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Protein

BRCA2 and CDKN1A-interacting protein

Gene

Bccip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA2 and CDKN1A-interacting protein
Gene namesi
Name:Bccip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913415. Bccip.

Subcellular locationi

  • Nucleus

  • Note: Colocalizes with BRCA2 in discrete nuclear foci.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316BRCA2 and CDKN1A-interacting proteinPRO_0000249688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441PhosphoserineBy similarity
Modified residuei114 – 1141PhosphoserineBy similarity
Modified residuei283 – 2831PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWI3.
MaxQBiQ9CWI3.
PaxDbiQ9CWI3.
PRIDEiQ9CWI3.

PTM databases

iPTMnetiQ9CWI3.
PhosphoSiteiQ9CWI3.

Expressioni

Gene expression databases

BgeeiQ9CWI3.
CleanExiMM_BCCIP.
GenevisibleiQ9CWI3. MM.

Interactioni

Subunit structurei

Interacts with BRCA2, CDKN1A and MTDH/LYRIC.By similarity

Protein-protein interaction databases

IntActiQ9CWI3. 1 interaction.
MINTiMINT-4615024.
STRINGi10090.ENSMUSP00000033282.

Structurei

3D structure databases

ProteinModelPortaliQ9CWI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni61 – 169109Interaction with BRCA2By similarityAdd
BLAST
Regioni163 – 26199Interaction with CDKN1ABy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the BCP1 family.Curated

Phylogenomic databases

eggNOGiKOG3034. Eukaryota.
ENOG4111GYV. LUCA.
GeneTreeiENSGT00390000000696.
HOGENOMiHOG000047210.
HOVERGENiHBG054955.
InParanoidiQ9CWI3.
KOiK15262.
OMAiRAHINCN.
OrthoDBiEOG7992RJ.
PhylomeDBiQ9CWI3.
TreeFamiTF320301.

Family and domain databases

InterProiIPR025602. BCP1_family.
[Graphical view]
PANTHERiPTHR13261. PTHR13261. 1 hit.
PfamiPF13862. BCIP. 1 hit.
[Graphical view]
PIRSFiPIRSF028983. BCP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKAKKRAV GNGIQRPLGA PGQREEEEEE EDEVEDEEED EDDSDEEEDE
60 70 80 90 100
VDEIVDEEVN IEFEAYSISD NDYGGIKKLL QQLFLKAPVN TAELTNLLMQ
110 120 130 140 150
QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI SLLNLTERKG TQCAEQIKEL
160 170 180 190 200
VLSFCEKTCE QSMVEQLDKL LNDTSKPVGL LLSERFINVP PQIALPMHQQ
210 220 230 240 250
LQKELSEARR TNKPCGKCCF YLLISKTFME AGKSSSRKRQ DSLQQGALMF
260 270 280 290 300
ANAEEEFFYE KAILKFSYSV QGESDTRLGG RWSFDDVPMT PLRTVMVIPD
310
DRMNEIMETL KDHLSV
Length:316
Mass (Da):35,942
Last modified:June 1, 2001 - v1
Checksum:i49E59C1AF93A149B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti83 – 831L → P in BAB22925 (PubMed:16141072).Curated
Sequence conflicti301 – 3011D → G in BAB22925 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003666 mRNA. Translation: BAB22925.1.
AK010684 mRNA. Translation: BAB27116.1.
BC048465 mRNA. Translation: AAH48465.1.
CCDSiCCDS21935.1.
RefSeqiNP_079668.2. NM_025392.2.
UniGeneiMm.389983.

Genome annotation databases

EnsembliENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983.
GeneIDi66165.
KEGGimmu:66165.
UCSCiuc009kdi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003666 mRNA. Translation: BAB22925.1.
AK010684 mRNA. Translation: BAB27116.1.
BC048465 mRNA. Translation: AAH48465.1.
CCDSiCCDS21935.1.
RefSeqiNP_079668.2. NM_025392.2.
UniGeneiMm.389983.

3D structure databases

ProteinModelPortaliQ9CWI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CWI3. 1 interaction.
MINTiMINT-4615024.
STRINGi10090.ENSMUSP00000033282.

PTM databases

iPTMnetiQ9CWI3.
PhosphoSiteiQ9CWI3.

Proteomic databases

EPDiQ9CWI3.
MaxQBiQ9CWI3.
PaxDbiQ9CWI3.
PRIDEiQ9CWI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983.
GeneIDi66165.
KEGGimmu:66165.
UCSCiuc009kdi.1. mouse.

Organism-specific databases

CTDi56647.
MGIiMGI:1913415. Bccip.

Phylogenomic databases

eggNOGiKOG3034. Eukaryota.
ENOG4111GYV. LUCA.
GeneTreeiENSGT00390000000696.
HOGENOMiHOG000047210.
HOVERGENiHBG054955.
InParanoidiQ9CWI3.
KOiK15262.
OMAiRAHINCN.
OrthoDBiEOG7992RJ.
PhylomeDBiQ9CWI3.
TreeFamiTF320301.

Miscellaneous databases

ChiTaRSiBccip. mouse.
PROiQ9CWI3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CWI3.
CleanExiMM_BCCIP.
GenevisibleiQ9CWI3. MM.

Family and domain databases

InterProiIPR025602. BCP1_family.
[Graphical view]
PANTHERiPTHR13261. PTHR13261. 1 hit.
PfamiPF13862. BCIP. 1 hit.
[Graphical view]
PIRSFiPIRSF028983. BCP1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Embryonic stem cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Liver, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiBCCIP_MOUSE
AccessioniPrimary (citable) accession number: Q9CWI3
Secondary accession number(s): Q9D1E0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.