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Protein

Developmental pluripotency-associated protein 2

Gene

Dppa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status of these genes.1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI

GO - Biological processi

  • lung-associated mesenchyme development Source: MGI
  • positive regulation of stem cell proliferation Source: MGI
  • regulation of histone methylation Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • stem cell population maintenance Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Developmental pluripotency-associated protein 2
Alternative name(s):
Embryonic stem cell-associated transcript 15-2 protein
Short name:
ECAT15-2
Pluripotent embryonic stem cell-related gene 1 protein
Gene namesi
Name:Dppa2
Synonyms:Phsecrg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2157523. Dppa2.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant animals show survival rates similar to wild-type until 16.5 dpc. Then mortality increases and no animals survive beyond weaning age. At 18.5 dpc, the lungs of mutants mice show a thicker mesenchyme and smaller alveolar space than those of wild-type animals.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392641 – 301Developmental pluripotency-associated protein 2Add BLAST301

Proteomic databases

MaxQBiQ9CWH0.
PaxDbiQ9CWH0.
PRIDEiQ9CWH0.

PTM databases

iPTMnetiQ9CWH0.
PhosphoSitePlusiQ9CWH0.

Expressioni

Tissue specificityi

Not detected in adult tissues.1 Publication

Developmental stagei

Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells. Expression decreases at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression rapidly decreases upon differentiation.2 Publications

Gene expression databases

BgeeiENSMUSG00000072419.
CleanExiMM_DPPA2.
ExpressionAtlasiQ9CWH0. baseline and differential.
GenevisibleiQ9CWH0. MM.

Interactioni

Subunit structurei

Interacts with DPPA4.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110183.

Structurei

3D structure databases

ProteinModelPortaliQ9CWH0.
SMRiQ9CWH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 119SAPAdd BLAST35

Sequence similaritiesi

Contains 1 SAP domain.Curated

Phylogenomic databases

eggNOGiENOG410IJEN. Eukaryota.
ENOG4111ADR. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG095578.
InParanoidiQ9CWH0.
OMAiAWARIAM.
OrthoDBiEOG091G0QL3.
PhylomeDBiQ9CWH0.
TreeFamiTF338129.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CWH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYFGLETFN ENQSEENLDE ESVILTLVPF KEEEEPNTDY ATQSNVSSST
60 70 80 90 100
LDHTPPARSL VRHAGIKHPT RTIPSTCPPP SLPPIRDVSR NTLREWCRYH
110 120 130 140 150
NLSTDGKKVE VYLRLRRHSY SKQECYIPNT SREARMKQGP KKSKIVFRGI
160 170 180 190 200
GPPSGCQRKK EESGVLEILT SPKESTFAAW ARIAMRAAQS MSKNRCPLPS
210 220 230 240 250
NVEAFLPQAT GSRWCVVHGR QLPADKKGWV RLQFLAGQTW VPDTPQRMNF
260 270 280 290 300
LFLLPACIIP EPGVEDNLLC PECVHSNKKI LRNFKIRSRA KKNALPPNMP

P
Length:301
Mass (Da):34,116
Last modified:June 1, 2001 - v1
Checksum:i3DAC9C0EE94984E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490346 mRNA. Translation: AAO84504.1.
AY561246 mRNA. Translation: AAS68013.1.
AK010743 mRNA. Translation: BAB27153.1.
AK145760 mRNA. Translation: BAE26632.1.
AK145645 mRNA. Translation: BAE26562.1.
AK163375 mRNA. Translation: BAE37324.1.
AK167211 mRNA. Translation: BAE39338.1.
CCDSiCCDS37350.1.
RefSeqiNP_082891.1. NM_028615.1.
UniGeneiMm.27857.

Genome annotation databases

EnsembliENSMUST00000097175; ENSMUSP00000110183; ENSMUSG00000072419.
GeneIDi73703.
KEGGimmu:73703.
UCSCiuc007zjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF490346 mRNA. Translation: AAO84504.1.
AY561246 mRNA. Translation: AAS68013.1.
AK010743 mRNA. Translation: BAB27153.1.
AK145760 mRNA. Translation: BAE26632.1.
AK145645 mRNA. Translation: BAE26562.1.
AK163375 mRNA. Translation: BAE37324.1.
AK167211 mRNA. Translation: BAE39338.1.
CCDSiCCDS37350.1.
RefSeqiNP_082891.1. NM_028615.1.
UniGeneiMm.27857.

3D structure databases

ProteinModelPortaliQ9CWH0.
SMRiQ9CWH0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110183.

PTM databases

iPTMnetiQ9CWH0.
PhosphoSitePlusiQ9CWH0.

Proteomic databases

MaxQBiQ9CWH0.
PaxDbiQ9CWH0.
PRIDEiQ9CWH0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097175; ENSMUSP00000110183; ENSMUSG00000072419.
GeneIDi73703.
KEGGimmu:73703.
UCSCiuc007zjn.1. mouse.

Organism-specific databases

CTDi151871.
MGIiMGI:2157523. Dppa2.

Phylogenomic databases

eggNOGiENOG410IJEN. Eukaryota.
ENOG4111ADR. LUCA.
GeneTreeiENSGT00390000004871.
HOGENOMiHOG000060113.
HOVERGENiHBG095578.
InParanoidiQ9CWH0.
OMAiAWARIAM.
OrthoDBiEOG091G0QL3.
PhylomeDBiQ9CWH0.
TreeFamiTF338129.

Miscellaneous databases

PROiQ9CWH0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000072419.
CleanExiMM_DPPA2.
ExpressionAtlasiQ9CWH0. baseline and differential.
GenevisibleiQ9CWH0. MM.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
InterProiIPR025891. Dppa2/4_C_dom.
IPR025892. Dppa2/4_central_dom.
IPR003034. SAP_dom.
[Graphical view]
PfamiPF14047. DCR. 1 hit.
PF14049. Dppa2_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPA2_MOUSE
AccessioniPrimary (citable) accession number: Q9CWH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.