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Protein

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Gene

Pin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC:5.2.1.8)
Alternative name(s):
Parvulin-14
Short name:
Par14
Peptidyl-prolyl cis-trans isomerase Pin4
Short name:
PPIase Pin4
Rotamase Pin4
Gene namesi
Name:Pin4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1916963 Pin4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934391 – 131Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphoserine; by CK2By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation occurs both in the nucleus and the cytoplasm. Phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated form associates with the pre-rRNP complexes in the nucleus (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWW6
MaxQBiQ9CWW6
PaxDbiQ9CWW6
PeptideAtlasiQ9CWW6
PRIDEiQ9CWW6

PTM databases

iPTMnetiQ9CWW6
PhosphoSitePlusiQ9CWW6

Expressioni

Gene expression databases

BgeeiENSMUSG00000079480
GenevisibleiQ9CWW6 MM

Interactioni

Subunit structurei

Found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.1 Publication

Protein-protein interaction databases

IntActiQ9CWW6, 1 interactor
MINTiQ9CWW6
STRINGi10090.ENSMUSP00000109257

Structurei

3D structure databases

ProteinModelPortaliQ9CWW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 129PpiCPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 41Necessary for association with the pre-rRNP complexesBy similarityAdd BLAST41
Regioni1 – 25Necessary for nuclear localization and DNA-bindingBy similarityAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3258 Eukaryota
COG0760 LUCA
GeneTreeiENSGT00510000047029
HOGENOMiHOG000275330
HOVERGENiHBG019150
InParanoidiQ9CWW6
KOiK09579
OMAiLGWKTKG
OrthoDBiEOG091G0Z6N
PhylomeDBiQ9CWW6
TreeFamiTF101102

Family and domain databases

InterProiView protein in InterPro
IPR000297 PPIase_PpiC
PROSITEiView protein in PROSITE
PS50198 PPIC_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKGKSGSG KGGKGGAASG SDSADKKSQG PKGGGNAVKV RHILCEKHGK
60 70 80 90 100
IMEAMEKLKS GMRFSEVATQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA
110 120 130
LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K
Length:131
Mass (Da):13,815
Last modified:June 1, 2001 - v1
Checksum:i290BDEF72DC69CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010338 mRNA Translation: BAB26863.1
AL807784 Genomic DNA Translation: CAM24632.1
CH466564 Genomic DNA Translation: EDL14129.1
BC119355 mRNA Translation: AAI19356.1
BC119357 mRNA Translation: AAI19358.1
CCDSiCCDS41082.1
RefSeqiNP_081457.1, NM_027181.1
XP_011249230.1, XM_011250928.1
UniGeneiMm.371635

Genome annotation databases

EnsembliENSMUST00000113627; ENSMUSP00000109257; ENSMUSG00000079480
GeneIDi105247253
69713
KEGGimmu:105247253
mmu:69713
UCSCiuc009tyj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPIN4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWW6
Secondary accession number(s): Q0VE57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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