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Protein

Cell division cycle-associated protein 4

Gene

Cdca4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:Cdca4
Synonyms:Hepp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919213. Cdca4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916181 – 237Cell division cycle-associated protein 4Add BLAST237

Proteomic databases

MaxQBiQ9CWM2.
PaxDbiQ9CWM2.
PRIDEiQ9CWM2.

PTM databases

PhosphoSitePlusiQ9CWM2.

Expressioni

Tissue specificityi

Expressed preferentially in hematopoietic progenitors and mature blood cells. Expressed at low levels in the heart, lung, spleen, and thymus and at a higher level in muscle.

Developmental stagei

Developmentally regulated. Preferential expression in both fetal and adult hematopoietic progenitors and mature blood cells during embryonic and adult hematopoiesis.

Gene expression databases

BgeeiENSMUSG00000047832.
CleanExiMM_CDCA4.
GenevisibleiQ9CWM2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058901.

Structurei

3D structure databases

ProteinModelPortaliQ9CWM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 73SERTAPROSITE-ProRule annotationAdd BLAST48

Phylogenomic databases

eggNOGiENOG410IM11. Eukaryota.
ENOG4111IXT. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9CWM2.
OMAiEPNLCRS.
OrthoDBiEOG091G0HZO.
PhylomeDBiQ9CWM2.
TreeFamiTF101069.

Family and domain databases

InterProiView protein in InterPro
IPR009263. SERTA_dom.
PfamiView protein in Pfam
PF06031. SERTA. 1 hit.
PROSITEiView protein in PROSITE
PS51053. SERTA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGLKRKY GDQEEGVEGF GTVPSYSLQR QSLLDMSLVK LQLCHMLVEP
60 70 80 90 100
NLCRSVLIAN TVRQIQEEMS QDGVWHGMAP QNVDRAPVER LVSTEILCRT
110 120 130 140 150
VRGAEEEHPA PELEDAPLQN SVSELPIVGS APGQRNPQSS LWEMDSPQEN
160 170 180 190 200
RGSFQKSLDQ IFETLENKNS SSVEELFSDV DSSYYDLDTV LTGMMSGTKS
210 220 230
SLCNGLEGFA AATPPPSSTC KSDLAELDHV VEILVET
Length:237
Mass (Da):26,107
Last modified:March 1, 2003 - v2
Checksum:i52EC046EFDDF326E
GO

Sequence cautioni

The sequence AAH12953 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196S → T in AAH12953 (PubMed:15489334).Curated1
Sequence conflicti213T → A in AAH12953 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010535 mRNA. Translation: BAB27012.2.
AK156081 mRNA. Translation: BAE33578.1.
AF322238 mRNA. Translation: AAK31074.1.
AK032980 mRNA. Translation: BAC28109.1.
BC012953 mRNA. Translation: AAH12953.1. Different initiation.
BC055824 mRNA. Translation: AAH55824.1.
CCDSiCCDS26198.1.
RefSeqiNP_082299.1. NM_028023.3.
XP_006516307.1. XM_006516244.1.
UniGeneiMm.313185.

Genome annotation databases

EnsembliENSMUST00000062092; ENSMUSP00000058901; ENSMUSG00000047832.
ENSMUST00000220899; ENSMUSP00000152315; ENSMUSG00000047832.
GeneIDi71963.
KEGGimmu:71963.
UCSCiuc007pfi.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCDCA4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWM2
Secondary accession number(s): Q3U1C0, Q921E8, Q99MP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot