Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CWL2

- CASZ1_MOUSE

UniProt

Q9CWL2 - CASZ1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein castor homolog 1

Gene

Casz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri667 – 69125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein castor homolog 1
Alternative name(s):
Castor-related protein
Gene namesi
Name:Casz1
Synonyms:Cst, D4Ertd432e, Kiaa3026
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1196251. Casz1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17611761Zinc finger protein castor homolog 1PRO_0000046913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei981 – 9811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CWL2.
PaxDbiQ9CWL2.
PRIDEiQ9CWL2.

PTM databases

PhosphoSiteiQ9CWL2.

Expressioni

Tissue specificityi

Expressed in the brain stem and the thalamencephalon.2 Publications

Developmental stagei

First expressed at E8.0 in the developing heart and throughout development. By E8.5, it is expressed in the lateral neural folds of the hindbrain and extends anteriorly and posteriorly to eventually cover the dorsal neural tube from the isthmus to its caudal end. From E9.5, it is expressed in the dorsomedial telencephalon. In the hindbrain, it is confined to trigeminal motor neurons and to migrating facial branchiomotor neurons. In the peripheral nervous system, it is expressed in cranial and in dorsal root ganglia. Also expressed in the developing eye and in the nasal placode.1 Publication

Inductioni

Up-regulated during myoblast differentiation.1 Publication

Gene expression databases

BgeeiQ9CWL2.
CleanExiMM_CASZ1.
ExpressionAtlasiQ9CWL2. baseline and differential.
GenevestigatoriQ9CWL2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi383 – 41634Pro-richAdd
BLAST
Compositional biasi1080 – 114364Pro-richAdd
BLAST
Compositional biasi1669 – 168113Poly-ThrAdd
BLAST
Compositional biasi1702 – 172928Asp-richAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri550 – 57425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri609 – 63325C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri667 – 69125C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1031 – 105525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1300 – 132425C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1457 – 148125C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1515 – 153723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1571 – 159525C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG324200.
GeneTreeiENSGT00390000008187.
HOVERGENiHBG080122.
InParanoidiQ9CWL2.
OMAiTAEGTRC.
OrthoDBiEOG73NG37.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CWL2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLGTAESTR CTDPPAGKPP MAAKRKGGLK LNAICAKLSR QVVVEKGAEA
60 70 80 90 100
GSQAEGSPLH PRDKERSGPE SGVSRAPRSE EDKRRAVIEK WVNGEYCEDP
110 120 130 140 150
APTPVLGRIA RDQELPPEGV YMVQPQGCSD EEDHAEEPSK DNSVLEEKES
160 170 180 190 200
DGTASKDDSG PSTRQASGET SSLRDYAAST MTEFLGMFGY DDQNTRDELA
210 220 230 240 250
KKISFEKPHA GSTPEVAASS MLPSSEDTLS KRARFSKYEE YIRKLKAGEQ
260 270 280 290 300
LPWPAHGSKA EDRAGKEVVG PLPSLRLPSN TAHLETKATI LPLPSHSSVQ
310 320 330 340 350
MQNLVARASK YDFFIHKLKT GENLRPQNGS TYKKPSKYDL ENVKYLHLFK
360 370 380 390 400
PGEGSPDMGG AIAFKTGKVG RPSKYDVRGI QKPGPTKIPP APSLVPTPLT
410 420 430 440 450
NVPSAPSTPG PGPEPPASLS FNTPEYLKST FSKTDSITTG TVSTVKNGLP
460 470 480 490 500
TDKPAVTEDV NIYQKYIARF SGSQHCGHIH CAYQYREHYH CLDPECNYQR
510 520 530 540 550
FTSKQDVIRH YNMHKKRDNS LQHGFMRFSP LDDCSVYYHG CHLNGKSTHY
560 570 580 590 600
HCMQVGCNKV YTSTSDVMTH ENFHKKNTQL INDGFQRFRA TEDCGTADCQ
610 620 630 640 650
FYGQKTTHFH CRRPGCTFTF KNKCDIEKHK SYHIKDDAYA KDGFKKFYKY
660 670 680 690 700
EECKYEGCMY SKATNHFHCI RAGCGFTFTS TSQMTSHKRK HERRHIRSSG
710 720 730 740 750
ALGLPASLLG AKDTEHEESS NDDLVDFSAL SSKNSSLSAS PTSQQSSASL
760 770 780 790 800
AAAAAATTAE AIPSATKPPN SKMAGLLPQG LSGSIPLALA LSNSGLPTTT
810 820 830 840 850
PYFPLLPNRG SASLPVGSPG LLGSMSSGAT TSATPDMPAL MASRAGDSAP
860 870 880 890 900
TAATSLSVPP ASIIERISAS KGLISPMMAR LAAAALKPSA TFDPGSGQQP
910 920 930 940 950
TPTKFPQAQV KQEPDSAGTP GPHEASQDRS LDLTVKDPSN ESNGHAVSAN
960 970 980 990 1000
SSLLSSLMNK MSQGNPSLES FLSIKTEAEG SPAGEPSPFL GKAVKALVQE
1010 1020 1030 1040 1050
KLSEPWKVYL RRFGTKDFCD AQCDFLHKAH FHCVVEECGA LFSTLDGAIK
1060 1070 1080 1090 1100
HANFHFRTEG GTAKGTPEAS FPTSAAETKP PLAPSSLPAP PGTMVAGSSL
1110 1120 1130 1140 1150
EGPAPSPVSV PSTPTLLAWK QLASTIPQMP QIPSSVPHLP TSPLATTSLE
1160 1170 1180 1190 1200
SAKPQVKPGF LQFQDNDPCL ATDCKYASKF HFHCLFGNCK YVCKTSGKAE
1210 1220 1230 1240 1250
SHCLDHINPS NSLVNVRDQF AYYSLQCLCP NQHCEFRMRG HYHCLRTGCY
1260 1270 1280 1290 1300
FVTNITTKLP WHIKKHEKAE RRAANGFKYF TKREECGRLG CKYNQVNSHF
1310 1320 1330 1340 1350
HCIREGCQFS FLLKHQMTSH ARKHMRRMLG KNFDRVPPSQ GPPSLMDAET
1360 1370 1380 1390 1400
DEGMDYTGCS PGAASSESST MDRSCSSTPV GNESTAAGNT ISMPTASGAK
1410 1420 1430 1440 1450
KRFWIIEDMS PFGKRRKTAS SRKMLDEGMM LEGFRRFDLY EDCKDTACQF
1460 1470 1480 1490 1500
SLKVTHYHCT RENCGYKFCG RTHMYKHAQH HDRVDNLVLD DFKRFKASLS
1510 1520 1530 1540 1550
CHFADCPFSG TSTHFHCLRC RFRCTDSTKV TAHRKHHGKQ DVISAAGFCQ
1560 1570 1580 1590 1600
FSSSADCAVP DCKYKLKCSH FHCTYPGCRH TVVGMSQMDS HKRKHEKQER
1610 1620 1630 1640 1650
GEPPAASPGA PVNLDGSLTL AAEQGSLLFL QTAAAGLGLL GDTGDPGPPV
1660 1670 1680 1690 1700
TASGTRDGPA APTPAAAATT TTTTTATATA TAGESSQEDD EELELPEEEA
1710 1720 1730 1740 1750
EDDDEDDDEE DDDDEDDDDD DDDEDLRTDS EESLPEAAGE AGARTPLAAL
1760
GGPGPAPTAA S

