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Protein

Prefoldin subunit 1

Gene

Pfdn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • B cell activation Source: MGI
  • cerebellum development Source: MGI
  • telencephalon development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 1
Gene namesi
Name:Pfdn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914449. Pfdn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 122121Prefoldin subunit 1PRO_0000124831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CWM4.
MaxQBiQ9CWM4.
PaxDbiQ9CWM4.
PRIDEiQ9CWM4.

2D gel databases

REPRODUCTION-2DPAGEQ9CWM4.

PTM databases

iPTMnetiQ9CWM4.
PhosphoSiteiQ9CWM4.

Expressioni

Gene expression databases

CleanExiMM_PFDN1.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9CWM4. 2 interactions.
MINTiMINT-4107265.
STRINGi10090.ENSMUSP00000025204.

Structurei

3D structure databases

ProteinModelPortaliQ9CWM4.
SMRiQ9CWM4. Positions 16-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiENOG410ISJS. Eukaryota.
ENOG4111Q46. LUCA.
HOGENOMiHOG000005946.
HOVERGENiHBG031813.
InParanoidiQ9CWM4.
PhylomeDBiQ9CWM4.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CWM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVDLELK KAFTELQAKV IDTQQKVKLA DIQIEQLNRT KKHAHLTDTE
60 70 80 90 100
IMTLVDETNM YEGVGRMFIL QSKEVIHNQL LEKQKIAKEK IKELEQKKSY
110 120
LERSVKEAED NIREMLMARR AQ
Length:122
Mass (Da):14,255
Last modified:June 1, 2001 - v1
Checksum:i923EEB94802C6664
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010532 mRNA. Translation: BAB27010.1.
CCDSiCCDS29152.1.
UniGeneiMm.30184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010532 mRNA. Translation: BAB27010.1.
CCDSiCCDS29152.1.
UniGeneiMm.30184.

3D structure databases

ProteinModelPortaliQ9CWM4.
SMRiQ9CWM4. Positions 16-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWM4. 2 interactions.
MINTiMINT-4107265.
STRINGi10090.ENSMUSP00000025204.

PTM databases

iPTMnetiQ9CWM4.
PhosphoSiteiQ9CWM4.

2D gel databases

REPRODUCTION-2DPAGEQ9CWM4.

Proteomic databases

EPDiQ9CWM4.
MaxQBiQ9CWM4.
PaxDbiQ9CWM4.
PRIDEiQ9CWM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1914449. Pfdn1.

Phylogenomic databases

eggNOGiENOG410ISJS. Eukaryota.
ENOG4111Q46. LUCA.
HOGENOMiHOG000005946.
HOVERGENiHBG031813.
InParanoidiQ9CWM4.
PhylomeDBiQ9CWM4.

Miscellaneous databases

PROiQ9CWM4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PFDN1.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPFD1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.