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Q9CWK8

- SNX2_MOUSE

UniProt

Q9CWK8 - SNX2_MOUSE

Protein

Sorting nexin-2

Gene

Snx2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei183 – 1831Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei185 – 1851Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei211 – 2111Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei235 – 2351Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: RefGenome

    GO - Biological processi

    1. endocytosis Source: InterPro
    2. intracellular protein transport Source: RefGenome

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-2
    Gene namesi
    Name:Snx2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1915054. Snx2.

    Subcellular locationi

    Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: RefGenome
    2. early endosome membrane Source: UniProtKB-SubCell
    3. endosome Source: RefGenome
    4. endosome membrane Source: UniProtKB
    5. retromer complex Source: InterPro

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Mice are born at the expected Mendelian ratio and are fertile. Mice lacking both Snx1 and Snx2 die during embryonic development, around 9.5 and 11.5 dpc.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 519519Sorting nexin-2PRO_0000213839Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei119 – 1191Phosphoserine1 Publication
    Modified residuei185 – 1851PhosphoserineBy similarity
    Modified residuei277 – 2771PhosphoserineBy similarity
    Modified residuei469 – 4691N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CWK8.
    PaxDbiQ9CWK8.
    PRIDEiQ9CWK8.

    PTM databases

    PhosphoSiteiQ9CWK8.

    Expressioni

    Gene expression databases

    BgeeiQ9CWK8.
    CleanExiMM_SNX2.
    GenevestigatoriQ9CWK8.

    Interactioni

    Subunit structurei

    Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with FNBP1. Interacts with SNX6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi212452. 1 interaction.
    MINTiMINT-1864976.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CWK8.
    SMRiQ9CWK8. Positions 140-510.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini140 – 269130PXPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    GeneTreeiENSGT00740000114933.
    HOGENOMiHOG000293327.
    HOVERGENiHBG000618.
    InParanoidiQ9CWK8.
    KOiK17917.
    OMAiCEEHTGL.
    OrthoDBiEOG7HHWSB.
    PhylomeDBiQ9CWK8.
    TreeFamiTF313698.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR028653. SNX2.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view]
    PANTHERiPTHR10555:SF31. PTHR10555:SF31. 1 hit.
    PfamiPF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CWK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEREPPPL GDVKPTDFEE LEDGEDLFTS TVSTLESSPS SPEPASLPAE    50
    DISANSNGSK PVEVVLDDDR EDLFAEATEE VSLDSPEREL ILSSEPSPAV 100
    TPVTPTTLIA PRIESKSISA PVIFDRSRDE IEEEANGDIF DIEIGVSDPE 150
    KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV KRRFSDFLGL HSKLASKYLH 200
    VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE RYLQRTVKHP 250
    TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN 300
    ESDAWFEEKQ QQFENLDQQL RKLHASVEAL VCHRKELSAN TAAFAKSAAM 350
    LGNSEDHTAL SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI 400
    AAVKGVFDHR MKCWQKWEDA QITLLKKRET EAKMMVANKP DKIQQAKNEI 450
    REWEAKVQQG ERDFEQISKT IRKEVGRFEK ERVKDFKAVI IKYLESLVQT 500
    QQQLIKYWEA FLPEAKAIA 519
    Length:519
    Mass (Da):58,471
    Last modified:March 27, 2002 - v2
    Checksum:i55DD0BB74E82CD82
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti245 – 2451R → I in BAB27035. (PubMed:16141072)Curated
    Sequence conflicti428 – 4281R → P in BAB27035. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002692 mRNA. Translation: BAB22287.1.
    AK005470 mRNA. Translation: BAB24060.1.
    AK010572 mRNA. Translation: BAB27035.1.
    AK075929 mRNA. Translation: BAC36060.1.
    AK145840 mRNA. Translation: BAE26688.1.
    CCDSiCCDS37821.1.
    RefSeqiNP_080662.1. NM_026386.1.
    UniGeneiMm.252171.

    Genome annotation databases

    EnsembliENSMUST00000037850; ENSMUSP00000039243; ENSMUSG00000034484.
    GeneIDi67804.
    KEGGimmu:67804.
    UCSCiuc008exr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002692 mRNA. Translation: BAB22287.1 .
    AK005470 mRNA. Translation: BAB24060.1 .
    AK010572 mRNA. Translation: BAB27035.1 .
    AK075929 mRNA. Translation: BAC36060.1 .
    AK145840 mRNA. Translation: BAE26688.1 .
    CCDSi CCDS37821.1.
    RefSeqi NP_080662.1. NM_026386.1.
    UniGenei Mm.252171.

    3D structure databases

    ProteinModelPortali Q9CWK8.
    SMRi Q9CWK8. Positions 140-510.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212452. 1 interaction.
    MINTi MINT-1864976.

    PTM databases

    PhosphoSitei Q9CWK8.

    Proteomic databases

    MaxQBi Q9CWK8.
    PaxDbi Q9CWK8.
    PRIDEi Q9CWK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037850 ; ENSMUSP00000039243 ; ENSMUSG00000034484 .
    GeneIDi 67804.
    KEGGi mmu:67804.
    UCSCi uc008exr.1. mouse.

    Organism-specific databases

    CTDi 6643.
    MGIi MGI:1915054. Snx2.

    Phylogenomic databases

    eggNOGi COG5391.
    GeneTreei ENSGT00740000114933.
    HOGENOMi HOG000293327.
    HOVERGENi HBG000618.
    InParanoidi Q9CWK8.
    KOi K17917.
    OMAi CEEHTGL.
    OrthoDBi EOG7HHWSB.
    PhylomeDBi Q9CWK8.
    TreeFami TF313698.

    Miscellaneous databases

    ChiTaRSi SNX2. mouse.
    NextBioi 325603.
    PROi Q9CWK8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CWK8.
    CleanExi MM_SNX2.
    Genevestigatori Q9CWK8.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR028653. SNX2.
    IPR005329. Sorting_nexin_N.
    IPR015404. Vps5_C.
    [Graphical view ]
    PANTHERi PTHR10555:SF31. PTHR10555:SF31. 1 hit.
    Pfami PF00787. PX. 1 hit.
    PF03700. Sorting_nexin. 1 hit.
    PF09325. Vps5. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell, Kidney and Placenta.
    2. "Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice."
      Schwarz D.G., Griffin C.T., Schneider E.A., Yee D., Magnuson T.
      Mol. Biol. Cell 13:3588-3600(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiSNX2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CWK8
    Secondary accession number(s): Q3UKW3, Q9CQV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3