Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-catenin-like protein 1

Gene

Ctnnbl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May induce apoptosis (By similarity). Participates in AID/AICDA-mediated Ig class switching recombination (CSR).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-catenin-like protein 1
Alternative name(s):
Nuclear-associated protein
Short name:
NAP
Gene namesi
Name:Ctnnbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1913892. Ctnnbl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Beta-catenin-like protein 1PRO_0000079491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei91 – 911N6-acetyllysineBy similarity
Modified residuei389 – 3891PhosphoserineBy similarity
Modified residuei545 – 5451PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CWL8.
MaxQBiQ9CWL8.
PaxDbiQ9CWL8.
PRIDEiQ9CWL8.

PTM databases

iPTMnetiQ9CWL8.
PhosphoSiteiQ9CWL8.

Expressioni

Gene expression databases

BgeeiQ9CWL8.
CleanExiMM_CTNNBL1.
GenevisibleiQ9CWL8. MM.

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex. Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA. Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211616. 12 interactions.
IntActiQ9CWL8. 13 interactions.
MINTiMINT-4092455.
STRINGi10090.ENSMUSP00000029178.

Structurei

3D structure databases

ProteinModelPortaliQ9CWL8.
SMRiQ9CWL8. Positions 50-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati79 – 12951HEAT 1Add
BLAST
Repeati134 – 17643HEAT 2Add
BLAST
Repeati178 – 22851ARM 1Add
BLAST
Repeati229 – 27345ARM 2Add
BLAST
Repeati274 – 32350ARM 3Add
BLAST
Repeati325 – 36339ARM 4Add
BLAST
Repeati364 – 41754ARM 5Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili476 – 54065By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi16 – 3318Nuclear localization signalBy similarityAdd
BLAST
Motifi130 – 14011Nuclear export signal (NES)By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 254Poly-Glu
Compositional biasi68 – 758Poly-Glu

Domaini

The surface residues of the concave side of the superhelical ARM repeat region contribute to, but are not essential for NLS binding.By similarity

Sequence similaritiesi

Contains 5 ARM repeats.Curated
Contains 2 HEAT repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2734. Eukaryota.
ENOG410XPFW. LUCA.
GeneTreeiENSGT00390000006931.
HOGENOMiHOG000186529.
HOVERGENiHBG051212.
InParanoidiQ9CWL8.
KOiK12864.
OMAiASMLRNC.
OrthoDBiEOG7353WH.
PhylomeDBiQ9CWL8.
TreeFamiTF314294.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013180. CTNNBL1_N.
[Graphical view]
PfamiPF08216. CTNNBL. 1 hit.
[Graphical view]
SMARTiSM01156. DUF1716. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVGELLSYQ PNRGTKRPRD DEEEELKTRR KQTGPRERGR YREEEATAAE
60 70 80 90 100
DTADDKKRLL QIIDRDGEEE EEEEEPLDES SVKKMILTFE KRSYKNQELR
110 120 130 140 150
IKFPDNPEKF MESELDLNDI IQEMHVVATM PDLYHLLVEL SAVQSLLGLL
160 170 180 190 200
GHDNTDVSIA VVDLLQELTD IDTLHESEEG AEVLIDALVD GQVAALLVQN
210 220 230 240 250
LERLDESVRE EADGVHNTLA IVENMAEFRP EMCTEAAQQG LLQWLLKRLK
260 270 280 290 300
AKMPFDANKL YCSEVLAILL QDNDENRELL GELDGIDVLL QQLSVFKRHN
310 320 330 340 350
PSTAEEQEMM ENLFDALCSC LMLSSNRERF LKGEGLQLMN LMLREKKVSR
360 370 380 390 400
SSALKVLDHA MIGPEGTDNC HKFVDILGLR TIFPLFMKSP RKIKKVGTTE
410 420 430 440 450
KEHEEHVCSI LASLLRNLRG QQRTRLLNKF TENDSEKVDR LMELHFKYLS
460 470 480 490 500
AMQVADKKIE GEKHDIVRRG EIIDNDMEDE FYLRRLDAGL FILQHICYIM
510 520 530 540 550
AEICNANVPQ IRQRVHQILN MRGSSIKIVR HIIKEYAENI GDGRSPEFRE
560
TEQKRILALL ENF
Length:563
Mass (Da):64,980
Last modified:June 1, 2001 - v1
Checksum:i89B67CF3A379C3D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211I → V in BAC32034 (PubMed:16141072).Curated
Sequence conflicti148 – 1481G → C in AAH50787 (PubMed:15489334).Curated
Sequence conflicti399 – 4002TE → QQ in AAK27389 (PubMed:12659813).Curated
Sequence conflicti418 – 4181L → M in BAC36902 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009405 mRNA. Translation: AAK27389.1.
AK010547 mRNA. Translation: BAB27020.1.
AK044690 mRNA. Translation: BAC32034.1.
AK077616 mRNA. Translation: BAC36902.1.
AK145598 mRNA. Translation: BAE26532.1.
AK145719 mRNA. Translation: BAE26609.1.
BC050787 mRNA. Translation: AAH50787.1.
CCDSiCCDS16982.1.
RefSeqiNP_079956.3. NM_025680.4.
UniGeneiMm.45193.

Genome annotation databases

EnsembliENSMUST00000029178; ENSMUSP00000029178; ENSMUSG00000027649.
GeneIDi66642.
KEGGimmu:66642.
UCSCiuc008nph.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009405 mRNA. Translation: AAK27389.1.
AK010547 mRNA. Translation: BAB27020.1.
AK044690 mRNA. Translation: BAC32034.1.
AK077616 mRNA. Translation: BAC36902.1.
AK145598 mRNA. Translation: BAE26532.1.
AK145719 mRNA. Translation: BAE26609.1.
BC050787 mRNA. Translation: AAH50787.1.
CCDSiCCDS16982.1.
RefSeqiNP_079956.3. NM_025680.4.
UniGeneiMm.45193.

3D structure databases

ProteinModelPortaliQ9CWL8.
SMRiQ9CWL8. Positions 50-563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211616. 12 interactions.
IntActiQ9CWL8. 13 interactions.
MINTiMINT-4092455.
STRINGi10090.ENSMUSP00000029178.

PTM databases

iPTMnetiQ9CWL8.
PhosphoSiteiQ9CWL8.

Proteomic databases

EPDiQ9CWL8.
MaxQBiQ9CWL8.
PaxDbiQ9CWL8.
PRIDEiQ9CWL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029178; ENSMUSP00000029178; ENSMUSG00000027649.
GeneIDi66642.
KEGGimmu:66642.
UCSCiuc008nph.2. mouse.

Organism-specific databases

CTDi56259.
MGIiMGI:1913892. Ctnnbl1.

Phylogenomic databases

eggNOGiKOG2734. Eukaryota.
ENOG410XPFW. LUCA.
GeneTreeiENSGT00390000006931.
HOGENOMiHOG000186529.
HOVERGENiHBG051212.
InParanoidiQ9CWL8.
KOiK12864.
OMAiASMLRNC.
OrthoDBiEOG7353WH.
PhylomeDBiQ9CWL8.
TreeFamiTF314294.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ9CWL8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWL8.
CleanExiMM_CTNNBL1.
GenevisibleiQ9CWL8. MM.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013180. CTNNBL1_N.
[Graphical view]
PfamiPF08216. CTNNBL. 1 hit.
[Graphical view]
SMARTiSM01156. DUF1716. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene - evidence for a role in apoptosis."
    Jabbour L.S., Welter J.F., Kollar J., Hering T.M.
    Genomics 81:292-303(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Spleen and Testis.
  5. "Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination."
    Han L., Masani S., Yu K.
    J. Immunol. 185:1379-1381(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCTBL1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWL8
Secondary accession number(s): Q3UL41, Q80X64, Q8VHE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.