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Q9CWP8

- DPOD4_MOUSE

UniProt

Q9CWP8 - DPOD4_MOUSE

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Protein

DNA polymerase delta subunit 4

Gene

Pold4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta (By similarity).By similarity

GO - Molecular functioni

  1. DNA-directed DNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of endothelial cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_216529. Removal of the Flap Intermediate from the C-strand.
REACT_219337. Removal of DNA patch containing abasic residue.
REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
REACT_223154. Processive synthesis on the C-strand of the telomere.
REACT_225604. Polymerase switching on the C-strand of the telomere.
REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 4
Alternative name(s):
DNA polymerase delta subunit p12
Gene namesi
Name:Pold4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1916995. Pold4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107DNA polymerase delta subunit 4PRO_0000186052Add
BLAST

Proteomic databases

PRIDEiQ9CWP8.

PTM databases

PhosphoSiteiQ9CWP8.

Expressioni

Gene expression databases

BgeeiQ9CWP8.
CleanExiMM_POLD4.
ExpressionAtlasiQ9CWP8. baseline and differential.
GenevestigatoriQ9CWP8.

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD2, POLD1 and PCNA (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70894.
GeneTreeiENSGT00390000005096.
HOGENOMiHOG000031022.
HOVERGENiHBG057838.
InParanoidiQ9CWP8.
KOiK03505.
OMAiQTHPGDP.
OrthoDBiEOG708W1X.
PhylomeDBiQ9CWP8.
TreeFamiTF103004.

Family and domain databases

InterProiIPR007218. DNA_pol_delta_4.
[Graphical view]
PfamiPF04081. DNA_pol_delta_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRKRFITDS YPVVKKREGP PGHSKGELAP ELGEDTQSLS QEETELELLR
60 70 80 90 100
QFDLAWQYGP CTGITRLQRW SRAEQMGLKP PLEVYQVLKA HPEDPHFQCS

LWHLYPL
Length:107
Mass (Da):12,403
Last modified:June 1, 2001 - v1
Checksum:i14A27054D4E7511E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010477 mRNA. Translation: BAB26970.1.
BC028520 mRNA. Translation: AAH28520.1.
CCDSiCCDS29424.1.
RefSeqiNP_081472.1. NM_027196.3.
UniGeneiMm.32518.

Genome annotation databases

EnsembliENSMUST00000025773; ENSMUSP00000025773; ENSMUSG00000024854.
ENSMUST00000180621; ENSMUSP00000137813; ENSMUSG00000097508.
GeneIDi69745.
KEGGimmu:69745.
UCSCiuc008fzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK010477 mRNA. Translation: BAB26970.1 .
BC028520 mRNA. Translation: AAH28520.1 .
CCDSi CCDS29424.1.
RefSeqi NP_081472.1. NM_027196.3.
UniGenei Mm.32518.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CWP8.

Proteomic databases

PRIDEi Q9CWP8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025773 ; ENSMUSP00000025773 ; ENSMUSG00000024854 .
ENSMUST00000180621 ; ENSMUSP00000137813 ; ENSMUSG00000097508 .
GeneIDi 69745.
KEGGi mmu:69745.
UCSCi uc008fzm.2. mouse.

Organism-specific databases

CTDi 57804.
MGIi MGI:1916995. Pold4.

Phylogenomic databases

eggNOGi NOG70894.
GeneTreei ENSGT00390000005096.
HOGENOMi HOG000031022.
HOVERGENi HBG057838.
InParanoidi Q9CWP8.
KOi K03505.
OMAi QTHPGDP.
OrthoDBi EOG708W1X.
PhylomeDBi Q9CWP8.
TreeFami TF103004.

Enzyme and pathway databases

Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_216529. Removal of the Flap Intermediate from the C-strand.
REACT_219337. Removal of DNA patch containing abasic residue.
REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
REACT_223154. Processive synthesis on the C-strand of the telomere.
REACT_225604. Polymerase switching on the C-strand of the telomere.
REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

Miscellaneous databases

NextBioi 330238.
PROi Q9CWP8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CWP8.
CleanExi MM_POLD4.
ExpressionAtlasi Q9CWP8. baseline and differential.
Genevestigatori Q9CWP8.

Family and domain databases

InterProi IPR007218. DNA_pol_delta_4.
[Graphical view ]
Pfami PF04081. DNA_pol_delta_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiDPOD4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3