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Protein

Metalloreductase STEAP1

Gene

Steap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor.1 Publication

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi175Iron (heme axial ligand)By similarity1
Metal bindingi268Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Ion transport, Iron transport, Transport

Keywords - Ligandi

Copper, FAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Metalloreductase STEAP1 (EC:1.16.1.-)
Alternative name(s):
Six-transmembrane epithelial antigen of prostate 1
Gene namesi
Name:Steap1
Synonyms:Steap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917608. Steap1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei283 – 303HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endosome Source: MGI
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916951 – 339Metalloreductase STEAP1Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9CWR7.
PRIDEiQ9CWR7.

PTM databases

iPTMnetiQ9CWR7.
PhosphoSitePlusiQ9CWR7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015652.
ExpressionAtlasiQ9CWR7. baseline and differential.
GenevisibleiQ9CWR7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015796.

Structurei

3D structure databases

ProteinModelPortaliQ9CWR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini118 – 265Ferric oxidoreductaseAdd BLAST148

Sequence similaritiesi

Belongs to the STEAP family.Curated
Contains 1 ferric oxidoreductase domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEI2. Eukaryota.
ENOG4111C63. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
InParanoidiQ9CWR7.
KOiK14737.
OMAiHGWEDVT.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ9CWR7.
TreeFamiTF332031.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISDDVTNP EQLWKMKPKG NLEDDSYSTK DSGETSMLKR PGLSHLQHAV
60 70 80 90 100
HVDAFDCPSE LQHTQEFFPN WRLPVKVAAI ISSLTFLYTL LREIIYPLVT
110 120 130 140 150
SREQYFYKIP ILVINKVLPM VAITLLALVY LPGELAAVVQ LRNGTKYKKF
160 170 180 190 200
PPWLDRWMLA RKQFGLLSFF FAVLHAVYSL SYPMRRSYRY KLLNWAYKQV
210 220 230 240 250
QQNKEDAWVE HDVWRMEIYV SLGIVGLAIL ALLAVTSIPS VSDSLTWREF
260 270 280 290 300
HYIQSKLGIV SLLLGTVHAL VFAWNKWVDV SQFVWYMPPT FMIAVFLPTL
310 320 330
VLICKIALCL PCLRKKILKI RCGWEDVSKI NRTEMASRL
Length:339
Mass (Da):39,292
Last modified:May 10, 2005 - v2
Checksum:iBF63B35AEE4356A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161R → K in BAB26938 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010437 mRNA. Translation: BAB26938.1.
BC061023 mRNA. Translation: AAH61023.1.
CCDSiCCDS19077.1.
RefSeqiNP_081675.2. NM_027399.3.
UniGeneiMm.85429.

Genome annotation databases

EnsembliENSMUST00000015796; ENSMUSP00000015796; ENSMUSG00000015652.
GeneIDi70358.
KEGGimmu:70358.
UCSCiuc008wjb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010437 mRNA. Translation: BAB26938.1.
BC061023 mRNA. Translation: AAH61023.1.
CCDSiCCDS19077.1.
RefSeqiNP_081675.2. NM_027399.3.
UniGeneiMm.85429.

3D structure databases

ProteinModelPortaliQ9CWR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015796.

PTM databases

iPTMnetiQ9CWR7.
PhosphoSitePlusiQ9CWR7.

Proteomic databases

PaxDbiQ9CWR7.
PRIDEiQ9CWR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015796; ENSMUSP00000015796; ENSMUSG00000015652.
GeneIDi70358.
KEGGimmu:70358.
UCSCiuc008wjb.2. mouse.

Organism-specific databases

CTDi26872.
MGIiMGI:1917608. Steap1.

Phylogenomic databases

eggNOGiENOG410IEI2. Eukaryota.
ENOG4111C63. LUCA.
GeneTreeiENSGT00390000008042.
HOGENOMiHOG000252937.
HOVERGENiHBG062286.
InParanoidiQ9CWR7.
KOiK14737.
OMAiHGWEDVT.
OrthoDBiEOG091G0F9X.
PhylomeDBiQ9CWR7.
TreeFamiTF332031.

Miscellaneous databases

PROiQ9CWR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015652.
ExpressionAtlasiQ9CWR7. baseline and differential.
GenevisibleiQ9CWR7. MM.

Family and domain databases

InterProiIPR013130. Fe3_Rdtase_TM_dom.
[Graphical view]
PfamiPF01794. Ferric_reduct. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTEA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWR7
Secondary accession number(s): Q6P8X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.