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Protein

BRCA2 and CDKN1A-interacting protein

Gene

Bccip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: CACAO
  • DNA repair Source: UniProtKB-KW
  • microtubule anchoring Source: UniProtKB
  • microtubule cytoskeleton organization Source: UniProtKB
  • mitotic spindle assembly Source: Ensembl
  • mitotic spindle organization Source: UniProtKB
  • neuroendocrine cell differentiation Source: MGI
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI

Keywordsi

Biological processCell cycle, DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
BRCA2 and CDKN1A-interacting protein
Gene namesi
Name:Bccip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1913415. Bccip.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • cytosol Source: MGI
  • mitotic spindle pole Source: UniProtKB
  • nuclear cyclin-dependent protein kinase holoenzyme complex Source: MGI
  • nucleoplasm Source: MGI

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002496881 – 316BRCA2 and CDKN1A-interacting proteinAdd BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44PhosphoserineBy similarity1
Modified residuei114PhosphoserineBy similarity1
Modified residuei283PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CWI3.
MaxQBiQ9CWI3.
PaxDbiQ9CWI3.
PeptideAtlasiQ9CWI3.
PRIDEiQ9CWI3.

PTM databases

iPTMnetiQ9CWI3.
PhosphoSitePlusiQ9CWI3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030983.
CleanExiMM_BCCIP.
GenevisibleiQ9CWI3. MM.

Interactioni

Subunit structurei

Interacts with BRCA2, CDKN1A and MTDH/LYRIC. Interacts with DCTN1/p150-glued and ACTR1A/ARP1. Interacts with alpha-, beta- and gamma-tubulins.By similarity

Protein-protein interaction databases

IntActiQ9CWI3. 1 interactor.
MINTiMINT-4615024.
STRINGi10090.ENSMUSP00000033282.

Structurei

3D structure databases

ProteinModelPortaliQ9CWI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 169Interaction with BRCA2By similarityAdd BLAST109
Regioni163 – 261Interaction with CDKN1ABy similarityAdd BLAST99

Sequence similaritiesi

Belongs to the BCP1 family.Curated

Phylogenomic databases

eggNOGiKOG3034. Eukaryota.
ENOG4111GYV. LUCA.
GeneTreeiENSGT00390000000696.
HOGENOMiHOG000047210.
HOVERGENiHBG054955.
InParanoidiQ9CWI3.
KOiK15262.
OMAiGSVICQC.
OrthoDBiEOG091G0IXA.
PhylomeDBiQ9CWI3.
TreeFamiTF320301.

Family and domain databases

InterProiView protein in InterPro
IPR025602. BCP1_family.
PANTHERiPTHR13261. PTHR13261. 1 hit.
PfamiView protein in Pfam
PF13862. BCIP. 1 hit.
PIRSFiPIRSF028983. BCP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CWI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKAKKRAV GNGIQRPLGA PGQREEEEEE EDEVEDEEED EDDSDEEEDE
60 70 80 90 100
VDEIVDEEVN IEFEAYSISD NDYGGIKKLL QQLFLKAPVN TAELTNLLMQ
110 120 130 140 150
QNHIGSVIKQ TDVSEDSDDE VDEDEIFGFI SLLNLTERKG TQCAEQIKEL
160 170 180 190 200
VLSFCEKTCE QSMVEQLDKL LNDTSKPVGL LLSERFINVP PQIALPMHQQ
210 220 230 240 250
LQKELSEARR TNKPCGKCCF YLLISKTFME AGKSSSRKRQ DSLQQGALMF
260 270 280 290 300
ANAEEEFFYE KAILKFSYSV QGESDTRLGG RWSFDDVPMT PLRTVMVIPD
310
DRMNEIMETL KDHLSV
Length:316
Mass (Da):35,942
Last modified:June 1, 2001 - v1
Checksum:i49E59C1AF93A149B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83L → P in BAB22925 (PubMed:16141072).Curated1
Sequence conflicti301D → G in BAB22925 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003666 mRNA. Translation: BAB22925.1.
AK010684 mRNA. Translation: BAB27116.1.
BC048465 mRNA. Translation: AAH48465.1.
CCDSiCCDS21935.1.
RefSeqiNP_079668.2. NM_025392.2.
UniGeneiMm.389983.

Genome annotation databases

EnsembliENSMUST00000033282; ENSMUSP00000033282; ENSMUSG00000030983.
GeneIDi66165.
KEGGimmu:66165.
UCSCiuc009kdi.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBCCIP_MOUSE
AccessioniPrimary (citable) accession number: Q9CWI3
Secondary accession number(s): Q9D1E0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: July 5, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families