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Q9CWP8

- DPOD4_MOUSE

UniProt

Q9CWP8 - DPOD4_MOUSE

Protein

DNA polymerase delta subunit 4

Gene

Pold4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta By similarity.By similarity

    GO - Molecular functioni

    1. DNA-directed DNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of endothelial cell proliferation Source: MGI

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Enzyme and pathway databases

    ReactomeiREACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase delta subunit 4
    Alternative name(s):
    DNA polymerase delta subunit p12
    Gene namesi
    Name:Pold4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1916995. Pold4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 107107DNA polymerase delta subunit 4PRO_0000186052Add
    BLAST

    Proteomic databases

    PRIDEiQ9CWP8.

    PTM databases

    PhosphoSiteiQ9CWP8.

    Expressioni

    Gene expression databases

    BgeeiQ9CWP8.
    CleanExiMM_POLD4.
    GenevestigatoriQ9CWP8.

    Interactioni

    Subunit structurei

    Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD2, POLD1 and PCNA By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG70894.
    GeneTreeiENSGT00390000005096.
    HOGENOMiHOG000031022.
    HOVERGENiHBG057838.
    InParanoidiQ9CWP8.
    KOiK03505.
    OMAiQTHPGDP.
    OrthoDBiEOG708W1X.
    PhylomeDBiQ9CWP8.
    TreeFamiTF103004.

    Family and domain databases

    InterProiIPR007218. DNA_pol_delta_4.
    [Graphical view]
    PfamiPF04081. DNA_pol_delta_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CWP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRKRFITDS YPVVKKREGP PGHSKGELAP ELGEDTQSLS QEETELELLR    50
    QFDLAWQYGP CTGITRLQRW SRAEQMGLKP PLEVYQVLKA HPEDPHFQCS 100
    LWHLYPL 107
    Length:107
    Mass (Da):12,403
    Last modified:June 1, 2001 - v1
    Checksum:i14A27054D4E7511E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010477 mRNA. Translation: BAB26970.1.
    BC028520 mRNA. Translation: AAH28520.1.
    CCDSiCCDS29424.1.
    RefSeqiNP_081472.1. NM_027196.3.
    UniGeneiMm.32518.

    Genome annotation databases

    EnsembliENSMUST00000025773; ENSMUSP00000025773; ENSMUSG00000024854.
    ENSMUST00000180621; ENSMUSP00000137813; ENSMUSG00000097508.
    GeneIDi69745.
    KEGGimmu:69745.
    UCSCiuc008fzm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK010477 mRNA. Translation: BAB26970.1 .
    BC028520 mRNA. Translation: AAH28520.1 .
    CCDSi CCDS29424.1.
    RefSeqi NP_081472.1. NM_027196.3.
    UniGenei Mm.32518.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CWP8.

    Proteomic databases

    PRIDEi Q9CWP8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025773 ; ENSMUSP00000025773 ; ENSMUSG00000024854 .
    ENSMUST00000180621 ; ENSMUSP00000137813 ; ENSMUSG00000097508 .
    GeneIDi 69745.
    KEGGi mmu:69745.
    UCSCi uc008fzm.2. mouse.

    Organism-specific databases

    CTDi 57804.
    MGIi MGI:1916995. Pold4.

    Phylogenomic databases

    eggNOGi NOG70894.
    GeneTreei ENSGT00390000005096.
    HOGENOMi HOG000031022.
    HOVERGENi HBG057838.
    InParanoidi Q9CWP8.
    KOi K03505.
    OMAi QTHPGDP.
    OrthoDBi EOG708W1X.
    PhylomeDBi Q9CWP8.
    TreeFami TF103004.

    Enzyme and pathway databases

    Reactomei REACT_209299. Repair synthesis of patch ~27-30 bases long by DNA polymerase.
    REACT_216529. Removal of the Flap Intermediate from the C-strand.
    REACT_219337. Removal of DNA patch containing abasic residue.
    REACT_219381. Repair synthesis for gap-filling by DNA polymerase in TC-NER.
    REACT_220175. Telomere C-strand (Lagging Strand) Synthesis.
    REACT_223154. Processive synthesis on the C-strand of the telomere.
    REACT_225604. Polymerase switching on the C-strand of the telomere.
    REACT_227394. Resolution of AP sites via the multiple-nucleotide patch replacement pathway.

    Miscellaneous databases

    NextBioi 330238.
    PROi Q9CWP8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CWP8.
    CleanExi MM_POLD4.
    Genevestigatori Q9CWP8.

    Family and domain databases

    InterProi IPR007218. DNA_pol_delta_4.
    [Graphical view ]
    Pfami PF04081. DNA_pol_delta_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiDPOD4_MOUSE
    AccessioniPrimary (citable) accession number: Q9CWP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3