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Protein

Palmitoyltransferase ZDHHC13

Gene

Zdhhc13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Palmitoyltransferase for HTT and GAD2 (PubMed:19299482). May play a role in Mg2+ transport (PubMed:18794299).2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei456S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: UniProtKB
  • palmitoyltransferase activity Source: UniProtKB
  • protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC13Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Huntingtin-interacting protein 14-related protein1 Publication
Short name:
HIP14-related protein1 Publication
Zinc finger DHHC domain-containing protein 13Imported
Short name:
DHHC-131 Publication
Gene namesi
Name:Zdhhc13Imported
Synonyms:Hip14l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1919227 Zdhhc13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128891 – 622Palmitoyltransferase ZDHHC13Add BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate

Proteomic databases

EPDiQ9CWU2
MaxQBiQ9CWU2
PaxDbiQ9CWU2
PeptideAtlasiQ9CWU2
PRIDEiQ9CWU2

PTM databases

iPTMnetiQ9CWU2
PhosphoSitePlusiQ9CWU2
SwissPalmiQ9CWU2

Expressioni

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiENSMUSG00000030471
CleanExiMM_ZDHHC13
ExpressionAtlasiQ9CWU2 baseline and differential
GenevisibleiQ9CWU2 MM

Interactioni

Subunit structurei

Interacts (via ANK repeats) with CLIP3 (PubMed:26198635). Interacts (via ANK repeats) with DNAJC5 (via C-terminus) (PubMed:25253725, PubMed:26198635). Interacts (via ANK repeats) with HTT (PubMed:26198635). Interacts (via ANK repeats) with MAP6 (PubMed:26198635). Interacts (via ANK repeats) with SNAP23 (PubMed:26198635). Interacts (via ANK repeats) with SNAP25 (PubMed:25253725, PubMed:26198635). May interact (via ANK repeats) with SPRED2 (PubMed:28882895).3 Publications

Protein-protein interaction databases

BioGridi232597, 4 interactors
IntActiQ9CWU2, 1 interactor
MINTiQ9CWU2
STRINGi10090.ENSMUSP00000112498

Structurei

3D structure databases

ProteinModelPortaliQ9CWU2
SMRiQ9CWU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 78ANK 1By similarityAdd BLAST36
Repeati81 – 110ANK 2Sequence analysisAdd BLAST30
Repeati115 – 144ANK 3Sequence analysisAdd BLAST30
Repeati148 – 177ANK 4Sequence analysisAdd BLAST30
Repeati181 – 211ANK 5Sequence analysisAdd BLAST31
Repeati216 – 245ANK 6Sequence analysisAdd BLAST30
Repeati249 – 277ANK 7Sequence analysisAdd BLAST29
Domaini426 – 476DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi328 – 391Phe-richAdd BLAST64

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0509 Eukaryota
COG0666 LUCA
COG5273 LUCA
GeneTreeiENSGT00530000063074
HOGENOMiHOG000290181
HOVERGENiHBG051907
InParanoidiQ9CWU2
KOiK20032
OMAiQCRNHSH
OrthoDBiEOG091G056H
PhylomeDBiQ9CWU2
TreeFamiTF317342

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001594 Palmitoyltrfase_DHHC
IPR030290 ZDHHC13
PANTHERiPTHR24161:SF16 PTHR24161:SF16, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF01529 DHHC, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CWU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGPGLGSQC RNHSHGSHVP GFGRHGICVH ENKELAKAKE ILPLIEDSSN
60 70 80 90 100
CDIVKATQYG IFERCKELVE AGYDVRQPDR ENVSLLHWAA INNRLELVKF
110 120 130 140 150
YISKGAVIDQ LGGDLNSTPL HWAIRQGHLP MVILLLQHGA DPTLIDGEGF
160 170 180 190 200
SSIHLAVLFQ HMPIIAYLIS KGQSVNMTDV NGQTPLMLSA YKVIGPEPTG
210 220 230 240 250
FLLKFNPSLS VVDKTHQNTP LHWAVAAGNV SAVDKLLEAG SSLDIRNAKG
260 270 280 290 300
ETPLDMALQS KNQLISHMLR TEAKMRANKQ FRLWRWLHKC ELFLLLILSM
310 320 330 340 350
ITLWAVGYIL DFNSDSWLLK GCLLVALFFL TSLFPRFLVG YKNLVYLPTV
360 370 380 390 400
FLLSSIFWIF MTWFILFFPD TAGSPLYFAF IFSIMAFLYF FYKTWATDPG
410 420 430 440 450
FTKASEEERK VNIVTLAETG SLDFRTFCTS CLIRKPLRSL HCHVCNSCVA
460 470 480 490 500
RFDQHCFWTG RCIGFGNHHH YIFFLLSLSM VCDWIIYGSF VYWSNHCATT
510 520 530 540 550
FKEDGLWTYL NQIVACSPWV LYIFMLAAFH FSWSTFLLIN QLFQIAFLGL
560 570 580 590 600
TSHERISLLK QSRHMKQTLS LRKTPYNLGF TQNLADFFQC GCFGLVKPCI
610 620
IDWTSQYTMV FHPAKEKVLR SV
Length:622
Mass (Da):70,890
Last modified:March 1, 2003 - v2
Checksum:iC34EB8AB76899E72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti110Q → L in BAE26700 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010382 mRNA Translation: BAB26899.2
AK145855 mRNA Translation: BAE26700.1
AK146196 mRNA Translation: BAE26970.1
BC046599 mRNA Translation: AAH46599.1
CCDSiCCDS52259.1
RefSeqiNP_082307.1, NM_028031.3
UniGeneiMm.279116

Genome annotation databases

EnsembliENSMUST00000118927; ENSMUSP00000112498; ENSMUSG00000030471
GeneIDi243983
KEGGimmu:243983
UCSCiuc009haw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiZDH13_MOUSE
AccessioniPrimary (citable) accession number: Q9CWU2
Secondary accession number(s): Q3UK32, Q3UKV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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