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Protein

CXXC-type zinc finger protein 1

Gene

Cxxc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 7649PHD-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 21350CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
Gene namesi
Name:Cxxc1
Synonyms:Cgbp, Pccx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1921572. Cxxc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660CXXC-type zinc finger protein 1PRO_0000079744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei231 – 2311PhosphothreonineBy similarity
Cross-linki254 – 254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CWW7.
MaxQBiQ9CWW7.
PaxDbiQ9CWW7.
PRIDEiQ9CWW7.

PTM databases

iPTMnetiQ9CWW7.
PhosphoSiteiQ9CWW7.

Expressioni

Gene expression databases

BgeeiQ9CWW7.
CleanExiMM_CXXC1.
ExpressionAtlasiQ9CWW7. baseline and differential.
GenevisibleiQ9CWW7. MM.

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A (By similarity). Interacts with ZNF335 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216665. 24 interactions.
IntActiQ9CWW7. 21 interactions.
STRINGi10090.ENSMUSP00000025444.

Structurei

3D structure databases

ProteinModelPortaliQ9CWW7.
SMRiQ9CWW7. Positions 27-73, 169-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili426 – 47954Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1616Poly-Gln
Compositional biasi260 – 32162Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi325 – 36339Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri28 – 7649PHD-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri164 – 21350CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1632. Eukaryota.
ENOG410YG6P. LUCA.
GeneTreeiENSGT00730000111044.
HOGENOMiHOG000116258.
HOVERGENiHBG051274.
InParanoidiQ9CWW7.
KOiK14960.
OMAiCEPCRRT.
OrthoDBiEOG7FXZZ0.
PhylomeDBiQ9CWW7.
TreeFamiTF320326.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022056. CpG-bd_C.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF12269. zf-CpG_bind_C. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDGSDLEP PDAGDDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKCR ERDGSERAGS
110 120 130 140 150
EPRDEGGGRK RPASDPELQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHHQQQQ QQQQQIKRSA RMCGECEACR RTEDCGHCDF CRDMKKFGGP
210 220 230 240 250
NKIRQKCRLR QCQLRARESY KYFPSSLSPV TPSEALPRPR RPPPTQQQPQ
260 270 280 290 300
QSQKLGRIRE DEGTVLSSVV KEPPEATATP EPLSDEDLAL DPDLYQDFCA
310 320 330 340 350
GAFDDHGLPW MSDAEESPFL DPALRKRAVK VKHVKRREKK SEKKKEERYK
360 370 380 390 400
RHRQKQKHKD KWKHPERADA KDPASLPQCL GPGCVRAAQP GSKYCSDDCG
410 420 430 440 450
MKLAANRIYE ILPQRIQQWQ QSPCIAEEHG KKLLERIRRE QQSARTRLQE
460 470 480 490 500
MERRFHELEA IILRAKQQAV REDEENNEND SDDTDLQIFC VSCGHPINPR
510 520 530 540 550
VALRHMERCY AKYESQTSFG SMYPTRIEGA TRLFCDVYNP QSKTYCKRLQ
560 570 580 590 600
VLCPEHSRDP KVPADEVCGC PLVRDVFELT GDFCRLPKRQ CNRHYCWEKL
610 620 630 640 650
RRAEVDLERV RVWYKLDELF EQERNVRTAM TNRAGLLALM LHQTIQHDPL
660
TTDLRSSADR
Length:660
Mass (Da):76,167
Last modified:June 1, 2001 - v1
Checksum:i9D92CB6DA82069EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010337 mRNA. Translation: BAB26862.1.
AK083655 mRNA. Translation: BAC38986.1.
BC030938 mRNA. Translation: AAH30938.1.
CCDSiCCDS50320.1.
RefSeqiNP_083144.1. NM_028868.3.
UniGeneiMm.17537.

Genome annotation databases

EnsembliENSMUST00000025444; ENSMUSP00000025444; ENSMUSG00000024560.
GeneIDi74322.
KEGGimmu:74322.
UCSCiuc008fpg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010337 mRNA. Translation: BAB26862.1.
AK083655 mRNA. Translation: BAC38986.1.
BC030938 mRNA. Translation: AAH30938.1.
CCDSiCCDS50320.1.
RefSeqiNP_083144.1. NM_028868.3.
UniGeneiMm.17537.

3D structure databases

ProteinModelPortaliQ9CWW7.
SMRiQ9CWW7. Positions 27-73, 169-221.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216665. 24 interactions.
IntActiQ9CWW7. 21 interactions.
STRINGi10090.ENSMUSP00000025444.

PTM databases

iPTMnetiQ9CWW7.
PhosphoSiteiQ9CWW7.

Proteomic databases

EPDiQ9CWW7.
MaxQBiQ9CWW7.
PaxDbiQ9CWW7.
PRIDEiQ9CWW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025444; ENSMUSP00000025444; ENSMUSG00000024560.
GeneIDi74322.
KEGGimmu:74322.
UCSCiuc008fpg.1. mouse.

Organism-specific databases

CTDi30827.
MGIiMGI:1921572. Cxxc1.

Phylogenomic databases

eggNOGiKOG1632. Eukaryota.
ENOG410YG6P. LUCA.
GeneTreeiENSGT00730000111044.
HOGENOMiHOG000116258.
HOVERGENiHBG051274.
InParanoidiQ9CWW7.
KOiK14960.
OMAiCEPCRRT.
OrthoDBiEOG7FXZZ0.
PhylomeDBiQ9CWW7.
TreeFamiTF320326.

Miscellaneous databases

ChiTaRSiCxxc1. mouse.
NextBioi340449.
PROiQ9CWW7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWW7.
CleanExiMM_CXXC1.
ExpressionAtlasiQ9CWW7. baseline and differential.
GenevisibleiQ9CWW7. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR022056. CpG-bd_C.
IPR019786. Zinc_finger_PHD-type_CS.
IPR002857. Znf_CXXC.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF12269. zf-CpG_bind_C. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS51058. ZF_CXXC. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiCXXC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.