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Protein

Palmitoyltransferase ZDHHC13

Gene

Zdhhc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Palmitoyltransferase for HD and GAD2 (PubMed:19299482). May play a role in Mg2+ transport (PubMed:18794299).2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei456 – 4561S-palmitoyl cysteine intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Huntingtin-interacting protein 14-related protein1 Publication
Short name:
HIP14-related protein1 Publication
Zinc finger DHHC domain-containing protein 13Imported
Short name:
DHHC-131 Publication
Gene namesi
Name:Zdhhc13Imported
Synonyms:Hip14l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919227. Zdhhc13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei292 – 31221HelicalSequence analysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei372 – 39221HelicalSequence analysisAdd
BLAST
Transmembranei471 – 49121HelicalSequence analysisAdd
BLAST
Transmembranei519 – 53921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • Golgi apparatus Source: UniProtKB
  • Golgi-associated vesicle membrane Source: UniProtKB
  • Golgi membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Palmitoyltransferase ZDHHC13PRO_0000212889Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ9CWU2.
MaxQBiQ9CWU2.
PaxDbiQ9CWU2.
PeptideAtlasiQ9CWU2.
PRIDEiQ9CWU2.

PTM databases

iPTMnetiQ9CWU2.
PhosphoSiteiQ9CWU2.
SwissPalmiQ9CWU2.

Expressioni

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiQ9CWU2.
CleanExiMM_ZDHHC13.
ExpressionAtlasiQ9CWU2. baseline and differential.
GenevisibleiQ9CWU2. MM.

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635).2 Publications

Protein-protein interaction databases

BioGridi232597. 4 interactions.
IntActiQ9CWU2. 1 interaction.
MINTiMINT-4140521.
STRINGi10090.ENSMUSP00000112498.

Structurei

3D structure databases

ProteinModelPortaliQ9CWU2.
SMRiQ9CWU2. Positions 15-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 7836ANK 1By similarityAdd
BLAST
Repeati81 – 11030ANK 2Sequence analysisAdd
BLAST
Repeati115 – 14430ANK 3Sequence analysisAdd
BLAST
Repeati148 – 17730ANK 4Sequence analysisAdd
BLAST
Repeati181 – 21131ANK 5Sequence analysisAdd
BLAST
Repeati216 – 24530ANK 6Sequence analysisAdd
BLAST
Repeati249 – 27729ANK 7Sequence analysisAdd
BLAST
Domaini426 – 47651DHHCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi328 – 39164Phe-richAdd
BLAST

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 DHHC domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ9CWU2.
KOiK20032.
OMAiHCATTFR.
OrthoDBiEOG70S74V.
PhylomeDBiQ9CWU2.
TreeFamiTF317342.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030290. ZDHHC13.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF16. PTHR24161:SF16. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGSHVP GFGRHGICVH ENKELAKAKE ILPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDR ENVSLLHWAA INNRLELVKF
110 120 130 140 150
YISKGAVIDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA YKVIGPEPTG
210 220 230 240 250
FLLKFNPSLS VVDKTHQNTP LHWAVAAGNV SAVDKLLEAG SSLDIRNAKG
260 270 280 290 300
ETPLDMALQS KNQLISHMLR TEAKMRANKQ FRLWRWLHKC ELFLLLILSM
310 320 330 340 350
ITLWAVGYIL DFNSDSWLLK GCLLVALFFL TSLFPRFLVG YKNLVYLPTV
360 370 380 390 400
FLLSSIFWIF MTWFILFFPD TAGSPLYFAF IFSIMAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEERK VNIVTLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNSCVA
460 470 480 490 500
RFDQHCFWTG RCIGFGNHHH YIFFLLSLSM VCDWIIYGSF VYWSNHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYIFMLAAFH FSWSTFLLIN QLFQIAFLGL
560 570 580 590 600
TSHERISLLK QSRHMKQTLS LRKTPYNLGF TQNLADFFQC GCFGLVKPCI
610 620
IDWTSQYTMV FHPAKEKVLR SV
Length:622
Mass (Da):70,890
Last modified:March 1, 2003 - v2
Checksum:iC34EB8AB76899E72
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101Q → L in BAE26700 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010382 mRNA. Translation: BAB26899.2.
AK145855 mRNA. Translation: BAE26700.1.
AK146196 mRNA. Translation: BAE26970.1.
BC046599 mRNA. Translation: AAH46599.1.
CCDSiCCDS52259.1.
RefSeqiNP_082307.1. NM_028031.3.
UniGeneiMm.279116.

