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Protein

DNA polymerase delta subunit 4

Gene

Pold4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA-dependent DNA replication Source: Ensembl
  • positive regulation of endothelial cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiREACT_276436. Processive synthesis on the lagging strand.
REACT_278371. Processive synthesis on the C-strand of the telomere.
REACT_278538. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_283766. Polymerase switching.
REACT_290560. Leading Strand Synthesis.
REACT_303193. Removal of the Flap Intermediate.
REACT_304724. Telomere C-strand (Lagging Strand) Synthesis.
REACT_320650. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_329955. Removal of the Flap Intermediate from the C-strand.
REACT_330619. Polymerase switching on the C-strand of the telomere.
REACT_331202. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_342741. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_358684. Recognition of DNA damage by PCNA-containing replication complex.
REACT_361486. PCNA-Dependent Long Patch Base Excision Repair.
REACT_362050. Termination of translesion DNA synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 4
Alternative name(s):
DNA polymerase delta subunit p12
Gene namesi
Name:Pold4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

MGIiMGI:1916995. Pold4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107DNA polymerase delta subunit 4PRO_0000186052Add
BLAST

Proteomic databases

PRIDEiQ9CWP8.

PTM databases

PhosphoSiteiQ9CWP8.

Expressioni

Gene expression databases

BgeeiQ9CWP8.
CleanExiMM_POLD4.
ExpressionAtlasiQ9CWP8. baseline and differential.
GenevisibleiQ9CWP8. MM.

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD2, POLD1 and PCNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025773.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG70894.
GeneTreeiENSGT00390000005096.
HOGENOMiHOG000031022.
HOVERGENiHBG057838.
InParanoidiQ9CWP8.
KOiK03505.
OMAiQTHPGDP.
OrthoDBiEOG708W1X.
PhylomeDBiQ9CWP8.
TreeFamiTF103004.

Family and domain databases

InterProiIPR007218. DNA_pol_delta_4.
[Graphical view]
PfamiPF04081. DNA_pol_delta_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKRFITDS YPVVKKREGP PGHSKGELAP ELGEDTQSLS QEETELELLR
60 70 80 90 100
QFDLAWQYGP CTGITRLQRW SRAEQMGLKP PLEVYQVLKA HPEDPHFQCS

LWHLYPL
Length:107
Mass (Da):12,403
Last modified:June 1, 2001 - v1
Checksum:i14A27054D4E7511E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010477 mRNA. Translation: BAB26970.1.
BC028520 mRNA. Translation: AAH28520.1.
CCDSiCCDS29424.1.
RefSeqiNP_081472.1. NM_027196.3.
UniGeneiMm.32518.

Genome annotation databases

EnsembliENSMUST00000025773; ENSMUSP00000025773; ENSMUSG00000024854.
ENSMUST00000180621; ENSMUSP00000137813; ENSMUSG00000097508.
GeneIDi69745.
KEGGimmu:69745.
UCSCiuc008fzm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010477 mRNA. Translation: BAB26970.1.
BC028520 mRNA. Translation: AAH28520.1.
CCDSiCCDS29424.1.
RefSeqiNP_081472.1. NM_027196.3.
UniGeneiMm.32518.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025773.

PTM databases

PhosphoSiteiQ9CWP8.

Proteomic databases

PRIDEiQ9CWP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025773; ENSMUSP00000025773; ENSMUSG00000024854.
ENSMUST00000180621; ENSMUSP00000137813; ENSMUSG00000097508.
GeneIDi69745.
KEGGimmu:69745.
UCSCiuc008fzm.2. mouse.

Organism-specific databases

CTDi57804.
MGIiMGI:1916995. Pold4.

Phylogenomic databases

eggNOGiNOG70894.
GeneTreeiENSGT00390000005096.
HOGENOMiHOG000031022.
HOVERGENiHBG057838.
InParanoidiQ9CWP8.
KOiK03505.
OMAiQTHPGDP.
OrthoDBiEOG708W1X.
PhylomeDBiQ9CWP8.
TreeFamiTF103004.

Enzyme and pathway databases

ReactomeiREACT_276436. Processive synthesis on the lagging strand.
REACT_278371. Processive synthesis on the C-strand of the telomere.
REACT_278538. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
REACT_283766. Polymerase switching.
REACT_290560. Leading Strand Synthesis.
REACT_303193. Removal of the Flap Intermediate.
REACT_304724. Telomere C-strand (Lagging Strand) Synthesis.
REACT_320650. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).
REACT_329955. Removal of the Flap Intermediate from the C-strand.
REACT_330619. Polymerase switching on the C-strand of the telomere.
REACT_331202. Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).
REACT_342741. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
REACT_358684. Recognition of DNA damage by PCNA-containing replication complex.
REACT_361486. PCNA-Dependent Long Patch Base Excision Repair.
REACT_362050. Termination of translesion DNA synthesis.

Miscellaneous databases

NextBioi330238.
PROiQ9CWP8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWP8.
CleanExiMM_POLD4.
ExpressionAtlasiQ9CWP8. baseline and differential.
GenevisibleiQ9CWP8. MM.

Family and domain databases

InterProiIPR007218. DNA_pol_delta_4.
[Graphical view]
PfamiPF04081. DNA_pol_delta_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiDPOD4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.