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Q9CWL2

- CASZ1_MOUSE

UniProt

Q9CWL2 - CASZ1_MOUSE

Protein

Zinc finger protein castor homolog 1

Gene

Casz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 3 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri550 – 57425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63325C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri667 – 69125C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein castor homolog 1
    Alternative name(s):
    Castor-related protein
    Gene namesi
    Name:Casz1
    Synonyms:Cst, D4Ertd432e, Kiaa3026
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1196251. Casz1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17611761Zinc finger protein castor homolog 1PRO_0000046913Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei981 – 9811PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9CWL2.
    PaxDbiQ9CWL2.
    PRIDEiQ9CWL2.

    PTM databases

    PhosphoSiteiQ9CWL2.

    Expressioni

    Tissue specificityi

    Expressed in the brain stem and the thalamencephalon.2 Publications

    Developmental stagei

    First expressed at E8.0 in the developing heart and throughout development. By E8.5, it is expressed in the lateral neural folds of the hindbrain and extends anteriorly and posteriorly to eventually cover the dorsal neural tube from the isthmus to its caudal end. From E9.5, it is expressed in the dorsomedial telencephalon. In the hindbrain, it is confined to trigeminal motor neurons and to migrating facial branchiomotor neurons. In the peripheral nervous system, it is expressed in cranial and in dorsal root ganglia. Also expressed in the developing eye and in the nasal placode.1 Publication

    Inductioni

    Up-regulated during myoblast differentiation.1 Publication

    Gene expression databases

    ArrayExpressiQ9CWL2.
    BgeeiQ9CWL2.
    CleanExiMM_CASZ1.
    GenevestigatoriQ9CWL2.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi383 – 41634Pro-richAdd
    BLAST
    Compositional biasi1080 – 114364Pro-richAdd
    BLAST
    Compositional biasi1669 – 168113Poly-ThrAdd
    BLAST
    Compositional biasi1702 – 172928Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri550 – 57425C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri609 – 63325C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri667 – 69125C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG324200.
    GeneTreeiENSGT00390000008187.
    HOVERGENiHBG080122.
    InParanoidiQ9CWL2.
    OMAiTAEGTRC.
    OrthoDBiEOG73NG37.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CWL2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDLGTAESTR CTDPPAGKPP MAAKRKGGLK LNAICAKLSR QVVVEKGAEA     50
    GSQAEGSPLH PRDKERSGPE SGVSRAPRSE EDKRRAVIEK WVNGEYCEDP 100
    APTPVLGRIA RDQELPPEGV YMVQPQGCSD EEDHAEEPSK DNSVLEEKES 150
    DGTASKDDSG PSTRQASGET SSLRDYAAST MTEFLGMFGY DDQNTRDELA 200
    KKISFEKPHA GSTPEVAASS MLPSSEDTLS KRARFSKYEE YIRKLKAGEQ 250
    LPWPAHGSKA EDRAGKEVVG PLPSLRLPSN TAHLETKATI LPLPSHSSVQ 300
    MQNLVARASK YDFFIHKLKT GENLRPQNGS TYKKPSKYDL ENVKYLHLFK 350
    PGEGSPDMGG AIAFKTGKVG RPSKYDVRGI QKPGPTKIPP APSLVPTPLT 400
    NVPSAPSTPG PGPEPPASLS FNTPEYLKST FSKTDSITTG TVSTVKNGLP 450
    TDKPAVTEDV NIYQKYIARF SGSQHCGHIH CAYQYREHYH CLDPECNYQR 500
    FTSKQDVIRH YNMHKKRDNS LQHGFMRFSP LDDCSVYYHG CHLNGKSTHY 550
    HCMQVGCNKV YTSTSDVMTH ENFHKKNTQL INDGFQRFRA TEDCGTADCQ 600
    FYGQKTTHFH CRRPGCTFTF KNKCDIEKHK SYHIKDDAYA KDGFKKFYKY 650
    EECKYEGCMY SKATNHFHCI RAGCGFTFTS TSQMTSHKRK HERRHIRSSG 700
    ALGLPASLLG AKDTEHEESS NDDLVDFSAL SSKNSSLSAS PTSQQSSASL 750
    AAAAAATTAE AIPSATKPPN SKMAGLLPQG LSGSIPLALA LSNSGLPTTT 800
    PYFPLLPNRG SASLPVGSPG LLGSMSSGAT TSATPDMPAL MASRAGDSAP 850
    TAATSLSVPP ASIIERISAS KGLISPMMAR LAAAALKPSA TFDPGSGQQP 900
    TPTKFPQAQV KQEPDSAGTP GPHEASQDRS LDLTVKDPSN ESNGHAVSAN 950
    SSLLSSLMNK MSQGNPSLES FLSIKTEAEG SPAGEPSPFL GKAVKALVQE 1000
    KLSEPWKVYL RRFGTKDFCD AQCDFLHKAH FHCVVEECGA LFSTLDGAIK 1050
    HANFHFRTEG GTAKGTPEAS FPTSAAETKP PLAPSSLPAP PGTMVAGSSL 1100
    EGPAPSPVSV PSTPTLLAWK QLASTIPQMP QIPSSVPHLP TSPLATTSLE 1150
    SAKPQVKPGF LQFQDNDPCL ATDCKYASKF HFHCLFGNCK YVCKTSGKAE 1200
    SHCLDHINPS NSLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY 1250
    FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF 1300
    HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPSLMDAET 1350
    DEGMDYTGCS PGAASSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK 1400
    KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDTACQF 1450
    SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS 1500
    CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ 1550
    FSSSADCAVP DCKYKLKCSH FHCTYPGCRH TVVGMSQMDS HKRKHEKQER 1600
    GEPPAASPGA PVNLDGSLTL AAEQGSLLFL QTAAAGLGLL GDTGDPGPPV 1650
    TASGTRDGPA APTPAAAATT TTTTTATATA TAGESSQEDD EELELPEEEA 1700
    EDDDEDDDEE DDDDEDDDDD DDDEDLRTDS EESLPEAAGE AGARTPLAAL 1750
    GGPGPAPTAA S 1761

