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Protein

CD2 antigen cytoplasmic tail-binding protein 2

Gene

Cd2bp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
CD2 antigen cytoplasmic tail-binding protein 2
Short name:
CD2 cytoplasmic domain-binding protein 2
Short name:
CD2 tail-binding protein 2
Gene namesi
Name:Cd2bp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1917483. Cd2bp2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342CD2 antigen cytoplasmic tail-binding protein 2PRO_0000089438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441N6-acetyllysineCombined sources
Modified residuei46 – 461PhosphoserineBy similarity
Modified residuei49 – 491PhosphoserineCombined sources
Modified residuei117 – 1171PhosphoserineBy similarity
Modified residuei196 – 1961PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CWK3.
MaxQBiQ9CWK3.
PaxDbiQ9CWK3.
PRIDEiQ9CWK3.

PTM databases

iPTMnetiQ9CWK3.
PhosphoSiteiQ9CWK3.

Expressioni

Gene expression databases

BgeeiQ9CWK3.
CleanExiMM_CD2BP2.
GenevisibleiQ9CWK3. MM.

Interactioni

Subunit structurei

Component of the U5 snRNP complex composed of the U5 snRNA and at least PRPF6, PRPF8, SNRNP200, EFTUD2, SNRNP40, DDX23, TXNL4A and CD2BP2. Interacts directly with TXNL4A and PRPF6. Interacts (via GYF domain) with CD2 (via Pro-rich sequence in the cytoplasmic domain). Interacts with PQBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213930. 1 interaction.
IntActiQ9CWK3. 1 interaction.
MINTiMINT-4090161.
STRINGi10090.ENSMUSP00000044790.

Structurei

3D structure databases

ProteinModelPortaliQ9CWK3.
SMRiQ9CWK3. Positions 281-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini281 – 33959GYFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GYF domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2950. Eukaryota.
ENOG4111KF5. LUCA.
GeneTreeiENSGT00390000012483.
HOVERGENiHBG056920.
InParanoidiQ9CWK3.
KOiK13099.
OMAiTGNMDIY.
OrthoDBiEOG7VMP6C.
PhylomeDBiQ9CWK3.
TreeFamiTF313042.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVTFQG VGDEDGEDEI SVPKKKLVDP VAAAGGPGSR FKGKHSLDSD
60 70 80 90 100
EEDDDEEGSS KYDILASEDV EGQEAATLPS EGGVRITPFN LQEEMEEGHF
110 120 130 140 150
DADGNYFLNQ DAQIRDSWLD NIDWVRIKER PPDKHQVSDS EEEDSLGQTP
160 170 180 190 200
MSAQALLEGL LELLLPRETV AGALRRLGAR GGGKGSNSKG TGRPNSPQRL
210 220 230 240 250
DRLSGLADQM VARGNLGVYQ ETRERLAMRL KGLGCRAQGS HDPTPPPSLD
260 270 280 290 300
MFAEEVAEGE LETPTPTQRE EAESAGDGLM DVMWEYKWEN TGDAELYGPF
310 320 330 340
TSAQMQTWVS EGYFPDGVYC RKLDPPGGQF YNSKRIDFEL YT
Length:342
Mass (Da):37,694
Last modified:June 1, 2001 - v1
Checksum:i6B00FBE777A19206
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006920 mRNA. Translation: AAH06920.1.
AK010582 mRNA. Translation: BAB27044.1.
AK030393 mRNA. Translation: BAC26940.1.
AK031694 mRNA. Translation: BAC27518.1.
AK034689 mRNA. Translation: BAC28798.1.
AK167249 mRNA. Translation: BAE39370.1.
CCDSiCCDS21859.1.
RefSeqiNP_001272834.1. NM_001285905.1.
NP_001272835.1. NM_001285906.1.
NP_001272836.1. NM_001285907.1.
NP_081629.1. NM_027353.4.
XP_006508260.1. XM_006508197.2.
XP_006508261.1. XM_006508198.2.
XP_011240200.1. XM_011241898.1.
UniGeneiMm.28050.

Genome annotation databases

EnsembliENSMUST00000035771; ENSMUSP00000044790; ENSMUSG00000042502.
ENSMUST00000166791; ENSMUSP00000132963; ENSMUSG00000042502.
ENSMUST00000205316; ENSMUSP00000145888; ENSMUSG00000042502.
ENSMUST00000206026; ENSMUSP00000146167; ENSMUSG00000042502.
GeneIDi70233.
KEGGimmu:70233.
UCSCiuc009juj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006920 mRNA. Translation: AAH06920.1.
AK010582 mRNA. Translation: BAB27044.1.
AK030393 mRNA. Translation: BAC26940.1.
AK031694 mRNA. Translation: BAC27518.1.
AK034689 mRNA. Translation: BAC28798.1.
AK167249 mRNA. Translation: BAE39370.1.
CCDSiCCDS21859.1.
RefSeqiNP_001272834.1. NM_001285905.1.
NP_001272835.1. NM_001285906.1.
NP_001272836.1. NM_001285907.1.
NP_081629.1. NM_027353.4.
XP_006508260.1. XM_006508197.2.
XP_006508261.1. XM_006508198.2.
XP_011240200.1. XM_011241898.1.
UniGeneiMm.28050.

3D structure databases

ProteinModelPortaliQ9CWK3.
SMRiQ9CWK3. Positions 281-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213930. 1 interaction.
IntActiQ9CWK3. 1 interaction.
MINTiMINT-4090161.
STRINGi10090.ENSMUSP00000044790.

PTM databases

iPTMnetiQ9CWK3.
PhosphoSiteiQ9CWK3.

Proteomic databases

EPDiQ9CWK3.
MaxQBiQ9CWK3.
PaxDbiQ9CWK3.
PRIDEiQ9CWK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035771; ENSMUSP00000044790; ENSMUSG00000042502.
ENSMUST00000166791; ENSMUSP00000132963; ENSMUSG00000042502.
ENSMUST00000205316; ENSMUSP00000145888; ENSMUSG00000042502.
ENSMUST00000206026; ENSMUSP00000146167; ENSMUSG00000042502.
GeneIDi70233.
KEGGimmu:70233.
UCSCiuc009juj.2. mouse.

Organism-specific databases

CTDi10421.
MGIiMGI:1917483. Cd2bp2.

Phylogenomic databases

eggNOGiKOG2950. Eukaryota.
ENOG4111KF5. LUCA.
GeneTreeiENSGT00390000012483.
HOVERGENiHBG056920.
InParanoidiQ9CWK3.
KOiK13099.
OMAiTGNMDIY.
OrthoDBiEOG7VMP6C.
PhylomeDBiQ9CWK3.
TreeFamiTF313042.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ9CWK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWK3.
CleanExiMM_CD2BP2.
GenevisibleiQ9CWK3. MM.

Family and domain databases

Gene3Di3.30.1490.40. 1 hit.
InterProiIPR003169. GYF.
[Graphical view]
PfamiPF02213. GYF. 1 hit.
[Graphical view]
SMARTiSM00444. GYF. 1 hit.
[Graphical view]
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiPS50829. GYF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Pituitary and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-44, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiCD2B2_MOUSE
AccessioniPrimary (citable) accession number: Q9CWK3
Secondary accession number(s): Q3TJX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.