Genome annotation databases

EnsembliENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471.
GeneIDi243983.
KEGGimmu:243983.
UCSCiuc009haw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010382 mRNA. Translation: BAB26899.2.
AK145855 mRNA. Translation: BAE26700.1.
AK146196 mRNA. Translation: BAE26970.1.
BC046599 mRNA. Translation: AAH46599.1.
CCDSiCCDS52259.1.
RefSeqiNP_082307.1. NM_028031.3.
UniGeneiMm.279116.

3D structure databases

ProteinModelPortaliQ9CWU2.
SMRiQ9CWU2. Positions 15-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi232597. 4 interactions.
IntActiQ9CWU2. 1 interaction.
MINTiMINT-4140521.
STRINGi10090.ENSMUSP00000112498.

PTM databases

iPTMnetiQ9CWU2.
PhosphoSiteiQ9CWU2.
SwissPalmiQ9CWU2.

Proteomic databases

EPDiQ9CWU2.
MaxQBiQ9CWU2.
PaxDbiQ9CWU2.
PeptideAtlasiQ9CWU2.
PRIDEiQ9CWU2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471.
GeneIDi243983.
KEGGimmu:243983.
UCSCiuc009haw.1. mouse.

Organism-specific databases

CTDi54503.
MGIiMGI:1919227. Zdhhc13.

Phylogenomic databases

eggNOGiKOG0509. Eukaryota.
COG0666. LUCA.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000290181.
HOVERGENiHBG051907.
InParanoidiQ9CWU2.
KOiK20032.
OMAiHCATTFR.
OrthoDBiEOG70S74V.
PhylomeDBiQ9CWU2.
TreeFamiTF317342.

Miscellaneous databases

PROiQ9CWU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWU2.
CleanExiMM_ZDHHC13.
ExpressionAtlasiQ9CWU2. baseline and differential.
GenevisibleiQ9CWU2. MM.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR030290. ZDHHC13.
IPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PANTHERiPTHR24161:SF16. PTHR24161:SF16. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF01529. zf-DHHC. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50216. DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  3. "Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport."
    Goytain A., Hines R.M., Quamme G.A.
    J. Biol. Chem. 283:33365-33374(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION.
  4. "Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity."
    Huang K., Sanders S., Singaraja R., Orban P., Cijsouw T., Arstikaitis P., Yanai A., Hayden M.R., El-Husseini A.
    FASEB J. 23:2605-2615(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  6. "The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity."
    Lemonidis K., Gorleku O.A., Sanchez-Perez M.C., Grefen C., Chamberlain L.H.
    Mol. Biol. Cell 25:3870-3883(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DNAJC5 AND SNAP25, SUBCELLULAR LOCATION.
  7. "Identification of a novel sequence motif recognized by the ankyrin repeat domain of zDHHC17/13 S-acyltransferases."
    Lemonidis K., Sanchez-Perez M.C., Chamberlain L.H.
    J. Biol. Chem. 290:21939-21950(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CLIP3; DNAJC5; HTT; MAP6; SNAP23 AND SNAP25.

Entry informationi

Entry nameiZDH13_MOUSE
AccessioniPrimary (citable) accession number: Q9CWU2
Secondary accession number(s): Q3UK32, Q3UKV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.