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Protein

Integrator complex subunit 11

Gene

Cpsf3l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 11 (EC:3.1.27.-)
Short name:
Int11
Alternative name(s):
Cleavage and polyadenylation-specific factor 3-like protein
Short name:
CPSF3-like protein
Gene namesi
Name:Cpsf3l
Synonyms:Ints11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919207. Cpsf3l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595641 – 600Integrator complex subunit 11Add BLAST600

Proteomic databases

EPDiQ9CWS4.
MaxQBiQ9CWS4.
PaxDbiQ9CWS4.
PRIDEiQ9CWS4.

PTM databases

iPTMnetiQ9CWS4.
PhosphoSitePlusiQ9CWS4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029034.
ExpressionAtlasiQ9CWS4. baseline and differential.
GenevisibleiQ9CWS4. MM.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.By similarity

Protein-protein interaction databases

IntActiQ9CWS4. 1 interactor.
MINTiMINT-4125626.
STRINGi10090.ENSMUSP00000030901.

Structurei

3D structure databases

ProteinModelPortaliQ9CWS4.
SMRiQ9CWS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi68 – 73HXHXDH motif6

Domaini

The HXHXDH motif is essential for the endoribonuclease activity of the CPSF complex.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1137. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00860000133746.
HOGENOMiHOG000231294.
HOVERGENiHBG080215.
InParanoidiQ9CWS4.
KOiK13148.
OMAiMHGTLIM.
OrthoDBiEOG091G03RH.
PhylomeDBiQ9CWS4.
TreeFamiTF105878.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR022712. Beta_Casp.
IPR001279. Metallo-B-lactamas.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF16661. Lactamase_B_6. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY
60 70 80 90 100
ITQSGRLTDF LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC
110 120 130 140 150
PILLEDYRKI AVDKKGEANF FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI
160 170 180 190 200
KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN MTPDRHLGAA WIDKCRPNLL
210 220 230 240 250
ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF ALGRAQELCI
260 270 280 290 300
LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF
310 320 330 340 350
EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM
360 370 380 390 400
PGYCVQGTVG HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ
410 420 430 440 450
LVGQAEPESV LLVHGEAKKM EFLRQKIEQE FRVSCYMPAN GETVTLPTSP
460 470 480 490 500
SIPVGISLGL LKREMVQGLL PEAKKPRLLH GTLIMKDSNF RLVSSEQALK
510 520 530 540 550
ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD HCVQHLPDGS
560 570 580 590 600
VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTTL LKNGLPQAPS
Length:600
Mass (Da):67,844
Last modified:June 1, 2001 - v1
Checksum:i1976D09E065BE2FA
GO

Sequence cautioni

The sequence AAH08240 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136V → D in AAH11155 (PubMed:15489334).Curated1
Sequence conflicti297R → G in BAE31460 (PubMed:16141072).Curated1
Sequence conflicti542C → R in BAE39661 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010425 mRNA. Translation: BAB26928.1.
AK090206 mRNA. Translation: BAC41135.1.
AK150436 mRNA. Translation: BAE29558.1.
AK152740 mRNA. Translation: BAE31460.1.
AK167607 mRNA. Translation: BAE39661.1.
AK172533 mRNA. Translation: BAE43054.1.
BC008240 mRNA. Translation: AAH08240.1. Different initiation.
BC011155 mRNA. Translation: AAH11155.1.
CCDSiCCDS19048.1.
RefSeqiNP_082296.1. NM_028020.3.
XP_006539258.1. XM_006539195.2.
UniGeneiMm.475640.

Genome annotation databases

EnsembliENSMUST00000030901; ENSMUSP00000030901; ENSMUSG00000029034.
GeneIDi71957.
KEGGimmu:71957.
UCSCiuc008wfh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010425 mRNA. Translation: BAB26928.1.
AK090206 mRNA. Translation: BAC41135.1.
AK150436 mRNA. Translation: BAE29558.1.
AK152740 mRNA. Translation: BAE31460.1.
AK167607 mRNA. Translation: BAE39661.1.
AK172533 mRNA. Translation: BAE43054.1.
BC008240 mRNA. Translation: AAH08240.1. Different initiation.
BC011155 mRNA. Translation: AAH11155.1.
CCDSiCCDS19048.1.
RefSeqiNP_082296.1. NM_028020.3.
XP_006539258.1. XM_006539195.2.
UniGeneiMm.475640.

3D structure databases

ProteinModelPortaliQ9CWS4.
SMRiQ9CWS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWS4. 1 interactor.
MINTiMINT-4125626.
STRINGi10090.ENSMUSP00000030901.

PTM databases

iPTMnetiQ9CWS4.
PhosphoSitePlusiQ9CWS4.

Proteomic databases

EPDiQ9CWS4.
MaxQBiQ9CWS4.
PaxDbiQ9CWS4.
PRIDEiQ9CWS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030901; ENSMUSP00000030901; ENSMUSG00000029034.
GeneIDi71957.
KEGGimmu:71957.
UCSCiuc008wfh.1. mouse.

Organism-specific databases

CTDi54973.
MGIiMGI:1919207. Cpsf3l.

Phylogenomic databases

eggNOGiKOG1137. Eukaryota.
COG1236. LUCA.
GeneTreeiENSGT00860000133746.
HOGENOMiHOG000231294.
HOVERGENiHBG080215.
InParanoidiQ9CWS4.
KOiK13148.
OMAiMHGTLIM.
OrthoDBiEOG091G03RH.
PhylomeDBiQ9CWS4.
TreeFamiTF105878.

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

PROiQ9CWS4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029034.
ExpressionAtlasiQ9CWS4. baseline and differential.
GenevisibleiQ9CWS4. MM.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR022712. Beta_Casp.
IPR001279. Metallo-B-lactamas.
IPR011108. RMMBL.
[Graphical view]
PfamiPF10996. Beta-Casp. 1 hit.
PF16661. Lactamase_B_6. 1 hit.
PF07521. RMMBL. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
SM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINT11_MOUSE
AccessioniPrimary (citable) accession number: Q9CWS4
Secondary accession number(s): Q3TJ34
, Q3U7B0, Q91X99, Q922F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.