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Protein

Cell division cycle-associated protein 4

Gene

Cdca4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle-associated protein 4
Alternative name(s):
Hematopoietic progenitor protein
Gene namesi
Name:Cdca4
Synonyms:Hepp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1919213. Cdca4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Cell division cycle-associated protein 4PRO_0000191618Add
BLAST

Proteomic databases

MaxQBiQ9CWM2.
PaxDbiQ9CWM2.
PRIDEiQ9CWM2.

PTM databases

PhosphoSiteiQ9CWM2.

Expressioni

Tissue specificityi

Expressed preferentially in hematopoietic progenitors and mature blood cells. Expressed at low levels in the heart, lung, spleen, and thymus and at a higher level in muscle.

Developmental stagei

Developmentally regulated. Preferential expression in both fetal and adult hematopoietic progenitors and mature blood cells during embryonic and adult hematopoiesis.

Gene expression databases

BgeeiQ9CWM2.
CleanExiMM_CDCA4.
GenevisibleiQ9CWM2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058901.

Structurei

3D structure databases

ProteinModelPortaliQ9CWM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 7348SERTAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IM11. Eukaryota.
ENOG4111IXT. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9CWM2.
OMAiTQDGTWQ.
OrthoDBiEOG7PCJHX.
PhylomeDBiQ9CWM2.
TreeFamiTF101069.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFARGLKRKY GDQEEGVEGF GTVPSYSLQR QSLLDMSLVK LQLCHMLVEP
60 70 80 90 100
NLCRSVLIAN TVRQIQEEMS QDGVWHGMAP QNVDRAPVER LVSTEILCRT
110 120 130 140 150
VRGAEEEHPA PELEDAPLQN SVSELPIVGS APGQRNPQSS LWEMDSPQEN
160 170 180 190 200
RGSFQKSLDQ IFETLENKNS SSVEELFSDV DSSYYDLDTV LTGMMSGTKS
210 220 230
SLCNGLEGFA AATPPPSSTC KSDLAELDHV VEILVET
Length:237
Mass (Da):26,107
Last modified:March 1, 2003 - v2
Checksum:i52EC046EFDDF326E
GO

Sequence cautioni

The sequence AAH12953.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961S → T in AAH12953 (PubMed:15489334).Curated
Sequence conflicti213 – 2131T → A in AAH12953 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010535 mRNA. Translation: BAB27012.2.
AK156081 mRNA. Translation: BAE33578.1.
AF322238 mRNA. Translation: AAK31074.1.
AK032980 mRNA. Translation: BAC28109.1.
BC012953 mRNA. Translation: AAH12953.1. Different initiation.
BC055824 mRNA. Translation: AAH55824.1.
CCDSiCCDS26198.1.
RefSeqiNP_082299.1. NM_028023.3.
XP_006516307.1. XM_006516244.1.
UniGeneiMm.313185.

Genome annotation databases

EnsembliENSMUST00000062092; ENSMUSP00000058901; ENSMUSG00000047832.
GeneIDi71963.
KEGGimmu:71963.
UCSCiuc007pfi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010535 mRNA. Translation: BAB27012.2.
AK156081 mRNA. Translation: BAE33578.1.
AF322238 mRNA. Translation: AAK31074.1.
AK032980 mRNA. Translation: BAC28109.1.
BC012953 mRNA. Translation: AAH12953.1. Different initiation.
BC055824 mRNA. Translation: AAH55824.1.
CCDSiCCDS26198.1.
RefSeqiNP_082299.1. NM_028023.3.
XP_006516307.1. XM_006516244.1.
UniGeneiMm.313185.

3D structure databases

ProteinModelPortaliQ9CWM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058901.

PTM databases

PhosphoSiteiQ9CWM2.

Proteomic databases

MaxQBiQ9CWM2.
PaxDbiQ9CWM2.
PRIDEiQ9CWM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062092; ENSMUSP00000058901; ENSMUSG00000047832.
GeneIDi71963.
KEGGimmu:71963.
UCSCiuc007pfi.1. mouse.

Organism-specific databases

CTDi55038.
MGIiMGI:1919213. Cdca4.

Phylogenomic databases

eggNOGiENOG410IM11. Eukaryota.
ENOG4111IXT. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG050861.
InParanoidiQ9CWM2.
OMAiTQDGTWQ.
OrthoDBiEOG7PCJHX.
PhylomeDBiQ9CWM2.
TreeFamiTF101069.

Miscellaneous databases

NextBioi335064.
PROiQ9CWM2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWM2.
CleanExiMM_CDCA4.
GenevisibleiQ9CWM2. MM.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of HEPP, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells."
    Abdullah J.M., Jing X., Spassov D.S., Nachtman R.G., Jurecic R.
    Blood Cells Mol. Dis. 27:667-676(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Mesonephros and Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Mammary tumor.

Entry informationi

Entry nameiCDCA4_MOUSE
AccessioniPrimary (citable) accession number: Q9CWM2
Secondary accession number(s): Q3U1C0, Q921E8, Q99MP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.