Note: Gene prediction based on similarity to human ortholog.

Length:1,761
Mass (Da):191,188
Last modified:July 24, 2007 - v3
Checksum:iC0C1959D68D62D50
GO
Isoform 2 (identifier: Q9CWL2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1166-1166: N → K
     1167-1761: Missing.

Show »
Length:1,166
Mass (Da):125,596
Checksum:i4804ED3BB3A77BD2
GO

Sequence cautioni

The sequence BAB27027.1 differs from that shown. Reason: Frameshift at position 946. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti884 – 8841A → S in BAD32619. (PubMed:15368895)Curated
Sequence conflicti912 – 9121Q → E in BAB27027. (PubMed:16141072)Curated
Sequence conflicti1087 – 10871L → P in BAB27027. (PubMed:16141072)Curated
Sequence conflicti1087 – 10871L → P in BAD32619. (PubMed:15368895)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1166 – 11661N → K in isoform 2. 2 PublicationsVSP_027095
Alternative sequencei1167 – 1761595Missing in isoform 2. 2 PublicationsVSP_027096Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607145 Genomic DNA. Translation: CAM18127.1.
AL611967 Genomic DNA. No translation available.
AK173341 mRNA. Translation: BAD32619.1.
AK010559 mRNA. Translation: BAB27027.1. Frameshift.
CCDSiCCDS38973.1. [Q9CWL2-2]
RefSeqiNP_081471.2. NM_027195.2. [Q9CWL2-2]
UniGeneiMm.233879.

Genome annotation databases

EnsembliENSMUST00000094464; ENSMUSP00000092035; ENSMUSG00000028977. [Q9CWL2-2]
GeneIDi69743.
KEGGimmu:69743.
UCSCiuc008vvl.1. mouse. [Q9CWL2-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607145 Genomic DNA. Translation: CAM18127.1 .
AL611967 Genomic DNA. No translation available.
AK173341 mRNA. Translation: BAD32619.1 .
AK010559 mRNA. Translation: BAB27027.1 . Frameshift.
CCDSi CCDS38973.1. [Q9CWL2-2 ]
RefSeqi NP_081471.2. NM_027195.2. [Q9CWL2-2 ]
UniGenei Mm.233879.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CWL2.

Proteomic databases

MaxQBi Q9CWL2.
PaxDbi Q9CWL2.
PRIDEi Q9CWL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094464 ; ENSMUSP00000092035 ; ENSMUSG00000028977 . [Q9CWL2-2 ]
GeneIDi 69743.
KEGGi mmu:69743.
UCSCi uc008vvl.1. mouse. [Q9CWL2-2 ]

Organism-specific databases

CTDi 54897.
MGIi MGI:1196251. Casz1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG324200.
GeneTreei ENSGT00390000008187.
HOVERGENi HBG080122.
InParanoidi Q9CWL2.
OMAi TAEGTRC.
OrthoDBi EOG73NG37.

Miscellaneous databases

NextBioi 330234.
PROi Q9CWL2.
SOURCEi Search...

Gene expression databases

Bgeei Q9CWL2.
CleanExi MM_CASZ1.
ExpressionAtlasi Q9CWL2. baseline and differential.
Genevestigatori Q9CWL2.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 286-1761 (ISOFORM 2).
    Tissue: Pancreatic islet.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 912-1761 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  4. "Cst, a novel mouse gene related to Drosophila Castor, exhibits dynamic expression patterns during neurogenesis and heart development."
    Vacalla C.M.H., Theil T.
    Mech. Dev. 118:265-268(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Molecular cloning and characterization of human Castor, a novel human gene upregulated during cell differentiation."
    Liu Z., Yang X., Tan F., Cullion K., Thiele C.J.
    Biochem. Biophys. Res. Commun. 344:834-844(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCASZ1_MOUSE
AccessioniPrimary (citable) accession number: Q9CWL2
Secondary accession number(s): A2A8A1, Q69Z25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3