Q9CWI3 (BCCIP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BRCA2 and CDKN1A-interacting protein

Gene names

Name:

Bccip

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) By similarity.
Subunit structure	Interacts with BRCA2, CDKN1A and MTDH/LYRIC By similarity.
Subcellular location	Nucleus. Note: Colocalizes with BRCA2 in discrete nuclear foci By similarity.
Sequence similarities	Belongs to the BCP1 family.

Ontologies

Keywords
Biological process	Cell cycle DNA damage DNA repair
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW neuroendocrine cell differentiation Inferred from electronic annotation. Source: Compara regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: Compara
Cellular_component	nuclear cyclin-dependent protein kinase holoenzyme complex Inferred from electronic annotation. Source: Compara
Molecular_function	kinase regulator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	BRCA2 and CDKN1A-interacting protein		PRO_0000249688
Regions
	Region	61 – 169	109	Interaction with BRCA2 By similarity
	Region	163 – 261	99	Interaction with CDKN1A By similarity
Amino acid modifications
	Modified residue	44	1	Phosphoserine By similarity
	Modified residue	117	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	83	1	L → P in BAB22925. Ref.1
	Sequence conflict	301	1	D → G in BAB22925. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9CWI3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 49E59C1AF93A149B	FASTA	316	35,942
	10 20 30 40 50 60 MASKAKKRAV GNGIQRPLGA PGQREEEEEE EDEVEDEEED EDDSDEEEDE VDEIVDEEVN 70 80 90 100 110 120 IEFEAYSISD NDYGGIKKLL QQLFLKAPVN TAELTNLLMQ QNHIGSVIKQ TDVSEDSDDE 130 140 150 160 170 180 VDEDEIFGFI SLLNLTERKG TQCAEQIKEL VLSFCEKTCE QSMVEQLDKL LNDTSKPVGL 190 200 210 220 230 240 LLSERFINVP PQIALPMHQQ LQKELSEARR TNKPCGKCCF YLLISKTFME AGKSSSRKRQ 250 260 270 280 290 300 DSLQQGALMF ANAEEEFFYE KAILKFSYSV QGESDTRLGG RWSFDDVPMT PLRTVMVIPD 310 DRMNEIMETL KDHLSV

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Embryonic stem cell.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK003666 mRNA. Translation: BAB22925.1. AK010684 mRNA. Translation: BAB27116.1. BC048465 mRNA. Translation: AAH48465.1.
IPI	IPI00133648.
RefSeq	NP_079668.2. NM_025392.2.
UniGene	Mm.389983.
3D structure databases
ProteinModelPortal	Q9CWI3.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000033282.
PTM databases
PhosphoSite	Q9CWI3.
Proteomic databases
PaxDb	Q9CWI3.
PRIDE	Q9CWI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983.
GeneID	66165.
KEGG	mmu:66165.
UCSC	uc009kdi.1. mouse.
Organism-specific databases
CTD	56647.
MGI	MGI:1913415. Bccip.
Phylogenomic databases
eggNOG	NOG310413.
GeneTree	ENSGT00390000000696.
HOGENOM	HOG000047210.
HOVERGEN	HBG054955.
InParanoid	Q9CWI3.
KO	K15262.
OMA	EFEAHSI.
OrthoDB	EOG441QC7.
Gene expression databases
Bgee	Q9CWI3.
CleanEx	MM_BCCIP.
Genevestigator	Q9CWI3.
GermOnline	ENSMUSG00000030983. Mus musculus.
Family and domain databases
InterPro	IPR025602. BCP1_family. [Graphical view]
PANTHER	PTHR13261. PTHR13261. 1 hit.
Pfam	PF13862. BCIP. 1 hit. [Graphical view]
PIRSF	PIRSF028983. BCP1. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	BCCIP. mouse.
NextBio	320826.
SOURCE	Search...

Entry information

Entry name

BCCIP_MOUSE

Accession

Primary (citable) accession number: Q9CWI3
Secondary accession number(s): Q9D1E0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program