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Q9CWK8

- SNX2_MOUSE

UniProt

Q9CWK8 - SNX2_MOUSE

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Protein

Sorting nexin-2

Gene
Snx2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei183 – 1831Phosphatidylinositol 3-phosphate By similarity
Binding sitei185 – 1851Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei211 – 2111Phosphatidylinositol 3-phosphate By similarity
Binding sitei235 – 2351Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: RefGenome

GO - Biological processi

  1. endocytosis Source: InterPro
  2. intracellular protein transport Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-2
Gene namesi
Name:Snx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1915054. Snx2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: RefGenome
  2. early endosome membrane Source: UniProtKB-SubCell
  3. endosome Source: RefGenome
  4. endosome membrane Source: UniProtKB
  5. retromer complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Mice are born at the expected Mendelian ratio and are fertile. Mice lacking both Snx1 and Snx2 die during embryonic development, around 9.5 and 11.5 dpc.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 519519Sorting nexin-2PRO_0000213839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei119 – 1191Phosphoserine1 Publication
Modified residuei185 – 1851Phosphoserine By similarity
Modified residuei277 – 2771Phosphoserine By similarity
Modified residuei469 – 4691N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CWK8.
PaxDbiQ9CWK8.
PRIDEiQ9CWK8.

PTM databases

PhosphoSiteiQ9CWK8.

Expressioni

Gene expression databases

BgeeiQ9CWK8.
CleanExiMM_SNX2.
GenevestigatoriQ9CWK8.

Interactioni

Subunit structurei

Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts with FNBP1. Interacts with SNX6 By similarity.

Protein-protein interaction databases

BioGridi212452. 1 interaction.
MINTiMINT-1864976.

Structurei

3D structure databases

ProteinModelPortaliQ9CWK8.
SMRiQ9CWK8. Positions 140-510.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 269130PXAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00740000114933.
HOGENOMiHOG000293327.
HOVERGENiHBG000618.
InParanoidiQ9CWK8.
KOiK17917.
OMAiCEEHTGL.
OrthoDBiEOG7HHWSB.
PhylomeDBiQ9CWK8.
TreeFamiTF313698.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028653. SNX2.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view]
PANTHERiPTHR10555:SF31. PTHR10555:SF31. 1 hit.
PfamiPF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWK8-1 [UniParc]FASTAAdd to Basket

« Hide

MAAEREPPPL GDVKPTDFEE LEDGEDLFTS TVSTLESSPS SPEPASLPAE    50
DISANSNGSK PVEVVLDDDR EDLFAEATEE VSLDSPEREL ILSSEPSPAV 100
TPVTPTTLIA PRIESKSISA PVIFDRSRDE IEEEANGDIF DIEIGVSDPE 150
KVGDGMNAYM AYRVTTKTSL SMFSKSEFSV KRRFSDFLGL HSKLASKYLH 200
VGYIVPPAPE KSIVGMTKVK VGKEDSSSTE FVEKRRAALE RYLQRTVKHP 250
TLLQDPDLRQ FLESSELPRA VNTQALSGAG ILRMVNKAAD AVNKMTIKMN 300
ESDAWFEEKQ QQFENLDQQL RKLHASVEAL VCHRKELSAN TAAFAKSAAM 350
LGNSEDHTAL SRALSQLAEV EEKIDQLHQE QAFADFYMFS ELLSDYIRLI 400
AAVKGVFDHR MKCWQKWEDA QITLLKKRET EAKMMVANKP DKIQQAKNEI 450
REWEAKVQQG ERDFEQISKT IRKEVGRFEK ERVKDFKAVI IKYLESLVQT 500
QQQLIKYWEA FLPEAKAIA 519
Length:519
Mass (Da):58,471
Last modified:March 27, 2002 - v2
Checksum:i55DD0BB74E82CD82
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti245 – 2451R → I in BAB27035. 1 Publication
Sequence conflicti428 – 4281R → P in BAB27035. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002692 mRNA. Translation: BAB22287.1.
AK005470 mRNA. Translation: BAB24060.1.
AK010572 mRNA. Translation: BAB27035.1.
AK075929 mRNA. Translation: BAC36060.1.
AK145840 mRNA. Translation: BAE26688.1.
CCDSiCCDS37821.1.
RefSeqiNP_080662.1. NM_026386.1.
UniGeneiMm.252171.

Genome annotation databases

EnsembliENSMUST00000037850; ENSMUSP00000039243; ENSMUSG00000034484.
GeneIDi67804.
KEGGimmu:67804.
UCSCiuc008exr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002692 mRNA. Translation: BAB22287.1 .
AK005470 mRNA. Translation: BAB24060.1 .
AK010572 mRNA. Translation: BAB27035.1 .
AK075929 mRNA. Translation: BAC36060.1 .
AK145840 mRNA. Translation: BAE26688.1 .
CCDSi CCDS37821.1.
RefSeqi NP_080662.1. NM_026386.1.
UniGenei Mm.252171.

3D structure databases

ProteinModelPortali Q9CWK8.
SMRi Q9CWK8. Positions 140-510.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212452. 1 interaction.
MINTi MINT-1864976.

PTM databases

PhosphoSitei Q9CWK8.

Proteomic databases

MaxQBi Q9CWK8.
PaxDbi Q9CWK8.
PRIDEi Q9CWK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037850 ; ENSMUSP00000039243 ; ENSMUSG00000034484 .
GeneIDi 67804.
KEGGi mmu:67804.
UCSCi uc008exr.1. mouse.

Organism-specific databases

CTDi 6643.
MGIi MGI:1915054. Snx2.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00740000114933.
HOGENOMi HOG000293327.
HOVERGENi HBG000618.
InParanoidi Q9CWK8.
KOi K17917.
OMAi CEEHTGL.
OrthoDBi EOG7HHWSB.
PhylomeDBi Q9CWK8.
TreeFami TF313698.

Miscellaneous databases

ChiTaRSi SNX2. mouse.
NextBioi 325603.
PROi Q9CWK8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CWK8.
CleanExi MM_SNX2.
Genevestigatori Q9CWK8.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028653. SNX2.
IPR005329. Sorting_nexin_N.
IPR015404. Vps5_C.
[Graphical view ]
PANTHERi PTHR10555:SF31. PTHR10555:SF31. 1 hit.
Pfami PF00787. PX. 1 hit.
PF03700. Sorting_nexin. 1 hit.
PF09325. Vps5. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell, Kidney and Placenta.
  2. "Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice."
    Schwarz D.G., Griffin C.T., Schneider E.A., Yee D., Magnuson T.
    Mol. Biol. Cell 13:3588-3600(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiSNX2_MOUSE
AccessioniPrimary (citable) accession number: Q9CWK8
Secondary accession number(s): Q3UKW3, Q9CQV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 27, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi