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Q9CWE0 (MFR1L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial fission regulator 1-like
Gene names
Name:Mtfr1l
Synonyms:Fam54b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the MTFR1 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9CWE0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9CWE0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     94-289: VMQRNASVPN...KEEDISRKGN → EIFFFHGLSPSRKEK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Mitochondrial fission regulator 1-like
PRO_0000341567

Amino acid modifications

Modified residue1001Phosphoserine Ref.3 Ref.5 Ref.6
Modified residue2351Phosphoserine Ref.4
Modified residue2581Phosphoserine By similarity
Modified residue2701Phosphoserine By similarity

Natural variations

Alternative sequence94 – 289196VMQRN…SRKGN → EIFFFHGLSPSRKEK in isoform 2.
VSP_034340

Experimental info

Sequence conflict331P → L in BAE27152. Ref.1
Sequence conflict1581S → Y in BAE27152. Ref.1
Sequence conflict1881E → K in BAE27152. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 3CA0B5A8F33699B5

FASTA28931,726
        10         20         30         40         50         60 
MEANVTIPIW QNKPHGAARS VVRRIGTNLP LKPCPRASFE TLPNISDLCL KDVPPVPTLA 

        70         80         90        100        110        120 
DIAWIAADEE ETYARVRSDT RPLRHTWKPS PLIVMQRNAS VPNLRGSEER LLALKKPALP 

       130        140        150        160        170        180 
ALSRTTELQD ELSHLRSQIA KIVAADAASA SLTPDFFSSG SSNVSSPLPC FGSSLHSTTS 

       190        200        210        220        230        240 
FVISDITEET EVEVPELPTV PLLCSASPEC CKPEHKTTCS SSEEDDCISL SKASSFADMM 

       250        260        270        280 
GILKDFHRIK QSQDLSRSLL KEEDPAVLIS EVLRRKFALK EEDISRKGN

« Hide

Isoform 2 [UniParc].

Checksum: 10A9DE8CB4AE3CAB
Show »

FASTA10812,225

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J, DBA/2 and NOD.
Tissue: Heart, Olfactory bulb and Spleen.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Liver.
[3]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, MASS SPECTROMETRY.
Tissue: Brain.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235, MASS SPECTROMETRY.
Tissue: Liver.
[5]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, MASS SPECTROMETRY.
Tissue: Liver.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, MASS SPECTROMETRY.
Tissue: Macrophage.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK010825 mRNA. Translation: BAB27207.1.
AK089141 mRNA. Translation: BAC40763.1.
AK145362 mRNA. Translation: BAE26389.1.
AK146416 mRNA. Translation: BAE27152.1.
AK164004 mRNA. Translation: BAE37584.1.
AK169047 mRNA. Translation: BAE40835.1.
AK171703 mRNA. Translation: BAE42619.1.
BC026808 mRNA. Translation: AAH26808.1.
IPIIPI00109033.
IPI00458939.
RefSeqNP_001243041.1. NM_001256112.1.
NP_084035.1. NM_029759.4.
UniGeneMm.30153.

3D structure databases

ProteinModelPortalQ9CWE0.
ModBaseSearch...

PTM databases

PhosphoSiteQ9CWE0.

Proteomic databases

PaxDbQ9CWE0.
PRIDEQ9CWE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102550; ENSMUSP00000099609; ENSMUSG00000046671.
ENSMUST00000116279; ENSMUSP00000111983; ENSMUSG00000046671.
GeneID76824.
KEGGmmu:76824.
UCSCuc008vfh.1. mouse.

Organism-specific databases

CTD56181.
MGIMGI:1924074. Mtfr1l.

Phylogenomic databases

eggNOGNOG41842.
GeneTreeENSGT00530000063223.
HOGENOMHOG000081765.
HOVERGENHBG103166.
InParanoidQ9CWE0.
OMAKPEHKAT.
OrthoDBEOG4KPTBJ.

Gene expression databases

ArrayExpressQ9CWE0.
BgeeQ9CWE0.
GenevestigatorQ9CWE0.

Family and domain databases

InterProIPR007972. Mtfr1.
[Graphical view]
PANTHERPTHR14215. PTHR14215. 1 hit.
PfamPF05308. Mito_fiss_reg. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio345897.
SOURCESearch...

Entry information

Entry nameMFR1L_MOUSE
AccessionPrimary (citable) accession number: Q9CWE0
Secondary accession number(s): Q3UJK3, Q8BTP7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents