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Protein

CXXC-type zinc finger protein 1

Gene

Cxxc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri164 – 213CXXC-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
CXXC-type zinc finger protein 1
Alternative name(s):
CpG-binding protein
PHD finger and CXXC domain-containing protein 1
Gene namesi
Name:Cxxc1
Synonyms:Cgbp, Pccx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1921572 Cxxc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000797441 – 660CXXC-type zinc finger protein 1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
Modified residuei231PhosphothreonineBy similarity1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CWW7
MaxQBiQ9CWW7
PaxDbiQ9CWW7
PRIDEiQ9CWW7

PTM databases

iPTMnetiQ9CWW7
PhosphoSitePlusiQ9CWW7
SwissPalmiQ9CWW7

Expressioni

Gene expression databases

BgeeiENSMUSG00000024560
CleanExiMM_CXXC1
ExpressionAtlasiQ9CWW7 baseline and differential
GenevisibleiQ9CWW7 MM

Interactioni

Subunit structurei

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Interacts with SETD1A (By similarity). Interacts with ZNF335 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216665, 24 interactors
IntActiQ9CWW7, 21 interactors
STRINGi10090.ENSMUSP00000025444

Structurei

3D structure databases

ProteinModelPortaliQ9CWW7
SMRiQ9CWW7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili426 – 479Sequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 161Poly-Gln6
Compositional biasi260 – 321Asp/Glu-rich (acidic)Add BLAST62
Compositional biasi325 – 363Arg/Lys-rich (basic)Add BLAST39

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri28 – 76PHD-typePROSITE-ProRule annotationAdd BLAST49
Zinc fingeri164 – 213CXXC-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1632 Eukaryota
ENOG410YG6P LUCA
GeneTreeiENSGT00730000111044
HOGENOMiHOG000116258
HOVERGENiHBG051274
InParanoidiQ9CWW7
KOiK14960
OMAiCINITEK
OrthoDBiEOG091G05JX
PhylomeDBiQ9CWW7
TreeFamiTF320326

Family and domain databases

InterProiView protein in InterPro
IPR022056 CpG-bd_C
IPR037852 CXXC1
IPR019786 Zinc_finger_PHD-type_CS
IPR002857 Znf_CXXC
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
PANTHERiPTHR12321:SF58 PTHR12321:SF58, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 1 hit
PF12269 zf-CpG_bind_C, 1 hit
PF02008 zf-CXXC, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS51058 ZF_CXXC, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDGSDLEP PDAGDDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF
60 70 80 90 100
HGDCIRITEK MAKAIREWYC RECREKDPKL EIRYRHKKCR ERDGSERAGS
110 120 130 140 150
EPRDEGGGRK RPASDPELQR RAGSGTGVGA MLARGSASPH KSSPQPLVAT
160 170 180 190 200
PSQHHHQQQQ QQQQQIKRSA RMCGECEACR RTEDCGHCDF CRDMKKFGGP
210 220 230 240 250
NKIRQKCRLR QCQLRARESY KYFPSSLSPV TPSEALPRPR RPPPTQQQPQ
260 270 280 290 300
QSQKLGRIRE DEGTVLSSVV KEPPEATATP EPLSDEDLAL DPDLYQDFCA
310 320 330 340 350
GAFDDHGLPW MSDAEESPFL DPALRKRAVK VKHVKRREKK SEKKKEERYK
360 370 380 390 400
RHRQKQKHKD KWKHPERADA KDPASLPQCL GPGCVRAAQP GSKYCSDDCG
410 420 430 440 450
MKLAANRIYE ILPQRIQQWQ QSPCIAEEHG KKLLERIRRE QQSARTRLQE
460 470 480 490 500
MERRFHELEA IILRAKQQAV REDEENNEND SDDTDLQIFC VSCGHPINPR
510 520 530 540 550
VALRHMERCY AKYESQTSFG SMYPTRIEGA TRLFCDVYNP QSKTYCKRLQ
560 570 580 590 600
VLCPEHSRDP KVPADEVCGC PLVRDVFELT GDFCRLPKRQ CNRHYCWEKL
610 620 630 640 650
RRAEVDLERV RVWYKLDELF EQERNVRTAM TNRAGLLALM LHQTIQHDPL
660
TTDLRSSADR
Length:660
Mass (Da):76,167
Last modified:June 1, 2001 - v1
Checksum:i9D92CB6DA82069EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010337 mRNA Translation: BAB26862.1
AK083655 mRNA Translation: BAC38986.1
BC030938 mRNA Translation: AAH30938.1
CCDSiCCDS50320.1
RefSeqiNP_083144.1, NM_028868.3
UniGeneiMm.17537

Genome annotation databases

EnsembliENSMUST00000025444; ENSMUSP00000025444; ENSMUSG00000024560
GeneIDi74322
KEGGimmu:74322
UCSCiuc008fpg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCXXC1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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