqiNP_080636.2. NM_026360.3.
UniGeneiMm.166524.

Genome annotation databases

EnsembliENSMUST00000032326; ENSMUSP00000032326; ENSMUSG00000030204.
GeneIDi67755.
KEGGimmu:67755.
UCSCiuc009eld.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010310 mRNA. Translation: BAB26843.2 .
AK076982 mRNA. Translation: BAC36547.1 .
CCDSi CCDS20643.1.
RefSeqi NP_080636.2. NM_026360.3.
UniGenei Mm.166524.

3D structure databases

ProteinModelPortali Q9CWX9.
SMRi Q9CWX9. Positions 13-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212421. 2 interactions.
IntActi Q9CWX9. 2 interactions.
MINTi MINT-4092978.

PTM databases

PhosphoSitei Q9CWX9.

Proteomic databases

MaxQBi Q9CWX9.
PaxDbi Q9CWX9.
PRIDEi Q9CWX9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032326 ; ENSMUSP00000032326 ; ENSMUSG00000030204 .
GeneIDi 67755.
KEGGi mmu:67755.
UCSCi uc009eld.2. mouse.

Organism-specific databases

CTDi 51202.
MGIi MGI:1915005. Ddx47.

Phylogenomic databases

eggNOGi COG0513.
GeneTreei ENSGT00730000110914.
HOGENOMi HOG000268802.
HOVERGENi HBG100512.
InParanoidi Q9CWX9.
KOi K14777.
OMAi NKFRAGS.
OrthoDBi EOG7GTT3T.
PhylomeDBi Q9CWX9.
TreeFami TF105714.

Miscellaneous databases

ChiTaRSi DDX47. mouse.
NextBioi 325481.
PROi Q9CWX9.
SOURCEi Search...

Gene expression databases

Bgeei Q9CWX9.
CleanExi MM_DDX47.
ExpressionAtlasi Q9CWX9. baseline and differential.
Genevestigatori Q9CWX9.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.

Entry informationi

Entry nameiDDX47_MOUSE
AccessioniPrimary (citable) accession number: Q9CWX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3