Reviewed, UniProtKB/Swiss-Prot Q9CWR8 (DNM3L_MOUSE)

Names and origin

Protein names

Recommended name:
    DNA (cytosine-5)-methyltransferase 3-like

Gene names

Name:

Dnmt3l

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably not catalytically active as it has lost the active site residues. May function not directly as a DNA methyltransferase but as a regulator of methylation at imprinted loci. It is required specifically for the establishment of genomic imprints but is dispensable for their propagation. It is essential for the de novo methylation of single-copy DNA sequences. Ref.5
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in testis, thymus, ovary, and heart.
Sequence similarities	Belongs to the C5-methyltransferase family. Contains 1 ADD-type zinc finger.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Gene Ontology (GO)
Biological process	in utero embryonic development Inferred from mutant phenotype. Source: MGI
Cellular component	condensed nuclear chromosome Inferred from direct assay. Source: MGI cytoplasm Inferred from direct assay. Source: MGI nuclear heterochromatin Inferred from direct assay. Source: MGI
Molecular function	enzyme activator activity Inferred from direct assay. Source: MGI enzyme binding Inferred from sequence or structural similarity. Source: UniProtKB transcription repressor activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	DNA (cytosine-5)-methyltransferase 3-like		PRO_0000088048
Regions
	Zinc finger	87 – 179	93	ADD-type

Sequences

	Sequence		Length	Mass (Da)
	Q9CWR8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 6C996D220C6F6D83	FASTA	421	47,993
	10 20 30 40 50 60 MGSRETPSSC SKTLETLDLE TSDSSSPDAD SPLEEQWLKS SPALKEDSVD VVLEDCKEPL 70 80 90 100 110 120 SPSSPPTGRE MIRYEVKVNR RSIEDICLCC GTLQVYTRHP LFEGGLCAPC KDKFLESLFL 130 140 150 160 170 180 YDDDGHQSYC TICCSGGTLF ICESPDCTRC YCFECVDILV GPGTSERINA MACWVCFLCL 190 200 210 220 230 240 PFSRSGLLQR RKRWRHQLKA FHDQEGAGPM EIYKTVSAWK RQPVRVLSLF RNIDKVLKSL 250 260 270 280 290 300 GFLESGSGSG GGTLKYVEDV TNVVRRDVEK WGPFDLVYGS TQPLGSSCDR CPGWYMFQFH 310 320 330 340 350 360 RILQYALPRQ ESQRPFFWIF MDNLLLTEDD QETTTRFLQT EAVTLQDVRG RDYQNAMRVW 370 380 390 400 410 420 SNIPGLKSKH APLTPKEEEY LQAQVRSRSK LDAPKVDLLV KNCLLPLREY FKYFSQNSLP L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and initial characterization of the mouse Dnmt3l gene." Aapola U., Lyle R., Krohn K., Antonarakis S.E., Peterson P. Cytogenet. Cell Genet. 92:122-126(2001) [PubMed: 11306809] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Full-length cDNA of a murine Dnmt3-like gene." Shaoping X., Hata K., Li E. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryonic stem cell.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo.
[5]	"Dnmt3L and the establishment of maternal genomic imprints." Bourc'his D., Xu G.L., Lin C.S., Bollman B., Bestor T.H. Science 294:2536-2539(2001) [PubMed: 11719692] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ404467 mRNA. Translation: CAB94726.1. AF220524 mRNA. Translation: AAF73868.1. AK010434 mRNA. Translation: BAB26936.1. BC083147 mRNA. Translation: AAH83147.1.
IPI	IPI00109459.
RefSeq	NP_001075164.1. NP_062321.1.
UniGene	Mm.13433
3D structure databases
ModBase	Search...
Protein family/group databases
REBASE	6168. M.MmuDnmt4P.
PTM databases
PhosphoSite	Q9CWR8.
Genome annotation databases
Ensembl	ENSMUSG00000000730. Mus musculus. [Contig view]
GeneID	54427.
KEGG	mmu:54427.
NMPDR	fig|10090.3.peg.13929.
Organism-specific databases
MGI	MGI:1859287. Dnmt3l.
Phylogenomic databases
HOGENOM	Q9CWR8.
HOVERGEN	Q9CWR8.
OMA	Q9CWR8. NQRNIED.
Gene expression databases
ArrayExpress	Q9CWR8.
Bgee	Q9CWR8.
CleanEx	MM_DNMT3L.
GermOnline	ENSMUSG00000000730. Mus musculus.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	311304.
SOURCE	Search...

Entry information

Entry name

DNM3L_MOUSE

Accession

Primary (citable) accession number: Q9CWR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)