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Protein

Sorting nexin-10

Gene

Snx10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Phosphatidylinositol 3-phosphateBy similarity
Binding sitei79 – 791Phosphatidylinositol 3-phosphateBy similarity
Binding sitei94 – 941Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-10
Gene namesi
Name:Snx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919232. Snx10.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: Ensembl
  • endoplasmic reticulum Source: UniProtKB
  • endosome Source: GO_Central
  • extrinsic component of endosome membrane Source: UniProtKB
  • extrinsic component of membrane Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Sorting nexin-10PRO_0000213855Add
BLAST

Proteomic databases

MaxQBiQ9CWT3.
PaxDbiQ9CWT3.
PRIDEiQ9CWT3.

PTM databases

iPTMnetiQ9CWT3.
PhosphoSiteiQ9CWT3.

Expressioni

Tissue specificityi

Expressed in femur, calvariae and teeth.1 Publication

Developmental stagei

Strongly up-regulated during osteoclastogenesis. Expressed in calvariae and developping teeth as early as 16.5 dpc (at protein level).1 Publication

Gene expression databases

BgeeiQ9CWT3.
CleanExiMM_SNX10.
ExpressionAtlasiQ9CWT3. baseline and differential.
GenevisibleiQ9CWT3. MM.

Interactioni

Subunit structurei

Interacts with ATP6V1D; may play a role in ciliogenesis.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044165.

Structurei

3D structure databases

ProteinModelPortaliQ9CWT3.
SMRiQ9CWT3. Positions 8-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 127118PXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 125118Required for interaction with ATP6V1DBy similarityAdd
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9CWT3.
KOiK17924.
OMAiYEIFIHT.
OrthoDBiEOG7GJ6FM.
PhylomeDBiQ9CWT3.
TreeFamiTF332117.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV
60 70 80 90 100
RRRYREFVWL RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED
110 120 130 140 150
FLRKVLQNAL LLSDSSLHLF LQSHLNSEDI EACVSGQTKY SVEEAIHKFA
160 170 180 190 200
LMNRRFPEEE EEGKKDADVE YDSESSSSGL GHSSDDSSSH GCKTSPALQE

S
Length:201
Mass (Da):23,542
Last modified:June 1, 2001 - v1
Checksum:i34F853BE23D23D80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681D → E in BAC25786 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010399 mRNA. Translation: BAB26910.1.
AK028163 mRNA. Translation: BAC25786.1.
BC010334 mRNA. Translation: AAH10334.1.
CCDSiCCDS20136.1.
RefSeqiNP_001120820.1. NM_001127348.1.
NP_001120821.1. NM_001127349.1.
NP_082311.3. NM_028035.4.
XP_006506716.1. XM_006506653.2.
UniGeneiMm.294166.

Genome annotation databases

EnsembliENSMUST00000049152; ENSMUSP00000044165; ENSMUSG00000038301.
ENSMUST00000114439; ENSMUSP00000110082; ENSMUSG00000038301.
ENSMUST00000179365; ENSMUSP00000136974; ENSMUSG00000038301.
GeneIDi71982.
KEGGimmu:71982.
UCSCiuc009bxs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010399 mRNA. Translation: BAB26910.1.
AK028163 mRNA. Translation: BAC25786.1.
BC010334 mRNA. Translation: AAH10334.1.
CCDSiCCDS20136.1.
RefSeqiNP_001120820.1. NM_001127348.1.
NP_001120821.1. NM_001127349.1.
NP_082311.3. NM_028035.4.
XP_006506716.1. XM_006506653.2.
UniGeneiMm.294166.

3D structure databases

ProteinModelPortaliQ9CWT3.
SMRiQ9CWT3. Positions 8-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044165.

PTM databases

iPTMnetiQ9CWT3.
PhosphoSiteiQ9CWT3.

Proteomic databases

MaxQBiQ9CWT3.
PaxDbiQ9CWT3.
PRIDEiQ9CWT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049152; ENSMUSP00000044165; ENSMUSG00000038301.
ENSMUST00000114439; ENSMUSP00000110082; ENSMUSG00000038301.
ENSMUST00000179365; ENSMUSP00000136974; ENSMUSG00000038301.
GeneIDi71982.
KEGGimmu:71982.
UCSCiuc009bxs.2. mouse.

Organism-specific databases

CTDi29887.
MGIiMGI:1919232. Snx10.

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9CWT3.
KOiK17924.
OMAiYEIFIHT.
OrthoDBiEOG7GJ6FM.
PhylomeDBiQ9CWT3.
TreeFamiTF332117.

Miscellaneous databases

ChiTaRSiSnx10. mouse.
PROiQ9CWT3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWT3.
CleanExiMM_SNX10.
ExpressionAtlasiQ9CWT3. baseline and differential.
GenevisibleiQ9CWT3. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. "SNX10 is required for osteoclast formation and resorption activity."
    Zhu C.H., Morse L.R., Battaglino R.A.
    J. Cell. Biochem. 113:1608-1615(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OSTEOCLASTOGENESIS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSNX10_MOUSE
AccessioniPrimary (citable) accession number: Q9CWT3
Secondary accession number(s): Q8C1E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.