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Protein

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Gene

Pin4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC:5.2.1.8)
Alternative name(s):
Parvulin-14
Short name:
Par14
Peptidyl-prolyl cis-trans isomerase Pin4
Short name:
PPIase Pin4
Rotamase Pin4
Gene namesi
Name:Pin4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1916963. Pin4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934391 – 131Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Phosphoserine; by CK2By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation occurs both in the nucleus and the cytoplasm. Phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated form associates with the pre-rRNP complexes in the nucleus (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWW6.
MaxQBiQ9CWW6.
PaxDbiQ9CWW6.
PeptideAtlasiQ9CWW6.
PRIDEiQ9CWW6.

PTM databases

iPTMnetiQ9CWW6.
PhosphoSitePlusiQ9CWW6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079480.
GenevisibleiQ9CWW6. MM.

Interactioni

Subunit structurei

Found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.1 Publication

Protein-protein interaction databases

IntActiQ9CWW6. 1 interactor.
STRINGi10090.ENSMUSP00000109257.

Structurei

3D structure databases

ProteinModelPortaliQ9CWW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 129PpiCPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 41Necessary for association with the pre-rRNP complexesBy similarityAdd BLAST41
Regioni1 – 25Necessary for nuclear localization and DNA-bindingBy similarityAdd BLAST25

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3258. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00510000047029.
HOGENOMiHOG000275330.
HOVERGENiHBG019150.
InParanoidiQ9CWW6.
KOiK09579.
OMAiHIIMIEG.
OrthoDBiEOG091G0Z6N.
PhylomeDBiQ9CWW6.
TreeFamiTF101102.

Family and domain databases

InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
PROSITEiView protein in PROSITE
PS50198. PPIC_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKGKSGSG KGGKGGAASG SDSADKKSQG PKGGGNAVKV RHILCEKHGK
60 70 80 90 100
IMEAMEKLKS GMRFSEVATQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA
110 120 130
LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K
Length:131
Mass (Da):13,815
Last modified:June 1, 2001 - v1
Checksum:i290BDEF72DC69CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010338 mRNA. Translation: BAB26863.1.
AL807784 Genomic DNA. Translation: CAM24632.1.
CH466564 Genomic DNA. Translation: EDL14129.1.
BC119355 mRNA. Translation: AAI19356.1.
BC119357 mRNA. Translation: AAI19358.1.
CCDSiCCDS41082.1.
RefSeqiNP_081457.1. NM_027181.1.
XP_011249230.1. XM_011250928.1.
UniGeneiMm.371635.

Genome annotation databases

EnsembliENSMUST00000113627; ENSMUSP00000109257; ENSMUSG00000079480.
GeneIDi105247253.
69713.
KEGGimmu:105247253.
mmu:69713.
UCSCiuc009tyj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010338 mRNA. Translation: BAB26863.1.
AL807784 Genomic DNA. Translation: CAM24632.1.
CH466564 Genomic DNA. Translation: EDL14129.1.
BC119355 mRNA. Translation: AAI19356.1.
BC119357 mRNA. Translation: AAI19358.1.
CCDSiCCDS41082.1.
RefSeqiNP_081457.1. NM_027181.1.
XP_011249230.1. XM_011250928.1.
UniGeneiMm.371635.

3D structure databases

ProteinModelPortaliQ9CWW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWW6. 1 interactor.
STRINGi10090.ENSMUSP00000109257.

PTM databases

iPTMnetiQ9CWW6.
PhosphoSitePlusiQ9CWW6.

Proteomic databases

EPDiQ9CWW6.
MaxQBiQ9CWW6.
PaxDbiQ9CWW6.
PeptideAtlasiQ9CWW6.
PRIDEiQ9CWW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113627; ENSMUSP00000109257; ENSMUSG00000079480.
GeneIDi105247253.
69713.
KEGGimmu:105247253.
mmu:69713.
UCSCiuc009tyj.1. mouse.

Organism-specific databases

CTDi5303.
MGIiMGI:1916963. Pin4.

Phylogenomic databases

eggNOGiKOG3258. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00510000047029.
HOGENOMiHOG000275330.
HOVERGENiHBG019150.
InParanoidiQ9CWW6.
KOiK09579.
OMAiHIIMIEG.
OrthoDBiEOG091G0Z6N.
PhylomeDBiQ9CWW6.
TreeFamiTF101102.

Miscellaneous databases

PROiPR:Q9CWW6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079480.
GenevisibleiQ9CWW6. MM.

Family and domain databases

InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
PROSITEiView protein in PROSITE
PS50198. PPIC_PPIASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIN4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWW6
Secondary accession number(s): Q0VE57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: March 15, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.