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Q9CWL2

- CASZ1_MOUSE

UniProt

Q9CWL2 - CASZ1_MOUSE

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Protein

Zinc finger protein castor homolog 1

Gene
Casz1, Cst, D4Ertd432e, Kiaa3026
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57425C2H2-type 1Add
BLAST
Zinc fingeri609 – 63325C2H2-type 2Add
BLAST
Zinc fingeri667 – 69125C2H2-type 3Add
BLAST
Zinc fingeri1031 – 105525C2H2-type 4Add
BLAST
Zinc fingeri1300 – 132425C2H2-type 5Add
BLAST
Zinc fingeri1457 – 148125C2H2-type 6Add
BLAST
Zinc fingeri1515 – 153723C2H2-type 7Add
BLAST
Zinc fingeri1571 – 159525C2H2-type 8Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein castor homolog 1
Alternative name(s):
Castor-related protein
Gene namesi
Name:Casz1
Synonyms:Cst, D4Ertd432e, Kiaa3026
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1196251. Casz1.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17611761Zinc finger protein castor homolog 1PRO_0000046913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei981 – 9811Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CWL2.
PaxDbiQ9CWL2.
PRIDEiQ9CWL2.

PTM databases

PhosphoSiteiQ9CWL2.

Expressioni

Tissue specificityi

Expressed in the brain stem and the thalamencephalon.2 Publications

Developmental stagei

First expressed at E8.0 in the developing heart and throughout development. By E8.5, it is expressed in the lateral neural folds of the hindbrain and extends anteriorly and posteriorly to eventually cover the dorsal neural tube from the isthmus to its caudal end. From E9.5, it is expressed in the dorsomedial telencephalon. In the hindbrain, it is confined to trigeminal motor neurons and to migrating facial branchiomotor neurons. In the peripheral nervous system, it is expressed in cranial and in dorsal root ganglia. Also expressed in the developing eye and in the nasal placode.1 Publication

Inductioni

Up-regulated during myoblast differentiation.1 Publication

Gene expression databases

ArrayExpressiQ9CWL2.
BgeeiQ9CWL2.
CleanExiMM_CASZ1.
GenevestigatoriQ9CWL2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi383 – 41634Pro-richAdd
BLAST
Compositional biasi1080 – 114364Pro-richAdd
BLAST
Compositional biasi1669 – 168113Poly-ThrAdd
BLAST
Compositional biasi1702 – 172928Asp-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG324200.
GeneTreeiENSGT00390000008187.
HOVERGENiHBG080122.
InParanoidiQ9CWL2.
OMAiTAEGTRC.
OrthoDBiEOG73NG37.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CWL2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDLGTAESTR CTDPPAGKPP MAAKRKGGLK LNAICAKLSR QVVVEKGAEA     50
GSQAEGSPLH PRDKERSGPE SGVSRAPRSE EDKRRAVIEK WVNGEYCEDP 100
APTPVLGRIA RDQELPPEGV YMVQPQGCSD EEDHAEEPSK DNSVLEEKES 150
DGTASKDDSG PSTRQASGET SSLRDYAAST MTEFLGMFGY DDQNTRDELA 200
KKISFEKPHA GSTPEVAASS MLPSSEDTLS KRARFSKYEE YIRKLKAGEQ 250
LPWPAHGSKA EDRAGKEVVG PLPSLRLPSN TAHLETKATI LPLPSHSSVQ 300
MQNLVARASK YDFFIHKLKT GENLRPQNGS TYKKPSKYDL ENVKYLHLFK 350
PGEGSPDMGG AIAFKTGKVG RPSKYDVRGI QKPGPTKIPP APSLVPTPLT 400
NVPSAPSTPG PGPEPPASLS FNTPEYLKST FSKTDSITTG TVSTVKNGLP 450
TDKPAVTEDV NIYQKYIARF SGSQHCGHIH CAYQYREHYH CLDPECNYQR 500
FTSKQDVIRH YNMHKKRDNS LQHGFMRFSP LDDCSVYYHG CHLNGKSTHY 550
HCMQVGCNKV YTSTSDVMTH ENFHKKNTQL INDGFQRFRA TEDCGTADCQ 600
FYGQKTTHFH CRRPGCTFTF KNKCDIEKHK SYHIKDDAYA KDGFKKFYKY 650
EECKYEGCMY SKATNHFHCI RAGCGFTFTS TSQMTSHKRK HERRHIRSSG 700
ALGLPASLLG AKDTEHEESS NDDLVDFSAL SSKNSSLSAS PTSQQSSASL 750
AAAAAATTAE AIPSATKPPN SKMAGLLPQG LSGSIPLALA LSNSGLPTTT 800
PYFPLLPNRG SASLPVGSPG LLGSMSSGAT TSATPDMPAL MASRAGDSAP 850
TAATSLSVPP ASIIERISAS KGLISPMMAR LAAAALKPSA TFDPGSGQQP 900
TPTKFPQAQV KQEPDSAGTP GPHEASQDRS LDLTVKDPSN ESNGHAVSAN 950
SSLLSSLMNK MSQGNPSLES FLSIKTEAEG SPAGEPSPFL GKAVKALVQE 1000
KLSEPWKVYL RRFGTKDFCD AQCDFLHKAH FHCVVEECGA LFSTLDGAIK 1050
HANFHFRTEG GTAKGTPEAS FPTSAAETKP PLAPSSLPAP PGTMVAGSSL 1100
EGPAPSPVSV PSTPTLLAWK QLASTIPQMP QIPSSVPHLP TSPLATTSLE 1150
SAKPQVKPGF LQFQDNDPCL ATDCKYASKF HFHCLFGNCK YVCKTSGKAE 1200
SHCLDHINPS NSLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY 1250
FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF 1300
HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPSLMDAET 1350
DEGMDYTGCS PGAASSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK 1400
KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDTACQF 1450
SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS 1500
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ 1550
FSSSADCAVP DCKYKLKCSH FHCTYPGCRH TVVGMSQMDS HKRKHEKQER 1600
GEPPAASPGA PVNLDGSLTL AAEQGSLLFL QTAAAGLGLL GDTGDPGPPV 1650
TASGTRDGPA APTPAAAATT TTTTTATATA TAGESSQEDD EELELPEEEA 1700
EDDDEDDDEE DDDDEDDDDD DDDEDLRTDS EESLPEAAGE AGARTPLAAL 1750
GGPGPAPTAA S 1761