    Note: Gene prediction based on similarity to human ortholog.

    Length:1,761
    Mass (Da):191,188
    Last modified:July 24, 2007 - v3
    Checksum:iC0C1959D68D62D50
    GO
    Isoform 2 (identifier: Q9CWL2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1166-1166: N → K
         1167-1761: Missing.

    Show »
    Length:1,166
    Mass (Da):125,596
    Checksum:i4804ED3BB3A77BD2
    GO

    Sequence cautioni

    The sequence BAB27027.1 differs from that shown. Reason: Frameshift at position 946.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti884 – 8841A → S in BAD32619. (PubMed:15368895)Curated
    Sequence conflicti912 – 9121Q → E in BAB27027. (PubMed:16141072)Curated
    Sequence conflicti1087 – 10871L → P in BAB27027. (PubMed:16141072)Curated
    Sequence conflicti1087 – 10871L → P in BAD32619. (PubMed:15368895)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1166 – 11661N → K in isoform 2. 2 PublicationsVSP_027095
    Alternative sequencei1167 – 1761595Missing in isoform 2. 2 PublicationsVSP_027096Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607145 Genomic DNA. Translation: CAM18127.1.
    AL611967 Genomic DNA. No translation available.
    AK173341 mRNA. Translation: BAD32619.1.
    AK010559 mRNA. Translation: BAB27027.1. Frameshift.
    CCDSiCCDS38973.1. [Q9CWL2-2]
    RefSeqiNP_081471.2. NM_027195.2. [Q9CWL2-2]
    UniGeneiMm.233879.

    Genome annotation databases

    EnsembliENSMUST00000094464; ENSMUSP00000092035; ENSMUSG00000028977. [Q9CWL2-2]
    GeneIDi69743.
    KEGGimmu:69743.
    UCSCiuc008vvl.1. mouse. [Q9CWL2-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL607145 Genomic DNA. Translation: CAM18127.1 .
    AL611967 Genomic DNA. No translation available.
    AK173341 mRNA. Translation: BAD32619.1 .
    AK010559 mRNA. Translation: BAB27027.1 . Frameshift.
    CCDSi CCDS38973.1. [Q9CWL2-2 ]
    RefSeqi NP_081471.2. NM_027195.2. [Q9CWL2-2 ]
    UniGenei Mm.233879.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CWL2.

    Proteomic databases

    MaxQBi Q9CWL2.
    PaxDbi Q9CWL2.
    PRIDEi Q9CWL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000094464 ; ENSMUSP00000092035 ; ENSMUSG00000028977 . [Q9CWL2-2 ]
    GeneIDi 69743.
    KEGGi mmu:69743.
    UCSCi uc008vvl.1. mouse. [Q9CWL2-2 ]

    Organism-specific databases

    CTDi 54897.
    MGIi MGI:1196251. Casz1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG324200.
    GeneTreei ENSGT00390000008187.
    HOVERGENi HBG080122.
    InParanoidi Q9CWL2.
    OMAi TAEGTRC.
    OrthoDBi EOG73NG37.

    Miscellaneous databases

    NextBioi 330234.
    PROi Q9CWL2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CWL2.
    Bgeei Q9CWL2.
    CleanExi MM_CASZ1.
    Genevestigatori Q9CWL2.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-1761 (ISOFORM 2).
      Tissue: Pancreatic islet.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 912-1761 (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    4. "Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development."
      Vacalla C.M.H., Theil T.
      Mech. Dev. 118:265-268(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    5. "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
      Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
      Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCASZ1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CWL2
    Secondary accession number(s): A2A8A1, Q69Z25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3