Note: Gene prediction based on similarity to human ortholog.

Length:1,761
Mass (Da):191,188
Last modified:July 24, 2007 - v3
Checksum:iC0C1959D68D62D50
GO
Isoform 2 (identifier: Q9CWL2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1166-1166: N → K
     1167-1761: Missing.

Show »
Length:1,166
Mass (Da):125,596
Checksum:i4804ED3BB3A77BD2
GO

Sequence cautioni

The sequence BAB27027.1 differs from that shown. Reason: Frameshift at position 946.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1166 – 11661N → K in isoform 2. VSP_027095
Alternative sequencei1167 – 1761595Missing in isoform 2. VSP_027096Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti884 – 8841A → S in BAD32619. 1 Publication
Sequence conflicti912 – 9121Q → E in BAB27027. 1 Publication
Sequence conflicti1087 – 10871L → P in BAB27027. 1 Publication
Sequence conflicti1087 – 10871L → P in BAD32619. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607145 Genomic DNA. Translation: CAM18127.1.
AL611967 Genomic DNA. No translation available.
AK173341 mRNA. Translation: BAD32619.1.
AK010559 mRNA. Translation: BAB27027.1. Frameshift.
CCDSiCCDS38973.1. [Q9CWL2-2]
RefSeqiNP_081471.2. NM_027195.2. [Q9CWL2-2]
UniGeneiMm.233879.

Genome annotation databases

EnsembliENSMUST00000094464; ENSMUSP00000092035; ENSMUSG00000028977. [Q9CWL2-2]
GeneIDi69743.
KEGGimmu:69743.
UCSCiuc008vvl.1. mouse. [Q9CWL2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL607145 Genomic DNA. Translation: CAM18127.1 .
AL611967 Genomic DNA. No translation available.
AK173341 mRNA. Translation: BAD32619.1 .
AK010559 mRNA. Translation: BAB27027.1 . Frameshift.
CCDSi CCDS38973.1. [Q9CWL2-2 ]
RefSeqi NP_081471.2. NM_027195.2. [Q9CWL2-2 ]
UniGenei Mm.233879.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CWL2.

Proteomic databases

MaxQBi Q9CWL2.
PaxDbi Q9CWL2.
PRIDEi Q9CWL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094464 ; ENSMUSP00000092035 ; ENSMUSG00000028977 . [Q9CWL2-2 ]
GeneIDi 69743.
KEGGi mmu:69743.
UCSCi uc008vvl.1. mouse. [Q9CWL2-2 ]

Organism-specific databases

CTDi 54897.
MGIi MGI:1196251. Casz1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG324200.
GeneTreei ENSGT00390000008187.
HOVERGENi HBG080122.
InParanoidi Q9CWL2.
OMAi TAEGTRC.
OrthoDBi EOG73NG37.

Miscellaneous databases

NextBioi 330234.
PROi Q9CWL2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9CWL2.
Bgeei Q9CWL2.
CleanExi MM_CASZ1.
Genevestigatori Q9CWL2.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-1761 (ISOFORM 2).
    Tissue: Pancreatic islet.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 912-1761 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  4. "Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development."
    Vacalla C.M.H., Theil T.
    Mech. Dev. 118:265-268(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
    Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
    Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWL2
Secondary accession number(s): A2A8A1, Q69Z25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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